LOCUS       NM_144918               2507 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SET and MYND domain containing 5 (Smyd5), mRNA.
ACCESSION   NM_144918
VERSION     NM_144918.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Miao,B., Ge,L., He,C., Wang,X., Wu,J., Li,X., Chen,K., Wan,J.,
            Xing,S., Ren,L., Shi,Z., Liu,S., Hu,Y., Chen,J., Yu,Y., Feng,L.,
            Flores,N.M., Liang,Z., Xu,X., Wang,R., Zhou,J., Fan,J., Xiang,B.,
            Li,E., Mao,Y., Cheng,J., Zhao,K., Mazur,P.K., Cai,J. and Lan,F.
  TITLE     SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine
            methylation to enhance translation output and promote
            hepatocellular carcinoma
  JOURNAL   Cell Res 34 (9), 648-660 (2024)
   PUBMED   39103523
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Rafnsdottir,S., Jang,K., Halldorsdottir,S.T., Vinod,M.,
            Tomasdottir,A., Moller,K., Halldorsdottir,K., Reynisdottir,T.,
            Atladottir,L.H., Allison,K.E., Ostacolo,K., He,J., Zhang,L.,
            Northington,F.J., Magnusdottir,E., Chavez-Valdez,R., Anderson,K.J.
            and Bjornsson,H.T.
  TITLE     SMYD5 is a regulator of the mild hypothermia response
  JOURNAL   Cell Rep 43 (8), 114554 (2024)
   PUBMED   39083378
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Park,J., Wu,J., Szkop,K.J., Jeong,J., Jovanovic,P., Husmann,D.,
            Flores,N.M., Francis,J.W., Chen,Y.C., Benitez,A.M., Zahn,E.,
            Song,S., Ajani,J.A., Wang,L., Singh,K., Larsson,O., Garcia,B.A.,
            Topisirovic,I., Gozani,O. and Mazur,P.K.
  TITLE     SMYD5 methylation of rpL40 links ribosomal output to gastric cancer
  JOURNAL   Nature 632 (8025), 656-663 (2024)
   PUBMED   39048817
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Zhang,Y., Fang,Y., Tang,Y., Han,S., Jia,J., Wan,X., Chen,J.,
            Yuan,Y., Zhao,B. and Fang,D.
  TITLE     SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters
  JOURNAL   Nat Commun 13 (1), 3190 (2022)
   PUBMED   35680905
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Stender,J.D., Pascual,G., Liu,W., Kaikkonen,M.U., Do,K.,
            Spann,N.J., Boutros,M., Perrimon,N., Rosenfeld,M.G. and Glass,C.K.
  TITLE     Control of proinflammatory gene programs by regulated
            trimethylation and demethylation of histone H4K20
  JOURNAL   Mol Cell 48 (1), 28-38 (2012)
   PUBMED   22921934
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Diehl,F., Brown,M.A., van Amerongen,M.J., Novoyatleva,T.,
            Wietelmann,A., Harriss,J., Ferrazzi,F., Bottger,T., Harvey,R.P.,
            Tucker,P.W. and Engel,F.B.
  TITLE     Cardiac deletion of Smyd2 is dispensable for mouse heart
            development
  JOURNAL   PLoS One 5 (3), e9748 (2010)
   PUBMED   20305823
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Plouhinec,J.L., Granier,C., Le Mentec,C., Lawson,K.A.,
            Saberan-Djoneidi,D., Aghion,J., Shi,D.L., Collignon,J. and Mazan,S.
  TITLE     Identification of the mammalian Not gene via a phylogenomic
            approach
  JOURNAL   Gene Expr Patterns 5 (1), 11-22 (2004)
   PUBMED   15533813
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Shago,M. and Giguere,V.
  TITLE     Isolation of a novel retinoic acid-responsive gene by selection of
            genomic fragments derived from CpG-island-enriched DNA
  JOURNAL   Mol Cell Biol 16 (8), 4337-4348 (1996)
   PUBMED   8754834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU847995.1, AK162926.1 and BE951851.1.
            
            On Aug 3, 2007 this sequence version replaced NM_144918.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.47549.1, AK162926.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BU847995.1         4-79
            77-2488             AK162926.1         1-2412
            2489-2507           BE951851.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.44 cM"
     gene            1..2507
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /note="SET and MYND domain containing 5"
                     /db_xref="GeneID:232187"
                     /db_xref="MGI:MGI:108048"
     exon            1..125
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1280
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /EC_number="2.1.1.359"
                     /EC_number="2.1.1.372"
                     /note="SET and MYND domain-containing protein 5; retinoic
                     acid-induced protein 15; retinoic acid responsive gene 1;
                     retinoic acid induced 15; [histone H4]-lysine20
                     N-trimethyltransferase SMYD5; histone-lysine
                     N-trimethyltransferase SMYD5; [histone H3]-lysine20
                     N-trimethyltransferase SMYD5; [histone H4]-lysine36
                     N-trimethyltransferase SMYD5"
                     /codon_start=1
                     /product="protein-lysine N-trimethyltransferase SMYD5"
                     /protein_id="NP_659167.2"
                     /db_xref="CCDS:CCDS51827.1"
                     /db_xref="GeneID:232187"
                     /db_xref="MGI:MGI:108048"
                     /translation="MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRK
                     GETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILPHPELCS
                     VRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRSVHYP
                     PETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKDQLEL
                     LLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQD
                     REQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHV
                     TALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSE
                     EEEEEDEEEGEPEDAELGDEMTDV"
     exon            126..234
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..374
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..493
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..563
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..668
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..731
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..802
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..909
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..966
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1061
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1132
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..2493
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2473..2478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /note="hexamer: AATAAA"
     polyA_site      2493
                     /gene="Smyd5"
                     /gene_synonym="NN8-4AG; Rai15; Rrg1"
                     /note="major polyA site"
ORIGIN      
        1 aagggtcaga aggcagaggc gtgcccaaga tggcggcctc catgtgcgac gtgttctcct
       61 tctgcgtggg cgtggcggac cgtgcccggg gttccgtgga agtccgttat gtggacagca
      121 tcaagggaaa gggactgttt gccacacagc tgattcggaa gggagagacc atcttcattg
      181 aaagacctct ggtagctgcg cagttcctct ggaatgcact ttatcagtac agggcctgtg
      241 accactgcct tcgggcactg gagaaggcag aggagaatgc ccagaggctg actgggaaac
      301 caagccagat tctaccacac ccagagctat gcagtgtgcg taaggacctc caccagaact
      361 gcccccattg ccaggtgatg tactgcagtg cagaatgtcg gctagcagct gcagagcagt
      421 accaccaaat cctgtgccca ggcccatccc atgacccccg gcaccccctc aataagctgc
      481 aggaggcatg gaggagtgtt cactatcctc ctgagactgc gagtataatg ctgatggccc
      541 ggatggtagc cacggtgaaa caggccaagg acaaggacca ctgggtcaga ctcttcaacc
      601 acttctgcag caggacagcc aaccaggagc aggcaattgt ccacaaactc ctaaagggca
      661 agttcaagga ccagctggaa cttctgcttg ggctcttcaa agaggccctt tatgaagagg
      721 ctctcagtct gtggttcaca ccagaaggat tccggtctct ctttgccctt gttgggacca
      781 atggtcaagg aatcggaacc agttccctca gccaatgggt gcacgcctgt gatgccctgg
      841 agctgacgcc tcaggaccgg gaacaactag acaccttcat tgaccagctg tacaaggaca
      901 tcgaggcagc aaccggagag ttccttaact gtgaaggatc tggcctcttc gtgcttcaaa
      961 gctgctgcaa ccacagctgt gtccccaacg cggagacctc ctttccagaa aacaacttcg
     1021 ttttacatgt tactgccctg gaggatatta agccaggcga ggaaatatgt atcagctact
     1081 tagactgctg tcagcgggag cgcagccgac acagccgaca caagatcctc agggagaact
     1141 acttgttcaa ctgttcctgt cccaaatgcc tggcagaggc tgatgacccc aatgtgacct
     1201 cagaagagga ggaagaggaa gatgaggagg aaggagagcc agaagatgca gagctagggg
     1261 atgagatgac cgacgtgtga tgttatctca cctggaaggc cctgcccaga ccctgctgga
     1321 aaaagggggc ctgtcctcca caaaagtggt tggaaggaac aacccctccc ctttgcaccc
     1381 attgcctgct ttctcccttc tagcatactg ctggagggta ggatagaggc tggacccgag
     1441 cccacccctt cccagacctc atgccctgag cactgctgct gagctgcatc ggccctgtgc
     1501 catcacaagc cttccagaac tggccttccc ctgccatgct ccactgcagc tgtgagacgg
     1561 gaatcaagtt tcaggtctca tagtgttctt cctctgggcc ccttagccca tattcagctc
     1621 atgcatccac gagaggcttg gctcctattg actggctatt aatttcaggg tggcaacata
     1681 atggccaatc agagagcaga ccggctttct tgagagaaag aggtgatgtg aagccttacc
     1741 tcttccttat tgttcacctg ccacagctgc agctgaagta ctggcctgcc actttccagc
     1801 aacaggcagg aacaagggac taggccttta gaacaacact gcaaaaagac tctgccaggg
     1861 gtgctgggct gttcccactg tacactgggg aggtagagat tgacctgttc gccaaacccc
     1921 agaattgctg tgcttacatc ttgcctctta ggctcagaca agggggctag cttgataagg
     1981 tgtggaagag gcctctatca ggatgaagac taccaccctc tctcagacca acagtagagc
     2041 agatgacaga ttgtgctcta taatttagga tgcccaatct tccccgagac cagctgcagt
     2101 ggcccagcaa agggtctctg ggtcaccgac accctccttt aggatctcca gaggaacacc
     2161 agtcttccag aagtctgaag gagctgggca gtacacacga agatgagcca ggacttgttc
     2221 cctcattgcc acagatgacc atccctcact tgggatgggc actgcggaat tacagctacc
     2281 attccccatt tgttccctga gaggcctgca catggctctg ctaggagctt tcagggagga
     2341 ccagtgccta tgctataggc ccttttcaag gtggagccag atggaacatg cctgactggc
     2401 cccctgacct attgggcaca ctccttcaca acagccagca gcccctctcc ctctggtctg
     2461 cccactggtc tcaataaaat gtgagtggtg ataaaaaaaa aaaaaaa
//
