LOCUS       NM_009214               3721 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus spermine synthase (Sms), transcript variant 1, mRNA.
ACCESSION   NM_009214
VERSION     NM_009214.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Yorgan,T.A., Zhu,Y., Wiedemann,P., Schoneck,K., Pohl,S.,
            Schweizer,M., Amling,M., Barvencik,F., Oheim,R. and Schinke,T.
  TITLE     Inactivation of spermine synthase in mice causes osteopenia due to
            reduced osteoblast activity
  JOURNAL   J Bone Miner Res 39 (11), 1606-1620 (2024)
   PUBMED   39331754
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Akinyele,O., Munir,A., Johnson,M.A., Perez,M.S., Gao,Y.,
            Foley,J.R., Nwafor,A., Wu,Y., Murray-Stewart,T., Casero,R.A. Jr.,
            Bayir,H. and Kemaladewi,D.U.
  TITLE     Impaired polyamine metabolism causes behavioral and neuroanatomical
            defects in a mouse model of Snyder-Robinson syndrome
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38463005
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Kim-Muller,J.Y., Fan,J., Kim,Y.J., Lee,S.A., Ishida,E., Blaner,W.S.
            and Accili,D.
  TITLE     Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic
            beta cells in diabetic mice
  JOURNAL   Nat Commun 7, 12631 (2016)
   PUBMED   27572106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Pegg,A.E. and Michael,A.J.
  TITLE     Spermine synthase
  JOURNAL   Cell Mol Life Sci 67 (1), 113-121 (2010)
   PUBMED   19859664
  REMARK    Review article
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Korhonen,V.P., Niiranen,K., Halmekyto,M., Pietila,M., Diegelman,P.,
            Parkkinen,J.J., Eloranta,T., Porter,C.W., Alhonen,L. and Janne,J.
  TITLE     Spermine deficiency resulting from targeted disruption of the
            spermine synthase gene in embryonic stem cells leads to enhanced
            sensitivity to antiproliferative drugs
  JOURNAL   Mol Pharmacol 59 (2), 231-238 (2001)
   PUBMED   11160858
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Meyer,R.A. Jr., Henley,C.M., Meyer,M.H., Morgan,P.L.,
            McDonald,A.G., Mills,C. and Price,D.K.
  TITLE     Partial deletion of both the spermine synthase gene and the Pex
            gene in the X-linked hypophosphatemic, gyro (Gy) mouse
  JOURNAL   Genomics 48 (3), 289-295 (1998)
   PUBMED   9545633
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Lorenz,B., Francis,F., Gempel,K., Boddrich,A., Josten,M.,
            Schmahl,W., Schmidt,J., Lehrach,H., Meitinger,T. and Strom,T.M.
  TITLE     Spermine deficiency in Gy mice caused by deletion of the spermine
            synthase gene
  JOURNAL   Hum Mol Genet 7 (3), 541-547 (1998)
   PUBMED   9467015
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Strom,T.M., Francis,F., Lorenz,B., Boddrich,A., Econs,M.J.,
            Lehrach,H. and Meitinger,T.
  TITLE     Pex gene deletions in Gy and Hyp mice provide mouse models for
            X-linked hypophosphatemia
  JOURNAL   Hum Mol Genet 6 (2), 165-171 (1997)
   PUBMED   9063736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058688.1 and AL663072.12.
            
            On Dec 23, 2017 this sequence version replaced NM_009214.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058688.1, AK049787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1915              BC058688.1         1-1915
            1916-3721           AL663072.12        81894-83699         c
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.48 cM"
     gene            1..3721
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /note="spermine synthase"
                     /db_xref="GeneID:20603"
                     /db_xref="MGI:MGI:109490"
     exon            1..383
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1435
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /EC_number="2.5.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermidine aminopropyltransferase"
                     /codon_start=1
                     /product="spermine synthase isoform 1"
                     /protein_id="NP_033240.3"
                     /db_xref="CCDS:CCDS41189.1"
                     /db_xref="GeneID:20603"
                     /db_xref="MGI:MGI:109490"
                     /translation="MAAARHSTLDFKLGAKADGEAILKGLQSIFQEQGMTESVHTWQD
                     HGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDSDVQGKQETDSLLNKIEEKMKELSQ
                     DSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGN
                     ILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTM
                     VEIDQMVIDGCKKYMRRTCGDVLDNLRGDCYQVLIEDCIPVLKMYAKEGREFDYVIND
                     LTAVPISTSPEEDSTWDFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGR
                     LYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP"
     exon            384..504
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            505..598
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            599..663
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            664..839
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            840..994
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1084
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1199
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1279
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1395
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3721
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1897..1902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /note="hexamer: ATTAAA"
     polyA_site      1915
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /note="major polyA site"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /note="hexamer: AATAAA"
     polyA_site      3720
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /note="major polyA site"
ORIGIN      
        1 cgaatggcgg gagagcatgg ccagagcttt agcgcagggc gcggccattg gtgacgcatg
       61 ccagggagcc cggcgcccgc gattccacca ttagcgaggc ctcacaccca gcgcttcaag
      121 ttcggggctg gaggcgtccc tgcttcctcc tctaagaggc gggtcggccc cgcccccgcg
      181 ccccgggtcg cttgcccgcg gcccctccca cctcctaact cctggcctcc cccggcgcag
      241 cgcactcccc gccggcccgc agcctgacac gccgcgcggt ccctcagtct cctgcggtcg
      301 cctccccagg catggcacag ggcctcgcca cactatggca gcagcaagac acagcacgct
      361 cgacttcaag ctcggcgcca aagctgatgg tgaggccatt ctgaaaggcc ttcagtccat
      421 ttttcaggag caggggatga cagagtcagt gcacacctgg caggaccatg gatatttagc
      481 aacttacacg aacaagaatg gcagctttgc caatttgcga atttatccac atggattggt
      541 gttgctggac cttcagagtt acgacagtga tgtgcaaggc aaacaagaaa ctgacagcct
      601 tttgaacaaa atagaagaaa aaatgaaaga attgagtcaa gacagtactg ggcgggtgaa
      661 gcgattacca cccatagttc gcggaggggc cattgacaga tactggccta ctgctgatgg
      721 gcgcctggtt gagtatgaca tagatgaagt ggtgtatgat gaagattcac catatcagaa
      781 catcaaaatc ctacactcga agcagtttgg gaatattctc atcctcagcg gggatgttaa
      841 tttggcagag agtgacttgg catatacccg tgccatcatg ggcagtggta aagaagacta
      901 cactggcaaa gatgtactga ttctgggagg cggcgatgga ggcatattgt gtgaaattgt
      961 caaactgaaa ccaaagatgg tcactatggt agagattgac caaatggtaa ttgatggatg
     1021 taagaaatac atgcggagaa catgtggaga tgtcttagac aatcttagag gagactgcta
     1081 tcaggttctt atagaagact gtatcccagt actgaagatg tacgccaaag aagggagaga
     1141 gtttgattat gtgattaatg atttgacagc tgtccctatc tctacatctc cagaagaaga
     1201 ttccacatgg gatttcctca gactgattct cgacctgtca atgaaggttc tgaaacagga
     1261 tggaaaatac ttcacacagg ggaactgtgt caacttgact gaagccctgt cgctctatga
     1321 agaacagctg gggcgtctgt attgtcctgt ggaattctca aaagagattg tctgtgtccc
     1381 ttcatacttg gaattgtggg tgttttacac tgtttggaag aaagctaagc cttaaagatg
     1441 agaatgacgt gtgctgcgag ccaccttcct gacctccata tgccgtatat gccatcaaat
     1501 gtgtcaggca actgctcatg aattccttct agtggttttc acttttaatt attattttta
     1561 atttaaaaaa gccaatggga aaaatgtata ttttgatgag ttaggatgtt aattttaaaa
     1621 agtcagccga aggacaatta gacagcccag caaagactgc agaatgcact gaccccctag
     1681 aatgtgattt tagtattttt ttttctctgt gtggggtttg ggttttcatt ttggtttcag
     1741 tagaccttta atttggacat gtggaggaat gaacatcatt gttttgttct ggagagaagt
     1801 tcctgatagt gtttctcccc tctcaccccc aaattgactt agatattaaa atttggtgct
     1861 tttaaaggtt ttaaaagagt gattagcagt gcttcaatta aaatgacaaa ggagacctct
     1921 tacggtgttt gtccctttat ttcagcctct cttcctcttt cttacctctg atggcctagg
     1981 gcaaaggtgt attctatcta gactgttaac tgcactcagc ataatgtcaa ggccttgagg
     2041 aacgatccac aacctattat atttgccgcc cccccattat aaagttgttc caaggatagc
     2101 agaagatttt tgcctgcctg aaaagggtga aagtcaaaga tgatttctgt tactgctctc
     2161 cctgattaga gatccaaagg cctttgagaa gactgtagga tgtgcaagtg cacactagag
     2221 ttcatgtagt cctgtggcaa aataacttaa ctcttaagaa agtgcatgtg aatagcaact
     2281 tggcattgta ttgtggataa tttgaattgt ctatcctatt gtttgtgtaa aatatttaca
     2341 ctgtatcagt agaatggtat ttttttttac agcaagtaaa acattgaaaa tttactaatg
     2401 gaaatcaggc tcaagtttca ttgtccctcc caagatagga aggaacaaat aagacaggac
     2461 aagacaaatg atctttaaaa gtgagcgcaa acctatgcca tttgttttag attgacatgg
     2521 aagaagaaac aatagagaat aaaaggagtt gatagttatg ttcaaattag atgcatttaa
     2581 caatattttt ggtgcatgca tagggtaaaa acagcccagt agacacttct ccacccaaat
     2641 tcttccccag tgctttgaaa actttgtata ttgtggagaa ttgaaaacaa atgtactgct
     2701 acagttagaa tattagctaa ggccaattgc cccttaccca ctgtactgtt attcttacga
     2761 ttacttttga aacagtgact gtatgtatgt agcccagtct aacctggagc ttattatgta
     2821 gcctaggctt tcctggaagc tcacaagaat tgagcttgta ccatcacaca gcttaattct
     2881 tgttaccatt taagtaaaga aagcaagtat atcagctgct ggggtaatat taatgagggg
     2941 actgacctgc gtgatccgtg aagagtaact tgaggccata accacagatc cactcataat
     3001 tcgggtgact cagttcctgc taagcaccag gtggtagaaa tgaagaggat aaggttatgt
     3061 gaggctaatt ggttatgaga tgcatttggg ataaaatgaa ggaagtggtg ttgaggaaag
     3121 gaggaagaaa gaggttttta tcttgagtga taaatgtgaa ctcagatgtg actgatttgc
     3181 tgaaggaggg tctccgtttt gagcccttgt tattttgaca ccgaagcatg caaactgaac
     3241 caacacccac cctaccctgt gctctactcc gacccacctt cgctttggct gcctcttaag
     3301 gaatgctaat ggatttgttg tttttcttaa tactgtagtg ttatgtagtg tgaaagattc
     3361 ttttaacagt ggaatatatt atggtgtcct gctttttttt taatgaaaga caaaacaaat
     3421 atggatagag tttaaattct gttcaacaca gcagatacta agaattgatt tattaagaca
     3481 tgaaatgctg ctttctcttg gaaatgtgat tgaatattta taaaagagct ccacctgggc
     3541 cggggaaggc tgggttggtg gtggttttag tgggctagaa cattactatc tgaataaaca
     3601 aatgtgctgc ttcttcctgt agacttggaa tagtcatgtc cttgctttcc ctaacaattg
     3661 ctgacacaag actttgtatt tctgcctgtc atctgtctct caataaatgg atcaatttca
     3721 t
//
