LOCUS       NM_001412626            4653 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus synaptosomal-associated protein 23 (Snap23),
            transcript variant 4, mRNA.
ACCESSION   NM_001412626 XM_006499057
VERSION     NM_001412626.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4653)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4653)
  AUTHORS   Huang,M., Chow,C.H., Gurdita,A., Harada,H., Pham Truong,V.Q.B.,
            Eide,S., Sun,H.S., Feng,Z.P., Monnier,P.P., Wallace,V.A. and
            Sugita,S.
  TITLE     SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice
  JOURNAL   Commun Biol 7 (1), 34 (2024)
   PUBMED   38182732
  REMARK    GeneRIF: SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4653)
  AUTHORS   Huang,M., Bin,N.R., Rai,J., Ma,K., Chow,C.H., Eide,S., Harada,H.,
            Xiao,J., Feng,D., Sun,H.S., Feng,Z.P., Gaisano,H.Y., Pessin,J.E.,
            Monnier,P.P., Okamoto,K., Zhang,L. and Sugita,S.
  TITLE     Neuronal SNAP-23 is critical for synaptic plasticity and spatial
            memory independently of NMDA receptor regulation
  JOURNAL   iScience 26 (5), 106664 (2023)
   PUBMED   37168570
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4653)
  AUTHORS   Gentile,G.M., Gamarra,J.R., Engels,N.M., Blue,R.E., Hoerr,I.,
            Wiedner,H.J., Hinkle,E.R., Cote,J.L., Leverence,E., Mills,C.A.,
            Herring,L.E., Tan,X. and Giudice,J.
  TITLE     The synaptosome-associated protein 23 (SNAP23) is necessary for
            proper myogenesis
  JOURNAL   FASEB J 36 (8), e22441 (2022)
   PUBMED   35816155
  REMARK    GeneRIF: The synaptosome-associated protein 23 (SNAP23) is
            necessary for proper myogenesis.
REFERENCE   5  (bases 1 to 4653)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4653)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   7  (bases 1 to 4653)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   8  (bases 1 to 4653)
  AUTHORS   Morikawa,Y., Nishida,H., Misawa,K., Nosaka,T., Miyajima,A.,
            Senba,E. and Kitamura,T.
  TITLE     Induction of synaptosomal-associated protein-23 kD (SNAP-23) by
            various cytokines
  JOURNAL   Blood 92 (1), 129-135 (1998)
   PUBMED   9639508
REFERENCE   9  (bases 1 to 4653)
  AUTHORS   Araki,S., Tamori,Y., Kawanishi,M., Shinoda,H., Masugi,J., Mori,H.,
            Niki,T., Okazawa,H., Kubota,T. and Kasuga,M.
  TITLE     Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c
  JOURNAL   Biochem Biophys Res Commun 234 (1), 257-262 (1997)
   PUBMED   9168999
REFERENCE   10 (bases 1 to 4653)
  AUTHORS   Wang,G., Witkin,J.W., Hao,G., Bankaitis,V.A., Scherer,P.E. and
            Baldini,G.
  TITLE     Syndet is a novel SNAP-25 related protein expressed in many tissues
  JOURNAL   J Cell Sci 110 (Pt 4), 505-513 (1997)
   PUBMED   9067602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772299.10.
            
            On Oct 13, 2022 this sequence version replaced XM_006499057.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.3851907.1,
                                           SRR13422598.116993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL772299.10        57653-57764
            113-269             AL772299.10        58007-58163
            270-366             AL772299.10        74227-74323
            367-408             AL772299.10        75109-75150
            409-457             AL772299.10        75514-75562
            458-575             AL772299.10        76117-76234
            576-731             AL772299.10        84759-84914
            732-876             AL772299.10        86601-86745
            877-4653            AL772299.10        89234-93010
FEATURES             Location/Qualifiers
     source          1..4653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..4653
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="synaptosomal-associated protein 23"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
     exon            1..112
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            113..269
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            270..366
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..942
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="isoform b is encoded by transcript variant 4;
                     vesicle-membrane fusion protein SNAP-23;
                     synaptosomal-associated protein, 23kD"
                     /codon_start=1
                     /product="synaptosomal-associated protein 23 isoform b"
                     /protein_id="NP_001399555.1"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
                     /translation="MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITM
                     LDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKAT
                     WGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGS
                     ILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS"
     exon            367..408
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            409..457
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            458..575
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            576..731
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            732..876
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            877..4653
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2190
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      2833..2838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2856
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4584..4589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      4612
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: ATTAAA"
     polyA_site      4653
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
ORIGIN      
        1 gcaccctgtc cgatcttcta gagtccgaga actgtggagg ctggagagga gtggccggag
       61 ccgccgggtg aggcttctgg aaagtagctg agggaactag tcagcgggac agtattaaca
      121 gactgtctgg ctggtggccc taatgaacac atagttctga aatggttgtt agaagaatga
      181 ccccgagggt cctggcgttg caggctccac tgtctaggaa attccctgct tatcttgagg
      241 cttccccgtg ggaaagcgcc aagaatatga gtatccgtat ttctgtgccc agcagtgtga
      301 cgactcacca tggataatct gtccccagag gaagttcagc tgcgggctca ccaggttact
      361 gatgagtctc tggaaagcac aaggagaatc ctgggtttag ccattgagtc tcaggatgca
      421 ggaatcaaga ccatcactat gctggatgag caaggggaac aactaaatcg catagaagaa
      481 ggcatggacc aaataaataa agacatgaga gaggcagaga agactttaac agaactcaac
      541 aagtgttgtg gcctctgcat ctgcccttgt aataggacaa agaactttga gtctggaaag
      601 aactataagg caacatgggg agatggtggc gacaactcac ctagcaatgt agtatctaag
      661 caaccgagcc ggattacaaa tggtcagcct cagcaaacta caggagcagc cagtggtgga
      721 tacattaaac gtataactaa tgatgccaga gaagatgaga tggaagagaa cctgactcaa
      781 gtgggcagca tcctaggcaa cctaaagaac atggctctgg atatgggcaa tgaaattgat
      841 gctcaaaacc agcaaataca gaagatcaca gaaaaggctg acaccaacaa gaatcgtatt
      901 gacattgcca atacaagagc aaagaaactc attgatagtt aaagccctgc tgtacttctt
      961 tacctgttaa ctcagttctc tagctccgct gagtcatttc ttattcagag tttgaaaggc
     1021 tgtgagaagg agcagaggag gaatgcctcg ctactttctt actttgtctt tagggggtag
     1081 gttcttgctc aggcttcctt acagtctttc tcagtcactc tcataggctt ctttccatac
     1141 atcaccgtct cttcatctct tcatttagct tcttttgcgt tcaagatttg gaagcattgc
     1201 caaagagcca tgaaagaagc agctgtataa gtagcttttg tcattattgg tattggttgg
     1261 ttggtttggt tttggttttg tggtaaagag caagaggaag gaataggaaa tgaagctgac
     1321 tcattaaaga aactacaggt cacaaaaaca cagacgagtg cttggggtgg gagctttcac
     1381 acatgtgttt tgttctgcat cactgttttt cagcttctgc tccaaaggag aatacaatga
     1441 gttttctaga agtgagcttc acttctgaac ccatagtgat ttgtacgtat atacataggt
     1501 tcttggatcc agtttcatat tgcacatgca ggaacattat ataaatgagt gccttttatt
     1561 ctcacacaat gagtcatggc atggtcccat tgtaggcctg ttaacttcat gaagttgacg
     1621 gtagccttta aaagatacac acacacacac acacacacat gaaataggag atttcctcaa
     1681 agttttgggg aaacttttac agtgtatcat gtgaattcag atttacctca atactaagaa
     1741 ttatgtttag atatgaaaaa aacttgtttt gatctcaggt agaaaaatag attgctttga
     1801 gttttgtgta gttttaaaca tttaaaaagt cataatttgt tactaaaagt tgtttggaaa
     1861 attatgcctt tatattaatt attgatgacc gcactgccat tctctctgcc ttatgcacag
     1921 aatcaagttt atgtagatcc tgaagtgtta gggaagctga aatggtattt gtcacatttg
     1981 tttaaaaatt agcatctgta cactttagag ctactaaagt agactggttt caccaataac
     2041 cattgcttta ttcttacaat taaattttat aattaatgat attgttcttt caaataggta
     2101 atgtttctat gacttatttg tgggggcaat cattttatca gcttctgttg acattaaata
     2161 aagcaaatgt ccatacatca agcactccaa tagaaagctg tattagctct cttctaattt
     2221 ttagcagaag tgtttacagg agtttctatg gtttgctatg agtccattct agacattatc
     2281 ttagtcattt gtacttaaat acactactga gtatttctga gtgagaatta caagtcactt
     2341 attgaagaag ataaatgtag cctaccaaca ttcagagggt gaagaggaca gtatttaaaa
     2401 caacagagaa atgcctggca tggtggcgca cacctttaat cccagcactc gggaggcaga
     2461 ggcaggcaga tttctgagtt cgaggccagc ctggtctaca gagtgagttc cagttcagcc
     2521 agggctatac agagaaaccc tgtctcgaaa aacaaacaaa aaaatcaaag aagcactcca
     2581 tgtcagagtg gttcatttgt caggtaaaga tactgaattt aagaggtgtg gctaagtcca
     2641 aaacactgaa ttgtgctgta cctaaaagtg ctttccttaa aaacatgctg atttgtctaa
     2701 aggaacggta ccaaaaggtg gcatccaagg tatatttggt tagaatatgc accaaaaccc
     2761 ctttgctctt gctggctggt gtgaatgtat gctatttctt tgtcttggtt tccatatctg
     2821 taaatgggga ttaataaatc ttattttata aacttattca cagaccagta atgcccagaa
     2881 atttcttaga atatgccagg ctcagagtcc atactggtaa tcccaaaatt tgggaacctg
     2941 aggcacaatc tacccagtga gttgtgggcc agcctaaatt gtgtcaaaaa acagcacccc
     3001 ctccccccaa aaaaagaatc aaccaacaaa actcttagaa cagtgcctat aagatgtaac
     3061 tgtcataaat gatagctatt ttctctagac tggaggaagc tctttttggt caaagatctt
     3121 aggtttcccc ttctccagag aaaaagcaaa gaagcagata ccaagtgcct ttgcctgctg
     3181 aaccatcatg cgcaccactt ccattatttt tgagatacga tagcaagtaa atacaagctg
     3241 gagatttatt tttggtctgt tttctagtat agtgatcttg aatacaatac ctgattacag
     3301 ataagagcta gtatcttgta ccaaactttt tgtttgttgt tttcgtttgt ttttcttgac
     3361 acagggtttc tctgtgtagc cttggctgtc ctagaaatca ctgtgtagac caggctggcc
     3421 tcaaactcag agatctacct gcctctgcct cccatgtgct gggattaaag gtgtgtgcca
     3481 ccaccacctg gcaacttttt atttttttaa actgggtctc accatgtaaa gctggctgac
     3541 ctcaaaccca gagatctacc agtcgctact ccgcagatac tgaaatcaag tgtgccacta
     3601 cacccaactt caaaatttta cgttttaaaa aattttaaag cccaaatttc atcttaactt
     3661 atacggctgt acctatttca tcccttcttc agttttaatg tattctttgg tcaattcttt
     3721 tttctttctt ttttattttt cttttttctt ttttggtttt tcgagacagg gtttctctgt
     3781 acagccttgg ctgtcctgga actcactctg tagaccaagc tggccttgaa ctcagaaatc
     3841 cgccggcctc tgcctcccaa gtgttaggat taaaggtgtg tgccaccact gcccggcctt
     3901 ttattattat tattattatt attattatta ttagtagtag tagtagtagt agtagtagta
     3961 gtagtacact gaaactgtct tcagacacat cagaagaggg cgtcagatct cattaagggt
     4021 ggttgtgagc caccatatgg ttgctgggat ttgaactcag gaccttcaga agagcagcca
     4081 gtgctcttaa cctctgagcc atctctccag ccctcttcag tcaattctta atctttcctt
     4141 atcacatatg gattctgact cttctattaa gttaaacatc ttattatgag catataaagt
     4201 taagtttcta ggactgggga tgtagaaccg ctcagttcat gaagtgcttg cctagtattc
     4261 aaaaactgga ttcagctctg gactaccgtg taagccaggt gtggtggttg ccctccaaac
     4321 gcagccctgg gtaggaggat caggggctca aggtcatcct caggctcagt tccaggacaa
     4381 cctggaatat gtgaaacacc acccaaaaac caaaatggcc aataatatgg cttagcaggt
     4441 aaggctggca acccaagttt gaactcctcc gggacctaaa tggtagaaga agcaagccaa
     4501 ctcctaaaag tattcttctg acttccacat gtgctgtagt ggatgcaagc ttgtgtacac
     4561 atatacataa aaaatgtaat gaaaataaaa agcaaaagct atttgaatgc cattttcctg
     4621 gatgctctta attaaaattc caagttatcc taa
//
