LOCUS       NM_028473                480 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus secondary ossification center associated regulator of
            chondrocyte maturation (Snorc), transcript variant 1, mRNA.
ACCESSION   NM_028473 XM_906193 XM_978146
VERSION     NM_028473.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Jaiswal,P.K., Aljebali,L., Gaumond,M.H., Oh,C.D., Yasuda,H. and
            Moffatt,P.
  TITLE     Biochemical characteristics of the chondrocyte-enriched SNORC
            protein and its transcriptional regulation by SOX9
  JOURNAL   Sci Rep 10 (1), 7790 (2020)
   PUBMED   32385306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 480)
  AUTHORS   Heinonen,J., Zhang,F.P., Surmann-Schmitt,C., Honkala,S., Stock,M.,
            Poutanen,M. and Saamanen,A.M.
  TITLE     Defects in chondrocyte maturation and secondary ossification in
            mouse knee joint epiphyses due to Snorc deficiency
  JOURNAL   Osteoarthritis Cartilage 25 (7), 1132-1142 (2017)
   PUBMED   28323137
  REMARK    GeneRIF: Snorc is expressed postnatally in knee epiphyses
            especially by prehypertrophic chondrocytes delineating the
            cartilage canals and secondary ossification center. Snorc core
            protein binds to FGF2 and inhibits FGF2 dependent cell growth of
            C3H101/2 cells. In Snorc deficient mice, Snorc deficiency caused
            defects in secondary ossification and growth plate maturation
            associated with increased Ihh and reduced MMP13 expression.
REFERENCE   4  (bases 1 to 480)
  AUTHORS   Lee,W.J., Chatterjee,S., Yap,S.P., Lim,S.L., Xing,X., Kraus,P.,
            Sun,W., Hu,X., Sivakamasundari,V., Chan,H.Y., Kolatkar,P.R.,
            Prabhakar,S. and Lufkin,T.
  TITLE     An Integrative Developmental Genomics and Systems Biology Approach
            to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in
            Murine Embryos
  JOURNAL   Biomed Res Int 2017, 8932583 (2017)
   PUBMED   28630873
REFERENCE   5  (bases 1 to 480)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 480)
  AUTHORS   Heinonen,J., Taipaleenmaki,H., Roering,P., Takatalo,M.,
            Harkness,L., Sandholm,J., Uusitalo-Jarvinen,H., Kassem,M.,
            Kiviranta,I., Laitala-Leinonen,T. and Saamanen,A.M.
  TITLE     Snorc is a novel cartilage specific small membrane proteoglycan
            expressed in differentiating and articular chondrocytes
  JOURNAL   Osteoarthritis Cartilage 19 (8), 1026-1035 (2011)
   PUBMED   21624478
  REMARK    GeneRIF: a novel cartilage-specific molecule, Snorc, was identified
            that may have functions associated with development and maintenance
            of chondrocyte phenotype
REFERENCE   7  (bases 1 to 480)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157811.3.
            
            On Nov 9, 2022 this sequence version replaced NM_028473.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KM657818.1, AA259365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC157811.3         117020-117162
            144-326             AC157811.3         121774-121956
            327-480             AC157811.3         122080-122233
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.41 cM"
     gene            1..480
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /note="secondary ossification center associated regulator
                     of chondrocyte maturation"
                     /db_xref="GeneID:73234"
                     /db_xref="MGI:MGI:1920484"
     exon            1..143
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..436
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C2orf82 homolog;
                     secondary ossification center-associated regulator of
                     chondrocyte maturation protein; protein SNORC transcript"
                     /codon_start=1
                     /product="protein SNORC isoform 1 precursor"
                     /protein_id="NP_082749.1"
                     /db_xref="CCDS:CCDS48305.1"
                     /db_xref="GeneID:73234"
                     /db_xref="MGI:MGI:1920484"
                     /translation="MASCLALRVALLLISGVLAPAVLTAEGPQEPDPTLWNEPIELPS
                     GEGPLESTSHNQEFAVSGPPFPTSAPAPEDSTPPARVDQDGGSLGPGAIAAIVIAALL
                     ATCVVLALVVVALRKFSAS"
     exon            144..326
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..480
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      441..446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      480
                     /gene="Snorc"
                     /gene_synonym="3110079O15Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcccg ctgcctgagc ccagccgcct agtcctctgt gtcccataag actgctcact
       61 ccctgccagg atggcatctt gtctggccct gcgcgtggcg ctgctgctca tctctggggt
      121 cctggcccct gcggtgctca cagcagaggg tccccaggag cccgatccca ccctgtggaa
      181 cgagcctatt gaattgccct ctggtgaagg tcccctggag agcacaagcc acaaccagga
      241 atttgctgtc tctggccctc cgttccccac ctctgctcca gcaccagagg acagcacccc
      301 tcctgccagg gtggaccagg atggaggatc gcttggacca ggcgccattg cagccatcgt
      361 gatcgctgcc ctgctggcta cctgcgtggt gctggcactc gtggtcgtcg cgctaaggaa
      421 gttttccgct tcttgaagcc aataaaggag ccgcacaggc cggcccgcgg cgactctgca
//
