LOCUS       NP_035560                123 aa            linear   ROD 06-MAY-2025
DEFINITION  gamma-synuclein [Mus musculus].
ACCESSION   NP_035560
VERSION     NP_035560.1
DBSOURCE    REFSEQ: accession NM_011430.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 123)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (residues 1 to 123)
  AUTHORS   Dudok,B., Fan,L.Z., Farrell,J.S., Malhotra,S., Homidan,J.,
            Kim,D.K., Wenardy,C., Ramakrishnan,C., Li,Y., Deisseroth,K. and
            Soltesz,I.
  TITLE     Retrograde endocannabinoid signaling at inhibitory synapses in vivo
  JOURNAL   Science 383 (6686), 967-970 (2024)
   PUBMED   38422134
REFERENCE   3  (residues 1 to 123)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 123)
  AUTHORS   Vargas,K.J., Colosi,P.L., Girardi,E., Park,J.M., Harmon,L.E. and
            Chandra,S.S.
  TITLE     alpha-Synuclein colocalizes with AP180 and affects the size of
            clathrin lattices
  JOURNAL   J Biol Chem 299 (9), 105091 (2023)
   PUBMED   37516240
REFERENCE   5  (residues 1 to 123)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 123)
  AUTHORS   Alimova-Kost,M.V., Ninkina,N.N., Imreh,S., Gnuchev,N.V., Adu,J.,
            Davies,A.M. and Buchman,V.L.
  TITLE     Genomic structure and chromosomal localization of the mouse persyn
            gene
  JOURNAL   Genomics 56 (2), 224-227 (1999)
   PUBMED   10051410
REFERENCE   7  (residues 1 to 123)
  AUTHORS   Ninkina,N.N., Privalova,E.M., Pinon,L.G., Davies,A.M. and
            Buchman,V.L.
  TITLE     Developmentally regulated expression of persyn, a member of the
            synuclein family, in skin
  JOURNAL   Exp Cell Res 246 (2), 308-311 (1999)
   PUBMED   9925745
REFERENCE   8  (residues 1 to 123)
  AUTHORS   Buchman,V.L., Hunter,H.J., Pinon,L.G., Thompson,J., Privalova,E.M.,
            Ninkina,N.N. and Davies,A.M.
  TITLE     Persyn, a member of the synuclein family, has a distinct pattern of
            expression in the developing nervous system
  JOURNAL   J Neurosci 18 (22), 9335-9341 (1998)
   PUBMED   9801372
REFERENCE   9  (residues 1 to 123)
  AUTHORS   Lavedan,C.
  TITLE     The synuclein family
  JOURNAL   Genome Res 8 (9), 871-880 (1998)
   PUBMED   9750188
  REMARK    Review article
REFERENCE   10 (residues 1 to 123)
  AUTHORS   Buchman,V.L., Adu,J., Pinon,L.G., Ninkina,N.N. and Davies,A.M.
  TITLE     Persyn, a member of the synuclein family, influences neurofilament
            network integrity
  JOURNAL   Nat Neurosci 1 (2), 101-103 (1998)
   PUBMED   10195122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA690669.1 and BC028508.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028508.1, AF017255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.81 cM"
     Protein         1..123
                     /product="gamma-synuclein"
                     /calculated_mol_wt=13028
     Region          1..>105
                     /region_name="Synuclein"
                     /note="pfam01387"
                     /db_xref="CDD:460186"
     Region          20..67
                     /region_name="4 X 11 AA tandem repeats of
                     [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0F7.1)"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63544; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0F7.1)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63544; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0F7.1)"
     Region          91..123
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0F7.1)"
     Site            120
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by BARK1, CaMK2 and CK2.
                     /evidence=ECO:0000250|UniProtKB:O76070; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0F7.1)"
     CDS             1..123
                     /gene="Sncg"
                     /gene_synonym="persyn"
                     /coded_by="NM_011430.3:90..461"
                     /db_xref="CCDS:CCDS26937.1"
                     /db_xref="GeneID:20618"
                     /db_xref="MGI:MGI:1298397"
ORIGIN      
        1 mdvfkkgfsi akegvvgave ktkqgvteaa ektkegvmyv gtktkenvvq svtsvaektk
       61 eqanavseav vssvntvank tveeaenivv ttgvvrkedl eppaqdqeak eqeeneeaks
      121 ged
//
