LOCUS       NM_133854               1916 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SNAP-associated protein (Snapin), mRNA.
ACCESSION   NM_133854 NM_011429
VERSION     NM_133854.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Yordanov,T.E., Hipolito,V.E.B., Liebscher,G., Vogel,G.F.,
            Stasyk,T., Herrmann,C., Geley,S., Teis,D., Botelho,R.J., Hess,M.W.
            and Huber,L.A.
  TITLE     Biogenesis of lysosome-related organelles complex-1 (BORC)
            regulates late endosomal/lysosomal size through PIKfyve-dependent
            phosphatidylinositol-3,5-bisphosphate
  JOURNAL   Traffic 20 (9), 674-696 (2019)
   PUBMED   31314175
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Liu,Y., Zhang,L., Li,W., Huang,Q., Yuan,S., Li,Y., Liu,J.,
            Zhang,S., Pin,G., Song,S., Ray,P.F., Arnoult,C., Cho,C.,
            Garcia-Reyes,B., Knippschild,U., Strauss,J.F. and Zhang,Z.
  TITLE     The sperm-associated antigen 6 interactome and its role in
            spermatogenesis
  JOURNAL   Reproduction 158 (2), 181-197 (2019)
   PUBMED   31146259
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Snouwaert,J.N., Church,R.J., Jania,L., Nguyen,M., Wheeler,M.L.,
            Saintsing,A., Mieczkowski,P., Manuel de Villena,F.P., Armao,D.,
            Moy,S.S., Lorenzo,D.N. and Koller,B.H.
  TITLE     A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC
            Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice
  JOURNAL   Cell Rep 24 (5), 1254-1265 (2018)
   PUBMED   30067980
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Erdozain,A.M., De Gois,S., Bernard,V., Gorgievski,V.,
            Pietrancosta,N., Dumas,S., Macedo,C.E., Vanhoutte,P., Ortega,J.E.,
            Meana,J.J., Tzavara,E.T., Vialou,V. and Giros,B.
  TITLE     Structural and Functional Characterization of the Interaction of
            Snapin with the Dopamine Transporter: Differential Modulation of
            Psychostimulant Actions
  JOURNAL   Neuropsychopharmacology 43 (5), 1041-1051 (2018)
   PUBMED   28905875
  REMARK    GeneRIF: snapin/DAT interaction represents a direct link between
            exocytotic and reuptake mechanisms.
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Starcevic,M. and Dell'Angelica,E.C.
  TITLE     Identification of snapin and three novel proteins (BLOS1, BLOS2,
            and BLOS3/reduced pigmentation) as subunits of biogenesis of
            lysosome-related organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 279 (27), 28393-28401 (2004)
   PUBMED   15102850
  REMARK    GeneRIF: Mutations in the human genes encoding Snapin and the BLOS
            proteins could underlie novel forms of Hermansky-Pudlak syndrome as
            seen in mouse models
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Buxton,P., Zhang,X.M., Walsh,B., Sriratana,A., Schenberg,I.,
            Manickam,E. and Rowe,T.
  TITLE     Identification and characterization of Snapin as a ubiquitously
            expressed SNARE-binding protein that interacts with SNAP23 in
            non-neuronal cells
  JOURNAL   Biochem J 375 (Pt 2), 433-440 (2003)
   PUBMED   12877659
REFERENCE   8  (bases 1 to 1916)
  AUTHORS   Evans,G.J. and Morgan,A.
  TITLE     Regulation of the exocytotic machinery by cAMP-dependent protein
            kinase: implications for presynaptic plasticity
  JOURNAL   Biochem Soc Trans 31 (Pt 4), 824-827 (2003)
   PUBMED   12887314
  REMARK    Review article
REFERENCE   9  (bases 1 to 1916)
  AUTHORS   Chheda,M.G., Ashery,U., Thakur,P., Rettig,J. and Sheng,Z.H.
  TITLE     Phosphorylation of Snapin by PKA modulates its interaction with the
            SNARE complex
  JOURNAL   Nat Cell Biol 3 (4), 331-338 (2001)
   PUBMED   11283605
REFERENCE   10 (bases 1 to 1916)
  AUTHORS   Ilardi,J.M., Mochida,S. and Sheng,Z.H.
  TITLE     Snapin: a SNARE-associated protein implicated in synaptic
            transmission
  JOURNAL   Nat Neurosci 2 (2), 119-124 (1999)
   PUBMED   10195194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050151.1, AK048007.1 and AC160552.13.
            
            On Jun 17, 2009 this sequence version replaced NM_133854.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050151.1, AK077840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1101              AK050151.1         2-1102
            1102-1569           AK048007.1         1091-1558
            1570-1916           AC160552.13        47706-48052         c
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.24 cM"
     gene            1..1916
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /note="SNAP-associated protein"
                     /db_xref="GeneID:20615"
                     /db_xref="MGI:MGI:1333745"
     exon            1..182
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..450
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /note="synaptosomal-associated protein 25 binding protein;
                     synaptosomal-associated protein, 25 kDa, binding protein;
                     BLOC-1 subunit 7; biogenesis of lysosome-related
                     organelles complex 1 subunit 7"
                     /codon_start=1
                     /product="SNARE-associated protein Snapin"
                     /protein_id="NP_598615.1"
                     /db_xref="CCDS:CCDS17531.1"
                     /db_xref="GeneID:20615"
                     /db_xref="MGI:MGI:1333745"
                     /translation="MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHV
                     HAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNA
                     QERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK"
     exon            183..229
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /inference="alignment:Splign:2.1.0"
     exon            230..348
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /inference="alignment:Splign:2.1.0"
     exon            349..1916
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /note="hexamer: AATAAA"
     polyA_site      1579
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /note="major polyA site"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
                     /note="hexamer: AATAAA"
     polyA_site      1916
                     /gene="Snapin"
                     /gene_synonym="25kDa; Bloc1s7; Snap25bp; Snapap"
ORIGIN      
        1 gaccctcgcg gcaggctgag ggcgtcaggg cagttcgcga tggccgcggc tggttccgct
       61 gctgtgtcag gggccgggac cccagtggcg gggcccacag gccgcgacct ctttgccgag
      121 gggctcctgg agttcctgcg acccgcggtg cagcagctcg actctcacgt gcacgcggtc
      181 agagaaagcc aagtagagct ccgggaacaa attgacaacc tagctacaga actgtgccgg
      241 atcaatgagg atcagaaagt ggccctggat ctggacccct atgttaagaa gctgcttaat
      301 gccaggcgac gagttgtctt ggtcaacaat attttacaga atgcacagga acgactaagg
      361 cggttaaacc acagcgtggc caaggaaaca gctcgcagga gagctatgct ggattcagga
      421 gtttaccctc ctggttctcc aagcaaataa gcacgggccc gtgacctgag tatacaagta
      481 caattctcca acggctttgt ctggtagaca cgagaagatt ccaggaaagt ctctgtagac
      541 ctttgatttt ttttgcacta tgtactcatt catgtagccg cctcaagaaa catgcgtacg
      601 gcaggactat ttcctaaaga acctccatca cagcttgtcc atccaagaaa gagcctctac
      661 cttttgggtt ttgttaatct tgagacaaga tctcagtatg tagtcccggc tggcctcaaa
      721 catgtcctct tgccttagcc tcctgaatgc tgggattata ataggcatgt gtcagagtgc
      781 cgggctcaag cctctatata tttcccccaa agaatactaa gtaaattagg catcgtgtgg
      841 tagaaaattg agaaaacacc agatttagtg agaaagtata ctcctatttc tccccctctg
      901 cttcaccaca gttcctctca gaaggtaata acctttccag gatcatctta cactctataa
      961 tgtttaggtt aactcctatt aacaagtttc gcaactgttg ccttcattgc tacccaagga
     1021 gagcatgcca gatagcgagg atccaaggtc aaggcagagc cttgacagct aagagtccta
     1081 agcttttgcg attttttttt ttgtttagac tacatatttt aagggctaga gggatggctc
     1141 aatggttaag aacactggtg attcttccag atggcgtcca gtgcttagcg cccacatggt
     1201 gactcacagc agcctctaac tccagctcca ggggaaccca atgcccttgt ctggcctttt
     1261 ggcccagcac acacacacat atgatgcaga tatatatgca ggcaaaacaa ccatcctcat
     1321 aaaataaaat ttaaaagtta catatttaag cgccatcctt tccaggctta gccagccagt
     1381 gttaaccatc ctgttactcc tattactggg gctgggcagt ttcctttacc tgtaactcca
     1441 ctttgtttac aactgaggac ttaggtaaag tcaaggtaaa taatttatcc tcttggccac
     1501 cctggcttga ctatgttaat attaagtatt gctcaacatt attaaataaa tgcttgtact
     1561 ggttatttta acaaaaaaat ttattttatt atggtttcaa agggttcagg acatggtcac
     1621 actgatgcat attttggggc ctattttgag acatgagaat gtgaggtgat caagcttcca
     1681 agagaaggga atgctggact ctgccattta tccctttatt ctgtccatgc actgagctca
     1741 taagatgctt tcaccccaca tttagggtta atcctttgca gaaatttcag gttattttag
     1801 gccaagctga agaaattagc catcacaatg gtatcctagg aatctattac tttcaattta
     1861 tataatttaa aacagcaatc tcaatgttta taataaaaga ctcaacttga attcta
//
