LOCUS       NM_001357774            5058 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SNF related kinase (Snrk), transcript variant 3, mRNA.
ACCESSION   NM_001357774
VERSION     NM_001357774.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5058)
  AUTHORS   Stanczyk,P.J., Tatekoshi,Y., Shapiro,J.S., Nayudu,K., Chen,Y.,
            Zilber,Z., Schipma,M., De Jesus,A., Mahmoodzadeh,A., Akrami,A.,
            Chang,H.C. and Ardehali,H.
  TITLE     DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy
            Are Mediated by SNRK Through Actin Depolymerization
  JOURNAL   Circulation 148 (20), 1582-1592 (2023)
   PUBMED   37721051
  REMARK    GeneRIF: DNA Damage and Nuclear Morphological Changes in Cardiac
            Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
REFERENCE   2  (bases 1 to 5058)
  AUTHORS   Thirugnanam,K., Cossette,S.M., Lu,Q., Chowdhury,S.R., Harmann,L.M.,
            Gupta,A., Spearman,A.D., Sonin,D.L., Bordas,M., Kumar,S.N.,
            Pan,A.Y., Simpson,P.M., Strande,J.L., Bishop,E., Zou,M.H. and
            Ramchandran,R.
  TITLE     Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart
  JOURNAL   J Am Heart Assoc 8 (22), e012792 (2019)
   PUBMED   31718444
  REMARK    GeneRIF: Cardiomyocyte-Specific Snrk Prevents Inflammation in the
            Heart.
REFERENCE   3  (bases 1 to 5058)
  AUTHORS   Li,J., An,R., Lai,S., Li,L., Liu,S. and Xu,H.
  TITLE     Dysregulation of PP2A-Akt interaction contributes to Sucrose
            non-fermenting related kinase (SNRK) deficiency induced insulin
            resistance in adipose tissue
  JOURNAL   Mol Metab 28, 26-35 (2019)
   PUBMED   31420304
  REMARK    GeneRIF: The SNRK regulates insulin signaling through controlling
            PPP2R5D phosphorylation, which subsequently impacts PP2A activity
            and then AKT phosphorylation in both WAT and BAT. SNRK may
            represent a promising potential target for treating insulin
            resistance-related metabolic disorders.
REFERENCE   4  (bases 1 to 5058)
  AUTHORS   Lu,Q., Ma,Z., Ding,Y., Bedarida,T., Chen,L., Xie,Z., Song,P. and
            Zou,M.H.
  TITLE     Circulating miR-103a-3p contributes to angiotensin II-induced renal
            inflammation and fibrosis via a SNRK/NF-kappaB/p65 regulatory axis
  JOURNAL   Nat Commun 10 (1), 2145 (2019)
   PUBMED   31086184
  REMARK    Erratum:[Nat Commun. 2019 Aug 6;10(1):3628. doi:
            10.1038/s41467-019-11515-z.. PMID: 31388007]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5058)
  AUTHORS   Li,J., Feng,B., Nie,Y., Jiao,P., Lin,X., Huang,M., An,R., He,Q.,
            Zhou,H.E., Salomon,A., Sigrist,K.S., Wu,Z., Liu,S. and Xu,H.
  TITLE     Sucrose Nonfermenting-Related Kinase Regulates Both Adipose
            Inflammation and Energy Homeostasis in Mice and Humans
  JOURNAL   Diabetes 67 (3), 400-411 (2018)
   PUBMED   29298809
REFERENCE   6  (bases 1 to 5058)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5058)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   8  (bases 1 to 5058)
  AUTHORS   Oki,T., Yamazaki,K., Kuromitsu,J., Okada,M. and Tanaka,I.
  TITLE     cDNA cloning and mapping of a novel subtype of
            glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human
            and mouse
  JOURNAL   Genomics 57 (2), 227-234 (1999)
   PUBMED   10198162
REFERENCE   9  (bases 1 to 5058)
  AUTHORS   Mishra,L., Cai,T., Yu,P., Monga,S.P. and Mishra,B.
  TITLE     Elf3 encodes a novel 200-kD beta-spectrin: role in liver
            development
  JOURNAL   Oncogene 18 (2), 353-364 (1999)
   PUBMED   9927192
REFERENCE   10 (bases 1 to 5058)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120394.10 and AK082185.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082185.1, SRR13422598.1544321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC120394.10        133953-134041
            90-1380             AK082185.1         488-1778
            1381-1745           AK082185.1         1780-2144
            1746-5058           AC120394.10        183077-186389
FEATURES             Location/Qualifiers
     source          1..5058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.89 cM"
     gene            1..5058
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="SNF related kinase"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
     exon            1..142
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            143..192
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            193..315
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            316..405
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1101
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..2759
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /EC_number="2.7.11.1"
                     /note="SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase"
                     /protein_id="NP_001344703.1"
                     /db_xref="CCDS:CCDS23644.1"
                     /db_xref="GeneID:20623"
                     /db_xref="MGI:MGI:108104"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAGDNVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASMKPAASGRKCLFRVEEDEE
                     EDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFAYSWHR
                     RDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSSRRC
                     AGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALFSSVKVQE
                     KSTWKMCISAPGPSPSADLDPVRTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASS
                     PASCCHVI"
     exon            1102..1243
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1456
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1591
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..5058
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5026..5031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="hexamer: AATAAA"
     polyA_site      5058
                     /gene="Snrk"
                     /gene_synonym="2010012F07Rik; E030034B15; mKIAA0096"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccgcg cctgcgcagc gcggccgcac ccccggccgc ccgctcggta ttatgattag
       61 ccctgggtgc ggggttccgg cggccgggag ggagttgtcg acgccgcggc cgctgcggac
      121 ggatgcccgc ctgccggctg aggagaaaca acaaatactg gtaacagagt gatttggtat
      181 gctgtttgca agaatgcatc ttaacagaaa tacagaggaa aagaataaag acgagaaaat
      241 ggcgtaggca gtcccaagaa atgttttgaa ggtgaaagtt gaatttgcaa aaatatgcag
      301 catatactta gacagtttcc ttggctttaa gatgagacag tctgacctca ggaacctgtg
      361 acagagtaca gtcccacttc cacgagtgcc tgtggaaaga tttcagtatc cattatgatg
      421 ttgacaatga aggccttatt tccaacagat atactcatat gagaagaccc acttcaagca
      481 cttttaagta tctttctgtt tgttgaacca gcatggcagg gttcaagcga ggatatgatg
      541 ggaaaattgc tggattatat gatctggata aaaccttggg tcgaggtcat tttgcagtgg
      601 tcaaacttgc caggcatgtc ttcacaggtg agaaggtggc agtgaaagtc attgacaaga
      661 cgaagctgga cactctagcc actggtcatc tcttccagga agtgaggtgc atgaaactag
      721 tgcagcaccc caacattgtg cgtctctatg aagtcataga cacccagacc aaactttatc
      781 tcattctaga acttggagat ggaggagata tgtttgatta tataatgaag cacgaggagg
      841 gtcttaatga agacttggcc aagaagtact ttgctcagat agttcatgct atatcttatt
      901 gccataaact ccatgtggtc cacagagact tgaaaccaga gaatgtagtc ttttttgaaa
      961 aacaaggtct tgtgaagttg acagactttg gcttcagcaa caaatttcag cctggaaaga
     1021 aactcaccac gagctgcggg tctcttgcat actctgctcc agaaatcctg cttggcgatg
     1081 agtacgatgc ccctgcagta gacatatgga gcctgggcgt gatccttttc atgctggtgt
     1141 gtgggcagcc acccttccaa gaagccaacg acagcgagac actgaccatg atcatggact
     1201 gcaagtacac ggtgccaccc cgcgtgtctg cagggtgcag ggacctgatc acacgaatgc
     1261 tacagagaga ccccaaaagg agagcctctc tggaagagat tgaaagccac ccttggctcc
     1321 agggagtgga cccatcacca gccaccaagt ataacattcc cctcgtgtcc tacaagaacc
     1381 tctccgagga agagcacaac agcatcatcc agcgcatggt gctcggggac atcgcggacc
     1441 gagacgccat cgtagaagcc ctggaaacca acaggtacaa ccacattacc gccacttact
     1501 ttttacttgc tgaaaggatc ctgagagaaa agcaagagaa agaaatacag accaggtctg
     1561 ctagccccag caacatcaag gcccagttta ggcagtcatg gccaaccaaa attgatgtac
     1621 cccaagacct tgaagatgat ctcactgcca cccctctgtc acatgccaca gtcccgcagt
     1681 ctcctgctag ggctggtgac aatgtcctca atggccacag gagcaaaggc ctgtgtgacc
     1741 cagccaagaa agatgagctc ccggagctgg ctgggccggc actgtccact gttccacctg
     1801 caagcatgaa gcccgcagcc agtgggcgca agtgtctctt cagggtggaa gaagatgagg
     1861 aggaggatga ggaggacaag aagcctgtgt ccctgtccac gcaggtggtg ctgcgccgga
     1921 agccatcggt caccaatcgc ctgacgtctc gcaagagtgc cccagtgctc aaccagatct
     1981 tcgaggaggg cgagtcagac gacgagtttg acatggacga gaacctgccg cccaagctga
     2041 gccggctgaa gatgaacatt gcctcaccag gcacagtgca caagcgctac caccgcagga
     2101 aaagccaggg ccggggctct agctgcagca gctctgagac cagcgatgac gactccgaga
     2161 gccggcggag gctggacaag gacagcggct ttgcttactc gtggcaccgg cgtgacagca
     2221 gtgaggggcc accaggcagc gagggcgatg gtggcggcca gagcaagcct agcagcggtg
     2281 gcggtgtgga caaggccagc ccgggtgagc agggcacggg tggtggcagc cagggaggct
     2341 ctggtgggac cccgtcgggt acagcagggt cctcaaggcg ctgtgcaggc cctgactcat
     2401 cctcaccctc ccccgcctca gcctctgccg ctccacgtgg tgcagagctt gtgcagagcc
     2461 tcaaactcgt gagcctgtgc ctaggctcac agctgcatgg cgccaagtac attctggacc
     2521 cgcagaaggc cttgttctcc agcgtgaagg tgcaggagaa gtccacgtgg aagatgtgca
     2581 tcagcgcccc aggccccagc ccctctgctg accttgaccc ggtgaggacc aagaagctga
     2641 ggaacaacgc gctccagcta cctctgtgcg aaaagaccat ctccgtgaac atccagcgca
     2701 gccgcaagga agggctgctc tgcgcctcca gccccgccag ctgctgccat gtcatctgac
     2761 ctgtaaagcg cgctcacttc atctgttctg acgtgacaat gcatggtctt tgtgcatgct
     2821 gctacacgct acttttcttt tccagccgaa aagtctactg tgtgatttta cattcatgat
     2881 tttcagtgtg gatgaccagg atgaaattgt gttatctgga acccaacgta aatggagcgc
     2941 ttagaaatcc atgttctgca cttaacctgg agggaaaatg ctttcgtttc cttgtgaaaa
     3001 gcccaaattc ctgtcttgac ctccggtgat agggaaactc catgctctga ggcacactgg
     3061 tgcccgagac agaaccaaag caataacgtg gtgatgccca caggcctggg aggagcaacc
     3121 cccgctgcca gccacccagg gcctgtgcac cgagaacctt agagccacgg tttgagcgcc
     3181 cacacctgtt tgtcttaacc aatagtgtga aagcagttgg ggctcttatc ttttcactga
     3241 cagagattgt cttgtttgtg ttaggtgagg tcagctcctt agctttgaga ggcagcttac
     3301 ccatagaatt acccaggaga caatcttctg tgaggcaatg aggtgaactc aagtcttaac
     3361 tctacttaga gtgtgtatgt ctgtctgaca gaacaaaaat taaaaaaaaa aaaaaaaaaa
     3421 aaaaaaaaga ggctctgtgt aagtttcccc tgcaggacac aaggcagggt ttccttcaaa
     3481 cctgtgtgga gaggagaagc ggagggcctg ctgcagtagc cacagtgcac acaggggcag
     3541 gcagcaaagt cagcactctg acgaggaggc aggacatcct gaggtggtgg ttcaggagct
     3601 tggtggtgag gtggcctcag gtttctccca tttcatggca gcatttggct cagctgtgaa
     3661 gagcggctgg taagaaactg ctcaggaaag ggtagtgctt ggagccgtca gtggcacact
     3721 gctgccttcc tgccacgtgc tgagcgcgga gcgctagctt gccctctccc gcaccgacga
     3781 ctccggactg atagctatct cctgaggcag gcctcctccc tgatcttggg aagcccagat
     3841 gctgggtttt cacacggtgc ccaagggatt gaaagcagtg tttaagcggc ctgtggggta
     3901 ggtgcggctg gcccagggtc ctttcctcac tcttcagctg ctgccctgtt ctgagggaca
     3961 acagtgcagc tgagcatgtg tctcagagcg ggcagggcac aggccaccac ttccttcagt
     4021 gctcagtgac tgctgcttta ggttagtgta tattactcag aacttcacag tgtaacctga
     4081 ctttactaag taaaatgata cttaagctac ttcctagagc tagctaactg cttgtgcttt
     4141 aagctgcagt cccattcagt gtgacattca catagttgag agctgtgagg ggagacgtgg
     4201 gtgaagccat agagcacatt tgcttgaaat tcttaagcag ggatcttcca agggccagaa
     4261 accagcgtgg ttctcagaga cggagccacg tctgtgtgag ccaggagaga tgtctatagg
     4321 ggcattgcaa taaactgtcg cagctgtttc ccaagtaatg tacatactct tctgtggtca
     4381 cggccagcct ctgagcggcg cctctgcact cacccgtctg cgtttggtct ccagtggttt
     4441 tctattcagg tgtatatacg gtgctcactt tagatcagca gtgtcggcca tttatgctgc
     4501 agagctgtgt catagcctta ttagttgtgt gtggttggtg accctctggg tacacaatgt
     4561 ctgttgagtg ctgtcttacc catttgttga caagtggatg tctgtgcatg tgttgtgtgt
     4621 cacggggtgt cgtcacagtg tcacgggtgt cgtcacagag ggaaggagca gaaccaccac
     4681 acccatagtg gaccaaacta cgtccttgct gtagccaggg actcgtcccc tagccgagtt
     4741 acagtagtgt ataattaaat attgtgggaa agttagtctt gtatttttct gtgtgtatat
     4801 atatataatt atgtacttct ggaattctat ctgtatttaa agatgtgaca atcttgacac
     4861 caattttaat agtcatgagc ctgaacaaag atgtcctaga gccagagttg gtatgtgctg
     4921 agaacacaaa cttgtcagct aattggtcag atgcctctag ttctgaccag tctttttcct
     4981 tgtgtgaaca ttgacaggta tgtgacagat gggaaataat ccaataataa agtgacatac
     5041 tgatgttcag caatagaa
//
