LOCUS       NM_144521               1938 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus synaptosomal-associated protein, 47 (Snap47),
            transcript variant 2, mRNA.
ACCESSION   NM_144521
VERSION     NM_144521.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Urbina,F.L., Menon,S., Goldfarb,D., Edwards,R., Ben Major,M.,
            Brennwald,P. and Gupton,S.L.
  TITLE     TRIM67 regulates exocytic mode and neuronal morphogenesis via
            SNAP47
  JOURNAL   Cell Rep 34 (6), 108743 (2021)
   PUBMED   33567284
  REMARK    GeneRIF: TRIM67 regulates exocytic mode and neuronal morphogenesis
            via SNAP47.
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Corradini,I., Donzelli,A., Antonucci,F., Welzl,H., Loos,M.,
            Martucci,R., De Astis,S., Pattini,L., Inverardi,F., Wolfer,D.,
            Caleo,M., Bozzi,Y., Verderio,C., Frassoni,C., Braida,D.,
            Clerici,M., Lipp,H.P., Sala,M. and Matteoli,M.
  TITLE     Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice
            are normalized by antiepileptic drugs
  JOURNAL   Cereb Cortex 24 (2), 364-376 (2014)
   PUBMED   23064108
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Jurado,S., Goswami,D., Zhang,Y., Molina,A.J., Sudhof,T.C. and
            Malenka,R.C.
  TITLE     LTP requires a unique postsynaptic SNARE fusion machinery
  JOURNAL   Neuron 77 (3), 542-558 (2013)
   PUBMED   23395379
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Holt,M., Varoqueaux,F., Wiederhold,K., Takamori,S., Urlaub,H.,
            Fasshauer,D. and Jahn,R.
  TITLE     Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous
            expression
  JOURNAL   J Biol Chem 281 (25), 17076-17083 (2006)
   PUBMED   16621800
  REMARK    GeneRIF: SNAP-47 is a novel Qbc-SNARE with ubiquitous expression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY104758.1, AK028053.1 and AI842642.1.
            
            On Oct 5, 2017 this sequence version replaced NM_144521.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.153434.1,
                                           SRR1660815.106525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY104758.1         1-63
            64-1809             AK028053.1         2-1747
            1810-1938           AI842642.1         1-129               c
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.7 cM"
     gene            1..1938
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="synaptosomal-associated protein, 47"
                     /db_xref="GeneID:67826"
                     /db_xref="MGI:MGI:1915076"
     exon            1..120
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     exon            121..656
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1401
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="isoform 1 is encoded by transcript variant 2;
                     synaptosomal-associated 47 kDa protein"
                     /codon_start=1
                     /product="synaptosomal-associated protein 47 isoform 1"
                     /protein_id="NP_653104.1"
                     /db_xref="CCDS:CCDS24767.1"
                     /db_xref="GeneID:67826"
                     /db_xref="MGI:MGI:1915076"
                     /translation="MSSDMRVHSWSCSYYLDLEKQWVSGKLTLTPHSLKFIVEKTEEV
                     LVGLPLSSIIEIRKESSLFIFGAITVLEKGQTKHWFSSLQPSRNVVFNVIEHFWRELL
                     LSQPGTAANIPSHVTRGQELIGLMANSQKRMEDTAKDLQQQSEQLDSVLKGLEKMESD
                     LDVADRLLTELETPSWWPFGSKFWKMPAEENLKEGVSSTCEPFGKEGVVITVPAIISE
                     RAESHSKLGKLTVLVSALEIYDSCSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPD
                     VAYQLISAKMPEVIPILEVQFSSKIELLEDALVLRNKVFASSAERHAASRPKGCTPHR
                     ELPTGGQEGEQLQLQKNLPLFSEGEAQELTQILSKMKGLALDTEAELERQDAALDGIT
                     VAVDRATLNVDKQNRRMRKLM"
     exon            657..1129
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1254
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1924
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="major polyA site"
ORIGIN      
        1 tctcgcgcag gcgtacaagc gctcgccgag tggctgacct gctccccagc tgctggcgtc
       61 tctgtctggt ggtccagtgg agcgtgccat tgcgtcttct gcgtgctcct cttgcctcag
      121 atactgcagc ctctgggtag cccagcaacc taggaacaga tgagttctga tatgcgtgtc
      181 cactcctggt cttgttccta ctatctggac cttgagaagc aatgggtttc tggaaaactg
      241 accctgactc ctcattcact gaagttcatt gtggaaaaaa cagaagaggt ccttgttggc
      301 ctgcccctct ccagcatcat tgagatcagg aaagagtcat ctctctttat cttcggtgcg
      361 atcacagtcc tggagaaggg ccagaccaag cactggttca gctcactgca gcctagtcga
      421 aatgtggtct tcaacgtcat cgaacatttc tggagggagc tgctactgtc ccagccaggc
      481 actgctgcca acataccctc ccacgtgacc aggggacagg agctgatagg actgatggca
      541 aattcccaga aacgcatgga agacacagcg aaggatctcc agcagcagag cgaacagctg
      601 gacagcgtcc tgaagggcct ggagaagatg gagtccgacc tggacgtggc tgacagattg
      661 ctgacagaat tggagacacc ttcctggtgg ccttttggct ctaagttttg gaagatgccg
      721 gcagaagaaa atctcaagga aggtgtgtct tccacttgtg agccctttgg aaaggaaggg
      781 gttgtgatca cggtccctgc tattatttct gagagagcag agtctcattc caagctggga
      841 aagctcactg tcctggtctc cgctctggaa atctatgact cctgctcgtt gctcctgcac
      901 agatttgaga aggaagatgt tgatgatatc aaggttcact ctccttatga ggtcagcata
      961 cgccagcgct tcattgggaa gccagacgtg gcttaccagc tgatatctgc caagatgcca
     1021 gaggtcattc ccatcttaga agtgcagttc agcagcaaga ttgagctcct ggaagacgcc
     1081 ttagtgctca ggaacaaggt ctttgcttcc tctgcagaga ggcatgcagc atccagaccg
     1141 aagggctgca ctccacaccg agagctgccc acaggaggac aggaaggcga gcagctgcag
     1201 ctgcagaaga acttgccact gttctctgag ggggaagccc aggagctgac acagatcctg
     1261 agcaaaatga agggactcgc actggacact gaggcagagc tggaacgcca ggatgcggct
     1321 ctggatggca tcaccgtagc tgtggaccgg gcaaccctga atgtggacaa gcaaaaccgg
     1381 cgtatgagaa agctgatgta gtggggcaag ctgtaaacag ccacccctgg catggctctg
     1441 ctgattctat tgctattagc ccttttcctt tcccctgaga cccgggaagc cattctgggt
     1501 actgtgaaac tatgaggccc tacctgggaa ctacaccttc ctaggatggg ccaggagagg
     1561 ccacaatatg catgagcatg tatgtttccc ggggccctaa gcatgagggc catgtcctgt
     1621 tcaggcaaga atcgccaccg tagcgtagcc atccttcctg tccacactga gaccccggcg
     1681 ttgagctgcc attgtggcat catgttgtca catcatattg tcatcttttc accatttttg
     1741 ccaaacagta gagaaaaatg tcagtcattc tggtctggct ctgccatcca cttgccagaa
     1801 acatcaattc ccccttcaaa tgctgctgta gcccctgcca ccttttcctg atcatcagtt
     1861 agagttctgt aaccagtagc ctctgtgtgt gcgtaataaa agaatgttta ttcgatgact
     1921 tacaaaaaaa aaaaaaaa
//
