LOCUS       NM_033610               1365 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus synuclein, beta (Sncb), transcript variant 1, mRNA.
ACCESSION   NM_033610
VERSION     NM_033610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Zhong,W., Yang,Q., Wang,F., Lin,X., Chen,Z., Xue,J., Zhao,W.,
            Liu,X., Rao,B. and Zhang,J.
  TITLE     Cell-specific localization of beta-synuclein in the mouse retina
  JOURNAL   Brain Struct Funct 229 (5), 1279-1298 (2024)
   PUBMED   38703218
  REMARK    GeneRIF: Cell-specific localization of beta-synuclein in the mouse
            retina.
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Vargas,K.J., Colosi,P.L., Girardi,E., Park,J.M., Harmon,L.E. and
            Chandra,S.S.
  TITLE     alpha-Synuclein colocalizes with AP180 and affects the size of
            clathrin lattices
  JOURNAL   J Biol Chem 299 (9), 105091 (2023)
   PUBMED   37516240
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Carnazza,K.E., Komer,L.E., Xie,Y.X., Pineda,A., Briano,J.A.,
            Gao,V., Na,Y., Ramlall,T., Buchman,V.L., Eliezer,D., Sharma,M. and
            Burre,J.
  TITLE     Synaptic vesicle binding of alpha-synuclein is modulated by beta-
            and gamma-synucleins
  JOURNAL   Cell Rep 39 (2), 110675 (2022)
   PUBMED   35417693
  REMARK    Erratum:[Cell Rep. 2024 May 28;43(5):114280. doi:
            10.1016/j.celrep.2024.114280.. PMID: 38758645]
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Windisch,M., Hutter-Paier,B., Rockenstein,E., Hashimoto,M.,
            Mallory,M. and Masliah,E.
  TITLE     Development of a new treatment for Alzheimer's disease and
            Parkinson's disease using anti-aggregatory beta-synuclein-derived
            peptides
  JOURNAL   J Mol Neurosci 19 (1-2), 63-69 (2002)
   PUBMED   12212795
  REMARK    GeneRIF: Beta-synuclein decreased formation of Lewy bodies by 40%,
            and prevented functional deficits associated with overexpression of
            alpha-synuclein. This is a preliminary in vivo proof of
            antiaggregatory function of beta-synuclein.
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Sopher,B.L., Koszdin,K.L., McClain,M.E., Myrick,S.B.,
            Martinez,R.A., Smith,A.C. and La Spada,A.R.
  TITLE     Genomic organization, chromosome location, and expression analysis
            of mouse beta-synuclein, a candidate for involvement in
            neurodegeneration
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 117-123 (2001)
   PUBMED   11474193
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Kahle,P.J., Neumann,M., Ozmen,L., Muller,V., Jacobsen,H.,
            Schindzielorz,A., Okochi,M., Leimer,U., van Der Putten,H.,
            Probst,A., Kremmer,E., Kretzschmar,H.A. and Haass,C.
  TITLE     Subcellular localization of wild-type and Parkinson's
            disease-associated mutant alpha -synuclein in human and transgenic
            mouse brain
  JOURNAL   J Neurosci 20 (17), 6365-6373 (2000)
   PUBMED   10964942
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Lavedan,C.
  TITLE     The synuclein family
  JOURNAL   Genome Res 8 (9), 871-880 (1998)
   PUBMED   9750188
  REMARK    Review article
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Hsu,L.J., Mallory,M., Xia,Y., Veinbergs,I., Hashimoto,M.,
            Yoshimoto,M., Thal,L.J., Saitoh,T. and Masliah,E.
  TITLE     Expression pattern of synucleins (non-Abeta component of
            Alzheimer's disease amyloid precursor protein/alpha-synuclein)
            during murine brain development
  JOURNAL   J Neurochem 71 (1), 338-344 (1998)
   PUBMED   9648883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236281.1 and BC019409.1.
            
            On Apr 14, 2018 this sequence version replaced NM_033610.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019409.1, BU562617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               CX236281.1         1-155
            156-1365            BC019409.1         1-1210
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.28 cM"
     gene            1..1365
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /note="synuclein, beta"
                     /db_xref="GeneID:104069"
                     /db_xref="MGI:MGI:1889011"
     exon            1..291
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     exon            292..421
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..702
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /codon_start=1
                     /product="beta-synuclein"
                     /protein_id="NP_291088.1"
                     /db_xref="CCDS:CCDS36670.1"
                     /db_xref="GeneID:104069"
                     /db_xref="MGI:MGI:1889011"
                     /translation="MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKT
                     SGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAA
                     EEPLIEPLMEPEGESYEDSPQEEYQEYEPEA"
     exon            422..460
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     exon            461..579
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     exon            580..669
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1351
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /note="hexamer: AATAAA"
     polyA_site      1351
                     /gene="Sncb"
                     /gene_synonym="betaSYN"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgcgg ccaccagggg ggagtgctga gctcagagct gccgcagcgc cggagcagga
       61 gccggagcgg agccggagcg cgcgagtagc atccttggtg gcagagcacc caaggccaga
      121 gcactgctgc actccagctc aggaaaggtg actcaagagc ctgaccacgg caggacacca
      181 ctggccccga gtccatccat acccagcgta gcccagcccc gcgcatctgc tcgcagtagc
      241 agccgctgcc gccaccacag ctccatcccc cagcccggcc ccgaaaccca ggccgccagg
      301 atggacgtgt tcatgaaggg cctgtccatg gccaaggagg gcgttgtggc tgcagctgag
      361 aaaaccaagc agggggtcac cgaggcagca gagaagacca aggaaggcgt cctctatgtc
      421 ggaagcaaga ccagtggagt ggtacaaggt gtagcctcag tggctgagaa aaccaaggag
      481 caggcatcgc atctgggagg agctgtgttc tctggggctg ggaacattgc agcagccacg
      541 ggcctggtga aaaaggaaga gttccccaca gacctgaagc cagaggaggt ggcccaagaa
      601 gccgctgagg agcccctgat tgagcctctg atggaaccag aaggggaaag ttatgaggac
      661 tcaccccagg aggaatacca ggaatacgag ccagaggcgt aaggggtcca ggagggcctc
      721 gcaccagcag cacaattcct tctgtccctg tccctgtccc tgccccatcc ctctccctcc
      781 caacccccca cccccacccc ccagagccag ggctgtcctt ctaccttttc ccccaaacac
      841 gagatcttcc ttcggctctg aggcacttcc tcagggcctg tgttagtgtc tgccctgccc
      901 ttccgtctgt cctacttgcc cgcgttcatc cctgaggcgt ggactggagt cgggcagaga
      961 ggtccggctg ggagccccgc cctaccagtg ttgcccctca ccctccattt ggtccagtgt
     1021 ctgctcggat gtagcatgtt ctatgtattt ttaaaccaag atgggaaaac tatggctcct
     1081 tccccatcct aacagaggtt cttcaatggg ctcccccccc cccgcagccc caattcgacc
     1141 cctaaaatgt tttgttttgt tttgtttttt aacccaaacc aggagccagg tcgtgccatg
     1201 ccccctccct cagcccgctc ggtccgagcg cgggcgtcgt ttgttgtgat tgtggcatgg
     1261 agagtccccc cacccaccgt gtgagcgtgt cccggggtgg gcggccaagc cgctccccag
     1321 tgtgtccatg aataaagcca atctgtctgt aaaaaaaaaa aaaaa
//
