LOCUS       NP_001271358             672 aa            linear   ROD 26-MAR-2025
DEFINITION  smoothelin isoform c [Mus musculus].
ACCESSION   NP_001271358
VERSION     NP_001271358.1
DBSOURCE    REFSEQ: accession NM_001284429.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 672)
  AUTHORS   Straube,P., Beckers,A., Jany,U.W.H., Bergmann,F., Ludtke,T.H.,
            Rudat,C., Trowe,M.O., Peters,I., Klopf,M.G., Mamo,T.M. and
            Kispert,A.
  TITLE     Interplay of SHH, WNT and BMP4 signaling regulates the development
            of the lamina propria in the murine ureter
  JOURNAL   Development 152 (3) (2025)
   PUBMED   39817691
REFERENCE   2  (residues 1 to 672)
  AUTHORS   Gong,Y., Liang,Y., Liu,J., Wei,J., Zhang,S., Chen,F., Zhang,Q.,
            Wang,L., Lan,H., Wu,L., Ge,W., Li,S., Wang,L., Shan,H. and He,H.
  TITLE     DDX24 Is Essential for Cell Cycle Regulation in Vascular Smooth
            Muscle Cells During Vascular Development via Binding to FANCA mRNA
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (9), 1653-1667 (2023)
   PUBMED   37470182
REFERENCE   3  (residues 1 to 672)
  AUTHORS   Gannoun,L., De Schrevel,C., Belle,M., Dauguet,N., Achouri,Y.,
            Loriot,A., Vanderaa,C., Cordi,S., Dili,A., Heremans,Y., Rooman,I.,
            Leclercq,I.A., Jacquemin,P., Gatto,L. and Lemaigre,F.P.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   4  (residues 1 to 672)
  AUTHORS   Godin,P., Tsoi,M., Paquet,M. and Boerboom,D.
  TITLE     YAP and TAZ are required for the postnatal development and the
            maintenance of the structural integrity of the oviduct
  JOURNAL   Reproduction 160 (2), 307-318 (2020)
   PUBMED   32520726
REFERENCE   5  (residues 1 to 672)
  AUTHORS   Guo,C., Balsara,Z.R., Hill,W.G. and Li,X.
  TITLE     Stage- and subunit-specific functions of polycomb repressive
            complex 2 in bladder urothelial formation and regeneration
  JOURNAL   Development 144 (3), 400-408 (2017)
   PUBMED   28049658
REFERENCE   6  (residues 1 to 672)
  AUTHORS   Rensen,S.S., Niessen,P.M., van Deursen,J.M., Janssen,B.J.,
            Heijman,E., Hermeling,E., Meens,M., Lie,N., Gijbels,M.J.,
            Strijkers,G.J., Doevendans,P.A., Hofker,M.H., De Mey,J.G. and van
            Eys,G.J.
  TITLE     Smoothelin-B deficiency results in reduced arterial contractility,
            hypertension, and cardiac hypertrophy in mice
  JOURNAL   Circulation 118 (8), 828-836 (2008)
   PUBMED   18678771
  REMARK    GeneRIF: smoothelins as key determinants of arterial smooth muscle
            contractility and cardiovascular performance
REFERENCE   7  (residues 1 to 672)
  AUTHORS   Niessen,P., Rensen,S., van Deursen,J., De Man,J., De Laet,A.,
            Vanderwinden,J.M., Wedel,T., Baker,D., Doevendans,P., Hofker,M.,
            Gijbels,M. and van Eys,G.
  TITLE     Smoothelin-a is essential for functional intestinal smooth muscle
            contractility in mice
  JOURNAL   Gastroenterology 129 (5), 1592-1601 (2005)
   PUBMED   16285958
  REMARK    GeneRIF: Smoothelin-A is essential for functional contractility of
            intestinal smooth muscle.
REFERENCE   8  (residues 1 to 672)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (residues 1 to 672)
  AUTHORS   Rensen,S., Merkx,G., Doevendans,P., Geurts Van Kessel,A. and van
            Eys,G.
  TITLE     Structure and chromosome location of Smtn, the mouse smoothelin
            gene
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 225-229 (2000)
   PUBMED   10965129
REFERENCE   10 (residues 1 to 672)
  AUTHORS   Kramer,J., Aguirre-Arteta,A.M., Thiel,C., Gross,C.M., Dietz,R.,
            Cardoso,M.C. and Leonhardt,H.
  TITLE     A novel isoform of the smooth muscle cell differentiation marker
            smoothelin
  JOURNAL   J Mol Med (Berl) 77 (2), 294-298 (1999)
   PUBMED   10023782
  REMARK    Erratum:[J Mol Med 1999 Apr;77(4):399]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713875.14, AK030932.1, AK085412.1 and AW490128.1.
            
            Transcript Variant: This variant (5) contains an alternate exon in
            the 5' end and differs in the 3' UTR and coding sequence compared
            to variant 3. The resulting isoform (c) is shorter at the
            N-terminus and has a shorter and distinct C-terminus compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR13862019.1447300.1, SRR17253014.920652.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.47 cM"
     Protein         1..672
                     /product="smoothelin isoform c"
                     /note="smoothelin A"
                     /calculated_mol_wt=72648
     Region          321..368
                     /region_name="Smoothelin"
                     /note="Smoothelin cytoskeleton protein; pfam12510"
                     /db_xref="CDD:463614"
     Region          557..668
                     /region_name="CH_SMTNB"
                     /note="calponin homology (CH) domain found in smoothelin-B
                     and similar proteins; cd21259"
                     /db_xref="CDD:409108"
     Site            order(558,562,612,614..615,618..619,621,630..638,646,
                     648..649,651..652,655..656,659)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409108"
     CDS             1..672
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /coded_by="NM_001284429.1:1045..3063"
                     /note="isoform c is encoded by transcript variant 5"
                     /db_xref="GeneID:29856"
                     /db_xref="MGI:MGI:1354727"
ORIGIN      
        1 mspvpsssrg rviskplpgp tepsdtldsi rgfsntkrad psetkscqrs lsvlsprqpt
       61 pnreptslag psqfrrvgsv rdrvqkftsd spvvarlqdg pprtalaspt ptrlpgpsli
      121 sttpasssss nssspspsdt sshkkqrela hslaelqscp qeegpggrgl alrslenrag
      181 gpkpcseeps tpppvavgtg epggsmkttf tieikdgrgq astgrvllpt gnqraeltlg
      241 lrapptllst ssggkntith isnpgtvtrl gsvthvttfs haspgnrggc nfkmepdpae
      301 ppsttveaan gaeqarvdkg pegrsplsae eltaiedegv ldkmldqttn feerkliraa
      361 lrelrqrkrd qrdkererrl reararpges rsnvatettt rhsqraadgs tvgtvtkter
      421 lvhsndgtqt artttvessf mrrlengsss sstttttvqt ksfsssssss sskkmgsifd
      481 redqtssrpg slaalerrqa ekkkelmkaq slpktsasqa rkamieklek egsaggpgtp
      541 rtavqrstsf gvpnansikq mlldwcrakt rgyehvdiqn fssswsdgma fcalvhnffp
      601 eafdygqlsp qnrrqnfema fssaethadc pqlldtedmv rlrepdwkcv ytyiqefyrc
      661 lvqkglvktk ks
//
