LOCUS       NM_001102611            3517 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SET and MYND domain containing 4 (Smyd4), mRNA.
ACCESSION   NM_001102611
VERSION     NM_001102611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3517)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3517)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3517)
  AUTHORS   Xiao,D., Wang,H., Hao,L., Guo,X., Ma,X., Qian,Y., Chen,H., Ma,J.,
            Zhang,J., Sheng,W., Shou,W., Huang,G. and Ma,D.
  TITLE     The roles of SMYD4 in epigenetic regulation of cardiac development
            in zebrafish
  JOURNAL   PLoS Genet 14 (8), e1007578 (2018)
   PUBMED   30110327
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3517)
  AUTHORS   Wang,K., Gan,T.Y., Li,N., Liu,C.Y., Zhou,L.Y., Gao,J.N., Chen,C.,
            Yan,K.W., Ponnusamy,M., Zhang,Y.H. and Li,P.F.
  TITLE     Circular RNA mediates cardiomyocyte death via miRNA-dependent
            upregulation of MTP18 expression
  JOURNAL   Cell Death Differ 24 (6), 1111-1120 (2017)
   PUBMED   28498369
  REMARK    GeneRIF: MFACR (mitochondrial fission and apoptosis-related
            circRNA) is derived from the splicing of exon 5 of Smyd4 gene.
            MFACR is crucial in regulating mitochondrial dynamics and apoptosis
            in the heart. MFACR mediates cardiomyocyte apoptosis and myocardial
            infarction by targeting miR-652-3p-dependent MTP18 activation and
            consequent mitochondrial fission.
REFERENCE   5  (bases 1 to 3517)
  AUTHORS   Saita,S., Shirane,M., Ishitani,T., Shimizu,N. and Nakayama,K.I.
  TITLE     Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog
            (Shh) signaling pathway
  JOURNAL   J Biol Chem 289 (37), 25639-25654 (2014)
   PUBMED   25077969
REFERENCE   6  (bases 1 to 3517)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3517)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 3517)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 3517)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3517)
  AUTHORS   Liu,H., Nakagawa,T., Kanematsu,T., Uchida,T. and Tsuji,S.
  TITLE     Isolation of 10 differentially expressed cDNAs in differentiated
            Neuro2a cells induced through controlled expression of the GD3
            synthase gene
  JOURNAL   J Neurochem 72 (5), 1781-1790 (1999)
   PUBMED   10217254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN693729.1, AK089959.1 and BC049810.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089959.1, BC095952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               CN693729.1         1-227
            228-1450            AK089959.1         164-1386
            1451-3125           BC049810.1         1302-2976
            3126-3517           AK089959.1         3062-3453
FEATURES             Location/Qualifiers
     source          1..3517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.82 cM"
     gene            1..3517
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /note="SET and MYND domain containing 4"
                     /db_xref="GeneID:319822"
                     /db_xref="MGI:MGI:2442796"
     exon            1..319
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..465
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..2731
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /codon_start=1
                     /product="SET and MYND domain-containing protein 4"
                     /protein_id="NP_001096081.1"
                     /db_xref="CCDS:CCDS48848.1"
                     /db_xref="GeneID:319822"
                     /db_xref="MGI:MGI:2442796"
                     /translation="MDLPVDEWKSYLLKKWASLPKSVQDTISTAETLSDIFLPSSSLL
                     QPEDEMFLKELSSSYSVEKDNDAPLFYREEGNRKFQEKEYTDAAVLYSKGVSHSRPNT
                     EDISLCYANRSAALFHLGQYEACLKDIVEAGMHGYPERLQPKMMVRKTECLVNLGRLQ
                     EARQTISDLESSLTAKPTLVLSSYQILQRNVQHLKIKIQEKETLPEPIPAALTNAFED
                     IALGEENTQISGASLSVSLCTHPLKGRHLVATKDILPGELLVKEDAFVSVLIPGEMPR
                     PHHCLENKWDTRVTSGDLYCHRCLKHTLATVPCGSCSYAKYCSQECMQQAWDLYHSTE
                     CSLGGLLLTLGVFCHVALRMTLLARFEDVDRVVRMLCDEVGSTDTCLPESKNLVKAFD
                     YTSQGESEEKSKIGEPPIPGCNVNGKYGSNYNAIFSLLPHTEKHSPEHRFICAISVSA
                     LCRQLKADSVQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQCNAQAITSICHT
                     GSNESIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEIL
                     HCYGPHESRMGVAERQQRLSSQYFFDCRCGACHAETLRAAAAPRWEAFCCKTCRALMQ
                     GNDVLSCSNESCTNSVSRDQLVSRLQDLQQQVCMAQKLLRTGKPEQAIQQLLRCREAA
                     ESFLSAEHTVLGEIEDGLAQAHATLGNWLKSAAHVQKSLQVVETRHGPSSVEIGHELF
                     KLAQVLFNGLAVPEALSAIWKAERILLVHCGPESEEVRELREMRSCLLDSSFVPVGPL
                     V"
     exon            466..610
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            611..700
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..1856
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2039
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2203
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2336
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2453
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2577
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..3517
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3476..3481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3499
                     /gene="Smyd4"
                     /gene_synonym="G430029E23Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcaggca gagcacgtga ctcttccgag gccgggttcg aggcctagtg gcgggatggc
       61 gggacgtgag ggcggggcgc tgggtcgcag tgcgcctgtg tcagcgcggt gctactgagt
      121 tgttcccccg ccagctgtcg gaactttgcc cgcccagtcc tttggcggac agacagaatg
      181 gcaacccagg gaacagtcgg agctctcccc tggtaactgc tgctaaatat agtcaaagca
      241 gtgacctggg tacttcttca cgcagtgcgt gcccggcgcc ggtgccaggc ccagagcttg
      301 gcactgtggg ataaacaaga gctgcggcag catggatcta ccggtggatg aatggaagtc
      361 ctacctactt aagaagtggg cttcactccc gaagtctgtg caggacacaa tttctacagc
      421 agagactttg agcgacatct tccttccttc ttcttccctt cttcaacctg aggatgagat
      481 gtttttgaag gaactttcta gtagttactc ggtggaaaag gacaatgatg ctcccctctt
      541 ctacagagaa gaaggaaaca ggaaattcca agaaaaggag tacacagatg ctgcagtgct
      601 gtactctaag ggagtgtctc attcaaggcc taacactgag gacatttcac tgtgctatgc
      661 caatcgctct gcagcgctct tccatctggg tcagtatgaa gcatgtctta aagacatagt
      721 ggaagcaggt atgcatgggt atcctgaaag actgcagccc aagatgatgg tgcgtaagac
      781 agaatgcctg gtgaacctgg ggagactcca ggaggcaaga cagaccatca gtgatctcga
      841 aagcagcctc actgccaagc caaccctggt gctttcctct taccagattc tgcaaaggaa
      901 tgtccagcat ctgaaaataa agatccaaga aaaggagact ctcccagaac ccatccctgc
      961 agctctcacc aatgccttcg aggatatagc cctgggggaa gagaacacac agatttctgg
     1021 ggcctccctc tctgtcagct tatgcacaca ccctttgaaa ggccgccatc tagttgccac
     1081 aaaagacatt ctcccaggag aactgctggt gaaggaagat gcttttgtaa gtgtccttat
     1141 cccaggagaa atgccacgac ctcatcattg ccttgagaac aagtgggata ccagagttac
     1201 cagtggagac ctctactgtc accgatgtct gaagcacact ttggccacag taccttgtgg
     1261 cagctgcagc tatgccaagt attgcagcca ggaatgtatg cagcaggcat gggacctcta
     1321 ccatagcaca gagtgttctc ttggggggct gctcctcaca ctcggggtct tctgccatgt
     1381 tgccctgaga atgactcttt tagccagatt tgaagatgtt gatagagttg taaggatgct
     1441 ttgtgacgag gttggtagca cagacacctg tttacctgaa agcaagaatc tggtcaaggc
     1501 atttgattac acaagtcagg gagagagtga agagaagagc aagataggtg aacccccaat
     1561 tcctggatgc aatgtcaatg gaaagtatgg aagtaattat aatgctatct tcagcctttt
     1621 gccccatact gaaaagcata gcccagaaca cagattcatc tgtgccatca gtgtctccgc
     1681 actgtgcaga caactcaaag ctgacagcgt gcaggcccaa accttaaagt cccctaagct
     1741 gaaagcagtg accccagggc tgtgtgcaga tttgactgtt tggggagcag ccatgctgcg
     1801 acacatgcta cagctgcagt gtaatgccca ggcaataaca tccatatgtc acacagggtc
     1861 taacgagagc atcattacca acagcaggca gatacgcctt gccacaggca tcttccctgt
     1921 tgtcagcctc ctgaaccact cctgcaggcc caacaccagt gtgtccttca ctggcactgt
     1981 cgccaccgtc cgggcagcac agaggatcgc aaaaggacag gagattctgc actgctatgg
     2041 gcctcacgag agccggatgg gcgttgctga gaggcagcag aggctgagtt ctcagtactt
     2101 ctttgactgc cgctgtgggg cctgtcacgc tgagacactg agagcagctg cagctcccag
     2161 atgggaagcc ttctgttgta agacttgcag agcgctcatg cagggaaatg atgtgctgag
     2221 ctgtagcaac gaatcttgca caaactctgt cagcagggac cagctagtct ctcgcctgca
     2281 ggaccttcag caacaggtct gcatggccca gaagcttctc cgaaccggta aaccagagca
     2341 agccattcag cagttgttgc ggtgccggga ggctgctgag agcttcttgt cagcagagca
     2401 caccgtactg ggggaaattg aagatggcct ggcccaggcc catgctacct tagggaactg
     2461 gctaaagtct gctgcccatg tacagaagag tctccaggtg gttgaaactc gccatgggcc
     2521 atccagtgtt gaaattggcc atgagctctt caaactggcc caagtcctat tcaatgggtt
     2581 ggcagtgcct gaagctctga gtgccatctg gaaggcagaa aggatcctgt tggtgcactg
     2641 tggccctgag agtgaggagg tccgggagct ccgggaaatg aggtcctgct tactggactc
     2701 gtcattcgtc cctgtggggc ccttggtgta gagcaatcat cctcaccctc aagaaggagc
     2761 tctggtgatg actgagatgt tctgttggct tggagctctc atcagagagg acgggacctt
     2821 cccacctgac ctgagcctag tgtctggcac agagagcact tgaaaacaga ttgagacact
     2881 cacctgccat gctggctgct gcttgcaaga gctaactgcc ctctgatgga aaccccatgc
     2941 ccagaaaaga ctaaatccag tatctaaagg ctgctttaaa gggttgtcac tgcagccggg
     3001 cttggtggca cacgccttta atcccagcac tcgggaggca ggcggatttc tgagttcaag
     3061 gccagcctgg tctacaaagt gagttctagg acagccaggg ctacagagaa accctgtctt
     3121 gaaaaaccaa aaaaataaaa aataaaaata agtaaaaaat aaataaataa ataaataaag
     3181 ggttgtcact gatctgcagg cagctcatgc tagcctaggc ttttggctcg atttcatctc
     3241 actaaacgat gaatctgttt ccctggaaca ttcctatggt ttctagtagt aatgaagtgc
     3301 tgtgttccac tccagtgaga acttcaattc ttagtcttgt attataattg aaaaataata
     3361 tatagcaaga aatcagtatg actgcttacc tcaagagaca tacaattcca cttacaatat
     3421 cctgcttcct taaatttttc attaagactg gtgatatata atttgtgaat ggagaaataa
     3481 atacgtctta ctgttggcag tttcttcctg ggatggc
//
