LOCUS       NM_001357776            4697 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA.
ACCESSION   NM_001357776 XM_006512003
VERSION     NM_001357776.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Stanczyk,P.J., Tatekoshi,Y., Shapiro,J.S., Nayudu,K., Chen,Y.,
            Zilber,Z., Schipma,M., De Jesus,A., Mahmoodzadeh,A., Akrami,A.,
            Chang,H.C. and Ardehali,H.
  TITLE     DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy
            Are Mediated by SNRK Through Actin Depolymerization
  JOURNAL   Circulation 148 (20), 1582-1592 (2023)
   PUBMED   37721051
  REMARK    GeneRIF: DNA Damage and Nuclear Morphological Changes in Cardiac
            Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Thirugnanam,K., Cossette,S.M., Lu,Q., Chowdhury,S.R., Harmann,L.M.,
            Gupta,A., Spearman,A.D., Sonin,D.L., Bordas,M., Kumar,S.N.,
            Pan,A.Y., Simpson,P.M., Strande,J.L., Bishop,E., Zou,M.H. and
            Ramchandran,R.
  TITLE     Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart
  JOURNAL   J Am Heart Assoc 8 (22), e012792 (2019)
   PUBMED   31718444
  REMARK    GeneRIF: Cardiomyocyte-Specific Snrk Prevents Inflammation in the
            Heart.
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Li,J., An,R., Lai,S., Li,L., Liu,S. and Xu,H.
  TITLE     Dysregulation of PP2A-Akt interaction contributes to Sucrose
            non-fermenting related kinase (SNRK) deficiency induced insulin
            resistance in adipose tissue
  JOURNAL   Mol Metab 28, 26-35 (2019)
   PUBMED   31420304
  REMARK    GeneRIF: The SNRK regulates insulin signaling through controlling
            PPP2R5D phosphorylation, which subsequently impacts PP2A activity
            and then AKT phosphorylation in both WAT and BAT. SNRK may
            represent a promising potential target for treating insulin
            resistance-related metabolic disorders.
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Lu,Q., Ma,Z., Ding,Y., Bedarida,T., Chen,L., Xie,Z., Song,P. and
            Zou,M.H.
  TITLE     Circulating miR-103a-3p contributes to angiotensin II-induced renal
            inflammation and fibrosis via a SNRK/NF-kappaB/p65 regulatory axis
  JOURNAL   Nat Commun 10 (1), 2145 (2019)
   PUBMED   31086184
  REMARK    Erratum:[Nat Commun. 2019 Aug 6;10(1):3628. doi:
            10.1038/s41467-019-11515-z.. PMID: 31388007]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Li,J., Feng,B., Nie,Y., Jiao,P., Lin,X., Huang,M., An,R., He,Q.,
            Zhou,H.E., Salomon,A., Sigrist,K.S., Wu,Z., Liu,S. and Xu,H.
  TITLE     Sucrose Nonfermenting-Related Kinase Regulates Both Adipose
            Inflammation and Energy Homeostasis in Mice and Humans
  JOURNAL   Diabetes 67 (3), 400-411 (2018)
   PUBMED   29298809
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Oki,T., Yamazaki,K., Kuromitsu,J., Okada,M. and Tanaka,I.
  TITLE     cDNA cloning and mapping of a novel subtype of
            glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human
            and mouse
  JOURNAL   Genomics 57 (2), 227-234 (1999)
   PUBMED   10198162
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Mishra,L., Cai,T., Yu,P., Monga,S.P. and Mishra,B.
  TITLE     Elf3 encodes a novel 200-kD beta-spectrin: role in liver
            development
  JOURNAL   Oncogene 18 (2), 353-364 (1999)
   PUBMED   9927192
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120394.10.
            
            On Nov 4, 2017 this sequence version replaced XM_006512003.3.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 3. All five variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.219141.1,
                                           SRR1660817.183117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC120394.10        134146-134189
            45-740              AC120394.10        153593-154288
            741-882             AC120394.10        173843-173984
            883-1095            AC120394.10        177010-177222
            1096-1230           AC120394.10        180604-180738
            1231-4697           AC120394.10        182923-186389
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.89 cM"
     gene            1..4697
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="SNF related kinase"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
     exon            1..44
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            45..740
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2398
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /EC_number="2.7.11.1"
                     /note="SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase"
                     /protein_id="NP_001344705.1"
                     /db_xref="CCDS:CCDS23644.1"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAGDNVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASMKPAASGRKCLFRVEEDEE
                     EDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHR
                     RDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSSRRC
                     AGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALFSSVKVQE
                     KSTWKMCISAPGPSPSADLDPVRTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASS
                     PASCCHVI"
     exon            741..882
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1095
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1230
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..4697
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4665..4670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="major polyA site"
ORIGIN      
        1 cggccgcctt agcggggctg ggctggcgcc gccgcaggcg gaaagtatcc attatgatgt
       61 tgacaatgaa ggccttattt ccaacagata tactcatatg agaagaccca cttcaagcac
      121 ttttaagtat ctttctgttt gttgaaccag catggcaggg ttcaagcgag gatatgatgg
      181 gaaaattgct ggattatatg atctggataa aaccttgggt cgaggtcatt ttgcagtggt
      241 caaacttgcc aggcatgtct tcacaggtga gaaggtggca gtgaaagtca ttgacaagac
      301 gaagctggac actctagcca ctggtcatct cttccaggaa gtgaggtgca tgaaactagt
      361 gcagcacccc aacattgtgc gtctctatga agtcatagac acccagacca aactttatct
      421 cattctagaa cttggagatg gaggagatat gtttgattat ataatgaagc acgaggaggg
      481 tcttaatgaa gacttggcca agaagtactt tgctcagata gttcatgcta tatcttattg
      541 ccataaactc catgtggtcc acagagactt gaaaccagag aatgtagtct tttttgaaaa
      601 acaaggtctt gtgaagttga cagactttgg cttcagcaac aaatttcagc ctggaaagaa
      661 actcaccacg agctgcgggt ctcttgcata ctctgctcca gaaatcctgc ttggcgatga
      721 gtacgatgcc cctgcagtag acatatggag cctgggcgtg atccttttca tgctggtgtg
      781 tgggcagcca cccttccaag aagccaacga cagcgagaca ctgaccatga tcatggactg
      841 caagtacacg gtgccacccc gcgtgtctgc agggtgcagg gacctgatca cacgaatgct
      901 acagagagac cccaaaagga gagcctctct ggaagagatt gaaagccacc cttggctcca
      961 gggagtggac ccatcaccag ccaccaagta taacattccc ctcgtgtcct acaagaacct
     1021 ctccgaggaa gagcacaaca gcatcatcca gcgcatggtg ctcggggaca tcgcggaccg
     1081 agacgccatc gtagaagccc tggaaaccaa caggtacaac cacattaccg ccacttactt
     1141 tttacttgct gaaaggatcc tgagagaaaa gcaagagaaa gaaatacaga ccaggtctgc
     1201 tagccccagc aacatcaagg cccagtttag gcagtcatgg ccaaccaaaa ttgatgtacc
     1261 ccaagacctt gaagatgatc tcactgccac ccctctgtca catgccacag tcccgcagtc
     1321 tcctgctagg gctggtgaca atgtcctcaa tggccacagg agcaaaggcc tgtgtgaccc
     1381 agccaagaaa gatgagctcc cggagctggc tgggccggca ctgtccactg ttccacctgc
     1441 aagcatgaag cccgcagcca gtgggcgcaa gtgtctcttc agggtggaag aagatgagga
     1501 ggaggatgag gaggacaaga agcctgtgtc cctgtccacg caggtggtgc tgcgccggaa
     1561 gccatcggtc accaatcgcc tgacgtctcg caagagtgcc ccagtgctca accagatctt
     1621 cgaggagggc gagtcagacg acgagtttga catggacgag aacctgccgc ccaagctgag
     1681 ccggctgaag atgaacattg cctcaccagg cacagtgcac aagcgctacc accgcaggaa
     1741 aagccagggc cggggctcta gctgcagcag ctctgagacc agcgatgacg actccgagag
     1801 ccggcggagg ctggacaagg acagcggctt tgcttactcg tggcaccggc gtgacagcag
     1861 tgaggggcca ccaggcagcg agggcgatgg tggcggccag agcaagccta gcagcggtgg
     1921 cggtgtggac aaggccagcc cgggtgagca gggcacgggt ggtggcagcc agggaggctc
     1981 tggtgggacc ccgtcgggta cagcagggtc ctcaaggcgc tgtgcaggcc ctgactcatc
     2041 ctcaccctcc cccgcctcag cctctgccgc tccacgtggt gcagagcttg tgcagagcct
     2101 caaactcgtg agcctgtgcc taggctcaca gctgcatggc gccaagtaca ttctggaccc
     2161 gcagaaggcc ttgttctcca gcgtgaaggt gcaggagaag tccacgtgga agatgtgcat
     2221 cagcgcccca ggccccagcc cctctgctga ccttgacccg gtgaggacca agaagctgag
     2281 gaacaacgcg ctccagctac ctctgtgcga aaagaccatc tccgtgaaca tccagcgcag
     2341 ccgcaaggaa gggctgctct gcgcctccag ccccgccagc tgctgccatg tcatctgacc
     2401 tgtaaagcgc gctcacttca tctgttctga cgtgacaatg catggtcttt gtgcatgctg
     2461 ctacacgcta cttttctttt ccagccgaaa agtctactgt gtgattttac attcatgatt
     2521 ttcagtgtgg atgaccagga tgaaattgtg ttatctggaa cccaacgtaa atggagcgct
     2581 tagaaatcca tgttctgcac ttaacctgga gggaaaatgc tttcgtttcc ttgtgaaaag
     2641 cccaaattcc tgtcttgacc tccggtgata gggaaactcc atgctctgag gcacactggt
     2701 gcccgagaca gaaccaaagc aataacgtgg tgatgcccac aggcctggga ggagcaaccc
     2761 ccgctgccag ccacccaggg cctgtgcacc gagaacctta gagccacggt ttgagcgccc
     2821 acacctgttt gtcttaacca atagtgtgaa agcagttggg gctcttatct tttcactgac
     2881 agagattgtc ttgtttgtgt taggtgaggt cagctcctta gctttgagag gcagcttacc
     2941 catagaatta cccaggagac aatcttctgt gaggcaatga ggtgaactca agtcttaact
     3001 ctacttagag tgtgtatgtc tgtctgacag aacaaaaatt aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaagag gctctgtgta agtttcccct gcaggacaca aggcagggtt tccttcaaac
     3121 ctgtgtggag aggagaagcg gagggcctgc tgcagtagcc acagtgcaca caggggcagg
     3181 cagcaaagtc agcactctga cgaggaggca ggacatcctg aggtggtggt tcaggagctt
     3241 ggtggtgagg tggcctcagg tttctcccat ttcatggcag catttggctc agctgtgaag
     3301 agcggctggt aagaaactgc tcaggaaagg gtagtgcttg gagccgtcag tggcacactg
     3361 ctgccttcct gccacgtgct gagcgcggag cgctagcttg ccctctcccg caccgacgac
     3421 tccggactga tagctatctc ctgaggcagg cctcctccct gatcttggga agcccagatg
     3481 ctgggttttc acacggtgcc caagggattg aaagcagtgt ttaagcggcc tgtggggtag
     3541 gtgcggctgg cccagggtcc tttcctcact cttcagctgc tgccctgttc tgagggacaa
     3601 cagtgcagct gagcatgtgt ctcagagcgg gcagggcaca ggccaccact tccttcagtg
     3661 ctcagtgact gctgctttag gttagtgtat attactcaga acttcacagt gtaacctgac
     3721 tttactaagt aaaatgatac ttaagctact tcctagagct agctaactgc ttgtgcttta
     3781 agctgcagtc ccattcagtg tgacattcac atagttgaga gctgtgaggg gagacgtggg
     3841 tgaagccata gagcacattt gcttgaaatt cttaagcagg gatcttccaa gggccagaaa
     3901 ccagcgtggt tctcagagac ggagccacgt ctgtgtgagc caggagagat gtctataggg
     3961 gcattgcaat aaactgtcgc agctgtttcc caagtaatgt acatactctt ctgtggtcac
     4021 ggccagcctc tgagcggcgc ctctgcactc acccgtctgc gtttggtctc cagtggtttt
     4081 ctattcaggt gtatatacgg tgctcacttt agatcagcag tgtcggccat ttatgctgca
     4141 gagctgtgtc atagccttat tagttgtgtg tggttggtga ccctctgggt acacaatgtc
     4201 tgttgagtgc tgtcttaccc atttgttgac aagtggatgt ctgtgcatgt gttgtgtgtc
     4261 acggggtgtc gtcacagtgt cacgggtgtc gtcacagagg gaaggagcag aaccaccaca
     4321 cccatagtgg accaaactac gtccttgctg tagccaggga ctcgtcccct agccgagtta
     4381 cagtagtgta taattaaata ttgtgggaaa gttagtcttg tatttttctg tgtgtatata
     4441 tatataatta tgtacttctg gaattctatc tgtatttaaa gatgtgacaa tcttgacacc
     4501 aattttaata gtcatgagcc tgaacaaaga tgtcctagag ccagagttgg tatgtgctga
     4561 gaacacaaac ttgtcagcta attggtcaga tgcctctagt tctgaccagt ctttttcctt
     4621 gtgtgaacat tgacaggtat gtgacagatg ggaaataatc caataataaa gtgacatact
     4681 gatgttcagc aatagaa
//
