LOCUS       NM_001356362             941 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SNF8, ESCRT-II complex subunit, homolog (S.
            cerevisiae) (Snf8), transcript variant 2, mRNA.
ACCESSION   NM_001356362 XM_006533468
VERSION     NM_001356362.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 941)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   3  (bases 1 to 941)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 941)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 941)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 941)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 941)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY143710.1, BY150130.1, AA002581.1, W53138.1 and BF715164.1.
            
            On Sep 30, 2017 this sequence version replaced XM_006533468.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. It encodes
            isoform 2, which has the same N- and C-termini but lacks an
            internal segment and is shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI903625.1, BI524963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY143710.1         2-54
            54-309              BY150130.1         2-257
            310-508             AA002581.1         142-340
            509-585             W53138.1           212-288
            586-941             BF715164.1         28-383
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.24 cM"
     gene            1..941
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /note="SNF8, ESCRT-II complex subunit, homolog (S.
                     cerevisiae)"
                     /db_xref="GeneID:27681"
                     /db_xref="MGI:MGI:1343161"
     exon            1..183
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..831
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vacuolar-sorting protein SNF8; ESCRT-II complex subunit
                     VPS22"
                     /codon_start=1
                     /product="vacuolar-sorting protein SNF8 isoform 2"
                     /protein_id="NP_001343291.1"
                     /db_xref="CCDS:CCDS88234.1"
                     /db_xref="GeneID:27681"
                     /db_xref="MGI:MGI:1343161"
                     /translation="MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFK
                     TNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGV
                     QIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGI
                     IPVGGTYLIQSVPAELNMDHTVVLQLAEEHLLKEGLAWLDLQAPGEAHYWLPALFTDL
                     YSQEISAEEAKEAFP"
     exon            184..234
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     exon            235..373
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     exon            374..478
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     exon            479..551
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     exon            552..693
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     exon            694..929
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /note="hexamer: TATAAA"
     polyA_site      929
                     /gene="Snf8"
                     /gene_synonym="D11Moh34"
                     /note="major polyA site"
ORIGIN      
        1 atatcgagac ttccggcgcg ctcaaatgac gcacggcacc cggcttccgt gttgggagct
       61 ggcgacagaa cctgggacgc ggagagctgg ggtcggggct gcggggcggc ccgcgggccc
      121 ggggtgggga tgcaccggcg cggggtggga gctggcgcca ttgccaagaa gaaactcgca
      181 gaggccaagt ataaggagcg agggactgtc ctggctgagg accagctggc ccagatgtca
      241 aaacagctgg acatgttcaa gaccaaccta gaagaatttg ccagcaagca caagcaagag
      301 atccggaaga atcctgagtt ccgagtccag ttccaagaca tgtgtgcaac cattggggtg
      361 gatcccctgg cctctggaaa aggcttttgg tctgagatgc tgggcgttgg ggacttctat
      421 tatgaactgg gtgtccagat tattgaagtg tgcctggccc tcaaacatcg gaatggaggt
      481 ctgataactc tggaggagct acatcagcag gtgttaaaag gaaggggcaa gtttgctcag
      541 gatgtcagcc aagacgacct gatcagggcc atcaagaagc tgaaagccct gggcactgga
      601 ttcggcatca tccctgtggg aggcacttac ctcatccagt ctgttcccgc tgagctcaat
      661 atggatcaca ctgttgtgct gcagctggcc gaggaacacc tgctgaagga aggactggcc
      721 tggctggatc tgcaggctcc aggggaggcc cactactggc tgccagctct tttcacagat
      781 ctctactccc aggagatatc agctgaggag gccaaagaag ccttcccttg actgagtgtg
      841 gaggggtaga cagcagcagg ccagaagatg ccctgtctgt gaataaacct ggacaacttt
      901 gtttataaaa aaaagttcat tccaagttaa aaaaaaaaaa a
//
