LOCUS       NM_133741               4860 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SNF related kinase (Snrk), transcript variant 1, mRNA.
ACCESSION   NM_133741 XM_003946309 XM_003946310 XM_003946311 XM_003946312
            XM_003946313 XM_003946314 XM_003946315
VERSION     NM_133741.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Stanczyk,P.J., Tatekoshi,Y., Shapiro,J.S., Nayudu,K., Chen,Y.,
            Zilber,Z., Schipma,M., De Jesus,A., Mahmoodzadeh,A., Akrami,A.,
            Chang,H.C. and Ardehali,H.
  TITLE     DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy
            Are Mediated by SNRK Through Actin Depolymerization
  JOURNAL   Circulation 148 (20), 1582-1592 (2023)
   PUBMED   37721051
  REMARK    GeneRIF: DNA Damage and Nuclear Morphological Changes in Cardiac
            Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
REFERENCE   2  (bases 1 to 4860)
  AUTHORS   Thirugnanam,K., Cossette,S.M., Lu,Q., Chowdhury,S.R., Harmann,L.M.,
            Gupta,A., Spearman,A.D., Sonin,D.L., Bordas,M., Kumar,S.N.,
            Pan,A.Y., Simpson,P.M., Strande,J.L., Bishop,E., Zou,M.H. and
            Ramchandran,R.
  TITLE     Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart
  JOURNAL   J Am Heart Assoc 8 (22), e012792 (2019)
   PUBMED   31718444
  REMARK    GeneRIF: Cardiomyocyte-Specific Snrk Prevents Inflammation in the
            Heart.
REFERENCE   3  (bases 1 to 4860)
  AUTHORS   Li,J., An,R., Lai,S., Li,L., Liu,S. and Xu,H.
  TITLE     Dysregulation of PP2A-Akt interaction contributes to Sucrose
            non-fermenting related kinase (SNRK) deficiency induced insulin
            resistance in adipose tissue
  JOURNAL   Mol Metab 28, 26-35 (2019)
   PUBMED   31420304
  REMARK    GeneRIF: The SNRK regulates insulin signaling through controlling
            PPP2R5D phosphorylation, which subsequently impacts PP2A activity
            and then AKT phosphorylation in both WAT and BAT. SNRK may
            represent a promising potential target for treating insulin
            resistance-related metabolic disorders.
REFERENCE   4  (bases 1 to 4860)
  AUTHORS   Lu,Q., Ma,Z., Ding,Y., Bedarida,T., Chen,L., Xie,Z., Song,P. and
            Zou,M.H.
  TITLE     Circulating miR-103a-3p contributes to angiotensin II-induced renal
            inflammation and fibrosis via a SNRK/NF-kappaB/p65 regulatory axis
  JOURNAL   Nat Commun 10 (1), 2145 (2019)
   PUBMED   31086184
  REMARK    Erratum:[Nat Commun. 2019 Aug 6;10(1):3628. doi:
            10.1038/s41467-019-11515-z.. PMID: 31388007]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4860)
  AUTHORS   Li,J., Feng,B., Nie,Y., Jiao,P., Lin,X., Huang,M., An,R., He,Q.,
            Zhou,H.E., Salomon,A., Sigrist,K.S., Wu,Z., Liu,S. and Xu,H.
  TITLE     Sucrose Nonfermenting-Related Kinase Regulates Both Adipose
            Inflammation and Energy Homeostasis in Mice and Humans
  JOURNAL   Diabetes 67 (3), 400-411 (2018)
   PUBMED   29298809
REFERENCE   6  (bases 1 to 4860)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4860)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   8  (bases 1 to 4860)
  AUTHORS   Oki,T., Yamazaki,K., Kuromitsu,J., Okada,M. and Tanaka,I.
  TITLE     cDNA cloning and mapping of a novel subtype of
            glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human
            and mouse
  JOURNAL   Genomics 57 (2), 227-234 (1999)
   PUBMED   10198162
REFERENCE   9  (bases 1 to 4860)
  AUTHORS   Mishra,L., Cai,T., Yu,P., Monga,S.P. and Mishra,B.
  TITLE     Elf3 encodes a novel 200-kD beta-spectrin: role in liver
            development
  JOURNAL   Oncogene 18 (2), 353-364 (1999)
   PUBMED   9927192
REFERENCE   10 (bases 1 to 4860)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ079755.1, BC150742.1, AC120394.10 and AI842097.1.
            
            On or before Oct 10, 2012 this sequence version replaced
            XM_003946309.1, XM_003946310.1, XM_003946311.1, XM_003946312.1,
            XM_003946313.1, XM_003946314.1, XM_003946315.1, NM_133741.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020189.1, SRR9219379.50844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               CJ079755.1         2-193
            193-2033            BC150742.1         14-1854
            2034-4842           AC120394.10        183578-186386
            4843-4860           AI842097.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.89 cM"
     gene            1..4860
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="SNF related kinase"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
     exon            1..142
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            143..192
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            193..888
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2546
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /EC_number="2.7.11.1"
                     /note="SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase"
                     /protein_id="NP_598502.2"
                     /db_xref="CCDS:CCDS23644.1"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAGDNVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASMKPAASGRKCLFRVEEDEE
                     EDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHR
                     RDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSSRRC
                     AGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALFSSVKVQE
                     KSTWKMCISAPGPSPSADLDPVRTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASS
                     PASCCHVI"
     exon            889..1030
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1243
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1378
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..4845
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4813..4818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="hexamer: AATAAA"
     polyA_site      4845
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccgcg cctgcgcagc gcggccgcac ccccggccgc ccgctcggta ttatgattag
       61 ccctgggtgc ggggttccgg cggccgggag ggagttgtcg acgccgcggc cgctgcggac
      121 ggatgcccgc ctgccggctg aggagaaaca acaaatactg gtaacagagt gatttggtat
      181 gctgtttgca aggtatccat tatgatgttg acaatgaagg ccttatttcc aacagatata
      241 ctcatatgag aagacccact tcaagcactt ttaagtatct ttctgtttgt tgaaccagca
      301 tggcagggtt caagcgagga tatgatggga aaattgctgg attatatgat ctggataaaa
      361 ccttgggtcg aggtcatttt gcagtggtca aacttgccag gcatgtcttc acaggtgaga
      421 aggtggcagt gaaagtcatt gacaagacga agctggacac tctagccact ggtcatctct
      481 tccaggaagt gaggtgcatg aaactagtgc agcaccccaa cattgtgcgt ctctatgaag
      541 tcatagacac ccagaccaaa ctttatctca ttctagaact tggagatgga ggagatatgt
      601 ttgattatat aatgaagcac gaggagggtc ttaatgaaga cttggccaag aagtactttg
      661 ctcagatagt tcatgctata tcttattgcc ataaactcca tgtggtccac agagacttga
      721 aaccagagaa tgtagtcttt tttgaaaaac aaggtcttgt gaagttgaca gactttggct
      781 tcagcaacaa atttcagcct ggaaagaaac tcaccacgag ctgcgggtct cttgcatact
      841 ctgctccaga aatcctgctt ggcgatgagt acgatgcccc tgcagtagac atatggagcc
      901 tgggcgtgat ccttttcatg ctggtgtgtg ggcagccacc cttccaagaa gccaacgaca
      961 gcgagacact gaccatgatc atggactgca agtacacggt gccaccccgc gtgtctgcag
     1021 ggtgcaggga cctgatcaca cgaatgctac agagagaccc caaaaggaga gcctctctgg
     1081 aagagattga aagccaccct tggctccagg gagtggaccc atcaccagcc accaagtata
     1141 acattcccct cgtgtcctac aagaacctct ccgaggaaga gcacaacagc atcatccagc
     1201 gcatggtgct cggggacatc gcggaccgag acgccatcgt agaagccctg gaaaccaaca
     1261 ggtacaacca cattaccgcc acttactttt tacttgctga aaggatcctg agagaaaagc
     1321 aagagaaaga aatacagacc aggtctgcta gccccagcaa catcaaggcc cagtttaggc
     1381 agtcatggcc aaccaaaatt gatgtacccc aagaccttga agatgatctc actgccaccc
     1441 ctctgtcaca tgccacagtc ccgcagtctc ctgctagggc tggtgacaat gtcctcaatg
     1501 gccacaggag caaaggcctg tgtgacccag ccaagaaaga tgagctcccg gagctggctg
     1561 ggccggcact gtccactgtt ccacctgcaa gcatgaagcc cgcagccagt gggcgcaagt
     1621 gtctcttcag ggtggaagaa gatgaggagg aggatgagga ggacaagaag cctgtgtccc
     1681 tgtccacgca ggtggtgctg cgccggaagc catcggtcac caatcgcctg acgtctcgca
     1741 agagtgcccc agtgctcaac cagatcttcg aggagggcga gtcagacgac gagtttgaca
     1801 tggacgagaa cctgccgccc aagctgagcc ggctgaagat gaacattgcc tcaccaggca
     1861 cagtgcacaa gcgctaccac cgcaggaaaa gccagggccg gggctctagc tgcagcagct
     1921 ctgagaccag cgatgacgac tccgagagcc ggcggaggct ggacaaggac agcggctttg
     1981 cttactcgtg gcaccggcgt gacagcagtg aggggccacc aggcagcgag ggcgatggtg
     2041 gcggccagag caagcctagc agcggtggcg gtgtggacaa ggccagcccg ggtgagcagg
     2101 gcacgggtgg tggcagccag ggaggctctg gtgggacccc gtcgggtaca gcagggtcct
     2161 caaggcgctg tgcaggccct gactcatcct caccctcccc cgcctcagcc tctgccgctc
     2221 cacgtggtgc agagcttgtg cagagcctca aactcgtgag cctgtgccta ggctcacagc
     2281 tgcatggcgc caagtacatt ctggacccgc agaaggcctt gttctccagc gtgaaggtgc
     2341 aggagaagtc cacgtggaag atgtgcatca gcgccccagg ccccagcccc tctgctgacc
     2401 ttgacccggt gaggaccaag aagctgagga acaacgcgct ccagctacct ctgtgcgaaa
     2461 agaccatctc cgtgaacatc cagcgcagcc gcaaggaagg gctgctctgc gcctccagcc
     2521 ccgccagctg ctgccatgtc atctgacctg taaagcgcgc tcacttcatc tgttctgacg
     2581 tgacaatgca tggtctttgt gcatgctgct acacgctact tttcttttcc agccgaaaag
     2641 tctactgtgt gattttacat tcatgatttt cagtgtggat gaccaggatg aaattgtgtt
     2701 atctggaacc caacgtaaat ggagcgctta gaaatccatg ttctgcactt aacctggagg
     2761 gaaaatgctt tcgtttcctt gtgaaaagcc caaattcctg tcttgacctc cggtgatagg
     2821 gaaactccat gctctgaggc acactggtgc ccgagacaga accaaagcaa taacgtggtg
     2881 atgcccacag gcctgggagg agcaaccccc gctgccagcc acccagggcc tgtgcaccga
     2941 gaaccttaga gccacggttt gagcgcccac acctgtttgt cttaaccaat agtgtgaaag
     3001 cagttggggc tcttatcttt tcactgacag agattgtctt gtttgtgtta ggtgaggtca
     3061 gctccttagc tttgagaggc agcttaccca tagaattacc caggagacaa tcttctgtga
     3121 ggcaatgagg tgaactcaag tcttaactct acttagagtg tgtatgtctg tctgacagaa
     3181 caaaaattaa aaaaaaaaaa aaaaaaaaaa aaaaagaggc tctgtgtaag tttcccctgc
     3241 aggacacaag gcagggtttc cttcaaacct gtgtggagag gagaagcgga gggcctgctg
     3301 cagtagccac agtgcacaca ggggcaggca gcaaagtcag cactctgacg aggaggcagg
     3361 acatcctgag gtggtggttc aggagcttgg tggtgaggtg gcctcaggtt tctcccattt
     3421 catggcagca tttggctcag ctgtgaagag cggctggtaa gaaactgctc aggaaagggt
     3481 agtgcttgga gccgtcagtg gcacactgct gccttcctgc cacgtgctga gcgcggagcg
     3541 ctagcttgcc ctctcccgca ccgacgactc cggactgata gctatctcct gaggcaggcc
     3601 tcctccctga tcttgggaag cccagatgct gggttttcac acggtgccca agggattgaa
     3661 agcagtgttt aagcggcctg tggggtaggt gcggctggcc cagggtcctt tcctcactct
     3721 tcagctgctg ccctgttctg agggacaaca gtgcagctga gcatgtgtct cagagcgggc
     3781 agggcacagg ccaccacttc cttcagtgct cagtgactgc tgctttaggt tagtgtatat
     3841 tactcagaac ttcacagtgt aacctgactt tactaagtaa aatgatactt aagctacttc
     3901 ctagagctag ctaactgctt gtgctttaag ctgcagtccc attcagtgtg acattcacat
     3961 agttgagagc tgtgagggga gacgtgggtg aagccataga gcacatttgc ttgaaattct
     4021 taagcaggga tcttccaagg gccagaaacc agcgtggttc tcagagacgg agccacgtct
     4081 gtgtgagcca ggagagatgt ctataggggc attgcaataa actgtcgcag ctgtttccca
     4141 agtaatgtac atactcttct gtggtcacgg ccagcctctg agcggcgcct ctgcactcac
     4201 ccgtctgcgt ttggtctcca gtggttttct attcaggtgt atatacggtg ctcactttag
     4261 atcagcagtg tcggccattt atgctgcaga gctgtgtcat agccttatta gttgtgtgtg
     4321 gttggtgacc ctctgggtac acaatgtctg ttgagtgctg tcttacccat ttgttgacaa
     4381 gtggatgtct gtgcatgtgt tgtgtgtcac ggggtgtcgt cacagtgtca cgggtgtcgt
     4441 cacagaggga aggagcagaa ccaccacacc catagtggac caaactacgt ccttgctgta
     4501 gccagggact cgtcccctag ccgagttaca gtagtgtata attaaatatt gtgggaaagt
     4561 tagtcttgta tttttctgtg tgtatatata tataattatg tacttctgga attctatctg
     4621 tatttaaaga tgtgacaatc ttgacaccaa ttttaatagt catgagcctg aacaaagatg
     4681 tcctagagcc agagttggta tgtgctgaga acacaaactt gtcagctaat tggtcagatg
     4741 cctctagttc tgaccagtct ttttccttgt gtgaacattg acaggtatgt gacagatggg
     4801 aaataatcca ataataaagt gacatactga tgttcagcaa tagaaaaaaa aaaaaaaaaa
//
