LOCUS       NM_198214               4750 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus syntaphilin (Snph), transcript variant 1, mRNA.
ACCESSION   NM_198214 XM_141552
VERSION     NM_198214.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4750)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4750)
  AUTHORS   Xu,X., Li,H., Lu,S. and Shen,Y.
  TITLE     Roles of syntaphilin and armadillo repeat-containing X-linked
            protein 1 in brain injury after experimental intracerebral
            hemorrhage
  JOURNAL   Neurosci Lett 809, 137300 (2023)
   PUBMED   37187340
  REMARK    GeneRIF: Roles of syntaphilin and armadillo repeat-containing
            X-linked protein 1 in brain injury after experimental intracerebral
            hemorrhage.
REFERENCE   3  (bases 1 to 4750)
  AUTHORS   Fu,S., Deng,H., Bertolini,I., Perego,M., Chen,E.S., Sanseviero,E.,
            Mostafa,A., Alicea-Torres,K., Garcia-Gerique,L., Stone,E.L.,
            Kossenkov,A.V., Schug,Z.T., Nam,B., Mulligan,C., Altieri,D.C.,
            Nefedova,Y. and Gabrilovich,D.I.
  TITLE     Syntaphilin Regulates Neutrophil Migration in Cancer
  JOURNAL   Cancer Immunol Res 11 (3), 278-289 (2023)
   PUBMED   36548516
  REMARK    GeneRIF: Syntaphilin Regulates Neutrophil Migration in Cancer.
REFERENCE   4  (bases 1 to 4750)
  AUTHORS   Joshi,D.C., Zhang,C.L., Mathur,D., Li,A., Kaushik,G., Sheng,Z.H.
            and Chiu,S.Y.
  TITLE     Tripartite Crosstalk between Cytokine IL-1beta, NMDA-R and
            Misplaced Mitochondrial Anchor in Neuronal Dendrites Is a Novel
            Pathway for Neurodegeneration in Inflammatory Diseases
  JOURNAL   J Neurosci 42 (38), 7318-7329 (2022)
   PUBMED   35970564
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4750)
  AUTHORS   Huang,N., Li,S., Xie,Y., Han,Q., Xu,X.M. and Sheng,Z.H.
  TITLE     Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply
            and facilitates neuron survival and regeneration after injury and
            ischemia
  JOURNAL   Curr Biol 31 (14), 3098-3114 (2021)
   PUBMED   34087103
REFERENCE   6  (bases 1 to 4750)
  AUTHORS   Chen,Y. and Sheng,Z.H.
  TITLE     Kinesin-1-syntaphilin coupling mediates activity-dependent
            regulation of axonal mitochondrial transport
  JOURNAL   J Cell Biol 202 (2), 351-364 (2013)
   PUBMED   23857772
  REMARK    GeneRIF: SNPH is required for activity-dependent regulation of
            mitochondrial transport.
REFERENCE   7  (bases 1 to 4750)
  AUTHORS   Zhu,Y.B. and Sheng,Z.H.
  TITLE     Increased axonal mitochondrial mobility does not slow amyotrophic
            lateral sclerosis (ALS)-like disease in mutant SOD1 mice
  JOURNAL   J Biol Chem 286 (26), 23432-23440 (2011)
   PUBMED   21518771
REFERENCE   8  (bases 1 to 4750)
  AUTHORS   Chen,Y.M., Gerwin,C. and Sheng,Z.H.
  TITLE     Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial
            docking in axons
  JOURNAL   J Neurosci 29 (30), 9429-9438 (2009)
   PUBMED   19641106
  REMARK    GeneRIF: Our studies suggest an unexpected role for LC8 and provide
            new mechanistic insights into how SNPH and LC8 together immobilize
            mitochondria through a dynamic interaction between the docking
            receptor and axonal cytoskeleton.
REFERENCE   9  (bases 1 to 4750)
  AUTHORS   Kang,J.S., Tian,J.H., Pan,P.Y., Zald,P., Li,C., Deng,C. and
            Sheng,Z.H.
  TITLE     Docking of axonal mitochondria by syntaphilin controls their
            mobility and affects short-term facilitation
  JOURNAL   Cell 132 (1), 137-148 (2008)
   PUBMED   18191227
  REMARK    GeneRIF: Here, we report a role for axon-targeted syntaphilin
            (SNPH) in mitochondrial docking through its interaction with
            microtubules. Axonal mitochondria that contain exogenously or
            endogenously expressed SNPH lose mobility.
REFERENCE   10 (bases 1 to 4750)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235740.1, BC072567.1, AK138230.1 and BX630275.1.
            
            On Mar 22, 2014 this sequence version replaced NM_198214.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122262.1, SRR1660811.41918.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY235740.1         1-37
            38-3589             BC072567.1         1-3552
            3590-4735           AK138230.1         3765-4910
            4736-4750           BX630275.1         3-17                c
FEATURES             Location/Qualifiers
     source          1..4750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..4750
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /note="syntaphilin"
                     /db_xref="GeneID:241727"
                     /db_xref="MGI:MGI:2139270"
     exon            1..138
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     exon            139..245
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     exon            246..342
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1879
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaphilin isoform a"
                     /protein_id="NP_937857.1"
                     /db_xref="CCDS:CCDS16871.1"
                     /db_xref="GeneID:241727"
                     /db_xref="MGI:MGI:2139270"
                     /translation="MAMSLQGSRRASAGSRSGGTLGRSGLAVFAQCPQVPASQNEQRP
                     LLPASRRTSPPVSVRDAYGTSSLSSSSNSGSCKGSDSSPTPRRSMKYTLCSDNHGIKP
                     PTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECH
                     RVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSME
                     VAQNGVAKEEGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSNTSAEDGADS
                     GYVAADDTLSRTDALEASSLLSSGVDCGLEEASLHSSFNLGPRFPASNTYEKLLCGME
                     AGVQVSCMQERAIQTDFVQYQPDLNTILEKVGQAQVCGSVLKDRHSELDPHPSGPRDP
                     DSAVVVTVGDELEAPEPITCGPATHRPAVNSNPGLPVSVVCPVEEEEEEAAAATTTEK
                     EPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIR
                     RISCRSLGQPSSSTAGGSQL"
     exon            343..549
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     exon            550..699
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     exon            700..4750
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4720..4725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /note="hexamer: ATTAAA"
     polyA_site      4742
                     /gene="Snph"
                     /gene_synonym="6430515A01; mKIAA0374"
                     /note="major polyA site"
ORIGIN      
        1 tctccttccc cgccctccac ctctccctcc ccgcagcccc agccccagca agcacccgct
       61 agccaccttc agctggggct cgggagagca atccggctgc cctcctgggg gcagcccaaa
      121 ccatggaagc cttcgcaggt tgctgatcac cgccaggcgg ctgctgcagc gactgcagag
      181 gcgctgcgcc aagcggcgcg ggagtcgtgc gagccggccg gactgcggag ggcgagtgga
      241 cccagccccg ggaacaccgc ccattccgcc gctcaccagg acccgcagcc tcatggccat
      301 gtccctgcag ggaagtagac gagcctctgc cggatctcgc agcgggggca ctttaggccg
      361 tagcggcctg gcagtgttcg cccagtgccc acaggtgccc gccagccaga atgagcagcg
      421 gcctcttctc cccgcctcca ggcgcacctc tccacctgtg agtgtgcggg acgcctacgg
      481 cacctcttcc ctcagcagca gcagcaactc tggctcctgc aagggcagtg acagcagccc
      541 cacaccgagg cgctccatga agtacacact atgcagcgac aatcacggca tcaagcctcc
      601 caccccagaa cagtatctga ctccactgca acagaaggag gtttgcatcc ggcacctgaa
      661 ggcccggctc aaggacacac aggaccggct ccaggatagg gacacggaga tcgatgacct
      721 taagacgcag ctgtcccgca tgcaagagga ctggattgag gaggagtgcc accgcgtaga
      781 agcacagctg gccctgaaag aggcccgcaa ggagatccgg cagctcaagc aggtcatcga
      841 cactgtcaag aacaacctga ttgacaagga caaggggctg cagaagtact ttgtggacat
      901 caatatccag aacaagaagc tggagacctt gctgcacagc atggaggtgg cccagaatgg
      961 agtcgccaag gaggaaggaa caggggagtc agcaggtggg tctcctgcac ggtccctcac
     1021 ccgcagctcc acctacacca agctgagtga cccagccgtc tgtggtgacc gccagccagg
     1081 ggatccctcc aacacctctg ccgaggatgg agctgatagt ggatatgtgg ctgccgatga
     1141 caccctgagt cggacggacg ccctggaggc cagtagccta ctgtcatcag gagtggactg
     1201 tggccttgag gaagcctcgc tgcacagctc cttcaacctg ggcccccgct tccctgccag
     1261 caacacctac gagaagctgc tgtgcggcat ggaggctggt gtgcaggtca gctgcatgca
     1321 ggagcgggcc atccagacag actttgtgca gtaccagcct gacctgaaca ccatcctgga
     1381 gaaagtgggc caggctcagg tgtgcggttc agtcctcaaa gacaggcact cagagctgga
     1441 tccccaccct tcagggccca gagaccctga ctcagcagtg gtagtcacag taggtgacga
     1501 gcttgaggcc ccagagccca tcacctgtgg gccagccaca caccggcctg cagtcaactc
     1561 taacccagga ctgcccgtga gtgtggtgtg tcccgtggaa gaggaggagg aggaggcagc
     1621 cgctgccacc accaccgaaa aggaacccaa gagttactgg agccgccact acatcgtgga
     1681 tctgctggct gtggtagtgc cagctgtgcc aacagtggcc tggctctgcc gctcccagcg
     1741 gcgtcagggc cagcccattt acaacatcag ctccctgctg cggggttgct gcacggtggc
     1801 cttgcactcc atccgtagga tcagctgccg ctcactgggc cagccgagct ccagcacagc
     1861 cggtggctct cagctctgag gctgccggct ctccactcct ggcagcctga ccattgattg
     1921 taggatgcca tttgctgccc cacacccaca cccacaccca tccccttttg gcttcctctt
     1981 atatactttc aggtctggaa tagcgcccca acccaagatg tcaatagtgt cagggattca
     2041 gaaagtcatc ccaaaacttg gagagaaaag gttaaaatgg ctaattgaag agggagaaac
     2101 tgctaagagc ttcccccctc tgtcccctct gtccacccag actttagaca aggcaggccc
     2161 tgctcaaaat gtctctggct gtattgatct gaggatcctc ccctcttttg aaccattcct
     2221 tccatcacct ggcccacccc atgccttctc ttccaggcca ccccttgccc ctctccttgg
     2281 gctcccggac cagtattacc tcctcaaatg gaggcagcca ggacccagaa cacagagagc
     2341 cactcccagc agggtctggc ttccctggtc ccactgaggc tccagctctc ctcccttgcc
     2401 ctgggatgca aaagtatggt ccagctggaa tgaccagctc aggcaggagg gtaggttctg
     2461 tgtctgtctg tctgtcctct tggcttctgg gtgtgttaga tctttgtgag atgtccaatg
     2521 cccatcacta ctaacacgct taccatggga gtggagggag cccttaccca agccccagct
     2581 tcctttgggc aaatctgcca gcacagagaa ggcaaggcta gcagctctag ggcacccttc
     2641 accttctgag atgagtccac ctcatctgta gcctagaggt acctcagtga gttgggaaag
     2701 tcagaggcca cttacccagg ctccattggc tccaagccct gactacattt gcactcagtt
     2761 tcctgaagga ctttgtttcc tgcccacccc agaaacccca ggctgcttgt tttctgggac
     2821 gagggcttct ctcatggagc tgacttcaga ggaatatggc catcaggggg cacctccaga
     2881 tgggtttctg aagtcacatc gtctgcctgt ctatgccaaa gcagagtctc tgagtgtgct
     2941 tcccaagtag gggcatggcc aggtggtggg agcctgtctg tgctgctcct ggtccaggcc
     3001 ccgtcagcct gagaaaatgc tctgatcctt acttccctct tcttcccaga gaggtcgttc
     3061 cgacctgact ggcccacctc cagggagctg gtagagtcct gcatctcacc ctctggctgg
     3121 gagcctctct ggttctctgc taaggtcgct tgccctcact gttgctccag tggccaccac
     3181 ttgactcatg agttctgccc ctccactctg tgccctccag aggggcacct gcatgcactg
     3241 ggagtgggca gccagcctag ccatcagggc aagagccctc tgccatgcgc tttgtgcctc
     3301 caaaactccc ccaccttggc tggggcctca gaccagccat ccttggtgga acatccctac
     3361 cccagctgaa ccaaacccaa atgcctgagg cctcgctggg gctgccccat aggacactgg
     3421 ggtggtacca tggagagaca ggggataaaa ctgatccaaa gccacgccag gactggccac
     3481 ggacccagcc tcctgcgccg tgtactcgtg gagctccaca tgtctcccta gcaacagtcg
     3541 aagctctgct gagaaaataa atgtatgaac tatatttgac aacataaaat ccatatattt
     3601 ttcaccactg gcatttagtc caactttgca gcccctctgt tccatgtctt gctgtctggg
     3661 cattcttgtc gtgtctcgtg tttggtggac ttgggcaggg ctaggactgt ggtctaccct
     3721 gttcctgctg ctggagaagc cattgaaaag ggtccaggtt tgtagaggca tcaagtggaa
     3781 ctggccacca ccctgcttct gctgtgaccc taaccctgcc tatgtgatca ccagaggacc
     3841 tcacctacag cagaggtcct ctctttctcg tgagttctgc ctctcagaag ggctctgctc
     3901 cttgccagag caagtggagt gagcagccca ttacccagcc ctgggatgac ctgtgaaccc
     3961 tgcaggctgg ggtaatggcc ctatccttaa gtttatataa gcccagagtc ccatatccgt
     4021 acaaaggggt tgcaatgccc gtgcaatcct aagaggtagg cttggaagta gacacttgag
     4081 cagcctgctg gttccagata tggagaaggg ggctgagagc aaggtggaac tgggccaggc
     4141 tccccttaga tgctcatccc taaagctctc cccatcccat aggctgcaat tttccctctt
     4201 gcccttggct cctggagcaa aaatgttaag ggtgctcctt tcccctgcct ccagtcagag
     4261 cacacaaggt cttgaggaag tgtccccagg aactaccttc tactgggccc ttggagccca
     4321 gtggcttgaa gtagtggctc ctttgttttg gagccctctg atggggttca gtgaggattt
     4381 ctgaacagag gcaacgttga acagagttca tgatcaatgt gttcaagcag gtagcataca
     4441 tagcttttca ctgagactcc tcttcaccta tacaggcaca ggacaacaaa tcccaggctt
     4501 tagggccaaa ggctactgag gggtctccac ccaaggaact cacagccctc ctctgatcta
     4561 ggtgacaatg taaacaggcc actgcgcact catattaggc tatcctcttg acaggaactt
     4621 caggggacag aggaggaggc ctgtgggaag gggtcataac tctcggtctc ctttgtctct
     4681 ttattcagac agagttgtgc ctgtagcaga cagctctgaa ttaaagcatg aacacgcaca
     4741 cagcccctca
//
