LOCUS       NM_001160127            3379 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus SET and MYND domain containing 1 (Smyd1), transcript
            variant 1, mRNA.
ACCESSION   NM_001160127
VERSION     NM_001160127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Shi,W., Wasson,L.K., Dorr,K.M., Robbe,Z.L., Wilczewski,C.M.,
            Hepperla,A.J., Davis,I.J., Seidman,C.E., Seidman,J.G. and
            Conlon,F.L.
  TITLE     CHD4 and SMYD1 repress common transcriptional programs in the
            developing heart
  JOURNAL   Development 151 (8) (2024)
   PUBMED   38619323
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Cicatiello,A.G., Nappi,A., Franchini,F., Nettore,I.C., Raia,M.,
            Rocca,C., Angelone,T., Dentice,M., Ungaro,P. and Macchia,P.E.
  TITLE     The histone methyltransferase SMYD1 is induced by thermogenic
            stimuli in adipose tissue
  JOURNAL   Epigenomics 16 (6), 359-374 (2024)
   PUBMED   38440863
  REMARK    GeneRIF: The histone methyltransferase SMYD1 is induced by
            thermogenic stimuli in adipose tissue.
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Tang,J., Wu,C., Xu,Y., Yang,B., Xi,Y., Cai,M. and Tian,Z.
  TITLE     Resistance training up-regulates Smyd1 expression and inhibits
            oxidative stress and endoplasmic reticulum stress in the heart of
            middle-aged mice
  JOURNAL   Free Radic Biol Med 210, 304-317 (2024)
   PUBMED   38042222
  REMARK    GeneRIF: Resistance training up-regulates Smyd1 expression and
            inhibits oxidative stress and endoplasmic reticulum stress in the
            heart of middle-aged mice.
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Singh,S., Gaur,A., Sharma,R.K., Kumari,R., Prakash,S., Kumari,S.,
            Chaudhary,A.D., Prasun,P., Pant,P., Hunkler,H., Thum,T.,
            Jagavelu,K., Bharati,P., Hanif,K., Chitkara,P., Kumar,S., Mitra,K.
            and Gupta,S.K.
  TITLE     Musashi-2 causes cardiac hypertrophy and heart failure by inducing
            mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
  JOURNAL   Basic Res Cardiol 118 (1), 46 (2023)
   PUBMED   37923788
  REMARK    GeneRIF: Musashi-2 causes cardiac hypertrophy and heart failure by
            inducing mitochondrial dysfunction through destabilizing Cluh and
            Smyd1 mRNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3379)
  AUTHORS   Szulik,M.W., Valdez,S., Walsh,M., Davis,K., Bia,R., Horiuchi,E.,
            O'Very,S., Laxman,A.K., Sandaklie-Nicolova,L., Eberhardt,D.R.,
            Durrant,J.R., Sheikh,H., Hickenlooper,S., Creed,M., Brady,C.,
            Miller,M., Wang,L., Garcia-Llana,J., Tracy,C., Drakos,S.G.,
            Funai,K., Chaudhuri,D., Boudina,S. and Franklin,S.
  TITLE     SMYD1a protects the heart from ischemic injury by regulating
            OPA1-mediated cristae remodeling and supercomplex formation
  JOURNAL   Basic Res Cardiol 118 (1), 20 (2023)
   PUBMED   37212935
  REMARK    GeneRIF: SMYD1a protects the heart from ischemic injury by
            regulating OPA1-mediated cristae remodeling and supercomplex
            formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3379)
  AUTHORS   Sims,R.J. 3rd, Weihe,E.K., Zhu,L., O'Malley,S., Harriss,J.V. and
            Gottlieb,P.D.
  TITLE     m-Bop, a repressor protein essential for cardiogenesis, interacts
            with skNAC, a heart- and muscle-specific transcription factor
  JOURNAL   J Biol Chem 277 (29), 26524-26529 (2002)
   PUBMED   12011100
  REMARK    GeneRIF: Similar kinetics of induction and localization of m-Bop
            and skNAC during the induction of myogenesis in cultured C2C12
            cells suggests a possible associated role for these proteins during
            this process.
REFERENCE   7  (bases 1 to 3379)
  AUTHORS   Gottlieb,P.D., Pierce,S.A., Sims,R.J., Yamagishi,H., Weihe,E.K.,
            Harriss,J.V., Maika,S.D., Kuziel,W.A., King,H.L., Olson,E.N.,
            Nakagawa,O. and Srivastava,D.
  TITLE     Bop encodes a muscle-restricted protein containing MYND and SET
            domains and is essential for cardiac differentiation and
            morphogenesis
  JOURNAL   Nat Genet 31 (1), 25-32 (2002)
   PUBMED   11923873
  REMARK    GeneRIF: Bop encodes a muscle-restricted protein containing MYND
            and SET domains and is essential for cardiac differentiation and
            morphogenesis.
REFERENCE   8  (bases 1 to 3379)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   9  (bases 1 to 3379)
  AUTHORS   Hwang,I. and Gottlieb,P.D.
  TITLE     The Bop gene adjacent to the mouse CD8b gene encodes distinct
            zinc-finger proteins expressed in CTLs and in muscle
  JOURNAL   J Immunol 158 (3), 1165-1174 (1997)
   PUBMED   9013956
REFERENCE   10 (bases 1 to 3379)
  AUTHORS   Hwang,I. and Gottlieb,P.D.
  TITLE     Bop: a new T-cell-restricted gene located upstream of and opposite
            to mouse CD8b
  JOURNAL   Immunogenetics 42 (5), 353-361 (1995)
   PUBMED   7590968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY089666.1 and BC076601.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076601.1, AK142252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY089666.1         2-23
            23-3379             BC076601.1         1-3357
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     gene            1..3379
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /note="SET and MYND domain containing 1"
                     /db_xref="GeneID:12180"
                     /db_xref="MGI:MGI:104790"
     exon            1..214
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1550
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     and MYND domain-containing protein 1; m-BOP;
                     CD8b-opposite; zinc finger protein BOP; CD8beta opposite
                     strand; histone-lysine N-methyltransferase Smyd1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase Smyd1 isoform
                     1"
                     /protein_id="NP_001153599.1"
                     /db_xref="CCDS:CCDS51805.1"
                     /db_xref="GeneID:12180"
                     /db_xref="MGI:MGI:104790"
                     /translation="MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVF
                     DSLINFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVPNE
                     NIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPP
                     QSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN
                     GNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSC
                     EHCQKGLKDDLFLAAKEDPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRE
                     CLEKQEPVFADTNLYVLRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQL
                     GMAVMRAGLTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRM
                     FRQNEFMYHKMREAALNNQPMQVMAEPSNEPAPALFHKKQ"
     exon            215..391
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            392..605
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            606..736
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            737..775
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            776..965
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1058
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1222
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1391
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..3361
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3336..3341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /note="hexamer: AATAAA"
     polyA_site      3361
                     /gene="Smyd1"
                     /gene_synonym="4632404M21Rik; Bop; Zmynd18"
                     /note="major polyA site"
ORIGIN      
        1 aggagctaaa tagcagcaag gacaagaggc ttggctcagt gtgagcgagc cacctcgaag
       61 gcctgacaga ctctgagatg acaataggca gcatggagaa cgtggaggtc ttcacttccg
      121 agggcaaagg cagaggtctg aaggctacga aggagttctg ggctgcggat gtcatctttg
      181 cggagagggc ttattctgca gtggtttttg acagcctcat taacttcgtg tgccacacct
      241 gcttcaagag gcaggagaag ctccatcgct gcgggcagtg caagttcgcc cattactgcg
      301 accgcacgtg ccagaaggat gcttggctga atcacaagaa cgagtgcgct gccatcaaga
      361 aatatgggaa agtgcccaac gagaacatca ggctggccgc ccgcatcatg tggcgggtgg
      421 agagagaggg cactgggctc acagagggct gcctggtgtc cgtggatgac ttacagaacc
      481 acgtggagca ctttggggag gaggagcaga aggaactccg agtagacgtg gacacgttct
      541 tgcagtactg gccaccacag agccagcagt tcagcatgca gtatatctca cacatctttg
      601 gtgtgatcaa ctgcaacggt ttcactctca gtgaccagag agggctacag gcagtaggtg
      661 tgggcatctt ccccaacctg ggcctggtga accatgattg ctggccaaac tgcactgtca
      721 tattcaacaa tggcaatcat gaggcagtga aatccatgtt tcacacgcag atgaggattg
      781 agctccgggc cctgggcaag atctcagaag gcgaggagct gactgtgtcc tacatagact
      841 tcctgcacct cagtgaggag cgcaggcggc agctgaagaa acagtactac tttgactgct
      901 cctgtgagca ctgccagaag gggctgaagg acgacctctt cctggcagcg aaggaagacc
      961 ccaagccctc ccaggaagtg gtgaaggaga tgatacaatt ctcaaaggat acactggaaa
     1021 aaatagacaa ggctcgctcc gagggtttgt atcacgaggt tgtgaagctg tgtcgggagt
     1081 gcctggagaa gcaggagcca gtgttcgccg acaccaacct ctacgtgctt cggctgctca
     1141 gcattgcatc agaggtcctc tcctacctcc aggcctatga ggaggcctca cattatgcca
     1201 ggaggatggt tgatggctac atgaaactct accaccataa caatgcccaa ctgggcatgg
     1261 ctgtgatgag ggcagggctt accaactggc atgctggtca catcgaagtg gggcatggga
     1321 tgatctgcaa agcctatgct attctcctgg tgacccatgg accctcccac cctatcacca
     1381 aagacttaga ggccatgcgg atgcagacag agatggagct gcgtatgttc cgccaaaacg
     1441 aattcatgta tcacaagatg cgagaggctg ccctgaacaa ccagcccatg caggtcatgg
     1501 ctgagcctag caatgaacca gcccccgctc tgttccataa gaagcagtga ggaccttgtt
     1561 ggagggtggg ggggctgtgg ctggggagct gaggaaatga ctactctgtg tcctccactg
     1621 tcgttttggt tcaattcaat tcagtttagt tctctttcat ttcagaccaa ctcttcctac
     1681 atgtgtcagg tgctagatcc caccatctat ttaataaggg agccccaaat ataattgtgc
     1741 tagaaagaaa aatgtaaaca aacaaggcac agcataatag taaatgccat ggtgagctct
     1801 atgcagaggg gtttgtttag gggaggtgag tttgtgtgtg tatcgggtgg gggtaacacc
     1861 tgagctaaga gtggcaggta cctagaatcc caggtgactg cttgtgtatc tgtgtaggca
     1921 tctctggggc tgctggtctc atctacagtt atgaatattt aggttttgca gactggggtg
     1981 ggtgatgtcc tgaatcctca ggccaaaagt gtttgaccct ttgagatata ctcagtgatg
     2041 cctagaaaga tgcagggatc ttgggatcct gtggtcttta ctcctaatca gagcttgaag
     2101 cataacttta aaataactct agaacacaca tagaaggaat ttttccctcc ctggtcctac
     2161 ccaccatgcc tgtagctctt tatgatgttg aagaaaagct gagtttttcc tggccattga
     2221 cttgtaaagc tgactgtgca tgcctgccag tgatggaccc atcagaagtg gtgtgtaggg
     2281 gcttccaaga ctgagaagtc tgcctcagcc taggcttcat cattggccca atgaggctct
     2341 actcattgta ttgagtgact gttagttcct ctgcttaatt tctttatcct gtctgtgctc
     2401 tgggggcttc tcccctttcg taaggcagtt cacctggcct ggatctcatt ggagagtggc
     2461 cagtttgctc tcatttactt ggaggctgac ttccagctga gaaatgaagg cccaagaagt
     2521 gtcttttagt ttctggaacc ccaactttca caccaacatg atgggaaatc atgaagtaaa
     2581 ttcttttggt tgagggtgtc accaaaactt ctacgaaacc ttgtgctacc actgacatct
     2641 cccagaactc taacatcttg aagtcacatg attcccacta aactgcaatt tatttctgcc
     2701 taaaatgtta gtttctccat ccccagcctt tcatcccaga acagtaccct acctgccctt
     2761 gagccctgcc cagcctctga ggcctatgat gcgggcacct ctttgtagaa tattagcact
     2821 gacccttggt tctttttgag gatttgttct tctctagaag gctttatgaa gactgacagt
     2881 gaagaccatg ctcagtataa acttacaatg gggggggggg ggggatgaca gagtggatcc
     2941 ttaaaatgtt aaaggagttg tggcttaact ggagactact cacaaaccct gagagccaca
     3001 gtaaacaagc ctaagagttc cacgcacccc cctcaccatc tgcatccacc ccattttggt
     3061 gaaccagagc actaatcaga catctgtcat tgcctggtga ctctattagg gactgcctct
     3121 ttaaagatct gaggaagaga actatggtga ggccttgacc atggccagaa ggattttcct
     3181 acaaagcact ttatttgcag agtgtaaatt catcattaag tacctgccgt ctcctggtca
     3241 agttcaaact ccaaagttaa aagattcaca gcagatgctc tgttctctct ctgtgtcctc
     3301 tcgtgtatgc ccattttcac tttacctgct tgcaaaataa attcccttgg atgctctcgg
     3361 aaaaaaaaaa aaaaaaaaa
//
