LOCUS       NM_175246               2365 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus Smad nuclear interacting protein 1 (Snip1), transcript
            variant 1, mRNA.
ACCESSION   NM_175246
VERSION     NM_175246.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2365)
  AUTHORS   Chen,W., Xu,Z., Jiang,J., Chen,L., Chen,Y., Yu,T., Chen,H. and
            Shi,R.
  TITLE     LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding
            to SENP1 to promote intestinal fibrosis in Crohn's disease
  JOURNAL   Int J Biol Macromol 262 (Pt 1), 129921 (2024)
   PUBMED   38309408
  REMARK    GeneRIF: LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by
            binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
REFERENCE   3  (bases 1 to 2365)
  AUTHORS   Matsui,Y., Djekidel,M.N., Lindsay,K., Samir,P., Connolly,N., Wu,G.,
            Yang,X., Fan,Y., Xu,B. and Peng,J.C.
  TITLE     SNIP1 and PRC2 coordinate cell fates of neural progenitors during
            brain development
  JOURNAL   Nat Commun 14 (1), 4754 (2023)
   PUBMED   37553330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2365)
  AUTHORS   Meng,D., Zheng,Q., Zhang,X., Piao,X., Luo,L. and Jia,Y.
  TITLE     A molecular brake that modulates spliceosome pausing at detained
            introns contributes to neurodegeneration
  JOURNAL   Protein Cell 14 (5), 318-336 (2023)
   PUBMED   37027487
REFERENCE   5  (bases 1 to 2365)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2365)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2365)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2365)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2365)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   10 (bases 1 to 2365)
  AUTHORS   Kim,R.H., Flanders,K.C., Birkey Reffey,S., Anderson,L.A.,
            Duckett,C.S., Perkins,N.D. and Roberts,A.B.
  TITLE     SNIP1 inhibits NF-kappa B signaling by competing for its binding to
            the C/H1 domain of CBP/p300 transcriptional co-activators
  JOURNAL   J Biol Chem 276 (49), 46297-46304 (2001)
   PUBMED   11567019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626775.11, AK040571.1 and BE336211.1.
            
            On Oct 9, 2017 this sequence version replaced NM_175246.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064067.1, AK143801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL626775.11        111027-111047
            22-2310             AK040571.1         2-2290
            2311-2365           BE336211.1         305-359
FEATURES             Location/Qualifiers
     source          1..2365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.99 cM"
     gene            1..2365
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /note="Smad nuclear interacting protein 1"
                     /db_xref="GeneID:76793"
                     /db_xref="MGI:MGI:2156003"
     exon            1..281
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1233
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /note="isoform 1 is encoded by transcript variant 1; smad
                     nuclear-interacting protein 1; Smad nuclear interacting
                     protein 1 Snip1"
                     /codon_start=1
                     /product="smad nuclear-interacting protein 1 isoform 1"
                     /protein_id="NP_780455.2"
                     /db_xref="CCDS:CCDS18636.1"
                     /db_xref="GeneID:76793"
                     /db_xref="MGI:MGI:2156003"
                     /translation="MKAGKSERERSGRRRHRSGDALTTVVVKQERLSPEPVAHRRPDA
                     PAASLSPPAAEPGHSGHRGSRARSPAKKKSKSSGRRSKSPRTKRSQSPHYPMVKVKQE
                     REDHPRRGREDRQHREPSEQEHRRARNSERDRHRGHSRQGRSSDERPVSGQDRDRDSQ
                     NLQAQEEERDFHNARRREHRQQNESAGSEAQEVIPRPAGNRSKEVPVKEKPSFELSGA
                     LLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRI
                     ADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQ
                     RYYELKEKDVLKFGFSSREYVLLHESSDTSELDRKEDEDDEEEEMVSDS"
     exon            282..384
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            385..968
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..2346
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2339
                     /gene="Snip1"
                     /gene_synonym="2410133M08Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgcaa agctgtccgt cacttcctac ggctcaagtg gctcaacgga ccgtgcaagt
       61 gactctcggt cgggccgcag gatgaaggcg gggaaaagcg agcgggagcg gagcggccgg
      121 cggcgacacc ggtcaggcga cgctctgacg accgtggtgg tgaaacagga gcgtctgagc
      181 cccgaacccg tcgcgcaccg ccggcccgac gctccagccg ctagcctgtc cccgcccgcc
      241 gccgagcctg gccactcggg tcaccgcggg agccgagccc ggtccccagc caagaagaaa
      301 agcaagtcct ctgggagaag aagcaagtca ccacggacca agagaagcca gagtccccac
      361 taccccatgg tcaaagtgaa gcaggaacgt gaggaccatc ctcggagagg acgagaggat
      421 cggcagcacc gggaaccatc agaacaggag cacaggagag ctcggaacag tgagcgagac
      481 cggcaccggg gccattcccg ccaagggagg agctctgatg agaggcccgt cagtggacag
      541 gatcgggata gagacagcca gaacctgcag gcccaggaag aagagaggga ctttcataat
      601 gccaggcgcc gggagcaccg ccagcagaat gaaagtgctg gcagtgaggc tcaggaggtg
      661 atccctcgtc ctgctgggaa cagaagcaaa gaggtgcccg ttaaagagaa accaagcttt
      721 gaactttctg gggcacttct tgaggacacc aataccttcc ggggtgtggt tattaaatac
      781 agtgagcccc cagaagcccg gatccccaaa aaacggtggc gcctctaccc ctttaaaaat
      841 gatgaggtac ttccagtcat gtacatccat cggcagagtg cataccttct gggtagacat
      901 cgacgcatcg cagacattcc catcgaccat ccctcttgct caaagcaaca tgcagtcttc
      961 cagtaccggc ttgtggagta cacccgtgct gacggcacgg ttggtcggag ggtgaagccc
     1021 tacattatcg accttggctc aggcaatgga acattcttga acaacaagcg tattgagcca
     1081 cagagatatt atgaactgaa agaaaaagac gtacttaaat ttgggttcag tagcagagaa
     1141 tatgtcttgc ttcatgagtc ttcagacacc tctgaacttg acaggaagga agatgaagat
     1201 gatgaggagg aagaaatggt atctgacagc tagcagctga gaggcagcct ctactgttag
     1261 aaaccgtccc taccggaggc tgtggtggtc actccagcgc ctcttcttgc cttaagtctt
     1321 ttctctgttg ctgcccagcc tatgttgcag tatgagaact gtcacttcat gttttcttga
     1381 agttggcaca gcagctgcct gcttgtgggc ccttgttttc tgaacagtct caccaattac
     1441 agcatgtcga gtctggtcag agcgtgtggt gggcaccttc agaactgctg catagcaaac
     1501 tgcccttgga aaggggatgg tggcttcttc tctttgtaca gtttcctatt tatatagctg
     1561 ttgagctttg tggaccagga gttttgtttt ggggacaaat cctagagtag agaatcttag
     1621 tcagctttgg ttgtcaccaa aacagcctcc agcctatacc aaagctttga cctgattcag
     1681 ctcttgagtc atagaagttg attttgcact tcgttttggg ggtgacagtt taccacgtga
     1741 cttctctatt ggctgtcttc gataaacaga cactctgtgc gatgtctgtg tgacaagact
     1801 gtagggaggt cgtggcttct accaacagga gctgctgtca tactgtgcac tggtctgtag
     1861 atctgcaccc tgaggattcc tgatttcttc atgaagcaga catcatagtt tgatcatctg
     1921 gtctttttct ttagctttga atttttattc aaatgtcgcc tctcttctcc ctttgagaaa
     1981 caccacactg actttgtagg aggggccttg ctgtggccta gggatgtgtg tatgtgtcta
     2041 aacgaggttg tgtagcttcc acacttccag ttcatctttg accatgtgtt catattttcc
     2101 tcccacgggt ggaaagtaag agacagccga gtgtctgaac ttcccacctg ggatctgtga
     2161 gtagaaagat actccttact gacagtctgt gtgcttcaga gctatgtgct gggtttcata
     2221 tgtcagtgtt ttgcgatata aataatacca catgataggc aaaggcctgt ctgcatttgg
     2281 agagcaggtt ttcatttata tgtatttttg agattaaaaa aataaaattt gtaaatatag
     2341 cctcataaaa aaaaaaaaaa aaaaa
//
