LOCUS       NM_001412616            2271 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus synaptosomal-associated protein 25 (Snap25),
            transcript variant 7, mRNA.
ACCESSION   NM_001412616
VERSION     NM_001412616.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Raveendran,V.A., Serranilla,M., Asgarihafshejani,A., de
            Saint-Rome,M., Cherednychenko,M., Mullany,S., Mitchell,J.A.,
            Pressey,J.C. and Woodin,M.A.
  TITLE     SNARE protein SNAP25 regulates the chloride-transporter KCC2 in
            neurons
  JOURNAL   iScience 27 (11), 111156 (2024)
   PUBMED   39507243
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2271)
  AUTHORS   Zhang,L., Nagel,M., Olson,W.P., Chesler,A.T. and O'Connor,D.H.
  TITLE     Trigeminal innervation and tactile responses in mouse tongue
  JOURNAL   Cell Rep 43 (9), 114665 (2024)
   PUBMED   39215998
REFERENCE   5  (bases 1 to 2271)
  AUTHORS   Woo,M.S., Bal,L.C., Winschel,I., Manca,E., Walkenhorst,M.,
            Sevgili,B., Sonner,J.K., Di Liberto,G., Mayer,C.,
            Binkle-Ladisch,L., Rothammer,N., Unger,L., Raich,L., Hadjilaou,A.,
            Noli,B., Manai,A.L., Vieira,V., Meurs,N., Wagner,I., Pless,O.,
            Cocco,C., Stephens,S.B., Glatzel,M., Merkler,D. and Friese,M.A.
  TITLE     The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration
            via promoting neuronal glycolysis
  JOURNAL   J Clin Invest 134 (16), e177692 (2024)
   PUBMED   39145444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2271)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 2271)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (bases 1 to 2271)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (bases 1 to 2271)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (bases 1 to 2271)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.382420.1,
                                           SRR17784651.107212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AL732447.9         39748-40058
            312-445             AL732447.9         81691-81824
            446-487             AL732447.9         83934-83975
            488-536             AL732447.9         89196-89244
            537-654             AL732447.9         95680-95797
            655-780             AL732447.9         99518-99643
            781-925             AL732447.9         102959-103103
            926-2271            AL732447.9         106698-108043
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     gene            1..2271
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="synaptosomal-associated protein 25"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
     exon            1..311
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..445
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..994
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="isoform a is encoded by transcript variant 7; super
                     protein; synaptosomal-associated 25 kDa protein; blind
                     drunk; synaptosomal-associated protein, 25 kDa"
                     /codon_start=1
                     /product="synaptosomal-associated protein 25 isoform a"
                     /protein_id="NP_001399545.1"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
                     /translation="MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGI
                     RTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYK
                     KAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNL
                     RHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG"
     exon            446..487
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            488..536
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            537..654
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            655..780
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..925
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            926..2271
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: AAGAAA"
     polyA_site      2134
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="major polyA site"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: ATTAAA"
     polyA_site      2205
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
     regulatory      2252..2257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: ATTAAA"
     polyA_site      2271
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
ORIGIN      
        1 aagctgagct gcggcagcgg cagcggcagc agcctccatg ccccacagac ttgatttatg
       61 ccgcctgccc caagtcagct acaggcgagc atgtgctgca aagtgggaga gctctggagg
      121 tttggtgcgg tgggctagac tagtgggggt gcgatggcgg gagctcagca ccctggacag
      181 gagtgctcgg cgcccgcgtc ggcgccctga cctttcagca ccgcggacag cgatccggct
      241 gcagcgccgc attacctgct gcagagatgc ctggctggga ctagaggcca aattttctct
      301 ctgagatcca ggttctttaa cgaagcacca ctgacttgct ggcccaagcg cccagcaacc
      361 ccccaccagt accatggccg aagacgcaga catgcgcaat gagctggagg agatgcagag
      421 gagggctgac cagctggctg atgagtccct ggaaagcacc cgtcgcatgc tgcagctggt
      481 tgaagagagt aaagatgctg gcatcaggac tttggttatg ttggatgagc aaggcgaaca
      541 actggaacgc attgaggaag ggatggacca aatcaataag gacatgaaag aagcagaaaa
      601 gaatttgacg gacctaggaa aattctgcgg gctttgtgtg tgtccctgta acaagcttaa
      661 atccagtgat gcttacaaaa aagcctgggg caataatcag gatggagtag tggccagcca
      721 gcctgcccgt gtggtggatg aacgggagca gatggccatc agtggtggct tcatccgcag
      781 ggtaacaaat gatgcccggg aaaatgagat ggatgagaac ctggagcagg tgagcggcat
      841 catcggaaac ctccgccata tggctctaga catgggcaat gagattgaca cccagaatcg
      901 ccagatcgac aggatcatgg agaaggctga ttccaacaaa accagaattg atgaagccaa
      961 ccaacgtgca acaaagatgc tgggaagtgg ttaaatttgc ccttctgctg tgctctcctc
     1021 caaatgttgt tggacaagag agctccttca tgcttctctc atggtattac ctagtaggtc
     1081 ttgcacatac acacacacac acacacacac acacacacac acacacacac acacacacag
     1141 agtcagtcac ccccattgta aatgtcctgt gtgctctgtc agcttcccaa tgataccatg
     1201 tgttttttgt ttttctctgg ctctctttct ttccaaaggc tgtacatagt ggtcatctgg
     1261 tggctctaat tcctaactta agatgtcttg ggtctcgttt tttttttttt cttttctcag
     1321 tggcgtttgc tgaatgacaa caatttagga atgctcaatg tgctgttgat tttctcaata
     1381 cacagtattg ttcttgtaaa actgtgacat tccacagagc tactgccaca atcctttctt
     1441 agggtgtcag gctctgaatc tctccaaatg tgctgtcttt ggttcctcat ggctattctt
     1501 tgtctttatg atttcataat tagacaatgt gaaattacat aacaggcatt gcactaaaag
     1561 tgatgtgatt tatgcattta tgcatgagaa ctaaatagac ttttagattc ctacttaaac
     1621 aaaaactttc catgacagta gcatactgac aagaaaacac acaacagcaa caataacaaa
     1681 gcaacaacta cgcatgctca gtattgggac actgtcaaga ttaagtcata ccagcaaaac
     1741 ctgcagctgt gtcaccttct ttctgtcaac ctacagactt actgattata atcatcccat
     1801 tttctttttt tcacatatac atacacacac acacacacac acaaagtgga tttaacacac
     1861 cattaatcat ttctagcaaa atatgtgttt ggctgaaact atgtgaaatg gatgtaatat
     1921 agggtttgtc gaatgctttt gaaagctatg ttttggagac aatactcttg ctatgtggaa
     1981 aacgtgaaga tcttctacgt ctggctcttg ttaatcacca tctccccgtg gtttgtcatc
     2041 agtacaattc tctgttgctt aatctagagc tatgcacacc aaattgctga gatgtttagt
     2101 agctgataaa gaaaccttta aaaaattata taaatgaatg aaatatagat aaactgtgag
     2161 ataaatatca ttacagcatg tatattaaat ccctcctgtc tcctctgttg gtttgtgaag
     2221 tgatttgaca ttttgtagct agtttaaaat tattaaaaat tatagatcac a
//
