LOCUS       NM_001412615            2185 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus synaptosomal-associated protein 25 (Snap25),
            transcript variant 6, mRNA.
ACCESSION   NM_001412615
VERSION     NM_001412615.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Raveendran,V.A., Serranilla,M., Asgarihafshejani,A., de
            Saint-Rome,M., Cherednychenko,M., Mullany,S., Mitchell,J.A.,
            Pressey,J.C. and Woodin,M.A.
  TITLE     SNARE protein SNAP25 regulates the chloride-transporter KCC2 in
            neurons
  JOURNAL   iScience 27 (11), 111156 (2024)
   PUBMED   39507243
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Zhang,L., Nagel,M., Olson,W.P., Chesler,A.T. and O'Connor,D.H.
  TITLE     Trigeminal innervation and tactile responses in mouse tongue
  JOURNAL   Cell Rep 43 (9), 114665 (2024)
   PUBMED   39215998
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Woo,M.S., Bal,L.C., Winschel,I., Manca,E., Walkenhorst,M.,
            Sevgili,B., Sonner,J.K., Di Liberto,G., Mayer,C.,
            Binkle-Ladisch,L., Rothammer,N., Unger,L., Raich,L., Hadjilaou,A.,
            Noli,B., Manai,A.L., Vieira,V., Meurs,N., Wagner,I., Pless,O.,
            Cocco,C., Stephens,S.B., Glatzel,M., Merkler,D. and Friese,M.A.
  TITLE     The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration
            via promoting neuronal glycolysis
  JOURNAL   J Clin Invest 134 (16), e177692 (2024)
   PUBMED   39145444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.957172.1,
                                           SRR17784643.1578463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL732447.9         39077-39223
            148-225             AL732447.9         60207-60284
            226-359             AL732447.9         81691-81824
            360-401             AL732447.9         83934-83975
            402-450             AL732447.9         89196-89244
            451-568             AL732447.9         95680-95797
            569-694             AL732447.9         99518-99643
            695-839             AL732447.9         102959-103103
            840-2185            AL732447.9         106698-108043
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     gene            1..2185
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="synaptosomal-associated protein 25"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
     exon            1..147
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            148..225
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            226..359
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..908
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="isoform a is encoded by transcript variant 6; super
                     protein; synaptosomal-associated 25 kDa protein; blind
                     drunk; synaptosomal-associated protein, 25 kDa"
                     /codon_start=1
                     /product="synaptosomal-associated protein 25 isoform a"
                     /protein_id="NP_001399544.1"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
                     /translation="MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGI
                     RTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYK
                     KAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNL
                     RHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG"
     exon            360..401
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            402..450
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            451..568
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            569..694
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            695..839
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..2185
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: AAGAAA"
     polyA_site      2048
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="major polyA site"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /note="hexamer: ATTAAA"
     polyA_site      2185
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
ORIGIN      
        1 atctttgatg agggcagagc tcacgttgca ttgaagaaga aacctcgggg aggtctggag
       61 ctgtctttcc ttccctccct acccggcggc tcctccactc ttgctacctg cagggatcag
      121 cggacagcat cctccggaga agacaagatg taggctgggt atctgagccc aggatatttt
      181 gagaaagaag aagtggcagg tgacaggtgg ctctgacggt cacaggttct ttaacgaagc
      241 accactgact tgctggccca agcgcccagc aaccccccac cagtaccatg gccgaagacg
      301 cagacatgcg caatgagctg gaggagatgc agaggagggc tgaccagctg gctgatgagt
      361 ccctggaaag cacccgtcgc atgctgcagc tggttgaaga gagtaaagat gctggcatca
      421 ggactttggt tatgttggat gagcaaggcg aacaactgga acgcattgag gaagggatgg
      481 accaaatcaa taaggacatg aaagaagcag aaaagaattt gacggaccta ggaaaattct
      541 gcgggctttg tgtgtgtccc tgtaacaagc ttaaatccag tgatgcttac aaaaaagcct
      601 ggggcaataa tcaggatgga gtagtggcca gccagcctgc ccgtgtggtg gatgaacggg
      661 agcagatggc catcagtggt ggcttcatcc gcagggtaac aaatgatgcc cgggaaaatg
      721 agatggatga gaacctggag caggtgagcg gcatcatcgg aaacctccgc catatggctc
      781 tagacatggg caatgagatt gacacccaga atcgccagat cgacaggatc atggagaagg
      841 ctgattccaa caaaaccaga attgatgaag ccaaccaacg tgcaacaaag atgctgggaa
      901 gtggttaaat ttgcccttct gctgtgctct cctccaaatg ttgttggaca agagagctcc
      961 ttcatgcttc tctcatggta ttacctagta ggtcttgcac atacacacac acacacacac
     1021 acacacacac acacacacac acacacacac acagagtcag tcacccccat tgtaaatgtc
     1081 ctgtgtgctc tgtcagcttc ccaatgatac catgtgtttt ttgtttttct ctggctctct
     1141 ttctttccaa aggctgtaca tagtggtcat ctggtggctc taattcctaa cttaagatgt
     1201 cttgggtctc gttttttttt ttttcttttc tcagtggcgt ttgctgaatg acaacaattt
     1261 aggaatgctc aatgtgctgt tgattttctc aatacacagt attgttcttg taaaactgtg
     1321 acattccaca gagctactgc cacaatcctt tcttagggtg tcaggctctg aatctctcca
     1381 aatgtgctgt ctttggttcc tcatggctat tctttgtctt tatgatttca taattagaca
     1441 atgtgaaatt acataacagg cattgcacta aaagtgatgt gatttatgca tttatgcatg
     1501 agaactaaat agacttttag attcctactt aaacaaaaac tttccatgac agtagcatac
     1561 tgacaagaaa acacacaaca gcaacaataa caaagcaaca actacgcatg ctcagtattg
     1621 ggacactgtc aagattaagt cataccagca aaacctgcag ctgtgtcacc ttctttctgt
     1681 caacctacag acttactgat tataatcatc ccattttctt tttttcacat atacatacac
     1741 acacacacac acacacaaag tggatttaac acaccattaa tcatttctag caaaatatgt
     1801 gtttggctga aactatgtga aatggatgta atatagggtt tgtcgaatgc ttttgaaagc
     1861 tatgttttgg agacaatact cttgctatgt ggaaaacgtg aagatcttct acgtctggct
     1921 cttgttaatc accatctccc cgtggtttgt catcagtaca attctctgtt gcttaatcta
     1981 gagctatgca caccaaattg ctgagatgtt tagtagctga taaagaaacc tttaaaaaat
     2041 tatataaatg aatgaaatat agataaactg tgagataaat atcattacag catgtatatt
     2101 aaatccctcc tgtctcctct gttggtttgt gaagtgattt gacattttgt agctagttta
     2161 aaattattaa aaattataga tcaca
//
