LOCUS       NM_011427               1633 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus snail family zinc finger 1 (Snai1), mRNA.
ACCESSION   NM_011427
VERSION     NM_011427.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Hoffmann,H., Wartenberg,M., Vorlova,S., Karl-Scholler,F.,
            Kallius,M., Reinhardt,O., Ozturk,A., Schuhmair,L.S., Burkhardt,V.,
            Gatzner,S., Scheld,D., Nandigama,R., Zernecke,A., Herterich,S.,
            Ergun,S., Rosenwald,A. and Henke,E.
  TITLE     Normalization of Snai1-mediated vessel dysfunction increases drug
            response in cancer
  JOURNAL   Oncogene 43 (35), 2661-2676 (2024)
   PUBMED   39095583
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Wang,P., Kang,Q., Wu,W.S. and Rui,L.
  TITLE     Hepatic Snai1 and Snai2 promote liver regeneration and suppress
            liver fibrosis in mice
  JOURNAL   Cell Rep 43 (3), 113875 (2024)
   PUBMED   38451818
  REMARK    GeneRIF: Hepatic Snai1 and Snai2 promote liver regeneration and
            suppress liver fibrosis in mice.
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Qing,F., Xue,J., Sui,L., Xiao,Q., Xie,T., Chen,Y., Huang,J. and
            Liu,Z.
  TITLE     Intestinal epithelial SNAI1 promotes the occurrence of colorectal
            cancer by enhancing EMT and Wnt/beta-catenin signaling
  JOURNAL   Med Oncol 41 (1), 34 (2023)
   PUBMED   38150048
  REMARK    GeneRIF: Intestinal epithelial SNAI1 promotes the occurrence of
            colorectal cancer by enhancing EMT and Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Collignon,J., Varlet,I. and Robertson,E.J.
  TITLE     Relationship between asymmetric nodal expression and the direction
            of embryonic turning
  JOURNAL   Nature 381 (6578), 155-158 (1996)
   PUBMED   8610012
REFERENCE   7  (bases 1 to 1633)
  AUTHORS   Grass,S., Arnold,H.H. and Braun,T.
  TITLE     Alterations in somite patterning of Myf-5-deficient mice: a
            possible role for FGF-4 and FGF-6
  JOURNAL   Development 122 (1), 141-150 (1996)
   PUBMED   8565825
REFERENCE   8  (bases 1 to 1633)
  AUTHORS   Holdener,B.C., Faust,C., Rosenthal,N.S. and Magnuson,T.
  TITLE     msd is required for mesoderm induction in mice
  JOURNAL   Development 120 (5), 1335-1346 (1994)
   PUBMED   8026341
REFERENCE   9  (bases 1 to 1633)
  AUTHORS   Smith,D.E., Franco del Amo,F. and Gridley,T.
  TITLE     Isolation of Sna, a mouse gene homologous to the Drosophila genes
            snail and escargot: its expression pattern suggests multiple roles
            during postimplantation development
  JOURNAL   Development 116 (4), 1033-1039 (1992)
   PUBMED   1295727
  REMARK    Erratum:[Development 1993 Mar;117(3):precedi]
REFERENCE   10 (bases 1 to 1633)
  AUTHORS   Nieto,M.A., Bennett,M.F., Sargent,M.G. and Wilkinson,D.G.
  TITLE     Cloning and developmental expression of Sna, a murine homologue of
            the Drosophila snail gene
  JOURNAL   Development 116 (1), 227-237 (1992)
   PUBMED   1483390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589870.30, AK144478.1 and BU756566.1.
            
            On Nov 24, 2015 this sequence version replaced NM_011427.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034857.1, M95604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL589870.30        94246-94254
            10-209              AK144478.1         2-201
            210-210             AL589870.30        94754-94754
            211-1615            AK144478.1         202-1606
            1616-1633           BU756566.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.33 cM"
     gene            1..1633
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /note="snail family zinc finger 1"
                     /db_xref="GeneID:20613"
                     /db_xref="MGI:MGI:98330"
     exon            1..177
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..890
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /note="snail homolog 1"
                     /codon_start=1
                     /product="zinc finger protein SNAI1"
                     /protein_id="NP_035557.1"
                     /db_xref="CCDS:CCDS17102.1"
                     /db_xref="GeneID:20613"
                     /db_xref="MGI:MGI:98330"
                     /translation="MPRSFLVRKPSDPRRKPNYSELQDACVEFTFQQPYDQAHLLAAI
                     PPPEVLNPAASLPTLIWDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGKSSQP
                     PSPPSPAPSSFSSTSASSLEAEAFIAFPGLGQLPKQLARLSVAKDPQSRKIFNCKYCN
                     KEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFA
                     DRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGCSGGPR"
     exon            178..705
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1621
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="Snai1"
                     /gene_synonym="Sna; Sna1; Snail; Snail1"
                     /note="major polyA site"
ORIGIN      
        1 ggggatcgta gtgtgcggcc gggcctcgcg agcggagttg actaccgacc ttgcgcgacc
       61 cggtgacccc gactacctag gtcgctctgg ccaacatgcc gcgctccttc ctggtcagga
      121 agccgtccga cccccgccgg aagcccaact atagcgagct gcaggacgcg tgtgtggagt
      181 tcaccttcca gcagccctac gaccaggccc acctgctggc cgccatccct ccgcccgagg
      241 tcctcaaccc cgccgcttcg ctgcccaccc tcatctggga ctctctcctg gtaccccaag
      301 tgcggccggt tgcctgggcc accctcccgc tgcgggagag ccccaaggcc gtagagctga
      361 cctcgctgtc cgatgaggac agtggcaaaa gctcccagcc gcccagcccg ccctcgccgg
      421 cgccgtcgtc cttctcgtcc acctcggcct cctccctgga ggccgaggcc ttcatcgcct
      481 tccctggctt gggccaactt cccaagcagc tggccaggct ctcggtggcc aaggaccccc
      541 agtcgcggaa gatcttcaac tgcaaatatt gtaacaagga gtacctcagc ctgggcgctc
      601 tgaagatgca catccgaagc cacacgctgc cttgtgtctg cacgacctgt ggaaaggcct
      661 tctctaggcc ctggctgctt cagggccacg tccgcaccca cactggtgag aagccattct
      721 cctgctccca ctgcaaccgt gcttttgctg accgctccaa cctgcgtgcc cacctccaaa
      781 cccactcgga tgtgaagaga taccagtgcc aggcctgtgc ccgaaccttc tcccgcatgt
      841 ccttgctcca caagcaccaa gagtctggct gctccggagg ccctcgctga ccctgctacc
      901 tccccatcct cgctggcatc ttcccggagc tcaccctcct cctcactgcc aggactcctt
      961 ccagccttgg tccggggacc tgtggcgtcc atgtctggac ctggttcctg cttggctctc
     1021 ttggtggcct ttgccgcagg tggctgatgg agtgcctttg tacccgccca gagcctccta
     1081 cccctcagta ttcatgaggt gtagcctctg gacacagctg cttcgagcca tagaactaaa
     1141 gccaacccac tggctgggaa gcttgaaccc cgctcagggg accccacttc cctacctccc
     1201 tcaaggaccc ttcaggccac cttctttgag gtacaacaga ctatgcaata gttcccctcc
     1261 cccccacccc gtccagctgt aaccatgcct cagcagggtg gttactggac acatgtccag
     1321 gtgcccctgg gcctgggcaa ctgtttcagc ccccgccccc atttgtcctg gtgacacctg
     1381 tttcacagca gtttaactgt ctcagaaggg accatgaata atggccatca cttgttaggg
     1441 gccaagtggg gtgcttcagc ctggccaatg tgtctcccag aactattttg gggcccaaca
     1501 ggtggccccg ggagaaagat gtttacattt taaaggtatt tatattgtaa gcagcatttt
     1561 gtatagttaa tatgtacagt ttattgatat tcaataaaat ggttaattta tatactaaaa
     1621 aaaaaaaaaa aaa
//
