LOCUS       NM_001357775            4968 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SNF related kinase (Snrk), transcript variant 4, mRNA.
ACCESSION   NM_001357775 XM_006511998
VERSION     NM_001357775.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Stanczyk,P.J., Tatekoshi,Y., Shapiro,J.S., Nayudu,K., Chen,Y.,
            Zilber,Z., Schipma,M., De Jesus,A., Mahmoodzadeh,A., Akrami,A.,
            Chang,H.C. and Ardehali,H.
  TITLE     DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy
            Are Mediated by SNRK Through Actin Depolymerization
  JOURNAL   Circulation 148 (20), 1582-1592 (2023)
   PUBMED   37721051
  REMARK    GeneRIF: DNA Damage and Nuclear Morphological Changes in Cardiac
            Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
REFERENCE   2  (bases 1 to 4968)
  AUTHORS   Thirugnanam,K., Cossette,S.M., Lu,Q., Chowdhury,S.R., Harmann,L.M.,
            Gupta,A., Spearman,A.D., Sonin,D.L., Bordas,M., Kumar,S.N.,
            Pan,A.Y., Simpson,P.M., Strande,J.L., Bishop,E., Zou,M.H. and
            Ramchandran,R.
  TITLE     Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart
  JOURNAL   J Am Heart Assoc 8 (22), e012792 (2019)
   PUBMED   31718444
  REMARK    GeneRIF: Cardiomyocyte-Specific Snrk Prevents Inflammation in the
            Heart.
REFERENCE   3  (bases 1 to 4968)
  AUTHORS   Li,J., An,R., Lai,S., Li,L., Liu,S. and Xu,H.
  TITLE     Dysregulation of PP2A-Akt interaction contributes to Sucrose
            non-fermenting related kinase (SNRK) deficiency induced insulin
            resistance in adipose tissue
  JOURNAL   Mol Metab 28, 26-35 (2019)
   PUBMED   31420304
  REMARK    GeneRIF: The SNRK regulates insulin signaling through controlling
            PPP2R5D phosphorylation, which subsequently impacts PP2A activity
            and then AKT phosphorylation in both WAT and BAT. SNRK may
            represent a promising potential target for treating insulin
            resistance-related metabolic disorders.
REFERENCE   4  (bases 1 to 4968)
  AUTHORS   Lu,Q., Ma,Z., Ding,Y., Bedarida,T., Chen,L., Xie,Z., Song,P. and
            Zou,M.H.
  TITLE     Circulating miR-103a-3p contributes to angiotensin II-induced renal
            inflammation and fibrosis via a SNRK/NF-kappaB/p65 regulatory axis
  JOURNAL   Nat Commun 10 (1), 2145 (2019)
   PUBMED   31086184
  REMARK    Erratum:[Nat Commun. 2019 Aug 6;10(1):3628. doi:
            10.1038/s41467-019-11515-z.. PMID: 31388007]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4968)
  AUTHORS   Li,J., Feng,B., Nie,Y., Jiao,P., Lin,X., Huang,M., An,R., He,Q.,
            Zhou,H.E., Salomon,A., Sigrist,K.S., Wu,Z., Liu,S. and Xu,H.
  TITLE     Sucrose Nonfermenting-Related Kinase Regulates Both Adipose
            Inflammation and Energy Homeostasis in Mice and Humans
  JOURNAL   Diabetes 67 (3), 400-411 (2018)
   PUBMED   29298809
REFERENCE   6  (bases 1 to 4968)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4968)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   8  (bases 1 to 4968)
  AUTHORS   Oki,T., Yamazaki,K., Kuromitsu,J., Okada,M. and Tanaka,I.
  TITLE     cDNA cloning and mapping of a novel subtype of
            glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human
            and mouse
  JOURNAL   Genomics 57 (2), 227-234 (1999)
   PUBMED   10198162
REFERENCE   9  (bases 1 to 4968)
  AUTHORS   Mishra,L., Cai,T., Yu,P., Monga,S.P. and Mishra,B.
  TITLE     Elf3 encodes a novel 200-kD beta-spectrin: role in liver
            development
  JOURNAL   Oncogene 18 (2), 353-364 (1999)
   PUBMED   9927192
REFERENCE   10 (bases 1 to 4968)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120394.10.
            
            On Nov 4, 2017 this sequence version replaced XM_006511998.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 3. All five variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.186988.1,
                                           SRR9219383.100391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC120394.10        133953-134094
            143-192             AC120394.10        148580-148629
            193-315             AC120394.10        149315-149437
            316-1011            AC120394.10        153593-154288
            1012-1153           AC120394.10        173843-173984
            1154-1366           AC120394.10        177010-177222
            1367-1501           AC120394.10        180604-180738
            1502-4968           AC120394.10        182923-186389
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.89 cM"
     gene            1..4968
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="SNF related kinase"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
     exon            1..142
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            143..192
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            193..315
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1011
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..2669
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /EC_number="2.7.11.1"
                     /note="SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase"
                     /protein_id="NP_001344704.1"
                     /db_xref="CCDS:CCDS23644.1"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAGDNVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASMKPAASGRKCLFRVEEDEE
                     EDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHR
                     RDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSSRRC
                     AGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALFSSVKVQE
                     KSTWKMCISAPGPSPSADLDPVRTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASS
                     PASCCHVI"
     exon            1012..1153
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1366
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1501
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..4968
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="hexamer: AATAAA"
     polyA_site      4968
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccgcg cctgcgcagc gcggccgcac ccccggccgc ccgctcggta ttatgattag
       61 ccctgggtgc ggggttccgg cggccgggag ggagttgtcg acgccgcggc cgctgcggac
      121 ggatgcccgc ctgccggctg aggagaaaca acaaatactg gtaacagagt gatttggtat
      181 gctgtttgca agaatgcatc ttaacagaaa tacagaggaa aagaataaag acgagaaaat
      241 ggcgtaggca gtcccaagaa atgttttgaa ggtgaaagtt gaatttgcaa aaatatgcag
      301 catatactta gacaggtatc cattatgatg ttgacaatga aggccttatt tccaacagat
      361 atactcatat gagaagaccc acttcaagca cttttaagta tctttctgtt tgttgaacca
      421 gcatggcagg gttcaagcga ggatatgatg ggaaaattgc tggattatat gatctggata
      481 aaaccttggg tcgaggtcat tttgcagtgg tcaaacttgc caggcatgtc ttcacaggtg
      541 agaaggtggc agtgaaagtc attgacaaga cgaagctgga cactctagcc actggtcatc
      601 tcttccagga agtgaggtgc atgaaactag tgcagcaccc caacattgtg cgtctctatg
      661 aagtcataga cacccagacc aaactttatc tcattctaga acttggagat ggaggagata
      721 tgtttgatta tataatgaag cacgaggagg gtcttaatga agacttggcc aagaagtact
      781 ttgctcagat agttcatgct atatcttatt gccataaact ccatgtggtc cacagagact
      841 tgaaaccaga gaatgtagtc ttttttgaaa aacaaggtct tgtgaagttg acagactttg
      901 gcttcagcaa caaatttcag cctggaaaga aactcaccac gagctgcggg tctcttgcat
      961 actctgctcc agaaatcctg cttggcgatg agtacgatgc ccctgcagta gacatatgga
     1021 gcctgggcgt gatccttttc atgctggtgt gtgggcagcc acccttccaa gaagccaacg
     1081 acagcgagac actgaccatg atcatggact gcaagtacac ggtgccaccc cgcgtgtctg
     1141 cagggtgcag ggacctgatc acacgaatgc tacagagaga ccccaaaagg agagcctctc
     1201 tggaagagat tgaaagccac ccttggctcc agggagtgga cccatcacca gccaccaagt
     1261 ataacattcc cctcgtgtcc tacaagaacc tctccgagga agagcacaac agcatcatcc
     1321 agcgcatggt gctcggggac atcgcggacc gagacgccat cgtagaagcc ctggaaacca
     1381 acaggtacaa ccacattacc gccacttact ttttacttgc tgaaaggatc ctgagagaaa
     1441 agcaagagaa agaaatacag accaggtctg ctagccccag caacatcaag gcccagttta
     1501 ggcagtcatg gccaaccaaa attgatgtac cccaagacct tgaagatgat ctcactgcca
     1561 cccctctgtc acatgccaca gtcccgcagt ctcctgctag ggctggtgac aatgtcctca
     1621 atggccacag gagcaaaggc ctgtgtgacc cagccaagaa agatgagctc ccggagctgg
     1681 ctgggccggc actgtccact gttccacctg caagcatgaa gcccgcagcc agtgggcgca
     1741 agtgtctctt cagggtggaa gaagatgagg aggaggatga ggaggacaag aagcctgtgt
     1801 ccctgtccac gcaggtggtg ctgcgccgga agccatcggt caccaatcgc ctgacgtctc
     1861 gcaagagtgc cccagtgctc aaccagatct tcgaggaggg cgagtcagac gacgagtttg
     1921 acatggacga gaacctgccg cccaagctga gccggctgaa gatgaacatt gcctcaccag
     1981 gcacagtgca caagcgctac caccgcagga aaagccaggg ccggggctct agctgcagca
     2041 gctctgagac cagcgatgac gactccgaga gccggcggag gctggacaag gacagcggct
     2101 ttgcttactc gtggcaccgg cgtgacagca gtgaggggcc accaggcagc gagggcgatg
     2161 gtggcggcca gagcaagcct agcagcggtg gcggtgtgga caaggccagc ccgggtgagc
     2221 agggcacggg tggtggcagc cagggaggct ctggtgggac cccgtcgggt acagcagggt
     2281 cctcaaggcg ctgtgcaggc cctgactcat cctcaccctc ccccgcctca gcctctgccg
     2341 ctccacgtgg tgcagagctt gtgcagagcc tcaaactcgt gagcctgtgc ctaggctcac
     2401 agctgcatgg cgccaagtac attctggacc cgcagaaggc cttgttctcc agcgtgaagg
     2461 tgcaggagaa gtccacgtgg aagatgtgca tcagcgcccc aggccccagc ccctctgctg
     2521 accttgaccc ggtgaggacc aagaagctga ggaacaacgc gctccagcta cctctgtgcg
     2581 aaaagaccat ctccgtgaac atccagcgca gccgcaagga agggctgctc tgcgcctcca
     2641 gccccgccag ctgctgccat gtcatctgac ctgtaaagcg cgctcacttc atctgttctg
     2701 acgtgacaat gcatggtctt tgtgcatgct gctacacgct acttttcttt tccagccgaa
     2761 aagtctactg tgtgatttta cattcatgat tttcagtgtg gatgaccagg atgaaattgt
     2821 gttatctgga acccaacgta aatggagcgc ttagaaatcc atgttctgca cttaacctgg
     2881 agggaaaatg ctttcgtttc cttgtgaaaa gcccaaattc ctgtcttgac ctccggtgat
     2941 agggaaactc catgctctga ggcacactgg tgcccgagac agaaccaaag caataacgtg
     3001 gtgatgccca caggcctggg aggagcaacc cccgctgcca gccacccagg gcctgtgcac
     3061 cgagaacctt agagccacgg tttgagcgcc cacacctgtt tgtcttaacc aatagtgtga
     3121 aagcagttgg ggctcttatc ttttcactga cagagattgt cttgtttgtg ttaggtgagg
     3181 tcagctcctt agctttgaga ggcagcttac ccatagaatt acccaggaga caatcttctg
     3241 tgaggcaatg aggtgaactc aagtcttaac tctacttaga gtgtgtatgt ctgtctgaca
     3301 gaacaaaaat taaaaaaaaa aaaaaaaaaa aaaaaaaaga ggctctgtgt aagtttcccc
     3361 tgcaggacac aaggcagggt ttccttcaaa cctgtgtgga gaggagaagc ggagggcctg
     3421 ctgcagtagc cacagtgcac acaggggcag gcagcaaagt cagcactctg acgaggaggc
     3481 aggacatcct gaggtggtgg ttcaggagct tggtggtgag gtggcctcag gtttctccca
     3541 tttcatggca gcatttggct cagctgtgaa gagcggctgg taagaaactg ctcaggaaag
     3601 ggtagtgctt ggagccgtca gtggcacact gctgccttcc tgccacgtgc tgagcgcgga
     3661 gcgctagctt gccctctccc gcaccgacga ctccggactg atagctatct cctgaggcag
     3721 gcctcctccc tgatcttggg aagcccagat gctgggtttt cacacggtgc ccaagggatt
     3781 gaaagcagtg tttaagcggc ctgtggggta ggtgcggctg gcccagggtc ctttcctcac
     3841 tcttcagctg ctgccctgtt ctgagggaca acagtgcagc tgagcatgtg tctcagagcg
     3901 ggcagggcac aggccaccac ttccttcagt gctcagtgac tgctgcttta ggttagtgta
     3961 tattactcag aacttcacag tgtaacctga ctttactaag taaaatgata cttaagctac
     4021 ttcctagagc tagctaactg cttgtgcttt aagctgcagt cccattcagt gtgacattca
     4081 catagttgag agctgtgagg ggagacgtgg gtgaagccat agagcacatt tgcttgaaat
     4141 tcttaagcag ggatcttcca agggccagaa accagcgtgg ttctcagaga cggagccacg
     4201 tctgtgtgag ccaggagaga tgtctatagg ggcattgcaa taaactgtcg cagctgtttc
     4261 ccaagtaatg tacatactct tctgtggtca cggccagcct ctgagcggcg cctctgcact
     4321 cacccgtctg cgtttggtct ccagtggttt tctattcagg tgtatatacg gtgctcactt
     4381 tagatcagca gtgtcggcca tttatgctgc agagctgtgt catagcctta ttagttgtgt
     4441 gtggttggtg accctctggg tacacaatgt ctgttgagtg ctgtcttacc catttgttga
     4501 caagtggatg tctgtgcatg tgttgtgtgt cacggggtgt cgtcacagtg tcacgggtgt
     4561 cgtcacagag ggaaggagca gaaccaccac acccatagtg gaccaaacta cgtccttgct
     4621 gtagccaggg actcgtcccc tagccgagtt acagtagtgt ataattaaat attgtgggaa
     4681 agttagtctt gtatttttct gtgtgtatat atatataatt atgtacttct ggaattctat
     4741 ctgtatttaa agatgtgaca atcttgacac caattttaat agtcatgagc ctgaacaaag
     4801 atgtcctaga gccagagttg gtatgtgctg agaacacaaa cttgtcagct aattggtcag
     4861 atgcctctag ttctgaccag tctttttcct tgtgtgaaca ttgacaggta tgtgacagat
     4921 gggaaataat ccaataataa agtgacatac tgatgttcag caatagaa
//
