LOCUS       NM_015782               1382 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus small nuclear ribonucleoprotein polypeptide A (Snrpa),
            transcript variant 1, mRNA.
ACCESSION   NM_015782
VERSION     NM_015782.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Subramania,S., Gagne,L.M., Campagne,S., Fort,V., O'Sullivan,J.,
            Mocaer,K., Feldmuller,M., Masson,J.Y., Allain,F.H.T., Hussein,S.M.
            and Huot,M.E.
  TITLE     SAM68 interaction with U1A modulates U1 snRNP recruitment and
            regulates mTor pre-mRNA splicing
  JOURNAL   Nucleic Acids Res 47 (8), 4181-4197 (2019)
   PUBMED   30767021
  REMARK    GeneRIF: SAM68 interaction with U1A modulates U1 snRNP recruitment
            and regulates mTor pre-mRNA splicing.
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Lee,N.C., Lee,Y.M., Chen,P.W., Byrne,B.J. and Hwu,W.L.
  TITLE     Mutation-adapted U1 snRNA corrects a splicing error of the dopa
            decarboxylase gene
  JOURNAL   Hum Mol Genet 25 (23), 5142-5147 (2016)
   PUBMED   27658936
  REMARK    GeneRIF: We found that only the modified U1 snRNA (IVS-AAA) that
            completely matched both the intronic and exonic U1 binding
            sequences of the mutated DDC gene could correct splicing errors of
            either the mutated human DDC minigene or the mouse artificial
            splicing construct in vitro
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Workman,E., Veith,A. and Battle,D.J.
  TITLE     U1A regulates 3' processing of the survival motor neuron mRNA
  JOURNAL   J Biol Chem 289 (6), 3703-3712 (2014)
   PUBMED   24362020
  REMARK    GeneRIF: a new mechanism for regulating SMN levels and provides new
            insight into the roles of U1A in 3' processing of mRNAs.
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Stefan,M., Simmons,R.A., Bertera,S., Trucco,M., Esni,F., Drain,P.
            and Nicholls,R.D.
  TITLE     Global deficits in development, function, and gene expression in
            the endocrine pancreas in a deletion mouse model of Prader-Willi
            syndrome
  JOURNAL   Am J Physiol Endocrinol Metab 300 (5), E909-E922 (2011)
   PUBMED   21343540
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Ma,J., Gunderson,S.I. and Phillips,C.
  TITLE     Non-snRNP U1A levels decrease during mammalian B-cell
            differentiation and release the IgM secretory poly(A) site from
            repression
  JOURNAL   RNA 12 (1), 122-132 (2006)
   PUBMED   16373497
  REMARK    GeneRIF: Endogenous non-snRNP associated U1A inhibits poly(A)
            polymerase activity proportional to U1A recovered, suggesting that
            available U1A level alone is responsible for changes in its
            inhibitory effect at the secretory IgM poly (A) site.
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Davies,S.R., Li,J., Okazaki,K. and Sandell,L.J.
  TITLE     Tissue-restricted expression of the Cdrap/Mia gene within a
            conserved multigenic housekeeping locus
  JOURNAL   Genomics 83 (4), 667-678 (2004)
   PUBMED   15028289
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Bennett,M.M., Baron,M.A. and Craft,J.
  TITLE     Nucleotide sequence analysis of the A protein of the U1 small
            nuclear ribonucleoprotein particle: the murine protein contains a
            5' amino-terminal tag
  JOURNAL   Nucleic Acids Res 21 (18), 4404 (1993)
   PUBMED   8415008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX206945.1, BC096648.1 and AI851424.1.
            
            On Sep 6, 2006 this sequence version replaced NM_015782.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003229.1, AK013886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               CX206945.1         1-321
            322-1358            BC096648.1         176-1212
            1359-1382           AI851424.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.84 cM"
     gene            1..1382
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:53607"
                     /db_xref="MGI:MGI:1855690"
     exon            1..281
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            282..394
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1167
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /note="protein A of the U1 small nuclear RNA; U1 snRNP A"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_056597.3"
                     /db_xref="CCDS:CCDS21014.1"
                     /db_xref="GeneID:53607"
                     /db_xref="MGI:MGI:1855690"
                     /translation="MATIATMPVPETRANHTIYINNLNEKIKKDELKKSLYAIFSQFG
                     QILDILVSRIMKMRGQAFVIFKEVTSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAK
                     MKGTYVERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMPQAPRIMH
                     HMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLT
                     NLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQ
                     NNAMKISFAKK"
     exon            395..567
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            568..744
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            745..918
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1007
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1366
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /note="hexamer: ATTAAA"
     polyA_site      1366
                     /gene="Snrpa"
                     /gene_synonym="C430021M15Rik; Rnu1a-1; Rnu1a1; U1-A; U1A"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgaaa ggcagtctta gaatgcacca gagctctaac catgtcccaa ttggccagaa
       61 gctcgtgccc ttctttgatt ggtccgttcc ctcgcgtcca gggggcggga ccccaagtgt
      121 tcctttggca gacgctgagg ccgggggaga gactctgaac ttaccgagtt tgcccgccgt
      181 gattagctcg cggaagggag aagccgttgc cggggaagat agttgtgtgt ctgtgcagcg
      241 tagctcggcg ggcgttgtcg gcgggagcga cggctcaggt gccgtacctg aacatctcac
      301 accatggcca ccatagccac catgccagtt cccgagaccc gtgccaacca cactatttat
      361 atcaacaatc tcaatgagaa gatcaagaag gatgagctca agaagtccct gtatgccatc
      421 ttctcccagt ttggccagat cctggatatc ctggtgtctc ggatcatgaa gatgaggggc
      481 caggccttcg tcatcttcaa ggaggtcacc agcgccacca atgccctgcg ctccatgcag
      541 ggcttccctt tctacgacaa gcccatgcgc atccagtacg caaagactga ctcggacatc
      601 attgccaaga tgaagggcac ctatgtggag agagatcgca aacgagagaa gaggaagccc
      661 aagagtcagg agacacctgc tgccaaaaag gctgttcagg gtggggcagc tgcgcccgtg
      721 gtgggggctg tccagcccgt accgggcatg ccaccgatgc ctcaggcacc ccgcatcatg
      781 caccatatgc caggacagcc tccctacatg ccgccacctg gcatgatccc gccaccaggc
      841 ctcgctcctg gccagatccc ccctggggcc atgcccccac agcagctcat gcctgggcag
      901 atgccgcctg cccagcctct ctccgagaac ccacccaatc acatcctgtt cctcaccaac
      961 ctgcctgagg agaccaacga gctcatgctc tccatgctct tcaaccagtt ccctggcttc
     1021 aaggaggtgc gtctggtccc tgggcgccat gacatcgcct tcgtggagtt tgacaatgaa
     1081 gtgcaggctg gggcagcacg agatgccctg caaggcttta agatcacaca aaacaatgct
     1141 atgaagatct cttttgccaa gaagtagcgc ctttccctat ggagtacccc agtcccttcc
     1201 ccccctccct tggctcagtc cctgaaggta agtccccctt agggaccttc tcagagccgt
     1261 gtgtgtgtgg ttgccacaca gcattgtacc cagagtctgt ccccagacat tgcacctggc
     1321 gctgttagat tgtgattaaa gtgagttttt gaggtttggt tttttaaaaa aaaaaaaaaa
     1381 aa
//
