LOCUS       NM_001252680             743 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus submaxillary gland androgen regulated protein 2
            (Smr2), transcript variant 3, mRNA.
ACCESSION   NM_001252680
VERSION     NM_001252680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 743)
  AUTHORS   Qi,L., Iskols,M., Shi,D., Reddy,P., Walker,C., Lezgiyeva,K.,
            Voisin,T., Pawlak,M., Kuchroo,V.K., Chiu,I.M., Ginty,D.D. and
            Sharma,N.
  TITLE     A mouse DRG genetic toolkit reveals morphological and physiological
            diversity of somatosensory neuron subtypes
  JOURNAL   Cell 187 (6), 1508-1526 (2024)
   PUBMED   38442711
REFERENCE   2  (bases 1 to 743)
  AUTHORS   Wolfson,R.L., Abdelaziz,A., Rankin,G., Kushner,S., Qi,L., Mazor,O.,
            Choi,S., Sharma,N. and Ginty,D.D.
  TITLE     DRG afferents that mediate physiologic and pathologic
            mechanosensation from the distal colon
  JOURNAL   Cell 186 (16), 3368-3385 (2023)
   PUBMED   37541195
REFERENCE   3  (bases 1 to 743)
  AUTHORS   Fu,S., Tar,M.T., Melman,A. and Davies,K.P.
  TITLE     Opiorphin is a master regulator of the hypoxic response in corporal
            smooth muscle cells
  JOURNAL   FASEB J 28 (8), 3633-3644 (2014)
   PUBMED   24803544
  REMARK    GeneRIF: In corporal smooth muscle cells from a sickle-cell-disese
            mouse, there was Smr2 up-regulation at a life stage prior to
            priapism, so the changes in gene expression are unlikely due to
            priapism, but rather due to the hypoxic conditions in SCD.
REFERENCE   4  (bases 1 to 743)
  AUTHORS   Erdreich-Epstein,A., Ganguly,A.K., Shi,X.H., Zimonjic,D.B. and
            Shackleford,G.M.
  TITLE     Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells
            correlates with an adjacent t(5;19) translocation
  JOURNAL   Genes Chromosomes Cancer 45 (2), 169-181 (2006)
   PUBMED   16252261
REFERENCE   5  (bases 1 to 743)
  AUTHORS   Senorale-Pose,M. and Rougeon,F.
  TITLE     The mouse Vcs2 gene is a composite structure which evolved by gene
            fusion and encodes five distinct salivary mRNA species
  JOURNAL   Gene 201 (1-2), 75-85 (1997)
   PUBMED   9409774
REFERENCE   6  (bases 1 to 743)
  AUTHORS   Tronik-Le Roux,D., Senorale-Pose,M. and Rougeon,F.
  TITLE     Three novel SMR1-related cDNAs characterized in the submaxillary
            gland of mice show extensive evolutionary divergence in the protein
            coding region
  JOURNAL   Gene 142 (2), 175-182 (1994)
   PUBMED   8194749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154123.10 and AC163331.8.
            
            Transcript Variant: This variant (3) contains an alternate internal
            exon and initiates translation at an alternate start codon,
            compared to variant 1. Variants 2, 3 and 4 encode the same isoform
            (2) which has a distinct N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U82376.1, BC111829.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC154123.10        2237-2310           c
            75-141              AC154123.10        622-688             c
            142-208             AC163331.8         232284-232350       c
            209-743             AC163331.8         228613-229147       c
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..743
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /note="submaxillary gland androgen regulated protein 2"
                     /db_xref="GeneID:20600"
                     /db_xref="MGI:MGI:102762"
     exon            1..74
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..141
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..208
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..586
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="submaxillary gland androgen regulated protein 2
                     isoform 2 precursor"
                     /protein_id="NP_001239609.1"
                     /db_xref="CCDS:CCDS80321.1"
                     /db_xref="GeneID:20600"
                     /db_xref="MGI:MGI:102762"
                     /translation="MKPLCLVFGLCVLIGCFLSSECQRGFRGQHDPTRPLSPSNPSSH
                     FYPQPDPNRVQISQPDNIPIFMFEQPHSLNICVPPPPLYLGEEFEKLPPNTHIPYILI
                     RPDIEPPSKYIQPVPRKKSNATPAANNFITTATAPNSTDSF"
     exon            209..743
                     /gene="Smr2"
                     /gene_synonym="MSG2; Vcs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattccacca ctcaaaaata attgaacaga ctgcttctga ccagcacatt caccagcaaa
       61 gaagcttctc caagactcta aaaaacgatg aaggcactgt atatggtatt tgtcctctgg
      121 gttcttatag gatgtttcct gaggctactg aaagatgaag ccactgtgtt tggtctttgg
      181 cctctgtgtt cttataggat gcttcctttc tagtgagtgc caaagaggct tcagaggaca
      241 gcatgatcct acaagaccac tatctccttc aaatccttct tctcattttt atcctcagcc
      301 tgatcccaat cgtgtacaga tttctcaacc agacaatatc cccattttca tgtttgaaca
      361 accacattct cttaatattt gtgttcctcc tcctccttta taccttggag aagaatttga
      421 aaaactacct cctaatactc atattcctta tatactaata cgtccagata ttgaacctcc
      481 aagcaaatat attcaaccag ttcccagaaa aaaatcaaat gcaacaccag ctgccaataa
      541 ctttataact actgctactg cccccaattc tactgatagc ttttgaaggt ggtggcaaat
      601 aaaattatcc ttttggcagt cagaataata taaaccaaac ctctgtagaa ttttgtgaga
      661 aataatcttt aaagtcttaa gaaacaacct ttaccctacc attatagaaa gtgaaaataa
      721 agagctgagc agcataataa agc
//
