LOCUS       NM_177214               6760 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus small nuclear ribonucleoprotein 200 (U5) (Snrnp200),
            mRNA.
ACCESSION   NM_177214
VERSION     NM_177214.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6760)
  AUTHORS   Thomas,J.W. and Green,E.D.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
REFERENCE   3  (bases 1 to 6760)
  AUTHORS   Lauber,J., Fabrizio,P., Teigelkamp,S., Lane,W.S., Hartmann,E. and
            Luhrmann,R.
  TITLE     The HeLa 200 kDa U5 snRNP-specific protein and its homologue in
            Saccharomyces cerevisiae are members of the DEXH-box protein family
            of putative RNA helicases
  JOURNAL   EMBO J 15 (15), 4001-4015 (1996)
   PUBMED   8670905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845368.6.
            
            On Apr 26, 2018 this sequence version replaced NM_177214.4.
            
            Summary: On February 19, 2002, this locus was switched from human
            to mouse. The source accession, Z70200.1, is almost identical to
            the mouse BAC clone AC074224, and it matches the mouse cDNA
            accession BC011390 as well. The human gene is LocusID 23020.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063261.1, SRR1660817.190241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL845368.6         13486-13638
            154-317             AL845368.6         14074-14237
            318-489             AL845368.6         15794-15965
            490-682             AL845368.6         16700-16892
            683-738             AL845368.6         17449-17504
            739-837             AL845368.6         19907-20005
            838-990             AL845368.6         21149-21301
            991-1090            AL845368.6         21454-21553
            1091-1227           AL845368.6         21713-21849
            1228-1311           AL845368.6         22329-22412
            1312-1485           AL845368.6         22492-22665
            1486-1623           AL845368.6         22973-23110
            1624-1779           AL845368.6         23453-23608
            1780-1950           AL845368.6         24129-24299
            1951-2144           AL845368.6         26845-27038
            2145-2268           AL845368.6         27231-27354
            2269-2418           AL845368.6         29681-29830
            2419-2529           AL845368.6         30183-30293
            2530-2661           AL845368.6         31106-31237
            2662-2850           AL845368.6         31395-31583
            2851-3048           AL845368.6         32045-32242
            3049-3201           AL845368.6         32977-33129
            3202-3282           AL845368.6         33245-33325
            3283-3366           AL845368.6         33642-33725
            3367-3473           AL845368.6         34159-34265
            3474-3592           AL845368.6         34586-34704
            3593-3747           AL845368.6         34986-35140
            3748-3937           AL845368.6         35234-35423
            3938-4111           AL845368.6         35614-35787
            4112-4272           AL845368.6         36787-36947
            4273-4500           AL845368.6         37506-37733
            4501-4692           AL845368.6         38001-38192
            4693-4871           AL845368.6         38280-38458
            4872-5023           AL845368.6         38600-38751
            5024-5132           AL845368.6         40064-40172
            5133-5241           AL845368.6         41060-41168
            5242-5431           AL845368.6         41559-41748
            5432-5596           AL845368.6         41840-42004
            5597-5718           AL845368.6         42561-42682
            5719-5862           AL845368.6         42923-43066
            5863-6039           AL845368.6         43159-43335
            6040-6200           AL845368.6         43600-43760
            6201-6282           AL845368.6         43839-43920
            6283-6375           AL845368.6         44979-45071
            6376-6760           AL845368.6         45169-45553
FEATURES             Location/Qualifiers
     source          1..6760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.84 cM"
     gene            1..6760
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /note="small nuclear ribonucleoprotein 200 (U5)"
                     /db_xref="GeneID:320632"
                     /db_xref="MGI:MGI:2444401"
     exon            1..153
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..6519
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /EC_number="3.6.4.13"
                     /note="activating signal cointegrator 1 complex subunit
                     3-like 1; U5 snRNP-specific protein, 200 kDa (DEXH RNA
                     helicase family); BRR2 homolog"
                     /codon_start=1
                     /product="U5 small nuclear ribonucleoprotein 200 kDa
                     helicase"
                     /protein_id="NP_796188.2"
                     /db_xref="CCDS:CCDS16695.1"
                     /db_xref="GeneID:320632"
                     /db_xref="MGI:MGI:2444401"
                     /translation="MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLV
                     GKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDMNKMKGYTLLSEGIDEMVGIIY
                     KPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRREIDLL
                     LGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYG
                     EVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFY
                     DDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLL
                     ASAQSEPEKERIVGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLE
                     TMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
                     KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG
                     KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITV
                     AELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDDR
                     GPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRP
                     VPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRD
                     MCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVE
                     DLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
                     GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAK
                     DAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKY
                     DKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVR
                     EEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSA
                     GRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKK
                     NFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTI
                     TPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPL
                     PPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
                     YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVY
                     ITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILS
                     RRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSL
                     SNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITK
                     HSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLK
                     ETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQY
                     YNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVES
                     HLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDH
                     LSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKV
                     RGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLS
                     RMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDS
                     YLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPN
                     IELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSN
                     SLISIKRLTLQQKAKVKLDFVAPATGGHNYTLYFMSDAYMGCDQEYKFSVDVKEAETD
                     SDSD"
     exon            154..317
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            318..489
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            490..682
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            683..738
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            739..837
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            838..990
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1090
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1227
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1311
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1485
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1623
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1779
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1950
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2144
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2268
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2418
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2529
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2661
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2850
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3048
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3201
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3282
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3366
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3473
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3592
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3747
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3937
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4111
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4272
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4500
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4692
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4871
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..5023
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..5132
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5241
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5242..5431
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5432..5596
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5597..5718
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5862
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..6039
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6040..6200
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6201..6282
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6283..6375
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6376..6760
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6737..6742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /note="hexamer: AATAAA"
     polyA_site      6758
                     /gene="Snrnp200"
                     /gene_synonym="A330064G03Rik; Ascc3l1; HELIC2; U5-200-KD;
                     U5-200KD"
                     /note="major polyA site"
ORIGIN      
        1 gtcccttacg ttcgtcctgc gttgtacctg ttgtgccagg gcggttcgct gaagcggttc
       61 ggagcgtgaa gaagagtgga accctgagtt cccggagcat cagcagccat ggcggatgtg
      121 actgcccgca gtttgcagta cgagtacaag gcgaactcaa atcttgtgct ccaagctgac
      181 cgctctctca ttgaccggac ccgccgggat gaaccgacgg gagaggttct gtccctggtt
      241 gggaagttgg agggaacccg aatgggagat aaggctcaac ggaccaaacc acagatgcag
      301 gaagaaagac gggccaagag gagaaaacgt gatgaggacc ggcatgacat gaacaagatg
      361 aaaggctaca cgctgctgtc tgagggcatt gatgagatgg tgggcatcat ctacaagcct
      421 aagacgaagg agacccgaga gacctacgag gtgctgctca gcttcatcca ggctgcgctg
      481 ggagatcagc ctcgagatat tctttgtgga gcagctgatg aagtcctggc tgtgctgaag
      541 aatgaaaagc ttcgagacaa ggagagaaga cgggagattg acctgctgct gggtcagaca
      601 gatgatacca gataccatgt gctggtaaac ctgggcaaga agatcacaga ctacggtggc
      661 gacaaggaga tacagaatat ggatgacaac attgatgaga cttatggtgt gaacgtgcag
      721 tttgagtctg atgaggagga aggtgatgaa gatgtgtatg gggaagtccg agaagaagct
      781 tctgatgatg acatggaagg ggacgaagct gttgtgcgct gcaccctctc tgctaatctt
      841 gtagcctcag gcgaactgat gagttctaag aagaaggatt tgcaccctcg ggatatcgat
      901 gccttctggc tgcagcgaca gctcagtcgt ttctatgatg atgccattgt gtcacagaag
      961 aaggcagatg aggtgttgga gattttgaag acagcaagtg atgaccgaga atgtgagaac
     1021 caactggttt tgctccttgg tttcaacacg tttgacttca ttaaagtgtt gcggcagcac
     1081 aggatgatga ttttatactg taccttgttg gccagtgctc agagtgaacc tgaaaaggag
     1141 aggatcgtgg gaaagatgga agctgatcca gagctctcca agttcctcta tcagctccat
     1201 gagactgaga aggaggacct gatcagagaa gaaaggtccc ggagagagag agtccgtcag
     1261 tcccgaatgg acacagatct ggaaaccatg gatttggacc agggtggaga ggctctggct
     1321 ccaaggcagg ttctggattt ggaggacctt gtttttaccc aaggaagcca cttcatggcc
     1381 aataagcgct gccagcttcc tgacgggtcc ttccgacgcc agcgtaaagg ctatgaagag
     1441 gtgcatgtgc ctgctttgaa gcccaagccc tttggctcag aagaacaatt gctcccggtg
     1501 gagaagctgc caaagtatgc ccaggcagga tttgagggct tcaaaacgct gaaccggatc
     1561 cagagtaagc tctaccgtgc tgccctggag actgatgaga acctgctgct gtgtgctccc
     1621 actggtgcgg gcaagaccaa cgtggccctg atgtgtatgc tccgagagat agggaaacac
     1681 atcaacatgg acggcacaat caatgtggat gacttcaaga tcatctacat agctcccatg
     1741 cggtccctgg tccaggagat ggtgggcagt tttggaaagc gcctggccac atatggcatc
     1801 actgttgctg agctgactgg ggatcaccag ctatgcaagg aggaaatcag tgccacacag
     1861 attatcgtct gcacccctga gaagtgggac atcatcacac gcaagggcgg ggagcgcacc
     1921 tacacccagc tggtgcgact cattgtcttg gatgagatcc atcttctaca tgatgacaga
     1981 ggtcctgtct tagaagcttt ggtggccagg gccatccgaa acattgagat gacccaagaa
     2041 gatgtccgac tcattggtct cagtgctacc ctccccaact atgaagatgt ggccaccttt
     2101 ctgcgagtcg accctgctaa gggcctcttc tactttgata acagcttccg ccccgtgcct
     2161 ctggaacaaa catatgtggg catcacagag aaaaaagcta tcaaacgttt ccagatcatg
     2221 aatgaaatag tctatgagaa aatcatggaa catgctggaa aaaatcaggt gctcgtgttt
     2281 gtccattctc gaaaagaaac tgggaagaca gcaagggcaa tccgtgacat gtgtctggag
     2341 aaggacactt tgggtctgtt tcttcgcgag ggttctgcct ccactgaagt ccttcgtaca
     2401 gaagcagagc agtgcaagaa cttggagctg aaggatcttt tgccctatgg ctttgctatt
     2461 catcatgcag gcatgactag agttgaccga acacttgtag aagatctttt tgctgacaag
     2521 catattcagg ttttagtttc caccgcaact ctggcgtggg gtgtaaatct tcctgcacat
     2581 acagtcatca ttaaaggtac ccaagtgtac agtccagaga aggggcgttg gacagagctg
     2641 ggagcactgg atatcctgca gatgctgggc cgtgctggac ggccgcagta tgacaccaag
     2701 ggtgaaggca tcctcatcac atcccatggg gagctccagt actacctctc cctcctcaac
     2761 cagcagctgc ctatcgagag ccagatggtc tccaagctgc ctgacatgct caatgcggaa
     2821 attgttctgg gcaatgtcca gaatgcaaag gatgcagtga actggctggg ctatgcctac
     2881 ctatacatcc gaatgctccg gtcccctacc ctctatggca tttctcatga tgacctcaag
     2941 ggagatccct tgctggacca gcgccgactc gatcttgttc acactgctgc cttgatgctg
     3001 gacaagaaca atctggtcaa gtacgacaag aagacaggca acttccaggt gacagaactt
     3061 ggccggatag caagtcacta ctatatcacc aatgatactg tgcagaccta caaccagctg
     3121 ctgaagccta ctctgagtga gattgagctt ttccgagtgt tctccttgtc ctcagagttc
     3181 aagaacatca ctgtaagaga ggaggagaag ctggagctgc agaagttgct ggagagagtg
     3241 cccatccctg taaaggagag cattgaggaa cccagcgcta agatcaacgt gcttctccaa
     3301 gccttcatct cacagctgaa actcgaaggc tttgcgctga tggctgacat ggtgtatgtg
     3361 acccagtcgg ctggccggtt gatgcgtgca atcttcgaaa ttgtcctgaa ccgaggttgg
     3421 gcacagctta cagataagac cctgaatctc tgcaagatga ttgacaagcg catgtggcag
     3481 tccatgtgtc ctcttcgcca gttccgaaaa cttcctgagg aagtagtgaa gaagattgag
     3541 aagaaaaact tcccctttga gcggctgtat gacttgaatc ataatgagat aggtgaactt
     3601 attcgaatgc cgaagatggg gaagaccatc cacaagtatg tccatctttt ccccaagttg
     3661 gagttgtcag tgcacctgca gcctattaca cgctctacgc tgaaagtaga gctgactatc
     3721 acaccagatt tccagtggga tgaaaaggtc catggttcgt cagaggcatt ttggattctg
     3781 gtggaggatg tggacagtga ggtgattctg caccatgaat attttctgct gaaggccaag
     3841 tatgcccagg atgagcacct catcacgttc tttgttccag tctttgaacc actacctcct
     3901 cagtacttca ttcgagtagt gtctgatcgc tggctctctt gtgagacgca gctacctgtc
     3961 tccttccggc atctgatcct accagagaag tacccacctc caaccgaact gttggacctg
     4021 cagccattgc ctgtgtctgc tctgagaaac agtgcttttg agagccttta ccaagataaa
     4081 tttcctttct tcaatcccat ccagactcaa gtatttaata ccgtgtacaa cagtgatgat
     4141 aacgtgtttg tgggggcccc cacgggcagc gggaagacta tctgcgcgga gtttgccatc
     4201 cttcggatgc tgctgcagaa ttctgaggga cgctgtgtct acattacccc tatggaggct
     4261 ctggcagagc aggtatacat ggactggtat gagaagtttc aggacaggct caacaagaag
     4321 gtagtgctgc tgacggggga gaccagcaca gatctgaagc tcctgggcaa aggcaacatc
     4381 atcatcagta cccctgagaa gtgggacatc ctctctcgga ggtggaagca gcgcaagaac
     4441 gtccagaaca ttaacctctt tgtggtggat gaggtccacc ttattggggg cgagaatggg
     4501 cctgtcttgg aagtgatctg ctcccggatg cgctacatct cctcccagat tgagcggccc
     4561 attcgcattg tggcacttag ctcctcactc tccaatgcca aggatgtggc tcactggctg
     4621 ggctgcagtg ccacctccac cttcaacttc catcctaatg tgcgccctgt acctttggaa
     4681 ctgcacatcc agggcttcaa catcagtcac acacagactc gcctgctctc tatggccaag
     4741 cctgtgtacc atgctatcac caaacactca cccaagaagc ctgtcatcgt ttttgtccca
     4801 tctcgtaagc agacccgcct cactgcaata gacatcctca ctacctgtgc agcagacatc
     4861 cagcggcaga ggttcctgca ctgcaccgag aaggacctga tcccttacct ggagaagctc
     4921 agtgacagca cactcaaaga gaccctgtta aatggggtgg gctacctgca tgaaggcctg
     4981 agccccatgg agaggcgcct ggtagagcag ctcttcagct ccggggctat ccaggtggtg
     5041 gtagcttctc ggagtctctg ctggggcatg aatgttgctg ctcatctagt gatcatcatg
     5101 gatactcagt actacaatgg caagatccat gcctatgtgg attaccccat ctatgatgtg
     5161 cttcagatgg tgggccatgc caaccggccc ctgcaggatg atgaggggcg ctgtgtcatc
     5221 atgtgtcagg gctctaaaaa ggattttttc aaaaaatttt tgtatgagcc attgccagta
     5281 gagtctcacc tggaccactg tatgcatgac cacttcaatg ctgagattgt caccaagacc
     5341 attgagaaca agcaggatgc tgtggactac ctcacctgga cctttctgta tcgcagaatg
     5401 acacagaacc ccaattacta caacctgcag gggatatccc atcgtcatct gtctgaccac
     5461 ctgtcagagc tggtggagca gaccctcagt gacctggagc agtccaaatg catcagtatt
     5521 gaggacgaga tggatgtggc ccctctgaac ctgggcatga ttgctgccta ctattacata
     5581 aactacacca ccattgagct cttcagcatg tctctgaatg ctaaaaccaa ggttcgagga
     5641 cttattgaga tcatttccaa tgcagcagag tatgagaaca ttccaatcag gcatcatgaa
     5701 gacaacctcc tgcgccagtt ggctcagaag gtcccccaca agctgaataa ccccaagttc
     5761 aatgatccac atgtgaagac caatctgctg ctgcaggctc acctgtcccg catgcagcta
     5821 agtgctgaac tacagtcaga cacagaggag atccttagta aggcaatccg gctaattcag
     5881 gcctgtgtgg atgtactctc cagcaatggg tggcttagtc ctgctctggc agccatggaa
     5941 ctggcccaga tggtcaccca agccatgtgg tctaaggact cttacctgaa gcagctgcca
     6001 cacttcacct cagagcatat caaacgttgc acagataagg gagtggagag tgtttttgac
     6061 atcatggaga tggaggatga agaacggaat gcattgcttc agttgactga cagccagatt
     6121 gcagatgtgg cccgcttctg taaccgctac ccgaatattg aactgtccta tgaagtggtg
     6181 gataaagaca gcatccgcag tggcggacca gttgtggtgc tagtgcaact ggagcgagag
     6241 gaggaagtca cgggcccagt tattgcacct ctcttcccac agaaacgtga agagggctgg
     6301 tgggttgtga ttggagacgc caagtccaac agcctcatct ccatcaagag gctgaccctg
     6361 cagcagaaag ccaaggtgaa gctagacttt gtggccccag ccacaggtgg ccacaactat
     6421 accctgtact tcatgagtga cgcatacatg ggctgtgacc aggagtataa gttcagtgtg
     6481 gatgtgaaag aagctgagac agacagtgat tcagattgag tctgaggcac tgaacctgaa
     6541 aacaggaatg tggactaggt ctgtcaggct gaggtctggc cattcaggcc gctgctgtcc
     6601 ccagtccaca tccagttact gtcccacttt ggaccttagt tcaaggtctg ggtcttgtat
     6661 tttcaagtgt catgtcaagc atgaactgta caatatttgg aggcatggtt ttctagttcc
     6721 ttgagtcaga cattctaata aataatttga aaaaactata
//
