LOCUS       NM_001159284            3397 bp    mRNA    linear   ROD 19-SEP-2023
DEFINITION  Mus musculus smoothelin (Smtn), transcript variant 1, mRNA.
ACCESSION   NM_001159284
VERSION     NM_001159284.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Gannoun L, De Schrevel C, Belle M, Dauguet N, Achouri Y, Loriot A,
            Vanderaa C, Cordi S, Dili A, Heremans Y, Rooman I, Leclercq IA,
            Jacquemin P, Gatto L and Lemaigre FP.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Godin P, Tsoi M, Paquet M and Boerboom D.
  TITLE     YAP and TAZ are required for the postnatal development and the
            maintenance of the structural integrity of the oviduct
  JOURNAL   Reproduction 160 (2), 307-318 (2020)
   PUBMED   32520726
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Guo C, Balsara ZR, Hill WG and Li X.
  TITLE     Stage- and subunit-specific functions of polycomb repressive
            complex 2 in bladder urothelial formation and regeneration
  JOURNAL   Development 144 (3), 400-408 (2017)
   PUBMED   28049658
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Gurdziel K, Vogt KR, Walton KD, Schneider GK and Gumucio DL.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz
            DB, Davis EC and Dichek DA.
  TITLE     Transforming growth factor-beta signaling in myogenic cells
            regulates vascular morphogenesis, differentiation, and matrix
            synthesis
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (1), e1-e11 (2012)
   PUBMED   21979435
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Rensen SS, Niessen PM, van Deursen JM, Janssen BJ, Heijman E,
            Hermeling E, Meens M, Lie N, Gijbels MJ, Strijkers GJ, Doevendans
            PA, Hofker MH, De Mey JG and van Eys GJ.
  TITLE     Smoothelin-B deficiency results in reduced arterial contractility,
            hypertension, and cardiac hypertrophy in mice
  JOURNAL   Circulation 118 (8), 828-836 (2008)
   PUBMED   18678771
  REMARK    GeneRIF: smoothelins as key determinants of arterial smooth muscle
            contractility and cardiovascular performance
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Niessen P, Rensen S, van Deursen J, De Man J, De Laet A,
            Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels
            M and van Eys G.
  TITLE     Smoothelin-a is essential for functional intestinal smooth muscle
            contractility in mice
  JOURNAL   Gastroenterology 129 (5), 1592-1601 (2005)
   PUBMED   16285958
  REMARK    GeneRIF: Smoothelin-A is essential for functional contractility of
            intestinal smooth muscle.
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Rensen S, Merkx G, Doevendans P, Geurts Van Kessel A and van Eys G.
  TITLE     Structure and chromosome location of Smtn, the mouse smoothelin
            gene
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 225-229 (2000)
   PUBMED   10965129
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Kramer J, Aguirre-Arteta AM, Thiel C, Gross CM, Dietz R, Cardoso MC
            and Leonhardt H.
  TITLE     A novel isoform of the smooth muscle cell differentiation marker
            smoothelin
  JOURNAL   J Mol Med (Berl) 77 (2), 294-298 (1999)
   PUBMED   10023782
  REMARK    Erratum:[J Mol Med 1999 Apr;77(4):399]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138898.1, BC066192.1, AK085412.1, AK166385.1 and AI480617.1.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_001159284.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR, the 3'
            UTR, and the 3' coding sequence compared to variant 3. The
            resulting isoform (b) has a shorter and distinct C-terminus
            compared to isoform a. Variants 1, 2, and 4 all encode the same
            isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069839.1, SRR17253011.9081693.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AK138898.1         2-123
            123-766             BC066192.1         1-644
            767-1620            AK085412.1         731-1584
            1621-1643           BC066192.1         1496-1518
            1644-2150           AK166385.1         1661-2167
            2151-2560           BC066192.1         2026-2435
            2561-2979           AK085412.1         2526-2944
            2980-3382           AK138898.1         2995-3397
            3383-3397           AI480617.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.47 cM"
     gene            1..3397
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /note="smoothelin"
                     /db_xref="GeneID:29856"
                     /db_xref="MGI:MGI:1354727"
     exon            1..181
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            182..232
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            233..346
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..3061
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /note="isoform b is encoded by transcript variant 1;
                     smoothelin A"
                     /codon_start=1
                     /product="smoothelin isoform b"
                     /protein_id="NP_001152756.1"
                     /db_xref="CCDS:CCDS24366.1"
                     /db_xref="GeneID:29856"
                     /db_xref="MGI:MGI:1354727"
                     /translation="MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELER
                     EEEALASKRFRAERQDNKENWLHSQQREAEQQAALARLAGRLESMNDVEELTTLLRSA
                     GEYEERKLIRAAIRRVRAQEIKAATLAGRLCSRLPSSGPREDSRRQAAHTLDPGKVPE
                     PEQQEQQTEVLEPTPTPEDTSQDVTTVTLLLRAPPGGRPSSPASPHNSPTSASPEPLL
                     EPAGAQCPAVEAPVSSEPLPHPSEAPSPEPPMSPVPSSSRGRVISKPLPGPTEPSDTL
                     DSIRGFSNTKRADPSETKSCQRSLSVLSPRQPTPNREPTSLAGPSQFRRVGSVRDRVQ
                     KFTSDSPVVARLQDGPPRTALASPTPTRLPGPSLISTTPASSSSSNSSSPSPSDTSSH
                     KKQRELAHSLAELQSCPQEEGPGGRGLALRSLENRAGGPKPCSEEPSTPPPVAVGTGE
                     PGGSMKTTFTIEIKDGRGQASTGRVLLPTGNQRAELTLGLRAPPTLLSTSSGGKNTIT
                     HISNPGTVTRLGSVTHVTTFSHASPGNRGGCNFKMEPDPAEPPSTTVEAANGAEQARV
                     DKGPEGRSPLSAEELTAIEDEGVLDKMLDQTTNFEERKLIRAALRELRQRKRDQRDKE
                     RERRLREARARPGESRSNVATETTTRHSQRAADGSTVGTVTKTERLVHSNDGTQTART
                     TTVESSFMRRLENGSSSSSTTTTTVQTKSFSSSSSSSSSKKMGSIFDREDQTSSRPGS
                     LAALERRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGSAGGPGTPRTAVQRSTS
                     FGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQ
                     LSPQNRRQNFEMAFSSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQEFYRCLVQKG
                     LVKTKKS"
     exon            347..495
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            496..589
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            590..668
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            669..766
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1087
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1160
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1232
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1748
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1921
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2074
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2150
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2315
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2378
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2472
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2646
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2764
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2916
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3081
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3387
                     /gene="Smtn"
                     /gene_synonym="smsmo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagccatc tggctggcgc cgcgggacag gcgtctgcag cagagtccag ggtacgttgc
       61 tgaaccggcc tgggctcctg ggctgcggct cctcccgtcg gtctgccggt ctctactgca
      121 tctaccgggt cccgaccaaa ctaacacgaa actgcgccgg aacggcgggc cggactgaga
      181 gcaaaatacc ctggggcaga ggacagttcc cagccaggag ccacatgtca ggaattctga
      241 gtgccaccag gacctggcgg gagctgacat actgaaggaa ttaggggcca gcaagatggc
      301 agacgaggct ttagctgggc tggatgaagg agccctccga aaactgctgg aggtcactgc
      361 agatctggca gaacggcggc ggatccgctc agccatccgg gagctgcagc gacaggagct
      421 ggaacgagaa gaggaggctc tggcgtccaa acgtttccgt gctgagcggc aagacaacaa
      481 ggagaactgg ctacactctc aacagcgaga agctgaacag caggccgccc tcgcacgatt
      541 ggcagggaga ctggagtcca tgaatgatgt cgaggagttg accacactgc ttcggagtgc
      601 cggtgaatat gaggagcgca agctgatcag agctgccatc cgccgagtgc gagctcagga
      661 gattaaggct gccaccttgg ctgggagact gtgcagtaga cttcccagta gtggcccccg
      721 agaggacagc aggaggcagg cagcacacac attggaccct ggtaaggtgc cagagccaga
      781 gcagcaggaa cagcagacag aagtactcga gccaacccca accccagagg acaccagcca
      841 ggatgtgacc acagtgacac tcctgctgag ggccccgcct gggggcaggc ccagctcacc
      901 tgcttccccc cacaattcac ccaccagtgc ctctccagag cctctgctgg agcctgctgg
      961 agcccagtgt cctgctgtgg aggctccagt cagctctgag ccacttccac acccttcaga
     1021 agctcctagc cctgagcccc ccatgtcgcc ggtaccgtcc agctctcggg ggcgggtcat
     1081 cagcaagccc ctgcctggcc ccacagagcc ctcagatacc ttggactcca tcagaggctt
     1141 ctccaacact aagagagcag acccgtctga aacgaaatcc tgccaacgtt cactatctgt
     1201 gctcagtccc cgacaaccaa ccccaaatcg agagccaacc tcacttgcag gaccgtccca
     1261 gttccgtcga gttggctctg tgagagacag agtccaaaag ttcacatctg attctcccgt
     1321 ggttgccagg ctccaggatg gcccaccccg aacagccctt gcttcaccga cccccacaag
     1381 gctcccgggc ccttccctca tcagcaccac ccctgcctcc tcctcctcca gcaactcctc
     1441 ctctccgagt cccagtgaca cttcctccca caagaagcag agagaacttg ctcattccct
     1501 ggccgagctt cagagctgcc ctcaagagga gggccctggg gggcggggct tggctctcag
     1561 gtcccttgaa aacagagcag gggggcccaa gccctgctca gaagagccca gtaccccacc
     1621 gcccgtggcc gttggcactg gggagccagg gggcagtatg aagactacgt ttaccattga
     1681 gatcaaggat ggccgtggtc aggcctccac aggccgggtg ctgctgccca caggcaacca
     1741 gagagcagaa ttgactttgg gattgcgggc acccccaacc cttctcagca ccagcagtgg
     1801 gggcaagaac accatcaccc acatcagcaa ccctgggact gtgacccgac tgggcagtgt
     1861 cactcacgtc actaccttca gccatgcctc ccctggtaac cgaggaggct gcaactttaa
     1921 gatggagcca gatcctgcag agcccccctc caccacagtg gaagcagcta atggcgcaga
     1981 gcaggctcga gtggacaaag gcccagaggg gcggagtccc ctgagtgcag aggagctgac
     2041 ggccattgag gacgaaggag tcctggacaa gatgctggac cagactacga actttgagga
     2101 gaggaagctc atccgggctg cactgcgtga gctccgacaa agaaagagag accagaggga
     2161 caaggaacga gaacggaggc tacgggaggc acgggcccgg ccgggcgaga gccgaagcaa
     2221 tgtggccacg gagaccacca ccaggcacag ccagcgggcg gctgatggct ctactgtcgg
     2281 cacagttacc aaaaccgagc gcctcgttca ctccaatgat ggcactcaga cggcccgcac
     2341 caccacagtg gagtccagtt tcatgaggcg cttggagaat ggcagcagca gcagcagcac
     2401 caccaccacc acggtccaaa ccaagagttt ttcctcttcc tcttcctcgt cctcgtccaa
     2461 aaagatgggc agtatcttcg accgagagga ccagaccagc tcacgtcctg gcagcctggc
     2521 agcccttgaa agacgccagg cagagaagaa gaaagagtta atgaaggcac agagtctgcc
     2581 caagacttca gcatcccaag cacgcaaggc catgattgag aagctagaga aagaaggctc
     2641 tgcaggtggt cctggcacac cccgtacagc tgtacagcgt tctaccagct tcggagtccc
     2701 caacgccaat agcatcaagc agatgttgct ggactggtgc cgagccaaga cccgcggcta
     2761 cgagcacgtg gacatccaga acttctcctc cagctggagt gatgggatgg ccttctgtgc
     2821 cctggtgcac aatttcttcc ctgaggcttt tgactatggg cagctgagcc cacaaaaccg
     2881 acgccagaac tttgaaatgg ccttctcatc cgctgagacc catgcggact gcccgcagct
     2941 cctggataca gaggacatgg tgcggcttcg agagccagac tggaagtgcg tgtacacgta
     3001 catccaggag ttctaccgct gtctggtcca gaaggggctg gtaaaaacca aaaagtccta
     3061 acccctgctt ggggccccac ggatgctggt ggactgtgta cccttggtgg aggtggagga
     3121 catgatgatc atgggcaaaa agcccgaccc caagtgcgtc ttcacctatg tgcaatcgct
     3181 gtacaaccac ctgcggcgcc atgagctgcg tttgcgcggc aagaatgtct agccactctg
     3241 ctcacaccgc ctgcgctgcg ggctgctgtc cccacgcccc cagcaccggc acctcccagt
     3301 gcgcctgccc actgctgccc cgtctgtcaa aacacctctc ccctttgtac acacgcagcg
     3361 ttttgataaa ttattggttt tcaacgaaaa aaaaaaa
//
