LOCUS       NM_172463               9147 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus sushi, nidogen and EGF-like domains 1 (Sned1), mRNA.
ACCESSION   NM_172463
VERSION     NM_172463.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9147)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   2  (bases 1 to 9147)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9147)
  AUTHORS   Martinez,M.E. and Hernandez,A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9147)
  AUTHORS   Vallet,S.D., Davis,M.N., Barque,A., Thahab,A.H., Ricard-Blum,S. and
            Naba,A.
  TITLE     Computational and experimental characterization of the novel ECM
            glycoprotein SNED1 and prediction of its interactome
  JOURNAL   Biochem J 478 (7), 1413-1434 (2021)
   PUBMED   33724335
REFERENCE   5  (bases 1 to 9147)
  AUTHORS   Barque,A., Jan,K., De La Fuente,E., Nicholas,C.L., Hynes,R.O. and
            Naba,A.
  TITLE     Knockout of the gene encoding the extracellular matrix protein
            SNED1 results in early neonatal lethality and craniofacial
            malformations
  JOURNAL   Dev Dyn 250 (2), 274-294 (2021)
   PUBMED   33012048
  REMARK    GeneRIF: Knockout of the gene encoding the extracellular matrix
            protein SNED1 results in early neonatal lethality and craniofacial
            malformations.
REFERENCE   6  (bases 1 to 9147)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   7  (bases 1 to 9147)
  AUTHORS   Machold,R., Klein,C. and Fishell,G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
REFERENCE   8  (bases 1 to 9147)
  AUTHORS   Leimeister,C., Schumacher,N., Diez,H. and Gessler,M.
  TITLE     Cloning and expression analysis of the mouse stroma marker Snep
            encoding a novel nidogen domain protein
  JOURNAL   Dev Dyn 230 (2), 371-377 (2004)
   PUBMED   15162516
  REMARK    GeneRIF: comparative expression analysis of kidney stroma markers
            suggests that Snep is expressed in a specific subpopulation of
            stromal cells and may provide environmental cues to support regular
            development
REFERENCE   9  (bases 1 to 9147)
  AUTHORS   Ueno,H., Sakita-Ishikawa,M., Morikawa,Y., Nakano,T., Kitamura,T.
            and Saito,M.
  TITLE     A stromal cell-derived membrane protein that supports hematopoietic
            stem cells
  JOURNAL   Nat Immunol 4 (5), 457-463 (2003)
   PUBMED   12665856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124669.8.
            
            On Nov 9, 2022 this sequence version replaced NM_172463.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ584850.1, BC145886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AC124669.8         44333-44693
            362-649             AC124669.8         64757-65044
            650-790             AC124669.8         67458-67598
            791-953             AC124669.8         68137-68299
            954-1079            AC124669.8         70141-70266
            1080-1193           AC124669.8         70596-70709
            1194-1307           AC124669.8         73530-73643
            1308-1421           AC124669.8         73771-73884
            1422-1547           AC124669.8         79634-79759
            1548-1652           AC124669.8         80091-80195
            1653-1766           AC124669.8         80347-80460
            1767-1883           AC124669.8         80984-81100
            1884-2000           AC124669.8         82541-82657
            2001-2117           AC124669.8         82836-82952
            2118-2231           AC124669.8         83097-83210
            2232-2405           AC124669.8         83789-83962
            2406-2519           AC124669.8         88973-89086
            2520-2633           AC124669.8         89729-89842
            2634-2747           AC124669.8         90144-90257
            2748-2861           AC124669.8         90761-90874
            2862-3158           AC124669.8         91184-91480
            3159-3342           AC124669.8         91694-91877
            3343-3455           AC124669.8         92067-92179
            3456-3737           AC124669.8         92877-93158
            3738-3882           AC124669.8         94288-94432
            3883-3965           AC124669.8         94504-94586
            3966-4061           AC124669.8         95420-95515
            4062-4178           AC124669.8         97800-97916
            4179-4266           AC124669.8         98490-98577
            4267-4348           AC124669.8         104212-104293
            4349-9147           AC124669.8         104759-109557
FEATURES             Location/Qualifiers
     source          1..9147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.21 cM"
     gene            1..9147
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /note="sushi, nidogen and EGF-like domains 1"
                     /db_xref="GeneID:208777"
                     /db_xref="MGI:MGI:3045960"
     exon            1..361
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..4360
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /note="secreted protein SST3; sushi, nidogen and EGF-like
                     domain-containing protein 1; secreted nidogen domain
                     protein; secreted protein SST-3; stromal nidogen
                     extracellular matrix protein"
                     /codon_start=1
                     /product="sushi, nidogen and EGF-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_766051.4"
                     /db_xref="CCDS:CCDS35670.1"
                     /db_xref="GeneID:208777"
                     /db_xref="MGI:MGI:3045960"
                     /translation="MRLGAAWALLLAAALGLGTRGVRAAVALADFYPFGTKRGDTVTP
                     KQDDGGSGLQPLSVPFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVA
                     AFWADVDNRRAGDVYYREATDPAMLNRATEDIRRYFPELPDFSATWVFVATWYRVTFF
                     GGSSSSPVNTFQTVLITDGRFSFTIFNYESILWTTGTHASSGGDTDGLGGIAAQAGFN
                     AGDGHRYFNIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLVLR
                     PCLNGGKCIDDCVTGNPSYTCSCLAGFTGRRCHLDVNECASHPCQNGGTCTHGVNSFS
                     CQCPAGFKGPTCESAQSPCDNKVCQNGGQCQAESSSAVCVCQAGYTGATCETDVDECS
                     SDPCQNGGSCVDLVGNYSCICVEPFEGPQCETGSYLVPSPCLSNPCQNGGTCVDADEG
                     YVCECPEGFMGLDCRERILNDCDCRNGGRCLGANTTLCQCPPGFFGLLCEFEVTATPC
                     NMNTQCPDGGYCMEYGGSYLCVCHTDHNISHSLPSPCDSDPCFNGGSCDAHEDSYTCE
                     CPRGFHGRHCEKARPHLCSSGPCRNGGTCKEMGDEYRCTCPYRFTGRHCEIGKPDSCA
                     SGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGTCEDLGTDFSCY
                     CQPGYTGHRCQAEVDCGHPEEVEHATMRFNGTHVGSVALYTCEPGFSLSALSHIRVCQ
                     PQGVWSQPPQCIEVDECRSQPCLHGGSCQDLIADYQCLCSPGYEGVHCELETDECQAQ
                     PCRNGGSCRDLPRAFICQCPEGFVGIHCETEVDACASSPCQHGGRCEDGGGAYLCVCP
                     EGFFGYNCETVSDPCFSSPCGSRGYCLASNGSHSCTCKVGYTGKDCTKELLPPTALRV
                     ERVEESGVSISWSPPEGTTARQVLDGYAVTYASSDGSSRRTDFVDRSRSSHQLRALAA
                     GRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPIEDFEVTNISANAISVQWALHRI
                     QHATVSRVRVSILYPEASAVQSTEVDRSVDRLTFGDLLPGRRYTVRLTTLSGPGGAEY
                     PTESLASAPLNVWTRPLPPANLTASRVTATSAHMVWDTPAPGISLEAYVINVTTSQST
                     KSRYIPNGKLVSYTVRDLMPGRRYQLSVTAVQSTEQGQLHSEPAHLYIITSPRDGTDR
                     RWHHGGHHSRMLRNRPAPVRLPELRLLNDHSAPETPTQSSRFSELVDGRGRVSARFGG
                     LPSRAVTVRSQPTTPVPLKNTEAPEQVHLALQLPKNSSKDTESTPGSCSEDACQNGGT
                     CVPGADAHSCDCRPGFKGRHCELACEKVPRPCTRLFSETKSFPVWEGDICHHVYKKVY
                     KVHQDVCFKERCQSTSLRKPKQETK"
     exon            362..649
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..790
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..953
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1079
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1193
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1307
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1421
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1547
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1652
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1766
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1883
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2000
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2117
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2231
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2405
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2519
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2633
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2747
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2861
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3158
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3342
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3455
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3737
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3882
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..3965
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4061
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4178
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4266
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4348
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..9147
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9125..9130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /note="hexamer: AATAAA"
     polyA_site      9147
                     /gene="Sned1"
                     /gene_synonym="6720455I24Rik; D430044C15Rik; Snep; SST3"
                     /note="major polyA site"
ORIGIN      
        1 ggtccgcagt cgtgcctcac gccttcctaa gctgcgcggg tctccggagt gcgacgcgag
       61 ctagcggaag ggaactgtgc ggccagtcgg tcgtgcggtg actgcagcca cctgcccgag
      121 ccccgtggcc cgccctcaga tcccggcgat gcgcctcggc gccgcctggg cgctgctgct
      181 ggccgcagcc ctggggctcg ggacgcgcgg ggtgcgcgct gccgtggccc tcgccgactt
      241 ctacccgttc ggcacgaagc gcggcgacac cgtcaccccg aagcaggacg acggcggctc
      301 agggctgcaa ccactctcgg tgccctttcc gttcttcggc gccgagcact ccggactcta
      361 cgtgaacaat aatgggatca tctccttcct gaaggaagtt tctcagttca cccccgtggc
      421 cttccccatc gccaaagacc gctgtgtggt agcagccttc tgggcagatg tagacaaccg
      481 gcgtgcaggt gatgtctact accgggaggc caccgaccca gccatgctga acagagccac
      541 ggaggacatc agacggtact ttcctgagct cccggacttc tctgctacct gggtttttgt
      601 tgcgacctgg taccgtgtga ccttctttgg aggcagcagc tcttcccccg ttaacacatt
      661 ccaaactgta ctcatcaccg atggccgatt ctccttcacc atcttcaact atgagtccat
      721 cttgtggact accggcacac acgccagcag cgggggtgac actgatggct tgggaggcat
      781 tgcagcccag gcaggtttca acgcaggtga tgggcaccgc tacttcaaca tccccgggtc
      841 gcgcacagca gacatggctg aggtggagac caccaccaac gtgggcgtgc ccggccgctg
      901 ggcgtttaga atcgatgatg cccaggtgcg cgtggggggc tgcggccata caacctctgt
      961 gtgcctggtc ctgcgtccat gcctcaatgg tggcaagtgc attgatgact gcgtcacggg
     1021 caatccctct tacacctgtt cctgtctcgc tggcttcaca ggccggagat gccacctgga
     1081 tgtgaacgag tgtgcttccc acccctgtca gaatggtggg acctgcaccc atggtgtcaa
     1141 cagcttcagc tgccagtgcc cagccggctt caagggaccc acctgtgaat cggcccaatc
     1201 tccgtgtgac aacaaagtat gtcaaaatgg tggccagtgc caggcagaga gcagctctgc
     1261 agtatgtgtg tgtcaggctg gatacactgg ggccacctgt gagacagatg tggatgaatg
     1321 cagttctgac ccatgccaga atgggggatc atgtgttgac ctggttggaa actacagctg
     1381 tatttgtgtg gagcccttcg agggacctca gtgtgagaca ggaagctacc tggtgccttc
     1441 accctgcctc tccaacccct gccagaacgg gggcacctgt gtggatgctg atgagggata
     1501 cgtgtgtgaa tgccctgaag gcttcatggg cttggactgc agagagagga tcctcaatga
     1561 ctgtgactgc cggaacggag gcagatgcct gggtgccaac accaccctct gccagtgtcc
     1621 tccaggcttc tttgggctcc tctgtgaatt tgaagtcaca gccacgccct gcaacatgaa
     1681 cacgcagtgt ccagatggag gctactgcat ggagtatggc ggaagctacc tatgtgtctg
     1741 ccacacagac cacaacatca gccactctct gccatccccc tgcgactcag acccttgctt
     1801 taatggaggt tcctgtgacg cccacgagga ctcctacacg tgcgagtgcc ctcgtggatt
     1861 ccacggcagg cactgtgaga aagcccggcc acacctgtgc agctcagggc cctgccggaa
     1921 tggaggcaca tgcaaggaaa tgggcgacga gtaccgctgc acctgccctt atagattcac
     1981 tgggagacac tgtgagattg gaaagccaga ctcctgtgcc tctggcccct gtcataatgg
     2041 tgggacttgt ttccactaca ttggcaaata caagtgtgac tgccctccag gattctctgg
     2101 acggcactgt gagatagctc cctcaccctg cttccggagc ccatgtatga atgggggtac
     2161 ctgtgaggat ctagggacag atttctcctg ctactgccag ccagggtata caggacaccg
     2221 gtgtcaggca gaggtggact gtggtcaccc tgaggaggtg gagcatgcta ccatgcgctt
     2281 caacggaact cacgtgggct cagtggccct gtacacatgt gagcccggct tcagcctgag
     2341 tgccctcagc catatacgtg tctgtcagcc acaaggggtc tggagccagc ctccccagtg
     2401 cattgaagta gatgagtgcc ggtctcagcc atgcctgcac ggaggctcct gccaggacct
     2461 cattgctgat taccagtgcc tctgcagccc ggggtatgaa ggagtccact gtgagctaga
     2521 gacagatgag tgccaagcac agccatgcag aaatgggggc tcctgcaggg acctccccag
     2581 ggctttcatc tgccagtgcc ctgaaggttt tgttggaatc cactgtgaaa cagaggtgga
     2641 tgcctgtgcc tccagcccct gccagcacgg aggccggtgt gaggacggtg gtggggccta
     2701 cctgtgcgtg tgtccagagg gcttctttgg ctacaactgt gagacagtga gtgacccctg
     2761 cttctctagc ccctgtggga gccgcggcta ctgcttggcc agcaacgggt cccacagctg
     2821 tacctgcaaa gtgggctaca caggcaagga ctgcaccaaa gagctcctcc caccaacagc
     2881 cctcagggta gaaagggtgg aggagagtgg ggtctccatc tcctggagtc cacccgaggg
     2941 caccacggcc aggcaggtgc tggatggcta tgcagtcacc tatgcctcct cggatggatc
     3001 gtcccggcgc acagactttg tggaccggag ccgctcctct caccagcttc gggccctagc
     3061 agccggccgc gcctacaata tctccgtttt ctcagtcaag agaaacacaa acaacaaaaa
     3121 tgacatcagc aggcctgcag cactgctcac ccgcacccga ccccgcccta tagaagactt
     3181 tgaggtcacc aacatttcag ccaatgccat ctcagtgcag tgggctcttc acaggatcca
     3241 gcacgccact gtcagcaggg tccgggtgtc catcctctac cccgaggcct ctgcggtcca
     3301 gtccactgag gtggacagga gtgtggaccg cctcacattt ggggacctgc tgccagggag
     3361 aagatacact gtgcggctaa ccacccttag tgggcctgga ggagctgaat atcctaccga
     3421 gagcctggct tcagctccac tgaacgtgtg gacccggcct ttgccaccag caaacctgac
     3481 tgcctctcga gtcacagcta cctctgccca tatggtctgg gacacccccg ctccaggtat
     3541 ctcactggag gcttatgtca tcaatgtgac cacaagtcaa agtaccaaga gccgctacat
     3601 ccccaatggg aagctggtgt cctatacagt gcgtgatctg atgccaggtc ggcggtacca
     3661 gctctcagtt acagctgtgc agagcacaga gcagggccag ctgcacagtg agcctgcaca
     3721 cctctacatc atcacctccc ccagggatgg caccgacaga cgctggcacc atggaggaca
     3781 ccactcacgg atgctcagaa acagaccagc ccctgtgcgc ctgcctgagc tgcgcctgct
     3841 caatgaccac agtgcccctg aaacaccaac tcagtcatcc aggttctcag agcttgtaga
     3901 tggaagagga agagtgagtg ccaggtttgg tggcttgccc agcagagcag taactgtgag
     3961 atcacaaccc accactccgg tgccactcaa gaacacagag gcccctgagc aggtccatct
     4021 ggccctccag ctacccaaga acagcagcaa agacacagaa agtacccctg gcagctgttc
     4081 agaagatgct tgtcagaatg gaggcacctg tgtcccaggt gccgatgccc acagctgtga
     4141 ctgcaggcct gggttcaaag gcagacactg tgagcttgcc tgtgaaaaag tgccccgccc
     4201 ctgcacacgg ctgttctctg agaccaagtc atttcctgtc tgggaaggcg acatctgcca
     4261 ccatgtgtat aagaaagtct acaaagttca ccaggacgtg tgctttaagg agcgctgcca
     4321 gagcacaagc ctcaggaaac ccaaacagga aacaaagtaa cagtcaaaca ctgaagagat
     4381 cttaaggaaa tcattctcct tcataccaag atctgttgag aactggagac accatcacac
     4441 ccagcaacct ggacaccaag gtcctttatc agacactgat ggtgacaact cagcactgtg
     4501 ctgttacaga cccaaccagg aaggttccag aattccctgt ctatagcctc tcaatagaca
     4561 taacctggtc tgagcttgca tatgaatcta ctttcaggtg gaaatgactc tctcattgca
     4621 gaccagttac aatgaggtac aagaatcacc tggccccttc aggaccatgg gccttgctgg
     4681 cagatggatc aaggatgcca aacagtccaa acaatgccaa aggaaaggac ctaaggacat
     4741 acccccaagc cctacgagca gcattctgct ggtagactag ggcgggagtc ttgtcatgta
     4801 acctgcagga gatcctaaat atagcctctc tctgggggtg ctagagtgga ccctggaatt
     4861 ctaagcacta ataaccctga aatcaaagaa actgcccgtt tgatccagca tgccccaccc
     4921 cgcctcccca agcataaact gtgagatgtt aaagggcatt ggaatttttt ttttcacagt
     4981 agtctggaaa atactgggtt acactacaga aatccctgta taggctgaac acagccccac
     5041 actgacttat tggcataatt ggaatgacag actggctagc cagagagaat ttactcctct
     5101 cccttggagg agccagggca gtccatcttt ccagtggtgg aagagaggca tatctggaaa
     5161 gctcccactt caggagtgac tatcaccttt ttcttctata gtgtaggaca tgaaggagaa
     5221 atgtcaccca aaggcctaag aacaaacaaa agcaatggag ttccgggtga aggtcatcct
     5281 aagaaaacag tgcctgcagt gacagtgaca ggcacagaca gaagctcaca gtcggaccct
     5341 gaaatcaggc aggcatcagg agggcaggct ctcagacggg cctagggagc agggcctgtg
     5401 cctcctgacc ggttcagatg tgaaactctg caggaagaac agccgacaag actcaagtcc
     5461 tgtgcaccca acagcatcgc cttttcagcc cagcaccaag aatgcacaca aaacaccctc
     5521 caacacttgt gagcaacaca tctggcaaag ataaaaaatc cacaaattat ttggttttaa
     5581 aatatttata tggtaataag tcacttgaaa tattaatgca tcttttacga actcacccag
     5641 aaaacccatt tttataaaaa aaaaaaagag agagagaatc ctagatactt accacataat
     5701 ggcttataga attcctattc tcagagcaac acacattaca cacagccctt tctctttctc
     5761 tgaagaaaaa caccagaatt tgcgacccac agctgccctg agaaagccgg cagtgccatc
     5821 cccgccaaaa gaaaggcagc agagggccaa gcagcctact gatgcaaagc cccaggctgg
     5881 gcacgagtgt cctcagggtg cgtggctcct gtccatccct ccctgcatcc cagccggctg
     5941 gaaatctggc tcctggggac agtgcttgct gtctccagag aaagacagtg ggtacaaaga
     6001 ggagtgtgcc ccagctcact gttactcctt caaaaggacc agcatgtgct ggtaacactg
     6061 cccacctccc ggatttccaa aactcaggaa aatgatgtcc aaaacttaaa agccaagctc
     6121 ctggctgaaa gcagtctccc ctgagatctc tgtcctcaga tttccagaaa agagacaacc
     6181 agacctgcac acccaaagcc gcctgccggg gaagcactga agcacctgcc atctcaatcc
     6241 agcctgctgt ttctgcagct ctggtcagtt cccctgtggg gagttacctg ggttaccagg
     6301 ctctgtgagt ggtgcttctg tgctcagaaa cccaccccca gatccccgtg ccagagacat
     6361 gacccttgaa ctcccaaaac atggagaagg aaaagactca actttcataa aaaatacaag
     6421 aaaggctgtg tggaaacagg tgacctctac cctgctcctc tcctcattta tactgaccta
     6481 aagaagaagt gctaattact actatggtgg agtttagaca cttggtctac aactcagggg
     6541 tggcagggca gtcagatgct caggcaggat tttgggcttc gaagatagaa tgacctctct
     6601 ggcacacacg tgaccctgct actgtactgc caacatggta acagatgtag atagcatagc
     6661 tacattccaa tgaaacttca tttacgaaaa caggcggtag gctagagttg gcaggcaggt
     6721 gcctggttta taagatgatc tagacttcag ccttctgtgg agaatgctat ctcctgaatg
     6781 acaagtagcc atcaagacat gaaaaacccc taaactttca tagaagaaaa gcaatcaaga
     6841 cccttgctca ggagcctaag gtatacatac ttacaccata gagcagcaaa agctatcagt
     6901 tcaaatctaa acgcagccca cagtagcaca gggcaggccg gctgcaggac acagggtcca
     6961 accaaggctt cttgtaatct gcgcctgaag tagatggctg tgggccacca aaacgaaaat
     7021 actttcttta cacagcctcc gctttccatc ccattcccaa ggctctaagc agcttcctcc
     7081 tccctgcagt gaccgcacaa tcagaaaagc caaccacacc tagattccat gagagcagag
     7141 ctgaccagca ccagcaccaa gaactgcatc ccgaccagag aggccttctg ccctccacag
     7201 ttcataaaaa catactttga agtataacct tttacatttt attctcacta gaaaattctg
     7261 agcctatgta ttactttttt ttttcttttt caaggagggt cagtcacatc aaaaactcac
     7321 tactgtatct tagataccca ctagagatct ggagaccgag taagctacag tgttaacagt
     7381 gaacagcaag atcaagcagc acctctggga acgtagatgg gatcttcgta ctatacctca
     7441 ggactctcac ccccaagccg atgctgccac attcccatct ccagttggag ccagcctgct
     7501 gtgtggcgct gtcgggcaat cattccaact ggagtggaga aagacttgcc tgtgctgagg
     7561 aattagtata catcattcca aacatgctgt ctctgctttc ttacacagaa taattaaatc
     7621 cctcaaaaca gtcagcgtcc acttgggaaa tgtcatagtg gaatcagcaa acagacaagg
     7681 tggagattta tttttgtgtc caactgaagt aattatgagt tgttgggctc accatttgct
     7741 aatcaaaact gaagatgagt agattaccta attgagctca cagttaggat tctattccgt
     7801 tctgatgagt ccaaggccaa acaccctaca ttcagggagg agagtgtcga tcacaaaaag
     7861 accacaaaat gggaagagta agcagcaaag aatggatcat tgttctcaaa cagctttgtc
     7921 cacagccaag aacaggcaga aggcattcgt tcccctctac tgcctatggg atgtggggta
     7981 gagaagatgg cttgctacgt cctgctttct gtggagagtc caacaggcaa ggacacgccc
     8041 ttgccaggaa tgagcttgcc tcacatacct gccatagtga gaactgtgtg tgtggagggt
     8101 aggggtgggg ggaggaatct tggaatgatt gcttttcttt gtaaacaccc tcctctttgc
     8161 agtcaggttc caggtaagtc aagagccgcc tcaccttggt gctgattcct cacaaaatgc
     8221 acctcagatc cagcagtatc tctgctttag acagaaatga tacatcaggt ccatttacaa
     8281 cacacattag ctgtagtcac agtacttttg tgggccaggt ctttgagcag tttctcagct
     8341 ttggcattgc tttgtgggcc taattattcc ttatgcggtg caatgtacaa tattttacag
     8401 catccctggc tctgaccaca agatcctgag gccatgacac acacacacac acacacacac
     8461 acacacacac acaaatcccc aaagattgtc agatgtctgg aggattaagg tcatcctcac
     8521 gtaagcactg gattcagtct aaacacaagg cccacattgg gtttcgtgtg actgttaaat
     8581 gtcaccaaat gggggaaaaa tactaccaag cactcctgac tttgatccta taaccaaaaa
     8641 gctttctgca tcaccctgtg cagtttcctg aggaagaggc acagacaact ttccaagagg
     8701 cctcagttct ctgaccctct aagcctgagc tccaccaaat caggcctctc ctccagctca
     8761 cctcatccta gtcccagtac atcacatggc tccactgcac acactccaca ctgcccagtg
     8821 ctccccagtg ctggtctctg agcagctcac tcttagcaca gtctacagag ccagaaagat
     8881 aggaggcctt gaagtggcaa ccagccagga accaacatga aggccaactt gcccaagcag
     8941 gaagggtcag caactgacag agaagcattt tgctagtctg acaaccgtgt gactaaagga
     9001 catgttacta acgtaaccaa ctgcctctca ctctgctgta cactcaacac gtcagaaggc
     9061 tgggaaatgg tgtcagattt agaagctgcc tattgtgtgg gaaacctgct acttgttttc
     9121 attaaataaa gtgctatgac atactaa
//
