LOCUS       NM_001356454            1813 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus synaptosomal-associated protein, 47 (Snap47),
            transcript variant 3, mRNA.
ACCESSION   NM_001356454 XM_006534025
VERSION     NM_001356454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Urbina,F.L., Menon,S., Goldfarb,D., Edwards,R., Ben Major,M.,
            Brennwald,P. and Gupton,S.L.
  TITLE     TRIM67 regulates exocytic mode and neuronal morphogenesis via
            SNAP47
  JOURNAL   Cell Rep 34 (6), 108743 (2021)
   PUBMED   33567284
  REMARK    GeneRIF: TRIM67 regulates exocytic mode and neuronal morphogenesis
            via SNAP47.
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Corradini,I., Donzelli,A., Antonucci,F., Welzl,H., Loos,M.,
            Martucci,R., De Astis,S., Pattini,L., Inverardi,F., Wolfer,D.,
            Caleo,M., Bozzi,Y., Verderio,C., Frassoni,C., Braida,D.,
            Clerici,M., Lipp,H.P., Sala,M. and Matteoli,M.
  TITLE     Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice
            are normalized by antiepileptic drugs
  JOURNAL   Cereb Cortex 24 (2), 364-376 (2014)
   PUBMED   23064108
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Jurado,S., Goswami,D., Zhang,Y., Molina,A.J., Sudhof,T.C. and
            Malenka,R.C.
  TITLE     LTP requires a unique postsynaptic SNARE fusion machinery
  JOURNAL   Neuron 77 (3), 542-558 (2013)
   PUBMED   23395379
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Holt,M., Varoqueaux,F., Wiederhold,K., Takamori,S., Urlaub,H.,
            Fasshauer,D. and Jahn,R.
  TITLE     Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous
            expression
  JOURNAL   J Biol Chem 281 (25), 17076-17083 (2006)
   PUBMED   16621800
  REMARK    GeneRIF: SNAP-47 is a novel Qbc-SNARE with ubiquitous expression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY104758.1, AK028053.1 and AI842642.1.
            
            On Oct 5, 2017 this sequence version replaced XM_006534025.3.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            3' coding region, leading to a frameshift and an early stop codon,
            compared to variant 1. It encodes isoform 2, which has a shorter
            and distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927937.5147186.1,
                                           SRR7345562.886250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY104758.1         1-63
            64-1129             AK028053.1         2-1067
            1130-1684           AK028053.1         1193-1747
            1685-1813           AI842642.1         1-129               c
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.7 cM"
     gene            1..1813
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="synaptosomal-associated protein, 47"
                     /db_xref="GeneID:67826"
                     /db_xref="MGI:MGI:1915076"
     exon            1..120
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     exon            121..656
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1167
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="isoform 2 is encoded by transcript variant 3;
                     synaptosomal-associated 47 kDa protein"
                     /codon_start=1
                     /product="synaptosomal-associated protein 47 isoform 2"
                     /protein_id="NP_001343383.1"
                     /db_xref="GeneID:67826"
                     /db_xref="MGI:MGI:1915076"
                     /translation="MSSDMRVHSWSCSYYLDLEKQWVSGKLTLTPHSLKFIVEKTEEV
                     LVGLPLSSIIEIRKESSLFIFGAITVLEKGQTKHWFSSLQPSRNVVFNVIEHFWRELL
                     LSQPGTAANIPSHVTRGQELIGLMANSQKRMEDTAKDLQQQSEQLDSVLKGLEKMESD
                     LDVADRLLTELETPSWWPFGSKFWKMPAEENLKEGVSSTCEPFGKEGVVITVPAIISE
                     RAESHSKLGKLTVLVSALEIYDSCSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPD
                     VAYQLISAKMPEVIPILEVQFSSKIELLEDALVLRNKVFASSAERHADPEQNEGTRTG
                     H"
     exon            657..1129
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1799
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="Snap47"
                     /gene_synonym="1110031B06Rik; SNAP-47"
                     /note="major polyA site"
ORIGIN      
        1 tctcgcgcag gcgtacaagc gctcgccgag tggctgacct gctccccagc tgctggcgtc
       61 tctgtctggt ggtccagtgg agcgtgccat tgcgtcttct gcgtgctcct cttgcctcag
      121 atactgcagc ctctgggtag cccagcaacc taggaacaga tgagttctga tatgcgtgtc
      181 cactcctggt cttgttccta ctatctggac cttgagaagc aatgggtttc tggaaaactg
      241 accctgactc ctcattcact gaagttcatt gtggaaaaaa cagaagaggt ccttgttggc
      301 ctgcccctct ccagcatcat tgagatcagg aaagagtcat ctctctttat cttcggtgcg
      361 atcacagtcc tggagaaggg ccagaccaag cactggttca gctcactgca gcctagtcga
      421 aatgtggtct tcaacgtcat cgaacatttc tggagggagc tgctactgtc ccagccaggc
      481 actgctgcca acataccctc ccacgtgacc aggggacagg agctgatagg actgatggca
      541 aattcccaga aacgcatgga agacacagcg aaggatctcc agcagcagag cgaacagctg
      601 gacagcgtcc tgaagggcct ggagaagatg gagtccgacc tggacgtggc tgacagattg
      661 ctgacagaat tggagacacc ttcctggtgg ccttttggct ctaagttttg gaagatgccg
      721 gcagaagaaa atctcaagga aggtgtgtct tccacttgtg agccctttgg aaaggaaggg
      781 gttgtgatca cggtccctgc tattatttct gagagagcag agtctcattc caagctggga
      841 aagctcactg tcctggtctc cgctctggaa atctatgact cctgctcgtt gctcctgcac
      901 agatttgaga aggaagatgt tgatgatatc aaggttcact ctccttatga ggtcagcata
      961 cgccagcgct tcattgggaa gccagacgtg gcttaccagc tgatatctgc caagatgcca
     1021 gaggtcattc ccatcttaga agtgcagttc agcagcaaga ttgagctcct ggaagacgcc
     1081 ttagtgctca ggaacaaggt ctttgcttcc tctgcagaga ggcatgcaga tcctgagcaa
     1141 aatgaaggga ctcgcactgg acactgaggc agagctggaa cgccaggatg cggctctgga
     1201 tggcatcacc gtagctgtgg accgggcaac cctgaatgtg gacaagcaaa accggcgtat
     1261 gagaaagctg atgtagtggg gcaagctgta aacagccacc cctggcatgg ctctgctgat
     1321 tctattgcta ttagcccttt tcctttcccc tgagacccgg gaagccattc tgggtactgt
     1381 gaaactatga ggccctacct gggaactaca ccttcctagg atgggccagg agaggccaca
     1441 atatgcatga gcatgtatgt ttcccggggc cctaagcatg agggccatgt cctgttcagg
     1501 caagaatcgc caccgtagcg tagccatcct tcctgtccac actgagaccc cggcgttgag
     1561 ctgccattgt ggcatcatgt tgtcacatca tattgtcatc ttttcaccat ttttgccaaa
     1621 cagtagagaa aaatgtcagt cattctggtc tggctctgcc atccacttgc cagaaacatc
     1681 aattccccct tcaaatgctg ctgtagcccc tgccaccttt tcctgatcat cagttagagt
     1741 tctgtaacca gtagcctctg tgtgtgcgta ataaaagaat gtttattcga tgacttacaa
     1801 aaaaaaaaaa aaa
//
