LOCUS       NM_001177792            4529 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus synaptosomal-associated protein 23 (Snap23),
            transcript variant 1, mRNA.
ACCESSION   NM_001177792
VERSION     NM_001177792.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4529)
  AUTHORS   Huang,M., Chow,C.H., Gurdita,A., Harada,H., Pham Truong,V.Q.B.,
            Eide,S., Sun,H.S., Feng,Z.P., Monnier,P.P., Wallace,V.A. and
            Sugita,S.
  TITLE     SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice
  JOURNAL   Commun Biol 7 (1), 34 (2024)
   PUBMED   38182732
  REMARK    GeneRIF: SNAP-25, but not SNAP-23, is essential for photoreceptor
            development, survival, and function in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4529)
  AUTHORS   Huang,M., Bin,N.R., Rai,J., Ma,K., Chow,C.H., Eide,S., Harada,H.,
            Xiao,J., Feng,D., Sun,H.S., Feng,Z.P., Gaisano,H.Y., Pessin,J.E.,
            Monnier,P.P., Okamoto,K., Zhang,L. and Sugita,S.
  TITLE     Neuronal SNAP-23 is critical for synaptic plasticity and spatial
            memory independently of NMDA receptor regulation
  JOURNAL   iScience 26 (5), 106664 (2023)
   PUBMED   37168570
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4529)
  AUTHORS   Gentile,G.M., Gamarra,J.R., Engels,N.M., Blue,R.E., Hoerr,I.,
            Wiedner,H.J., Hinkle,E.R., Cote,J.L., Leverence,E., Mills,C.A.,
            Herring,L.E., Tan,X. and Giudice,J.
  TITLE     The synaptosome-associated protein 23 (SNAP23) is necessary for
            proper myogenesis
  JOURNAL   FASEB J 36 (8), e22441 (2022)
   PUBMED   35816155
  REMARK    GeneRIF: The synaptosome-associated protein 23 (SNAP23) is
            necessary for proper myogenesis.
REFERENCE   5  (bases 1 to 4529)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4529)
  AUTHORS   Min,J., Okada,S., Kanzaki,M., Elmendorf,J.S., Coker,K.J.,
            Ceresa,B.P., Syu,L.J., Noda,Y., Saltiel,A.R. and Pessin,J.E.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   7  (bases 1 to 4529)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   8  (bases 1 to 4529)
  AUTHORS   Morikawa,Y., Nishida,H., Misawa,K., Nosaka,T., Miyajima,A.,
            Senba,E. and Kitamura,T.
  TITLE     Induction of synaptosomal-associated protein-23 kD (SNAP-23) by
            various cytokines
  JOURNAL   Blood 92 (1), 129-135 (1998)
   PUBMED   9639508
REFERENCE   9  (bases 1 to 4529)
  AUTHORS   Araki,S., Tamori,Y., Kawanishi,M., Shinoda,H., Masugi,J., Mori,H.,
            Niki,T., Okazawa,H., Kubota,T. and Kasuga,M.
  TITLE     Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c
  JOURNAL   Biochem Biophys Res Commun 234 (1), 257-262 (1997)
   PUBMED   9168999
REFERENCE   10 (bases 1 to 4529)
  AUTHORS   Wang,G., Witkin,J.W., Hao,G., Bankaitis,V.A., Scherer,P.E. and
            Baldini,G.
  TITLE     Syndet is a novel SNAP-25 related protein expressed in many tissues
  JOURNAL   J Cell Sci 110 (Pt 4), 505-513 (1997)
   PUBMED   9067602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772299.10.
            
            On Oct 13, 2022 this sequence version replaced NM_001177792.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017311.1, SRR7345562.1430223.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL772299.10        57653-57764
            113-209             AL772299.10        74227-74323
            210-251             AL772299.10        75109-75150
            252-300             AL772299.10        75514-75562
            301-418             AL772299.10        76117-76234
            419-451             AL772299.10        80621-80653
            452-607             AL772299.10        84759-84914
            608-752             AL772299.10        86601-86745
            753-4529            AL772299.10        89234-93010
FEATURES             Location/Qualifiers
     source          1..4529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..4529
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="synaptosomal-associated protein 23"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
     exon            1..112
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            113..209
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..818
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="isoform a is encoded by transcript variant 1;
                     vesicle-membrane fusion protein SNAP-23;
                     synaptosomal-associated protein, 23kD"
                     /codon_start=1
                     /product="synaptosomal-associated protein 23 isoform a"
                     /protein_id="NP_001171263.1"
                     /db_xref="CCDS:CCDS50681.1"
                     /db_xref="GeneID:20619"
                     /db_xref="MGI:MGI:109356"
                     /translation="MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITM
                     LDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRFSVGDCFFETRTK
                     NFESGKNYKATWGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDARED
                     EMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKL
                     IDS"
     exon            210..251
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            252..300
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            301..418
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            419..451
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            452..607
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            608..752
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     exon            753..4529
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2066
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      2709..2714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      2732
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4460..4465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: AATAAA"
     polyA_site      4488
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="major polyA site"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
                     /note="hexamer: ATTAAA"
     polyA_site      4529
                     /gene="Snap23"
                     /gene_synonym="23kDa; SNAP-23; Sndt; Syndet"
ORIGIN      
        1 gcaccctgtc cgatcttcta gagtccgaga actgtggagg ctggagagga gtggccggag
       61 ccgccgggtg aggcttctgg aaagtagctg agggaactag tcagcgggac agagtatccg
      121 tatttctgtg cccagcagtg tgacgactca ccatggataa tctgtcccca gaggaagttc
      181 agctgcgggc tcaccaggtt actgatgagt ctctggaaag cacaaggaga atcctgggtt
      241 tagccattga gtctcaggat gcaggaatca agaccatcac tatgctggat gagcaagggg
      301 aacaactaaa tcgcatagaa gaaggcatgg accaaataaa taaagacatg agagaggcag
      361 agaagacttt aacagaactc aacaagtgtt gtggcctctg catctgccct tgtaatagat
      421 tctcagttgg tgactgtttc tttgaaacca ggacaaagaa ctttgagtct ggaaagaact
      481 ataaggcaac atggggagat ggtggcgaca actcacctag caatgtagta tctaagcaac
      541 cgagccggat tacaaatggt cagcctcagc aaactacagg agcagccagt ggtggataca
      601 ttaaacgtat aactaatgat gccagagaag atgagatgga agagaacctg actcaagtgg
      661 gcagcatcct aggcaaccta aagaacatgg ctctggatat gggcaatgaa attgatgctc
      721 aaaaccagca aatacagaag atcacagaaa aggctgacac caacaagaat cgtattgaca
      781 ttgccaatac aagagcaaag aaactcattg atagttaaag ccctgctgta cttctttacc
      841 tgttaactca gttctctagc tccgctgagt catttcttat tcagagtttg aaaggctgtg
      901 agaaggagca gaggaggaat gcctcgctac tttcttactt tgtctttagg gggtaggttc
      961 ttgctcaggc ttccttacag tctttctcag tcactctcat aggcttcttt ccatacatca
     1021 ccgtctcttc atctcttcat ttagcttctt ttgcgttcaa gatttggaag cattgccaaa
     1081 gagccatgaa agaagcagct gtataagtag cttttgtcat tattggtatt ggttggttgg
     1141 tttggttttg gttttgtggt aaagagcaag aggaaggaat aggaaatgaa gctgactcat
     1201 taaagaaact acaggtcaca aaaacacaga cgagtgcttg gggtgggagc tttcacacat
     1261 gtgttttgtt ctgcatcact gtttttcagc ttctgctcca aaggagaata caatgagttt
     1321 tctagaagtg agcttcactt ctgaacccat agtgatttgt acgtatatac ataggttctt
     1381 ggatccagtt tcatattgca catgcaggaa cattatataa atgagtgcct tttattctca
     1441 cacaatgagt catggcatgg tcccattgta ggcctgttaa cttcatgaag ttgacggtag
     1501 cctttaaaag atacacacac acacacacac acacatgaaa taggagattt cctcaaagtt
     1561 ttggggaaac ttttacagtg tatcatgtga attcagattt acctcaatac taagaattat
     1621 gtttagatat gaaaaaaact tgttttgatc tcaggtagaa aaatagattg ctttgagttt
     1681 tgtgtagttt taaacattta aaaagtcata atttgttact aaaagttgtt tggaaaatta
     1741 tgcctttata ttaattattg atgaccgcac tgccattctc tctgccttat gcacagaatc
     1801 aagtttatgt agatcctgaa gtgttaggga agctgaaatg gtatttgtca catttgttta
     1861 aaaattagca tctgtacact ttagagctac taaagtagac tggtttcacc aataaccatt
     1921 gctttattct tacaattaaa ttttataatt aatgatattg ttctttcaaa taggtaatgt
     1981 ttctatgact tatttgtggg ggcaatcatt ttatcagctt ctgttgacat taaataaagc
     2041 aaatgtccat acatcaagca ctccaataga aagctgtatt agctctcttc taatttttag
     2101 cagaagtgtt tacaggagtt tctatggttt gctatgagtc cattctagac attatcttag
     2161 tcatttgtac ttaaatacac tactgagtat ttctgagtga gaattacaag tcacttattg
     2221 aagaagataa atgtagccta ccaacattca gagggtgaag aggacagtat ttaaaacaac
     2281 agagaaatgc ctggcatggt ggcgcacacc tttaatccca gcactcggga ggcagaggca
     2341 ggcagatttc tgagttcgag gccagcctgg tctacagagt gagttccagt tcagccaggg
     2401 ctatacagag aaaccctgtc tcgaaaaaca aacaaaaaaa tcaaagaagc actccatgtc
     2461 agagtggttc atttgtcagg taaagatact gaatttaaga ggtgtggcta agtccaaaac
     2521 actgaattgt gctgtaccta aaagtgcttt ccttaaaaac atgctgattt gtctaaagga
     2581 acggtaccaa aaggtggcat ccaaggtata tttggttaga atatgcacca aaaccccttt
     2641 gctcttgctg gctggtgtga atgtatgcta tttctttgtc ttggtttcca tatctgtaaa
     2701 tggggattaa taaatcttat tttataaact tattcacaga ccagtaatgc ccagaaattt
     2761 cttagaatat gccaggctca gagtccatac tggtaatccc aaaatttggg aacctgaggc
     2821 acaatctacc cagtgagttg tgggccagcc taaattgtgt caaaaaacag caccccctcc
     2881 ccccaaaaaa agaatcaacc aacaaaactc ttagaacagt gcctataaga tgtaactgtc
     2941 ataaatgata gctattttct ctagactgga ggaagctctt tttggtcaaa gatcttaggt
     3001 ttccccttct ccagagaaaa agcaaagaag cagataccaa gtgcctttgc ctgctgaacc
     3061 atcatgcgca ccacttccat tatttttgag atacgatagc aagtaaatac aagctggaga
     3121 tttatttttg gtctgttttc tagtatagtg atcttgaata caatacctga ttacagataa
     3181 gagctagtat cttgtaccaa actttttgtt tgttgttttc gtttgttttt cttgacacag
     3241 ggtttctctg tgtagccttg gctgtcctag aaatcactgt gtagaccagg ctggcctcaa
     3301 actcagagat ctacctgcct ctgcctccca tgtgctggga ttaaaggtgt gtgccaccac
     3361 cacctggcaa ctttttattt ttttaaactg ggtctcacca tgtaaagctg gctgacctca
     3421 aacccagaga tctaccagtc gctactccgc agatactgaa atcaagtgtg ccactacacc
     3481 caacttcaaa attttacgtt ttaaaaaatt ttaaagccca aatttcatct taacttatac
     3541 ggctgtacct atttcatccc ttcttcagtt ttaatgtatt ctttggtcaa ttcttttttc
     3601 tttctttttt atttttcttt tttctttttt ggtttttcga gacagggttt ctctgtacag
     3661 ccttggctgt cctggaactc actctgtaga ccaagctggc cttgaactca gaaatccgcc
     3721 ggcctctgcc tcccaagtgt taggattaaa ggtgtgtgcc accactgccc ggccttttat
     3781 tattattatt attattatta ttattattag tagtagtagt agtagtagta gtagtagtag
     3841 tacactgaaa ctgtcttcag acacatcaga agagggcgtc agatctcatt aagggtggtt
     3901 gtgagccacc atatggttgc tgggatttga actcaggacc ttcagaagag cagccagtgc
     3961 tcttaacctc tgagccatct ctccagccct cttcagtcaa ttcttaatct ttccttatca
     4021 catatggatt ctgactcttc tattaagtta aacatcttat tatgagcata taaagttaag
     4081 tttctaggac tggggatgta gaaccgctca gttcatgaag tgcttgccta gtattcaaaa
     4141 actggattca gctctggact accgtgtaag ccaggtgtgg tggttgccct ccaaacgcag
     4201 ccctgggtag gaggatcagg ggctcaaggt catcctcagg ctcagttcca ggacaacctg
     4261 gaatatgtga aacaccaccc aaaaaccaaa atggccaata atatggctta gcaggtaagg
     4321 ctggcaaccc aagtttgaac tcctccggga cctaaatggt agaagaagca agccaactcc
     4381 taaaagtatt cttctgactt ccacatgtgc tgtagtggat gcaagcttgt gtacacatat
     4441 acataaaaaa tgtaatgaaa ataaaaagca aaagctattt gaatgccatt ttcctggatg
     4501 ctcttaatta aaattccaag ttatcctaa
//
