LOCUS       NM_024230               1761 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus smoothelin-like 1 (Smtnl1), mRNA.
ACCESSION   NM_024230
VERSION     NM_024230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Keller,I., Ungvari,A., Kinter,R., Szalmas,F., Kokai,E. and
            Lontay,B.
  TITLE     Smoothelin-like protein 1 promotes insulin sensitivity and
            modulates the contractile properties of endometrial epithelial
            cells with insulin resistance
  JOURNAL   Front Endocrinol (Lausanne) 15, 1375771 (2024)
   PUBMED   38883605
  REMARK    GeneRIF: Smoothelin-like protein 1 promotes insulin sensitivity and
            modulates the contractile properties of endometrial epithelial
            cells with insulin resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Murali,M., Turner,S.R., Belke,D.D., Cole,W.C. and MacDonald,J.A.
  TITLE     Smoothelin-like 1 knockout mice display sex-dependent alterations
            in blood flow and cardiac function
  JOURNAL   Can J Physiol Pharmacol 101 (1), 27-40 (2023)
   PUBMED   36342379
  REMARK    GeneRIF: Smoothelin-like 1 knockout mice display sex-dependent
            alterations in blood flow and cardiac function.
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Tamas,I., Major,E., Horvath,D., Keller,I., Ungvari,A.,
            Haystead,T.A., MacDonald,J.A. and Lontay,B.
  TITLE     Mechanisms by which smoothelin-like protein 1 reverses insulin
            resistance in myotubules and mice
  JOURNAL   Mol Cell Endocrinol 551, 111663 (2022)
   PUBMED   35508278
  REMARK    GeneRIF: Mechanisms by which smoothelin-like protein 1 reverses
            insulin resistance in myotubules and mice.
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Major,E., Gyory,F., Horvath,D., Keller,I., Tamas,I., Uray,K.,
            Fulop,P. and Lontay,B.
  TITLE     Smoothelin-Like Protein 1 Regulates Development and Metabolic
            Transformation of Skeletal Muscle in Hyperthyroidism
  JOURNAL   Front Endocrinol (Lausanne) 12, 751488 (2021)
   PUBMED   34675885
  REMARK    GeneRIF: Smoothelin-Like Protein 1 Regulates Development and
            Metabolic Transformation of Skeletal Muscle in Hyperthyroidism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Turner,S.R., Chappellaz,M., Popowich,B., Wooldridge,A.A.,
            Haystead,T.A.J., Cole,W.C. and MacDonald,J.A.
  TITLE     Smoothelin-like 1 deletion enhances myogenic reactivity of
            mesenteric arteries with alterations in PKC and myosin phosphatase
            signaling
  JOURNAL   Sci Rep 9 (1), 481 (2019)
   PUBMED   30679490
  REMARK    GeneRIF: deletion of SMTNL1 contributes to enhancement of
            pressure-induced contractility of mesenteric resistance vessels by
            influencing the activity of myosin phosphatase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Lontay,B., Bodoor,K., Weitzel,D.H., Loiselle,D., Fortner,C.,
            Lengyel,S., Zheng,D., Devente,J., Hickner,R. and Haystead,T.A.
  TITLE     Smoothelin-like 1 protein regulates myosin phosphatase-targeting
            subunit 1 expression during sexual development and pregnancy
  JOURNAL   J Biol Chem 285 (38), 29357-29366 (2010)
   PUBMED   20634291
  REMARK    GeneRIF: Findings define a new conserved pathway in which sexual
            development and pregnancy mediate smooth and striated muscle
            adaptations through SMTNL1 and MYPT1.
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Ulke-Lemee,A., Ishida,H., Borman,M.A., Valderrama,A., Vogel,H.J.
            and MacDonald,J.A.
  TITLE     Tropomyosin-binding properties of the CHASM protein are dependent
            upon its calponin homology domain
  JOURNAL   FEBS Lett 584 (15), 3311-3316 (2010)
   PUBMED   20627103
  REMARK    GeneRIF: An interaction between CHASM and tropomyosin, is
            demonstrated.
REFERENCE   8  (bases 1 to 1761)
  AUTHORS   Ishida,H., Borman,M.A., Ostrander,J., Vogel,H.J. and MacDonald,J.A.
  TITLE     Solution structure of the calponin homology (CH) domain from the
            smoothelin-like 1 protein: a unique apocalmodulin-binding mode and
            the possible role of the C-terminal type-2 CH-domain in smooth
            muscle relaxation
  JOURNAL   J Biol Chem 283 (29), 20569-20578 (2008)
   PUBMED   18477568
  REMARK    GeneRIF: revealed a close interaction of SMTNL1-homology with the
            two Ca(2+) binding loop regions of the C-terminal domain of
            apo-calmodulin
REFERENCE   9  (bases 1 to 1761)
  AUTHORS   Wooldridge,A.A., Fortner,C.N., Lontay,B., Akimoto,T., Neppl,R.L.,
            Facemire,C., Datto,M.B., Kwon,A., McCook,E., Li,P., Wang,S.,
            Thresher,R.J., Miller,S.E., Perriard,J.C., Gavin,T.P.,
            Hickner,R.C., Coffman,T.M., Somlyo,A.V., Yan,Z. and Haystead,T.A.
  TITLE     Deletion of the protein kinase A/protein kinase G target SMTNL1
            promotes an exercise-adapted phenotype in vascular smooth muscle
  JOURNAL   J Biol Chem 283 (17), 11850-11859 (2008)
   PUBMED   18310078
  REMARK    GeneRIF: SMTNL1 has roles in cGMP/cAMP-mediated adaptations to
            exercise through mechanisms involving direct modulation of
            contractile activity
            GeneRIF: A knock out mouse for this gene shows an exercise adapted
            phenotype. The encoded protein has a unique expression profile in
            striated muscle both in mice and human.
REFERENCE   10 (bases 1 to 1761)
  AUTHORS   Borman,M.A., MacDonald,J.A. and Haystead,T.A.
  TITLE     Modulation of smooth muscle contractility by CHASM, a novel member
            of the smoothelin family of proteins
  JOURNAL   FEBS Lett 573 (1-3), 207-213 (2004)
   PUBMED   15327999
  REMARK    GeneRIF: CHASM is a novel member of the smoothelin protein family
            that elicits Ca2+ desensitization in smooth muscle
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL928914.15.
            
            On Nov 17, 2006 this sequence version replaced NM_024230.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002317.1, AK003989.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL928914.15        104846-105005       c
            161-795             AL928914.15        100629-101263       c
            796-928             AL928914.15        99477-99609         c
            929-974             AL928914.15        99331-99376         c
            975-1130            AL928914.15        98237-98392         c
            1131-1245           AL928914.15        97960-98074         c
            1246-1397           AL928914.15        97644-97795         c
            1398-1761           AL928914.15        93529-93892         c
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..1761
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /note="smoothelin-like 1"
                     /db_xref="GeneID:68678"
                     /db_xref="MGI:MGI:1915928"
     exon            1..160
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            161..795
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1542
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /note="calponin homology-associated smooth muscle protein"
                     /codon_start=1
                     /product="smoothelin-like protein 1"
                     /protein_id="NP_077192.1"
                     /db_xref="CCDS:CCDS16195.1"
                     /db_xref="GeneID:68678"
                     /db_xref="MGI:MGI:1915928"
                     /translation="MEQTEGNSSEDGTTVSPTAGNLETPGSQGIAEEVAEGTVGTSDK
                     EGPSDWAEHLCKAASKSGESGGSPGEASILDELKTDLQGEARGKDEAQGDLAEEKVGK
                     EDTTAASQEDTGKKEETKPEPNEVREKEEAMLASEKQKVDEKETNLESKEKSDVNDKA
                     KPEPKEDAGAEVTVNEAETESQEEADVKDQAKPELPEVDGKETGSDTKELVEPESPTE
                     EQEQGKENESEERAAVIPSSPEEWPESPTDEGPSLSPDGLAPESTGETSPSASESSPS
                     EVPGSPTEPQPSEKKKDRAPERRVSAPSRPRGPRAQNRKAIMDKFGGAASGPTALFRN
                     TKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPEAFDY
                     AELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQ
                     KGLVKTKKK"
     exon            796..928
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            929..974
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1130
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1245
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1397
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1761
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /note="hexamer: AATAAA"
     polyA_site      1761
                     /gene="Smtnl1"
                     /gene_synonym="1110030K22Rik; CHASM"
                     /note="major polyA site"
ORIGIN      
        1 ttcccgaagc ccgggcctct tgaaggtggg gtggggtgga agcaaggagg tgggactttg
       61 agctgaaggc tccaagccac cagagcttaa agaacgatga gagtgaggca gctcggctag
      121 aacgaggcaa gagctccgag ctgcaggcag aaccccacag acatggagca gacagaaggg
      181 aactcctctg aggatgggac cactgtctcc ccaactgcag ggaatcttga gacaccagga
      241 agtcaaggca ttgcagagga ggtggccgaa ggcacagttg ggacaagtga caaagaaggg
      301 ccttcagatt gggcagaaca tttgtgtaaa gcagcatcta agagtggcga atcagggggg
      361 tccccagggg aagcaagtat attagatgag ctcaagacag acttgcaagg ggaagccaga
      421 gggaaggacg aagcccaggg tgaccttgct gaggagaagg ttgggaagga agacaccaca
      481 gcggcttctc aggaagacac tggtaagaaa gaagaaacaa aacctgaacc caatgaagtt
      541 agggagaaag aggaggccat gctggcctcg gagaagcaga aggttgatga gaaagagacc
      601 aatctagaat ctaaggagaa atcggatgtg aatgacaaag ccaagcctga acccaaggag
      661 gatgctggag cagaggttac tgtcaacgag gctgagactg agtctcagga ggaggctgat
      721 gtgaaggacc aggccaagcc cgagcttcca gaagttgatg ggaaagagac cggaagtgac
      781 acaaaggagt tggtggagcc agagagtccc actgaagagc aagagcaggg taaggaaaat
      841 gaatcagaag aaagggctgc agtgattccc agctcccccg aggagtggcc cgaaagcccc
      901 acagatgagg ggcccagcct cagcccagat ggattggctc cagagtctac aggagagacc
      961 agtccttcag ccagtgaatc ttcgcccagt gaggtgccag ggagtcccac agagcctcaa
     1021 ccctcagaga aaaagaagga tcgagcacca gaacgcagag tgtcggcacc cagccggccc
     1081 cgggggcccc gtgcacagaa tcggaaggcc atcatggaca aatttggcgg ggcagcctct
     1141 ggccccactg cactgttccg gaacacaaag gcagccgggg cagccatcgg tggtgtcaag
     1201 aacatgcttt tggagtggtg ccgggccatg acgagaaact acgagcacgt ggatatccaa
     1261 aacttctcct ccagctggag cagcggcatg gccttctgtg ccctcatcca caagtttttt
     1321 ccagaagcct ttgactatgc agagctggac ccagcaaagc gccggcacaa cttcacccta
     1381 gctttctcga ctgcagagaa actagccgac tgtgcccagc tgctggaggt ggatgacatg
     1441 gtgcggctgg cagtgcccga ttccaagtgt gtctacacct acatccagga gctataccgt
     1501 agccttgtgc agaaagggct ggtgaagacg aaaaagaaat gaatggcaaa gccatgcggg
     1561 aggaggaagc ggagcccagc tgccaaccgt ggcctcgggg tgctttcgca ccaccagaca
     1621 taaagcaggt gacaccagta tcaaccgcac cgaaagtgct ttttcaaaat tcctctcatt
     1681 ccttgctgct ccccgcaccc caaccagcca cacgtatgtt acaggcggtg ggccaaaaat
     1741 aaaaagaaac ctgcatttgg a
//
