LOCUS       NM_001277986            4353 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus synaptosomal-associated protein 91 (Snap91),
            transcript variant 2, mRNA.
ACCESSION   NM_001277986
VERSION     NM_001277986.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4353)
  AUTHORS   Azarnia Tehran,D., Kochlamazashvili,G., Pampaloni,N.P., Sposini,S.,
            Shergill,J.K., Lehmann,M., Pashkova,N., Schmidt,C., Lowe,D.,
            Napieczynska,H., Heuser,A., Plested,A.J.R., Perrais,D., Piper,R.C.,
            Haucke,V. and Maritzen,T.
  TITLE     Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's
            disease risk factor CALM bidirectionally controls synaptic
            plasticity
  JOURNAL   Sci Adv 8 (21), eabl5032 (2022)
   PUBMED   35613266
REFERENCE   2  (bases 1 to 4353)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4353)
  AUTHORS   Kroll,J., Ozcete,O.D., Jung,S., Maritzen,T., Milosevic,I.,
            Wichmann,C. and Moser,T.
  TITLE     AP180 promotes release site clearance and clathrin-dependent
            vesicle reformation in mouse cochlear inner hair cells
  JOURNAL   J Cell Sci 133 (2) (2020)
   PUBMED   31843760
  REMARK    GeneRIF: AP180 promotes release site clearance and
            clathrin-dependent vesicle reformation in mouse cochlear inner hair
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4353)
  AUTHORS   Japel,M., Gerth,F., Sakaba,T., Bacetic,J., Yao,L., Koo,S.J.,
            Maritzen,T., Freund,C. and Haucke,V.
  TITLE     Intersectin-Mediated Clearance of SNARE Complexes Is Required for
            Fast Neurotransmission
  JOURNAL   Cell Rep 30 (2), 409-420 (2020)
   PUBMED   31940485
REFERENCE   5  (bases 1 to 4353)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   6  (bases 1 to 4353)
  AUTHORS   Morgan,J.R., Zhao,X., Womack,M., Prasad,K., Augustine,G.J. and
            Lafer,E.M.
  TITLE     A role for the clathrin assembly domain of AP180 in synaptic
            vesicle endocytosis
  JOURNAL   J Neurosci 19 (23), 10201-10212 (1999)
   PUBMED   10575017
REFERENCE   7  (bases 1 to 4353)
  AUTHORS   Hao,W., Luo,Z., Zheng,L., Prasad,K. and Lafer,E.M.
  TITLE     AP180 and AP-2 interact directly in a complex that cooperatively
            assembles clathrin
  JOURNAL   J Biol Chem 274 (32), 22785-22794 (1999)
   PUBMED   10428863
REFERENCE   8  (bases 1 to 4353)
  AUTHORS   Woodman,P.G.
  TITLE     The roles of NSF, SNAPs and SNAREs during membrane fusion
  JOURNAL   Biochim Biophys Acta 1357 (2), 155-172 (1997)
   PUBMED   9223620
  REMARK    Review article
REFERENCE   9  (bases 1 to 4353)
  AUTHORS   Hao,W., Tan,Z., Prasad,K., Reddy,K.K., Chen,J., Prestwich,G.D.,
            Falck,J.R., Shears,S.B. and Lafer,E.M.
  TITLE     Regulation of AP-3 function by inositides. Identification of
            phosphatidylinositol 3,4,5-trisphosphate as a potent ligand
  JOURNAL   J Biol Chem 272 (10), 6393-6398 (1997)
   PUBMED   9045662
REFERENCE   10 (bases 1 to 4353)
  AUTHORS   Zhou,S., Sousa,R., Tannery,N.H. and Lafer,E.M.
  TITLE     Characterization of a novel synapse-specific protein. II. cDNA
            cloning and sequence analysis of the F1-20 protein
  JOURNAL   J Neurosci 12 (6), 2144-2155 (1992)
   PUBMED   1607933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052454.1, BC031773.1 and CA315349.1.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-984               BC052454.1         1-984
            985-2628            BC031773.1         873-2516
            2629-4323           BC052454.1         2800-4494
            4324-4353           CA315349.1         30-59               c
FEATURES             Location/Qualifiers
     source          1..4353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     gene            1..4353
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="synaptosomal-associated protein 91"
                     /db_xref="GeneID:20616"
                     /db_xref="MGI:MGI:109132"
     exon            1..189
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            190..349
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2910
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="isoform 2 is encoded by transcript variant 2;
                     clathrin coat assembly protein AP180; phosphoprotein
                     F1-20; 91 kDa synaptosomal-associated protein; clathrin
                     coat-associated protein AP180; synaptosomal-associated
                     protein, 91 kDa"
                     /codon_start=1
                     /product="clathrin coat assembly protein AP180 isoform 2"
                     /protein_id="NP_001264915.1"
                     /db_xref="GeneID:20616"
                     /db_xref="MGI:MGI:109132"
                     /translation="MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDY
                     LIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNT
                     LFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMV
                     PEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINL
                     LEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLME
                     TLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATA
                     SAAAPVSSAKPSSDLLDLQPDFSGAAAGAAAPVVPPSGGATAWGDLLGEDSLAALSSV
                     PCEAPISDPFAPEPSPPTTTTEPASASASTTTAVTAVTTEVDLFGDAFAASPGEAPAA
                     SEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTA
                     STAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLF
                     DSAPEVAAAPKPDAAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSVDAFAAPSPAS
                     TASPAKAESSGVIDLFGDAFGSGASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTP
                     VTPAQNNLLQPSFEAAFGTTPSTSSSSSFDPSGDLLMPTMAPSGQPAPVSMVPPSPAM
                     AASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWS
                     AGVPPQGTVPPTSSVPPGAGAPSVGQPGAGFGMPPSGTGMTMMSQQPVMFAQPMMRPP
                     FGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL"
     exon            350..492
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            493..568
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            569..671
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            672..765
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            766..877
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            878..984
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1026
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1097
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1103
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1131
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1241
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1354
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1369
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1531
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1639
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1909
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1987
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2059
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2143
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2227
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2362
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2497
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2528
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2628
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2712
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2817
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2920
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..4330
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="hexamer: AATAAA"
     polyA_site      4328
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="major polyA site"
ORIGIN      
        1 tgcgccgagc gctagagaga cgcggcggcg ctggcggagg cggcggcggg tggggaccgc
       61 ggggaccgcg gagctgagac aggggccggg ccggggctac aggcatcgcg gcccggggac
      121 accagggcgg tgcgtgtctg cactcagcta cctcgcgcgg cgtccgggct gcggtgctcc
      181 tggggcggga agaggaggcg gtagacgcgg ccggtgaaga tgtcgggcca aacgctcacg
      241 gatcggatcg ccgccgctca gtacagcgtg actggctctg ctgtagcaag agcagtctgc
      301 aaagccacca ctcatgaggt gatgggcccc aagaagaagc acctggacta tttgatccag
      361 gctaccaatg agaccaatgt caatatccct cagatggccg acaccctctt tgagcgggcg
      421 acaaacagta gctgggtggt ggtatttaaa gctttagtga ccacacacca tctcatggtg
      481 catggaaatg agagatttat tcagtatttg gcctctagga atacgctatt caatctcagc
      541 aactttctag ataaaagtgg atcccacggt tatgatatgt ctacgttcat acggcgttac
      601 agtagatact tgaatgaaaa ggctttctcc tacagacaga tggcatttga ctttgccaga
      661 gtgaagaaag gggctgacgg tgtcatgagg acgatggttc ctgaaaagct cctgaagagt
      721 atgccaatcc tgcaggggca gatcgatgca ctgctggagt ttgatgtgca tccaaatgaa
      781 ctaaccaatg gtgtcataaa tgctgcattt atgcttcttt tcaaagatct tatcaaactg
      841 tttgcttgct acaatgacgg cgtcattaac ttacttgaaa aatttttcga gatgaagaaa
      901 ggtcaatgca aagacgcgct agaaatttac aagcgatttc taactagaat gacgagggtg
      961 tctgaattcc tcaaggtcgc cgagcaagtt ggtattgata aaggtgacat tcccgacctc
     1021 acacaggctc ccagcagtct tatggagacc cttgaacaac atctaaatac cctagaagga
     1081 aagaaacctg gaaacaatga aggatctggt gctccctctc cactaagtaa gtcttctcca
     1141 gccacaactg ttacatctcc taattctaca ccagctaaaa ctatcgacac atccccgcca
     1201 gttgacatat ttgcaacagc atccgcggct gccccagtca gctctgctaa gccatcaagc
     1261 gatctccttg atcttcagcc cgacttctct ggagcagctg cgggggcagc agcacctgta
     1321 gtgcctcctt ctgggggtgc gaccgcctgg ggagaccttt tgggagagga ttccttggct
     1381 gcactttcct ctgttccctg tgaagcaccg atttcagacc catttgcacc agagccttcc
     1441 cctcctacta caaccactga gcctgcttca gcctctgcct cgaccaccac agctgtgacg
     1501 gctgtcacta cggaagtgga tctctttgga gatgcctttg cagcttctcc tggggaggcc
     1561 cctgcagcat ccgaaggggc taccgcacca gctaccccgg ccccagtggc tgcagctctt
     1621 gatgcatgct caggaaatga cccttttgcc ccatctgaag gtagcgcaga ggctgcacct
     1681 gagctggacc tctttgcaat gaagccacct gagaccagcg ctcctgtagt tacccctaca
     1741 gctagcacag cccctccagt tcccgcaact gctccttctc ctgctcccac ggctgtggca
     1801 gccactgctg ccaccaccac cgccgccgct gcagctacca ccactgccac cacctctgct
     1861 gctgctgcca ccaccgccgc tgctcctcct gctctagata tctttggtga tttgtttgat
     1921 tctgctcctg aagttgctgc agcacctaag ccagacgcgg ctcctagcat agacctgttt
     1981 ggcacagatg ctttctcctc cccgccacga ggggcctctc cggtgcctga gagttctctc
     2041 actgctgacc tcttatctgt ggacgcattt gcagcgccgt ctcctgcatc cactgcctct
     2101 cctgcaaagg cggagtcctc gggtgtcata gacctttttg gggatgcgtt tggaagtggt
     2161 gcttctgaaa cccagccagc accacaggct gtttctagtt catcagcatc ggcagatcta
     2221 ctagctggat ttgggggttc tttcatggcc ccttctacaa cgccagtgac tccagctcag
     2281 aataacctgc tgcaacccag tttcgaggca gcttttggaa cgacgccttc gacttcaagc
     2341 agcagctctt ttgacccatc aggcgatctt ctgatgccaa ccatggcacc atccgggcag
     2401 cctgcccctg tctcaatggt cccacccagt cctgcaatgg cagccagcaa aggcctcgga
     2461 agtgaccttg actcgtctct ggccagttta gtaggcaatc ttgggatttc tggtaccaca
     2521 tcaaaaaagg gagatctcca gtggaatgct ggggagaaaa agctgactgg tggagccaac
     2581 tggcaaccga aagtcactcc agccacatgg tcagcgggtg ttcccccgca aggcactgtt
     2641 ccaccaacca gctcagtccc tccgggtgcc ggggccccgt ccgttgggca acctggagca
     2701 ggatttggaa tgcctccttc agggacaggc atgaccatga tgtctcagca gccagtcatg
     2761 tttgcacagc ccatgatgag gccacccttt ggagctgcag ctgtgcccgg cacacagctt
     2821 tctccaagcc ctacacctgc cactcagagt cccaagaaac ctccagccaa ggacccgtta
     2881 gcggatctta acatcaagga tttcttgtaa acaatttaag ctgcaatttt tgtgactgaa
     2941 taggaaaaaa ctaacctgag tttggaaact tcagataaga ttgatgctca gtttcaaagt
     3001 gagccaccag taccaaaccc agtgctgacg cgtaacttcc tctcccaagc acacagccca
     3061 gctgtggcag tgaacattag gaatgtgtac tctttagctg ttaccctgct cttccagctc
     3121 gtagcgtatt cgggttcttt gtgtgttgta cgaagtaaac catgagtgaa tgaatggttc
     3181 caatgccttt agtgcttttc tggacgttgc ccgtggacgg aggatgacgc agctgttctg
     3241 tggtgagcca tttggaaaga tgtgtctgtg ttttcgaaag gtttcgatgt atatataact
     3301 tttggacaaa ctcaagtcct cccatgaact ttctcttctc ttctgtacct ctgttacaag
     3361 cgtaatgtga tactatcagc tagtgagaca aacactctta actatacaaa aactttttcg
     3421 gtgtggagta catttttcca atcacagaaa cttccaactt gttgtgagaa atgtttattt
     3481 ttgtgcactg tatatgttaa gaaattttat tttaaaaaaa aatgaagtct aatgtccata
     3541 ataaaacttc tccttgatga agctacctta tcaagaatga gaaaaaccat atgagaagtc
     3601 catatttatc actgctatat taagatatat attttaatta tatttgcagg gtttgcatct
     3661 aaattgacct atttattcat ttgtgatcaa aggcaccgaa aagtggagct tgtttctatt
     3721 gtgtctgtga caatgcagtt agagatgtgc tgtttctgtg actacgaacg tgccccaaga
     3781 gacatctgta acttaaagag aactgcaaat attttttatt tcagtgtggg tttacgtaca
     3841 tctgttcagt tagtatttct ttgtgtgttc tatagagtag tgtttctcca tccttcaatt
     3901 gagctcaaag tgacttctat tgtacctttg tgataggatt gaaaccaatt cagcgaattg
     3961 tatcttttaa tgtacataat gtattctttg attttcagtt tgttgtcata ctgtctgtgc
     4021 cgatggcttg gctgaagatt ttgatgcgta cacaaggtca ctgttgatca gtgttgttta
     4081 gtggcttggc agctctttgt aaaagcatat tgggttggaa aggcatttgc ctatttttca
     4141 aattatttaa tagatgtatg gtacccttta aagtggttgt atctgaattt actgtgggga
     4201 taacatacac tgtaatgggg gaaaattacc taaaaccaat ttcaaaatgg cttttctttg
     4261 tattttggtt taaaaaccca gtgcatgtct gccctctgag atgcaataaa caccttgaac
     4321 caagaaaatg aaaaaaaaaa aaaaaaaaaa aaa
//
