LOCUS       NM_009222               4496 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus synaptosomal-associated protein 23 (Snap23),
            transcript variant 2, mRNA.
ACCESSION   NM_009222
VERSION     NM_009222.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4496)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4496)
  AUTHORS   Huang,M., Chow,C.H., Gurdita,A., Harada,H., Pham Truong,V.Q.B.,
            Eide,S., Sun,H.S., Feng,Z.P., Monnier,P.P., Wallace,V.A. and
            Sugita,S.
  TITLE     SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice
  JOURNAL   Commun Biol 7 (1), 34 (2024)
   PUBMED   38182732
  REMARK    GeneRIF: SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4496)
  AUTHORS   Huang,M., Bin,N.R., Rai,J., Ma,K., Chow,C.H., Eide,S., Harada,H.,
            Xiao,J., Feng,D., Sun,H.S., Feng,Z.P., Gaisano,H.Y., Pessin,J.E.,
            Monnier,P.P., Okamoto,K., Zhang,L. and Sugita,S.
  TITLE     Neuronal SNAP-23 is critical for synaptic plasticity and spatial
            memory independently of NMDA receptor regulation
  JOURNAL   iScience 26 (5), 106664 (2023)
   PUBMED   37168570
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4496)
  AUTHORS   Gentile,G.M., Gamarra,J.R., Engels,N.M., Blue,R.E., Hoerr,I.,
            Wiedner,H.J., Hinkle,E.R., Cote,J.L., Leverence,E., Mills,C.A.,
            Herring,L.E., Tan,X. and Giudice,J.
  TITLE     The synaptosome-associated protein 23 (SNAP23) is necessary for
            proper myogenesis
  JOURNAL   FASEB J 36 (8), e22441 (2022)
   PUBMED   35816155
  REMARK    GeneRIF: The synaptosome-associated protein 23 (SNAP23) is
            necessary for proper myogenesis.
REFERENCE   5  (bases 1 to 4496)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4496)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   7  (bases 1 to 4496)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   8  (bases 1 to 4496)
  AUTHORS   Morikawa,Y., Nishida,H., Misawa,K., Nosaka,T., Miyajima,A.,
            Senba,E. and Kitamura,T.
  TITLE     Induction of synaptosomal-associated protein-23 kD (SNAP-23) by
            various cytokines
  JOURNAL   Blood 92 (1), 129-135 (1998)
   PUBMED   9639508
REFERENCE   9  (bases 1 to 4496)
  AUTHORS   Araki,S., Tamori,Y., Kawanishi,M., Shinoda,H., Masugi,J., Mori,H.,
            Niki,T., Okazawa,H., Kubota,T. and Kasuga,M.
  TITLE     Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c
  JOURNAL   Biochem Biophys Res Commun 234 (1), 257-262 (1997)
   PUBMED   9168999
REFERENCE   10 (bases 1 to 4496)
  AUTHORS   Wang,G., Witkin,J.W., Hao,G., Bankaitis,V.A., Scherer,P.E. and
            Baldini,G.
  TITLE     Syndet is a novel SNAP-25 related protein expressed in many tissues
  JOURNAL   J Cell Sci 110 (Pt 4), 505-513 (1997)
   PUBMED   9067602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772299.10.
            
            On Oct 13, 2022 this sequence version replaced NM_009222.3.
            
            Transcript Variant: This variant (2) lacks an alternate, in-frame,
            exon, compared to variant 1. Variants 2 and 3 encode the same
            protein (isoform b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019162.1, AB007444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL772299.10        57653-57764
            113-209             AL772299.10        74227-74323
            210-251             AL772299.10        75109-75150
            252-300             AL772299.10        75514-75562
            301-418             AL772299.10        76117-76234
            419-574             AL772299.10        84759-84914
            575-719             AL772299.10        86601-86745
            720-4496            AL772299.10        89234-93010
FEATURES             Location/Qualifiers
     source          1..4496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..4496
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="synaptosomal-associated protein 23"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
     exon            1..112
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            113..209
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..785
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="isoform b is encoded by transcript variant 2;
                     vesicle-membrane fusion protein SNAP-23;
                     synaptosomal-associated protein, 23kD"
                     /codon_start=1
                     /product="synaptosomal-associated protein 23 isoform b"
                     /protein_id="NP_033248.1"
                     /db_xref="CCDS:CCDS16622.1"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
                     /translation="MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITM
                     LDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKAT
                     WGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGS
                     ILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS"
     exon            210..251
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            252..300
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            301..418
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            419..574
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            575..719
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            720..4496
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4427..4432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      4455
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4474..4479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: ATTAAA"
     polyA_site      4496
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
ORIGIN      
        1 gcaccctgtc cgatcttcta gagtccgaga actgtggagg ctggagagga gtggccggag
       61 ccgccgggtg aggcttctgg aaagtagctg agggaactag tcagcgggac agagtatccg
      121 tatttctgtg cccagcagtg tgacgactca ccatggataa tctgtcccca gaggaagttc
      181 agctgcgggc tcaccaggtt actgatgagt ctctggaaag cacaaggaga atcctgggtt
      241 tagccattga gtctcaggat gcaggaatca agaccatcac tatgctggat gagcaagggg
      301 aacaactaaa tcgcatagaa gaaggcatgg accaaataaa taaagacatg agagaggcag
      361 agaagacttt aacagaactc aacaagtgtt gtggcctctg catctgccct tgtaatagga
      421 caaagaactt tgagtctgga aagaactata aggcaacatg gggagatggt ggcgacaact
      481 cacctagcaa tgtagtatct aagcaaccga gccggattac aaatggtcag cctcagcaaa
      541 ctacaggagc agccagtggt ggatacatta aacgtataac taatgatgcc agagaagatg
      601 agatggaaga gaacctgact caagtgggca gcatcctagg caacctaaag aacatggctc
      661 tggatatggg caatgaaatt gatgctcaaa accagcaaat acagaagatc acagaaaagg
      721 ctgacaccaa caagaatcgt attgacattg ccaatacaag agcaaagaaa ctcattgata
      781 gttaaagccc tgctgtactt ctttacctgt taactcagtt ctctagctcc gctgagtcat
      841 ttcttattca gagtttgaaa ggctgtgaga aggagcagag gaggaatgcc tcgctacttt
      901 cttactttgt ctttaggggg taggttcttg ctcaggcttc cttacagtct ttctcagtca
      961 ctctcatagg cttctttcca tacatcaccg tctcttcatc tcttcattta gcttcttttg
     1021 cgttcaagat ttggaagcat tgccaaagag ccatgaaaga agcagctgta taagtagctt
     1081 ttgtcattat tggtattggt tggttggttt ggttttggtt ttgtggtaaa gagcaagagg
     1141 aaggaatagg aaatgaagct gactcattaa agaaactaca ggtcacaaaa acacagacga
     1201 gtgcttgggg tgggagcttt cacacatgtg ttttgttctg catcactgtt tttcagcttc
     1261 tgctccaaag gagaatacaa tgagttttct agaagtgagc ttcacttctg aacccatagt
     1321 gatttgtacg tatatacata ggttcttgga tccagtttca tattgcacat gcaggaacat
     1381 tatataaatg agtgcctttt attctcacac aatgagtcat ggcatggtcc cattgtaggc
     1441 ctgttaactt catgaagttg acggtagcct ttaaaagata cacacacaca cacacacaca
     1501 catgaaatag gagatttcct caaagttttg gggaaacttt tacagtgtat catgtgaatt
     1561 cagatttacc tcaatactaa gaattatgtt tagatatgaa aaaaacttgt tttgatctca
     1621 ggtagaaaaa tagattgctt tgagttttgt gtagttttaa acatttaaaa agtcataatt
     1681 tgttactaaa agttgtttgg aaaattatgc ctttatatta attattgatg accgcactgc
     1741 cattctctct gccttatgca cagaatcaag tttatgtaga tcctgaagtg ttagggaagc
     1801 tgaaatggta tttgtcacat ttgtttaaaa attagcatct gtacacttta gagctactaa
     1861 agtagactgg tttcaccaat aaccattgct ttattcttac aattaaattt tataattaat
     1921 gatattgttc tttcaaatag gtaatgtttc tatgacttat ttgtgggggc aatcatttta
     1981 tcagcttctg ttgacattaa ataaagcaaa tgtccataca tcaagcactc caatagaaag
     2041 ctgtattagc tctcttctaa tttttagcag aagtgtttac aggagtttct atggtttgct
     2101 atgagtccat tctagacatt atcttagtca tttgtactta aatacactac tgagtatttc
     2161 tgagtgagaa ttacaagtca cttattgaag aagataaatg tagcctacca acattcagag
     2221 ggtgaagagg acagtattta aaacaacaga gaaatgcctg gcatggtggc gcacaccttt
     2281 aatcccagca ctcgggaggc agaggcaggc agatttctga gttcgaggcc agcctggtct
     2341 acagagtgag ttccagttca gccagggcta tacagagaaa ccctgtctcg aaaaacaaac
     2401 aaaaaaatca aagaagcact ccatgtcaga gtggttcatt tgtcaggtaa agatactgaa
     2461 tttaagaggt gtggctaagt ccaaaacact gaattgtgct gtacctaaaa gtgctttcct
     2521 taaaaacatg ctgatttgtc taaaggaacg gtaccaaaag gtggcatcca aggtatattt
     2581 ggttagaata tgcaccaaaa cccctttgct cttgctggct ggtgtgaatg tatgctattt
     2641 ctttgtcttg gtttccatat ctgtaaatgg ggattaataa atcttatttt ataaacttat
     2701 tcacagacca gtaatgccca gaaatttctt agaatatgcc aggctcagag tccatactgg
     2761 taatcccaaa atttgggaac ctgaggcaca atctacccag tgagttgtgg gccagcctaa
     2821 attgtgtcaa aaaacagcac cccctccccc caaaaaaaga atcaaccaac aaaactctta
     2881 gaacagtgcc tataagatgt aactgtcata aatgatagct attttctcta gactggagga
     2941 agctcttttt ggtcaaagat cttaggtttc cccttctcca gagaaaaagc aaagaagcag
     3001 ataccaagtg cctttgcctg ctgaaccatc atgcgcacca cttccattat ttttgagata
     3061 cgatagcaag taaatacaag ctggagattt atttttggtc tgttttctag tatagtgatc
     3121 ttgaatacaa tacctgatta cagataagag ctagtatctt gtaccaaact ttttgtttgt
     3181 tgttttcgtt tgtttttctt gacacagggt ttctctgtgt agccttggct gtcctagaaa
     3241 tcactgtgta gaccaggctg gcctcaaact cagagatcta cctgcctctg cctcccatgt
     3301 gctgggatta aaggtgtgtg ccaccaccac ctggcaactt tttatttttt taaactgggt
     3361 ctcaccatgt aaagctggct gacctcaaac ccagagatct accagtcgct actccgcaga
     3421 tactgaaatc aagtgtgcca ctacacccaa cttcaaaatt ttacgtttta aaaaatttta
     3481 aagcccaaat ttcatcttaa cttatacggc tgtacctatt tcatcccttc ttcagtttta
     3541 atgtattctt tggtcaattc ttttttcttt cttttttatt tttctttttt cttttttggt
     3601 ttttcgagac agggtttctc tgtacagcct tggctgtcct ggaactcact ctgtagacca
     3661 agctggcctt gaactcagaa atccgccggc ctctgcctcc caagtgttag gattaaaggt
     3721 gtgtgccacc actgcccggc cttttattat tattattatt attattatta ttattagtag
     3781 tagtagtagt agtagtagta gtagtagtac actgaaactg tcttcagaca catcagaaga
     3841 gggcgtcaga tctcattaag ggtggttgtg agccaccata tggttgctgg gatttgaact
     3901 caggaccttc agaagagcag ccagtgctct taacctctga gccatctctc cagccctctt
     3961 cagtcaattc ttaatctttc cttatcacat atggattctg actcttctat taagttaaac
     4021 atcttattat gagcatataa agttaagttt ctaggactgg ggatgtagaa ccgctcagtt
     4081 catgaagtgc ttgcctagta ttcaaaaact ggattcagct ctggactacc gtgtaagcca
     4141 ggtgtggtgg ttgccctcca aacgcagccc tgggtaggag gatcaggggc tcaaggtcat
     4201 cctcaggctc agttccagga caacctggaa tatgtgaaac accacccaaa aaccaaaatg
     4261 gccaataata tggcttagca ggtaaggctg gcaacccaag tttgaactcc tccgggacct
     4321 aaatggtaga agaagcaagc caactcctaa aagtattctt ctgacttcca catgtgctgt
     4381 agtggatgca agcttgtgta cacatataca taaaaaatgt aatgaaaata aaaagcaaaa
     4441 gctatttgaa tgccattttc ctggatgctc ttaattaaaa ttccaagtta tcctaa
//
