LOCUS       NM_001177793            4451 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus synaptosomal-associated protein 23 (Snap23),
            transcript variant 3, mRNA.
ACCESSION   NM_001177793
VERSION     NM_001177793.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Huang,M., Chow,C.H., Gurdita,A., Harada,H., Pham Truong,V.Q.B.,
            Eide,S., Sun,H.S., Feng,Z.P., Monnier,P.P., Wallace,V.A. and
            Sugita,S.
  TITLE     SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice
  JOURNAL   Commun Biol 7 (1), 34 (2024)
   PUBMED   38182732
  REMARK    GeneRIF: SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Huang,M., Bin,N.R., Rai,J., Ma,K., Chow,C.H., Eide,S., Harada,H.,
            Xiao,J., Feng,D., Sun,H.S., Feng,Z.P., Gaisano,H.Y., Pessin,J.E.,
            Monnier,P.P., Okamoto,K., Zhang,L. and Sugita,S.
  TITLE     Neuronal SNAP-23 is critical for synaptic plasticity and spatial
            memory independently of NMDA receptor regulation
  JOURNAL   iScience 26 (5), 106664 (2023)
   PUBMED   37168570
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Gentile,G.M., Gamarra,J.R., Engels,N.M., Blue,R.E., Hoerr,I.,
            Wiedner,H.J., Hinkle,E.R., Cote,J.L., Leverence,E., Mills,C.A.,
            Herring,L.E., Tan,X. and Giudice,J.
  TITLE     The synaptosome-associated protein 23 (SNAP23) is necessary for
            proper myogenesis
  JOURNAL   FASEB J 36 (8), e22441 (2022)
   PUBMED   35816155
  REMARK    GeneRIF: The synaptosome-associated protein 23 (SNAP23) is
            necessary for proper myogenesis.
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Morikawa,Y., Nishida,H., Misawa,K., Nosaka,T., Miyajima,A.,
            Senba,E. and Kitamura,T.
  TITLE     Induction of synaptosomal-associated protein-23 kD (SNAP-23) by
            various cytokines
  JOURNAL   Blood 92 (1), 129-135 (1998)
   PUBMED   9639508
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Araki,S., Tamori,Y., Kawanishi,M., Shinoda,H., Masugi,J., Mori,H.,
            Niki,T., Okazawa,H., Kubota,T. and Kasuga,M.
  TITLE     Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c
  JOURNAL   Biochem Biophys Res Commun 234 (1), 257-262 (1997)
   PUBMED   9168999
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Wang,G., Witkin,J.W., Hao,G., Bankaitis,V.A., Scherer,P.E. and
            Baldini,G.
  TITLE     Syndet is a novel SNAP-25 related protein expressed in many tissues
  JOURNAL   J Cell Sci 110 (Pt 4), 505-513 (1997)
   PUBMED   9067602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772299.10.
            
            On Oct 13, 2022 this sequence version replaced NM_001177793.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.10536376.1, BC070456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AL772299.10        57653-57719
            68-164              AL772299.10        74227-74323
            165-206             AL772299.10        75109-75150
            207-255             AL772299.10        75514-75562
            256-373             AL772299.10        76117-76234
            374-529             AL772299.10        84759-84914
            530-674             AL772299.10        86601-86745
            675-4451            AL772299.10        89234-93010
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..4451
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="synaptosomal-associated protein 23"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
     exon            1..67
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            68..164
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..740
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="isoform b is encoded by transcript variant 3;
                     vesicle-membrane fusion protein SNAP-23;
                     synaptosomal-associated protein, 23kD"
                     /codon_start=1
                     /product="synaptosomal-associated protein 23 isoform b"
                     /protein_id="NP_001171264.1"
                     /db_xref="CCDS:CCDS16622.1"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
                     /translation="MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITM
                     LDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKAT
                     WGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGS
                     ILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS"
     exon            165..206
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            207..255
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            256..373
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            374..529
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            530..674
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            675..4451
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      1988
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2654
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4382..4387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      4410
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4429..4434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: ATTAAA"
     polyA_site      4451
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
ORIGIN      
        1 gcaccctgtc cgatcttcta gagtccgaga actgtggagg ctggagagga gtggccggag
       61 ccgccggagt atccgtattt ctgtgcccag cagtgtgacg actcaccatg gataatctgt
      121 ccccagagga agttcagctg cgggctcacc aggttactga tgagtctctg gaaagcacaa
      181 ggagaatcct gggtttagcc attgagtctc aggatgcagg aatcaagacc atcactatgc
      241 tggatgagca aggggaacaa ctaaatcgca tagaagaagg catggaccaa ataaataaag
      301 acatgagaga ggcagagaag actttaacag aactcaacaa gtgttgtggc ctctgcatct
      361 gcccttgtaa taggacaaag aactttgagt ctggaaagaa ctataaggca acatggggag
      421 atggtggcga caactcacct agcaatgtag tatctaagca accgagccgg attacaaatg
      481 gtcagcctca gcaaactaca ggagcagcca gtggtggata cattaaacgt ataactaatg
      541 atgccagaga agatgagatg gaagagaacc tgactcaagt gggcagcatc ctaggcaacc
      601 taaagaacat ggctctggat atgggcaatg aaattgatgc tcaaaaccag caaatacaga
      661 agatcacaga aaaggctgac accaacaaga atcgtattga cattgccaat acaagagcaa
      721 agaaactcat tgatagttaa agccctgctg tacttcttta cctgttaact cagttctcta
      781 gctccgctga gtcatttctt attcagagtt tgaaaggctg tgagaaggag cagaggagga
      841 atgcctcgct actttcttac tttgtcttta gggggtaggt tcttgctcag gcttccttac
      901 agtctttctc agtcactctc ataggcttct ttccatacat caccgtctct tcatctcttc
      961 atttagcttc ttttgcgttc aagatttgga agcattgcca aagagccatg aaagaagcag
     1021 ctgtataagt agcttttgtc attattggta ttggttggtt ggtttggttt tggttttgtg
     1081 gtaaagagca agaggaagga ataggaaatg aagctgactc attaaagaaa ctacaggtca
     1141 caaaaacaca gacgagtgct tggggtggga gctttcacac atgtgttttg ttctgcatca
     1201 ctgtttttca gcttctgctc caaaggagaa tacaatgagt tttctagaag tgagcttcac
     1261 ttctgaaccc atagtgattt gtacgtatat acataggttc ttggatccag tttcatattg
     1321 cacatgcagg aacattatat aaatgagtgc cttttattct cacacaatga gtcatggcat
     1381 ggtcccattg taggcctgtt aacttcatga agttgacggt agcctttaaa agatacacac
     1441 acacacacac acacacatga aataggagat ttcctcaaag ttttggggaa acttttacag
     1501 tgtatcatgt gaattcagat ttacctcaat actaagaatt atgtttagat atgaaaaaaa
     1561 cttgttttga tctcaggtag aaaaatagat tgctttgagt tttgtgtagt tttaaacatt
     1621 taaaaagtca taatttgtta ctaaaagttg tttggaaaat tatgccttta tattaattat
     1681 tgatgaccgc actgccattc tctctgcctt atgcacagaa tcaagtttat gtagatcctg
     1741 aagtgttagg gaagctgaaa tggtatttgt cacatttgtt taaaaattag catctgtaca
     1801 ctttagagct actaaagtag actggtttca ccaataacca ttgctttatt cttacaatta
     1861 aattttataa ttaatgatat tgttctttca aataggtaat gtttctatga cttatttgtg
     1921 ggggcaatca ttttatcagc ttctgttgac attaaataaa gcaaatgtcc atacatcaag
     1981 cactccaata gaaagctgta ttagctctct tctaattttt agcagaagtg tttacaggag
     2041 tttctatggt ttgctatgag tccattctag acattatctt agtcatttgt acttaaatac
     2101 actactgagt atttctgagt gagaattaca agtcacttat tgaagaagat aaatgtagcc
     2161 taccaacatt cagagggtga agaggacagt atttaaaaca acagagaaat gcctggcatg
     2221 gtggcgcaca cctttaatcc cagcactcgg gaggcagagg caggcagatt tctgagttcg
     2281 aggccagcct ggtctacaga gtgagttcca gttcagccag ggctatacag agaaaccctg
     2341 tctcgaaaaa caaacaaaaa aatcaaagaa gcactccatg tcagagtggt tcatttgtca
     2401 ggtaaagata ctgaatttaa gaggtgtggc taagtccaaa acactgaatt gtgctgtacc
     2461 taaaagtgct ttccttaaaa acatgctgat ttgtctaaag gaacggtacc aaaaggtggc
     2521 atccaaggta tatttggtta gaatatgcac caaaacccct ttgctcttgc tggctggtgt
     2581 gaatgtatgc tatttctttg tcttggtttc catatctgta aatggggatt aataaatctt
     2641 attttataaa cttattcaca gaccagtaat gcccagaaat ttcttagaat atgccaggct
     2701 cagagtccat actggtaatc ccaaaatttg ggaacctgag gcacaatcta cccagtgagt
     2761 tgtgggccag cctaaattgt gtcaaaaaac agcaccccct ccccccaaaa aaagaatcaa
     2821 ccaacaaaac tcttagaaca gtgcctataa gatgtaactg tcataaatga tagctatttt
     2881 ctctagactg gaggaagctc tttttggtca aagatcttag gtttcccctt ctccagagaa
     2941 aaagcaaaga agcagatacc aagtgccttt gcctgctgaa ccatcatgcg caccacttcc
     3001 attatttttg agatacgata gcaagtaaat acaagctgga gatttatttt tggtctgttt
     3061 tctagtatag tgatcttgaa tacaatacct gattacagat aagagctagt atcttgtacc
     3121 aaactttttg tttgttgttt tcgtttgttt ttcttgacac agggtttctc tgtgtagcct
     3181 tggctgtcct agaaatcact gtgtagacca ggctggcctc aaactcagag atctacctgc
     3241 ctctgcctcc catgtgctgg gattaaaggt gtgtgccacc accacctggc aactttttat
     3301 ttttttaaac tgggtctcac catgtaaagc tggctgacct caaacccaga gatctaccag
     3361 tcgctactcc gcagatactg aaatcaagtg tgccactaca cccaacttca aaattttacg
     3421 ttttaaaaaa ttttaaagcc caaatttcat cttaacttat acggctgtac ctatttcatc
     3481 ccttcttcag ttttaatgta ttctttggtc aattcttttt tctttctttt ttatttttct
     3541 tttttctttt ttggtttttc gagacagggt ttctctgtac agccttggct gtcctggaac
     3601 tcactctgta gaccaagctg gccttgaact cagaaatccg ccggcctctg cctcccaagt
     3661 gttaggatta aaggtgtgtg ccaccactgc ccggcctttt attattatta ttattattat
     3721 tattattatt agtagtagta gtagtagtag tagtagtagt agtacactga aactgtcttc
     3781 agacacatca gaagagggcg tcagatctca ttaagggtgg ttgtgagcca ccatatggtt
     3841 gctgggattt gaactcagga ccttcagaag agcagccagt gctcttaacc tctgagccat
     3901 ctctccagcc ctcttcagtc aattcttaat ctttccttat cacatatgga ttctgactct
     3961 tctattaagt taaacatctt attatgagca tataaagtta agtttctagg actggggatg
     4021 tagaaccgct cagttcatga agtgcttgcc tagtattcaa aaactggatt cagctctgga
     4081 ctaccgtgta agccaggtgt ggtggttgcc ctccaaacgc agccctgggt aggaggatca
     4141 ggggctcaag gtcatcctca ggctcagttc caggacaacc tggaatatgt gaaacaccac
     4201 ccaaaaacca aaatggccaa taatatggct tagcaggtaa ggctggcaac ccaagtttga
     4261 actcctccgg gacctaaatg gtagaagaag caagccaact cctaaaagta ttcttctgac
     4321 ttccacatgt gctgtagtgg atgcaagctt gtgtacacat atacataaaa aatgtaatga
     4381 aaataaaaag caaaagctat ttgaatgcca ttttcctgga tgctcttaat taaaattcca
     4441 agttatccta a
//
