LOCUS       NM_001252591            1070 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus small muscle protein, X-linked (Smpx), transcript
            variant 2, mRNA.
ACCESSION   NM_001252591
VERSION     NM_001252591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Tu,H., Zhang,A., Fu,X., Xu,S., Bai,X., Wang,H. and Gao,J.
  TITLE     SMPX Deficiency Causes Stereocilia Degeneration and Progressive
            Hearing Loss in CBA/CaJ Mice
  JOURNAL   Front Cell Dev Biol 9, 750023 (2021)
   PUBMED   34722533
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Yang,L.M., Stout,L., Rauchman,M. and Ornitz,D.M.
  TITLE     Analysis of FGF20-regulated genes in organ of Corti progenitors by
            translating ribosome affinity purification
  JOURNAL   Dev Dyn 249 (10), 1217-1242 (2020)
   PUBMED   32492250
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Lee,S., Shin,J.O., Sagong,B., Kim,U.K. and Bok,J.
  TITLE     Spatiotemporal expression patterns of clusterin in the mouse inner
            ear
  JOURNAL   Cell Tissue Res 370 (1), 89-97 (2017)
   PUBMED   28687930
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Palmer,S., Groves,N., Schindeler,A., Yeoh,T., Biben,C., Wang,C.C.,
            Sparrow,D.B., Barnett,L., Jenkins,N.A., Copeland,N.G., Koentgen,F.,
            Mohun,T. and Harvey,R.P.
  TITLE     The small muscle-specific protein Csl modifies cell shape and
            promotes myocyte fusion in an insulin-like growth factor
            1-dependent manner
  JOURNAL   J Cell Biol 153 (5), 985-998 (2001)
   PUBMED   11381084
  REMARK    GeneRIF: In knockout mice, mutates to no overt phenotype.
            Overexpression in C2C12 cells alters cell shape, migration and
            responsiveness to IGF signaling.
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Kemp,T.J., Sadusky,T.J., Simon,M., Brown,R., Eastwood,M.,
            Sassoon,D.A. and Coulton,G.R.
  TITLE     Identification of a novel stretch-responsive skeletal muscle gene
            (Smpx)
  JOURNAL   Genomics 72 (3), 260-271 (2001)
   PUBMED   11401441
  REMARK    Erratum:[Genomics 2001 Jun 1;74(2):251]
REFERENCE   8  (bases 1 to 1070)
  AUTHORS   Bruneau,B.G., Bao,Z.Z., Fatkin,D., Xavier-Neto,J.,
            Georgakopoulos,D., Maguire,C.T., Berul,C.I., Kass,D.A., Kuroski-de
            Bold,M.L., de Bold,A.J., Conner,D.A., Rosenthal,N., Cepko,C.L.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Cardiomyopathy in Irx4-deficient mice is preceded by abnormal
            ventricular gene expression
  JOURNAL   Mol Cell Biol 21 (5), 1730-1736 (2001)
   PUBMED   11238910
REFERENCE   9  (bases 1 to 1070)
  AUTHORS   Christoffels,V.M., Habets,P.E., Franco,D., Campione,M., de Jong,F.,
            Lamers,W.H., Bao,Z.Z., Palmer,S., Biben,C., Harvey,R.P. and
            Moorman,A.F.
  TITLE     Chamber formation and morphogenesis in the developing mammalian
            heart
  JOURNAL   Dev Biol 223 (2), 266-278 (2000)
   PUBMED   10882515
  REMARK    Erratum:[Dev Biol 2000 Sep 1;225(1):266]
REFERENCE   10 (bases 1 to 1070)
  AUTHORS   Patzak,D., Zhuchenko,O., Lee,C.C. and Wehnert,M.
  TITLE     Identification, mapping, and genomic structure of a novel
            X-chromosomal human gene (SMPX) encoding a small muscular protein
  JOURNAL   Hum Genet 105 (5), 506-512 (1999)
   PUBMED   10598820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731811.24, AI035961.1 and BQ176246.1.
            
            On Nov 28, 2011 this sequence version replaced NM_001252591.1.
            
            Transcript Variant: This variant (2) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB321070.1, CB574257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AL731811.24        89480-89665
            187-672             AI035961.1         1-486
            673-1070            BQ176246.1         1-398               c
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.67 cM"
     gene            1..1070
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /note="small muscle protein, X-linked"
                     /db_xref="GeneID:66106"
                     /db_xref="MGI:MGI:1913356"
     exon            1..341
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /inference="alignment:Splign:2.1.0"
     exon            342..398
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..617
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /note="chisel protein; stretch-responsive skeletal muscle
                     protein; cardiac and skeletal muscle protein"
                     /codon_start=1
                     /product="small muscular protein"
                     /protein_id="NP_001239520.1"
                     /db_xref="CCDS:CCDS41190.1"
                     /db_xref="GeneID:66106"
                     /db_xref="MGI:MGI:1913356"
                     /translation="MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGA
                     PTTSEEKKPIPGMKKFPGPVVNLSEIQNVKSELKFVPKGEQ"
     exon            399..485
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /inference="alignment:Splign:2.1.0"
     exon            486..634
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1054
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /note="major polyA site"
ORIGIN      
        1 atctgagccc tgctttccac acggtcaagc ctttcagagg cagccagcct atggcttgta
       61 tcaaactcta tatttaggaa gaacaactgt gagctatgac aggaattctc tttaacactt
      121 tagccttaaa gcgagttccc ttctagcccg agccaggagc agctctcagg actggagaga
      181 gacagagcac tccagctatt tcagccacat gaaaagcact ggaattgaga tccccgctca
      241 gaggacaccg ggagttcctt ctatcctgta aagcgctttt tgtgtttttg cacctggccg
      301 cctgggactg tcctcaggca gtaaaccaat ccagagagca gggctaagac cttgtgaata
      361 tgtcgaagca gccaatttcc aacgtcagag ccatccaggc gaatatcaat attccaatgg
      421 gagcctttcg tccgggagct gggcagcctc ccagaaggaa agagagtact cctgaaactg
      481 aggagggagc tcctaccacc tcagaggaaa agaagccaat tcctggaatg aagaaatttc
      541 caggacctgt tgtcaacttg tctgagatcc aaaatgttaa aagtgaactg aaatttgtcc
      601 ccaaaggtga acagtagtcg aaaggacaca aaagcgttga cgtgtttttc caagggagaa
      661 aaaacaatgg gttgaaataa acaacttcct gaacatttta tacatttgta tgatgatcac
      721 aaacctcctg aatgcccaag actctagcaa aaatatcctg tttgtacatt tatatttctt
      781 ccttttactt ggttgcattt ctcactttag ctacattttt ggcaccttgt agagcaaatc
      841 agcacacgaa tttacaacct gggaagtgtg gttttgagga gagatgtgat ttttatgaag
      901 ggggggatgg caacgtgcaa gcagtgattt tgatgttaag tactttaagt tacttcccac
      961 ggtcttttgg tcaatatttg aaatggtttc ttcacctttt aaattatctc aattaacttt
     1021 ttatgagttc aaataaatat ttgagtaaat gtaaaaaaaa aaaaaaaaaa
//
