LOCUS       NM_001277982            4186 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus synaptosomal-associated protein 91 (Snap91),
            transcript variant 3, mRNA.
ACCESSION   NM_001277982
VERSION     NM_001277982.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Azarnia Tehran,D., Kochlamazashvili,G., Pampaloni,N.P., Sposini,S.,
            Shergill,J.K., Lehmann,M., Pashkova,N., Schmidt,C., Lowe,D.,
            Napieczynska,H., Heuser,A., Plested,A.J.R., Perrais,D., Piper,R.C.,
            Haucke,V. and Maritzen,T.
  TITLE     Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's
            disease risk factor CALM bidirectionally controls synaptic
            plasticity
  JOURNAL   Sci Adv 8 (21), eabl5032 (2022)
   PUBMED   35613266
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Kroll,J., Ozcete,O.D., Jung,S., Maritzen,T., Milosevic,I.,
            Wichmann,C. and Moser,T.
  TITLE     AP180 promotes release site clearance and clathrin-dependent
            vesicle reformation in mouse cochlear inner hair cells
  JOURNAL   J Cell Sci 133 (2) (2020)
   PUBMED   31843760
  REMARK    GeneRIF: AP180 promotes release site clearance and
            clathrin-dependent vesicle reformation in mouse cochlear inner hair
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Japel,M., Gerth,F., Sakaba,T., Bacetic,J., Yao,L., Koo,S.J.,
            Maritzen,T., Freund,C. and Haucke,V.
  TITLE     Intersectin-Mediated Clearance of SNARE Complexes Is Required for
            Fast Neurotransmission
  JOURNAL   Cell Rep 30 (2), 409-420 (2020)
   PUBMED   31940485
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Morgan,J.R., Zhao,X., Womack,M., Prasad,K., Augustine,G.J. and
            Lafer,E.M.
  TITLE     A role for the clathrin assembly domain of AP180 in synaptic
            vesicle endocytosis
  JOURNAL   J Neurosci 19 (23), 10201-10212 (1999)
   PUBMED   10575017
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Hao,W., Luo,Z., Zheng,L., Prasad,K. and Lafer,E.M.
  TITLE     AP180 and AP-2 interact directly in a complex that cooperatively
            assembles clathrin
  JOURNAL   J Biol Chem 274 (32), 22785-22794 (1999)
   PUBMED   10428863
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Woodman,P.G.
  TITLE     The roles of NSF, SNAPs and SNAREs during membrane fusion
  JOURNAL   Biochim Biophys Acta 1357 (2), 155-172 (1997)
   PUBMED   9223620
  REMARK    Review article
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Hao,W., Tan,Z., Prasad,K., Reddy,K.K., Chen,J., Prestwich,G.D.,
            Falck,J.R., Shears,S.B. and Lafer,E.M.
  TITLE     Regulation of AP-3 function by inositides. Identification of
            phosphatidylinositol 3,4,5-trisphosphate as a potent ligand
  JOURNAL   J Biol Chem 272 (10), 6393-6398 (1997)
   PUBMED   9045662
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Zhou,S., Sousa,R., Tannery,N.H. and Lafer,E.M.
  TITLE     Characterization of a novel synapse-specific protein. II. cDNA
            cloning and sequence analysis of the F1-20 protein
  JOURNAL   J Neurosci 12 (6), 2144-2155 (1992)
   PUBMED   1607933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156831.2, BC031773.1 and CT025628.2.
            
            On Nov 4, 2017 this sequence version replaced NM_001277982.1.
            
            Transcript Variant: This variant (3) has an alternate splice site
            and lacks an in-frame exon in the 3' coding region, compared to
            variant 1. The resulting isoform (3) is shorter and lacks two
            segments in the C-terminal region, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC156831.2         82279-82330         c
            53-3378             BC031773.1         1-3326
            3379-4186           CT025628.2         125577-126384       c
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     gene            1..4186
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="synaptosomal-associated protein 91"
                     /db_xref="GeneID:20616"
                     /db_xref="MGI:MGI:109132"
     exon            1..129
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            130..289
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2766
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="isoform 3 is encoded by transcript variant 3;
                     clathrin coat assembly protein AP180; phosphoprotein
                     F1-20; 91 kDa synaptosomal-associated protein; clathrin
                     coat-associated protein AP180; synaptosomal-associated
                     protein, 91 kDa"
                     /codon_start=1
                     /product="clathrin coat assembly protein AP180 isoform 3"
                     /protein_id="NP_001264911.1"
                     /db_xref="GeneID:20616"
                     /db_xref="MGI:MGI:109132"
                     /translation="MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDY
                     LIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNT
                     LFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMV
                     PEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINL
                     LEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLME
                     TLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATA
                     SAAAPVSSAKPSSDLLDLQPDFSGAAAGAAAPVVPPSGGATAWGDLLGEDSLAALSSV
                     PCEAPISDPFAPEPSPPTTTTEPASASASTTTAVTAVTTEVDLFGDAFAASPGEAPAA
                     SEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTA
                     STAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLF
                     DSAPEVAAAPKPDAAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSVDAFAAPSPAS
                     TASPAKAESSGVIDLFGDAFGSGASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTP
                     VTPAQNNLLQPSFEAAFGTTPSTSSSSSFDPSGDLLMPTMAPSGQPAPVSMVPPSPAM
                     AASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWS
                     AGVPPPPSGTGMTMMSQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAK
                     DPLADLNIKDFL"
     exon            290..432
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            433..508
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            509..611
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            612..705
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            706..817
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            818..924
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            925..966
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1037
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1043
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1071
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1181
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1294
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1309
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1471
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1579
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1849
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1927
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1999
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2083
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2167
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2302
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2437
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2468
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2568
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2673
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2776
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..4186
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="hexamer: AATAAA"
     polyA_site      4184
                     /gene="Snap91"
                     /gene_synonym="91kDa; AP180; F1-20; mKIAA0656"
                     /note="major polyA site"
ORIGIN      
        1 tgcgccgagc gctagagaga cgcggcggcg ctggcggagg cggcggcggg tggggaccgc
       61 ggggaccgcg gagctgagac aggggccggg ccggggctac aggcatcgcg gcccggggac
      121 accagggcga agaggaggcg gtagacgcgg ccggtgaaga tgtcgggcca aacgctcacg
      181 gatcggatcg ccgccgctca gtacagcgtg actggctctg ctgtagcaag agcagtctgc
      241 aaagccacca ctcatgaggt gatgggcccc aagaagaagc acctggacta tttgatccag
      301 gctaccaatg agaccaatgt caatatccct cagatggccg acaccctctt tgagcgggcg
      361 acaaacagta gctgggtggt ggtatttaaa gctttagtga ccacacacca tctcatggtg
      421 catggaaatg agagatttat tcagtatttg gcctctagga atacgctatt caatctcagc
      481 aactttctag ataaaagtgg atcccacggt tatgatatgt ctacgttcat acggcgttac
      541 agtagatact tgaatgaaaa ggctttctcc tacagacaga tggcatttga ctttgccaga
      601 gtgaagaaag gggctgacgg tgtcatgagg acgatggttc ctgaaaagct cctgaagagt
      661 atgccaatcc tgcaggggca gatcgatgca ctgctggagt ttgatgtgca tccaaatgaa
      721 ctaaccaatg gtgtcataaa tgctgcattt atgcttcttt tcaaagatct tatcaaactg
      781 tttgcttgct acaatgacgg cgtcattaac ttacttgaaa aatttttcga gatgaagaaa
      841 ggtcaatgca aagacgcgct agaaatttac aagcgatttc taactagaat gacgagggtg
      901 tctgaattcc tcaaggtcgc cgagcaagtt ggtattgata aaggtgacat tcccgacctc
      961 acacaggctc ccagcagtct tatggagacc cttgaacaac atctaaatac cctagaagga
     1021 aagaaacctg gaaacaatga aggatctggt gctccctctc cactaagtaa gtcttctcca
     1081 gccacaactg ttacatctcc taattctaca ccagctaaaa ctatcgacac atccccgcca
     1141 gttgacatat ttgcaacagc atccgcggct gccccagtca gctctgctaa gccatcaagc
     1201 gatctccttg atcttcagcc cgacttctct ggagcagctg cgggggcagc agcacctgta
     1261 gtgcctcctt ctgggggtgc gaccgcctgg ggagaccttt tgggagagga ttccttggct
     1321 gcactttcct ctgttccctg tgaagcaccg atttcagacc catttgcacc agagccttcc
     1381 cctcctacta caaccactga gcctgcttca gcctctgcct cgaccaccac agctgtgacg
     1441 gctgtcacta cggaagtgga tctctttgga gatgcctttg cagcttctcc tggggaggcc
     1501 cctgcagcat ccgaaggggc taccgcacca gctaccccgg ccccagtggc tgcagctctt
     1561 gatgcatgct caggaaatga cccttttgcc ccatctgaag gtagcgcaga ggctgcacct
     1621 gagctggacc tctttgcaat gaagccacct gagaccagcg ctcctgtagt tacccctaca
     1681 gctagcacag cccctccagt tcccgcaact gctccttctc ctgctcccac ggctgtggca
     1741 gccactgctg ccaccaccac cgccgccgct gcagctacca ccactgccac cacctctgct
     1801 gctgctgcca ccaccgccgc tgctcctcct gctctagata tctttggtga tttgtttgat
     1861 tctgctcctg aagttgctgc agcacctaag ccagacgcgg ctcctagcat agacctgttt
     1921 ggcacagatg ctttctcctc cccgccacga ggggcctctc cggtgcctga gagttctctc
     1981 actgctgacc tcttatctgt ggacgcattt gcagcgccgt ctcctgcatc cactgcctct
     2041 cctgcaaagg cggagtcctc gggtgtcata gacctttttg gggatgcgtt tggaagtggt
     2101 gcttctgaaa cccagccagc accacaggct gtttctagtt catcagcatc ggcagatcta
     2161 ctagctggat ttgggggttc tttcatggcc ccttctacaa cgccagtgac tccagctcag
     2221 aataacctgc tgcaacccag tttcgaggca gcttttggaa cgacgccttc gacttcaagc
     2281 agcagctctt ttgacccatc aggcgatctt ctgatgccaa ccatggcacc atccgggcag
     2341 cctgcccctg tctcaatggt cccacccagt cctgcaatgg cagccagcaa aggcctcgga
     2401 agtgaccttg actcgtctct ggccagttta gtaggcaatc ttgggatttc tggtaccaca
     2461 tcaaaaaagg gagatctcca gtggaatgct ggggagaaaa agctgactgg tggagccaac
     2521 tggcaaccga aagtcactcc agccacatgg tcagcgggtg ttcccccgcc tccttcaggg
     2581 acaggcatga ccatgatgtc tcagcagcca gtcatgtttg cacagcccat gatgaggcca
     2641 ccctttggag ctgcagctgt gcccggcaca cagctttctc caagccctac acctgccact
     2701 cagagtccca agaaacctcc agccaaggac ccgttagcgg atcttaacat caaggatttc
     2761 ttgtaaacaa tttaagctgc aatttttgtg actgaatagg aaaaaactaa cctgagtttg
     2821 gaaacttcag ataagattga tgctcagttt caaagtgagc caccagtacc aaacccagtg
     2881 ctgacgcgta acttcctctc ccaagcacac agcccagctg tggcagtgaa cattaggaat
     2941 gtgtactctt tagctgttac cctgctcttc cagctcgtag cgtattcggg ttctttgtgt
     3001 gttgtacgaa gtaaaccatg agtgaatgaa tggttccaat gcctttagtg cttttctgga
     3061 cgttgcccgt ggacggagga tgacgcagct gttctgtggt gagccatttg gaaagatgtg
     3121 tctgtgtttt cgaaaggttt cgatgtatat ataacttttg gacaaactca agtcctccca
     3181 tgaactttct cttctcttct gtacctctgt tacaagcgta atgtgatact atcagctagt
     3241 gagacaaaca ctcttaacta tacaaaaact ttttcggtgt ggagtacatt tttccaatca
     3301 cagaaacttc caacttgttg tgagaaatgt ttatttttgt gcactgtata tgttaagaaa
     3361 ttttatttta aaaaaaaatg aagtctaatg tccataataa aacttctcct tgatgaagct
     3421 accttatcaa gaatgagaaa aaccatatga gaagtccata tttatcactg ctatattaag
     3481 atatatattt taattatatt tgcagggttt gcatctaaat tgacctattt attcatttgt
     3541 gatcaaaggc accgaaaagt ggagcttgtt tctattgtgt ctgtgacaat gcagttagag
     3601 atgtgctgtt tctgtgacta cgaacgtgcc ccaagagaca tctgtaactt aaagagaact
     3661 gcaaatattt tttatttcag tgtgggttta cgtacatctg ttcagttagt atttctttgt
     3721 gtgttctata gagtagtgtt tctccatcct tcaattgagc tcaaagtgac ttctattgta
     3781 cctttgtgat aggattgaaa ccaattcagc gaattgtatc ttttaatgta cataatgtat
     3841 tctttgattt tcagtttgtt gtcatactgt ctgtgccgat ggcttggctg aagattttga
     3901 tgcgtacaca aggtcactgt tgatcagtgt tgtttagtgg cttggcagct ctttgtaaaa
     3961 gcatattggg ttggaaaggc atttgcctat ttttcaaatt atttaataga tgtatggtac
     4021 cctttaaagt ggttgtatct gaatttactg tggggataac atacactgta atgggggaaa
     4081 attacctaaa accaatttca aaatggcttt tctttgtatt ttggtttaaa aacccagtgc
     4141 atgtctgccc tctgagatgc aataaacacc ttgaaccaag aaaatg
//
