LOCUS       NM_001042451            1304 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus synuclein, alpha (Snca), transcript variant 1, mRNA.
ACCESSION   NM_001042451
VERSION     NM_001042451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Matsuo,K., Asamitsu,S., Maeda,K., Suzuki,H., Kawakubo,K.,
            Komiya,G., Kudo,K., Sakai,Y., Hori,K., Ikenoshita,S., Usuki,S.,
            Funahashi,S., Oizumi,H., Takeda,A., Kawata,Y., Mizobata,T.,
            Shioda,N. and Yabuki,Y.
  TITLE     RNA G-quadruplexes form scaffolds that promote neuropathological
            alpha-synuclein aggregation
  JOURNAL   Cell 187 (24), 6835-6848 (2024)
   PUBMED   39426376
REFERENCE   2  (bases 1 to 1304)
  AUTHORS   Kim,Y., McInnes,J., Kim,J., Liang,Y.H.W., Veeraragavan,S.,
            Garza,A.R., Belfort,B.D.W., Arenkiel,B., Samaco,R. and Zoghbi,H.Y.
  TITLE     Olfactory deficit and gastrointestinal dysfunction precede motor
            abnormalities in alpha-Synuclein G51D knock-in mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2406479121 (2024)
   PUBMED   39284050
  REMARK    GeneRIF: Olfactory deficit and gastrointestinal dysfunction precede
            motor abnormalities in alpha-Synuclein G51D knock-in mice.
REFERENCE   3  (bases 1 to 1304)
  AUTHORS   Gcwensa,N.Z., Russell,D.L., Long,K.Y., Brzozowski,C.F., Liu,X.,
            Gamble,K.L., Cowell,R.M. and Volpicelli-Daley,L.A.
  TITLE     Excitatory synaptic structural abnormalities produced by templated
            aggregation of alpha-syn in the basolateral amygdala
  JOURNAL   Neurobiol Dis 199, 106595 (2024)
   PUBMED   38972360
  REMARK    GeneRIF: Excitatory synaptic structural abnormalities produced by
            templated aggregation of alpha-syn in the basolateral amygdala.
            Erratum:[Neurobiol Dis. 2025 Jan;204:106757. doi:
            10.1016/j.nbd.2024.106757. PMID: 39779046]
REFERENCE   4  (bases 1 to 1304)
  AUTHORS   Bido,S., Nannoni,M., Muggeo,S., Gambare,D., Ruffini,G., Bellini,E.,
            Passeri,L., Iaia,S., Luoni,M., Provinciali,M., Giannelli,S.G.,
            Giannese,F., Lazarevic,D., Gregori,S. and Broccoli,V.
  TITLE     Microglia-specific IL-10 gene delivery inhibits neuroinflammation
            and neurodegeneration in a mouse model of Parkinson's disease
  JOURNAL   Sci Transl Med 16 (761), eadm8563 (2024)
   PUBMED   39167665
REFERENCE   5  (bases 1 to 1304)
  AUTHORS   Dadgar-Kiani,E., Bieri,G., Melki,R., Hossain,A., Gitler,A.D. and
            Lee,J.H.
  TITLE     Neuromodulation modifies alpha-synuclein spreading dynamics in vivo
            and the pattern is predicted by changes in whole-brain function
  JOURNAL   Brain Stimul 17 (4), 938-946 (2024)
   PUBMED   39096960
  REMARK    GeneRIF: Neuromodulation modifies alpha-synuclein spreading
            dynamics in vivo and the pattern is predicted by changes in
            whole-brain function.
REFERENCE   6  (bases 1 to 1304)
  AUTHORS   Masliah,E., Rockenstein,E., Veinbergs,I., Mallory,M., Hashimoto,M.,
            Takeda,A., Sagara,Y., Sisk,A. and Mucke,L.
  TITLE     Dopaminergic loss and inclusion body formation in alpha-synuclein
            mice: implications for neurodegenerative disorders
  JOURNAL   Science 287 (5456), 1265-1269 (2000)
   PUBMED   10678833
REFERENCE   7  (bases 1 to 1304)
  AUTHORS   Abeliovich,A., Schmitz,Y., Farinas,I., Choi-Lundberg,D., Ho,W.H.,
            Castillo,P.E., Shinsky,N., Verdugo,J.M., Armanini,M., Ryan,A.,
            Hynes,M., Phillips,H., Sulzer,D. and Rosenthal,A.
  TITLE     Mice lacking alpha-synuclein display functional deficits in the
            nigrostriatal dopamine system
  JOURNAL   Neuron 25 (1), 239-252 (2000)
   PUBMED   10707987
REFERENCE   8  (bases 1 to 1304)
  AUTHORS   Lavedan,C.
  TITLE     The synuclein family
  JOURNAL   Genome Res 8 (9), 871-880 (1998)
   PUBMED   9750188
  REMARK    Review article
REFERENCE   9  (bases 1 to 1304)
  AUTHORS   Hsu,L.J., Mallory,M., Xia,Y., Veinbergs,I., Hashimoto,M.,
            Yoshimoto,M., Thal,L.J., Saitoh,T. and Masliah,E.
  TITLE     Expression pattern of synucleins (non-Abeta component of
            Alzheimer's disease amyloid precursor protein/alpha-synuclein)
            during murine brain development
  JOURNAL   J Neurochem 71 (1), 338-344 (1998)
   PUBMED   9648883
REFERENCE   10 (bases 1 to 1304)
  AUTHORS   Hong,L., Ko,H.W., Gwag,B.J., Joe,E., Lee,S., Kim,Y.T. and Suh,Y.H.
  TITLE     The cDNA cloning and ontogeny of mouse alpha-synuclein
  JOURNAL   Neuroreport 9 (6), 1239-1243 (1998)
   PUBMED   9601701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY782503.1 and BC046764.1.
            
            On Oct 26, 2013 this sequence version replaced NM_001042451.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046764.1, AF033261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               BY782503.1         2-258
            258-1304            BC046764.1         1-1047
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 29.15 cM"
     gene            1..1304
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="synuclein, alpha"
                     /db_xref="GeneID:20617"
                     /db_xref="MGI:MGI:1277151"
     exon            1..281
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     exon            282..428
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..730
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="non-A beta component of AD amyloid; non-A4
                     component of amyloid"
                     /codon_start=1
                     /product="alpha-synuclein"
                     /protein_id="NP_001035916.1"
                     /db_xref="CCDS:CCDS20201.1"
                     /db_xref="GeneID:20617"
                     /db_xref="MGI:MGI:1277151"
                     /translation="MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKT
                     KEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGK
                     GEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA"
     exon            429..470
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     exon            471..613
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     exon            614..697
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1286
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="hexamer: AATAAA"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="hexamer: AATAAA"
     polyA_site      1279
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="major polyA site"
     polyA_site      1284
                     /gene="Snca"
                     /gene_synonym="alpha-Syn; alphaSYN; NACP"
                     /note="major polyA site"
ORIGIN      
        1 agatacccac agccctcacg caccgcacct ccaaccaacc cgtcccctcc ctaggaagag
       61 gagcgaaggc acgaggcagg cgaggggcgg ggagaggcgc tgacaaatca gctgcggggg
      121 cgacgtgaag gagccaggga gccagagcgc ccggcagcag gcagcagacg gcaggagacc
      181 agcaggtgtt ccccctgccc ctgcctgccc ttgcctcttt cattgaaatt agattgggga
      241 aaacaggaag aatcggagtt cttcagaagc ctagggagcc gtgtggagca aaaatacatc
      301 tttagccatg gatgtgttca tgaaaggact ttcaaaggcc aaggagggag ttgtggctgc
      361 tgctgagaaa accaagcagg gtgtggcaga ggcagctgga aagacaaaag agggagtcct
      421 ctatgtaggt tccaaaacta aggaaggagt ggttcatgga gtgacaacag tggctgagaa
      481 gaccaaagag caagtgacaa atgttggagg agcagtggtg actggtgtga cagcagtcgc
      541 tcagaagaca gtggagggag ctgggaatat agctgctgcc actggctttg tcaagaagga
      601 ccagatgggc aagggtgagg aggggtaccc acaggaagga atcctggaag acatgcctgt
      661 ggatcctggc agtgaggctt atgaaatgcc ttcagaggaa ggctaccaag actatgagcc
      721 tgaagcctaa gaatgtcatt gcacccaatc tcctaagatc tgccggctgc tcttccatgg
      781 cgtacaagtg ctcagttcca atgtgcccag tcatgacctt ttctcaaagc tgtacagtgt
      841 gtttcaaagt cttccatcag cagtgatcgg cgtcctgtac ctgcccctca gcatcccggt
      901 gctcccctct cactacagtg aaaacctggt agcagggtct tgtgtgctgt ggatattgtt
      961 gtggcttcac acttaaattg ttagaagaaa cttaaaacac ctaagtgact accacttatt
     1021 tctaaatctt catcgttttc tttttgttgc tgttcttaag aagttgtgat ttgctccaag
     1081 agttttaggt gtcctgaatg actctttctg tctaagaatg atgtgttgtg aaatttgtta
     1141 atatatattt taaaattatg tgagcatgag actatgcacc tataaatatt aatttatgaa
     1201 ttttacagtt ttgtgatgtg ttttattaac ttgtgtttgt atataaatgg tggaaaataa
     1261 aataaaatat tatccattgc aaaatcaaaa aaaaaaaaaa aaaa
//
