LOCUS       NP_001239520              85 aa            linear   ROD 03-JUN-2024
DEFINITION  small muscular protein [Mus musculus].
ACCESSION   NP_001239520
VERSION     NP_001239520.1
DBSOURCE    REFSEQ: accession NM_001252591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 85)
  AUTHORS   Tu,H., Zhang,A., Fu,X., Xu,S., Bai,X., Wang,H. and Gao,J.
  TITLE     SMPX Deficiency Causes Stereocilia Degeneration and Progressive
            Hearing Loss in CBA/CaJ Mice
  JOURNAL   Front Cell Dev Biol 9, 750023 (2021)
   PUBMED   34722533
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 85)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   3  (residues 1 to 85)
  AUTHORS   Yang,L.M., Stout,L., Rauchman,M. and Ornitz,D.M.
  TITLE     Analysis of FGF20-regulated genes in organ of Corti progenitors by
            translating ribosome affinity purification
  JOURNAL   Dev Dyn 249 (10), 1217-1242 (2020)
   PUBMED   32492250
REFERENCE   4  (residues 1 to 85)
  AUTHORS   Lee,S., Shin,J.O., Sagong,B., Kim,U.K. and Bok,J.
  TITLE     Spatiotemporal expression patterns of clusterin in the mouse inner
            ear
  JOURNAL   Cell Tissue Res 370 (1), 89-97 (2017)
   PUBMED   28687930
REFERENCE   5  (residues 1 to 85)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 85)
  AUTHORS   Palmer,S., Groves,N., Schindeler,A., Yeoh,T., Biben,C., Wang,C.C.,
            Sparrow,D.B., Barnett,L., Jenkins,N.A., Copeland,N.G., Koentgen,F.,
            Mohun,T. and Harvey,R.P.
  TITLE     The small muscle-specific protein Csl modifies cell shape and
            promotes myocyte fusion in an insulin-like growth factor
            1-dependent manner
  JOURNAL   J Cell Biol 153 (5), 985-998 (2001)
   PUBMED   11381084
  REMARK    GeneRIF: In knockout mice, mutates to no overt phenotype.
            Overexpression in C2C12 cells alters cell shape, migration and
            responsiveness to IGF signaling.
REFERENCE   7  (residues 1 to 85)
  AUTHORS   Kemp,T.J., Sadusky,T.J., Simon,M., Brown,R., Eastwood,M.,
            Sassoon,D.A. and Coulton,G.R.
  TITLE     Identification of a novel stretch-responsive skeletal muscle gene
            (Smpx)
  JOURNAL   Genomics 72 (3), 260-271 (2001)
   PUBMED   11401441
  REMARK    Erratum:[Genomics 2001 Jun 1;74(2):251]
REFERENCE   8  (residues 1 to 85)
  AUTHORS   Bruneau,B.G., Bao,Z.Z., Fatkin,D., Xavier-Neto,J.,
            Georgakopoulos,D., Maguire,C.T., Berul,C.I., Kass,D.A., Kuroski-de
            Bold,M.L., de Bold,A.J., Conner,D.A., Rosenthal,N., Cepko,C.L.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Cardiomyopathy in Irx4-deficient mice is preceded by abnormal
            ventricular gene expression
  JOURNAL   Mol Cell Biol 21 (5), 1730-1736 (2001)
   PUBMED   11238910
REFERENCE   9  (residues 1 to 85)
  AUTHORS   Christoffels,V.M., Habets,P.E., Franco,D., Campione,M., de Jong,F.,
            Lamers,W.H., Bao,Z.Z., Palmer,S., Biben,C., Harvey,R.P. and
            Moorman,A.F.
  TITLE     Chamber formation and morphogenesis in the developing mammalian
            heart
  JOURNAL   Dev Biol 223 (2), 266-278 (2000)
   PUBMED   10882515
  REMARK    Erratum:[Dev Biol 2000 Sep 1;225(1):266]
REFERENCE   10 (residues 1 to 85)
  AUTHORS   Patzak,D., Zhuchenko,O., Lee,C.C. and Wehnert,M.
  TITLE     Identification, mapping, and genomic structure of a novel
            X-chromosomal human gene (SMPX) encoding a small muscular protein
  JOURNAL   Hum Genet 105 (5), 506-512 (1999)
   PUBMED   10598820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731811.24, AI035961.1 and BQ176246.1.
            
            Transcript Variant: This variant (2) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB321070.1, CB574257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..85
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.67 cM"
     Protein         1..85
                     /product="small muscular protein"
                     /note="chisel protein; stretch-responsive skeletal muscle
                     protein; cardiac and skeletal muscle protein"
                     /calculated_mol_wt=9121
     Region          1..84
                     /region_name="Chisel"
                     /note="Stretch-responsive small skeletal muscle X protein,
                     Chisel; pfam15355"
                     /db_xref="CDD:405939"
     Region          19..63
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC77.2)"
     Site            36
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q925F0; propagated from
                     UniProtKB/Swiss-Prot (Q9DC77.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q925F0; propagated from
                     UniProtKB/Swiss-Prot (Q9DC77.2)"
     CDS             1..85
                     /gene="Smpx"
                     /gene_synonym="1010001C09Rik; Csl"
                     /coded_by="NM_001252591.2:360..617"
                     /db_xref="CCDS:CCDS41190.1"
                     /db_xref="GeneID:66106"
                     /db_xref="MGI:MGI:1913356"
ORIGIN      
        1 mskqpisnvr aiqaninipm gafrpgagqp prrkestpet eegapttsee kkpipgmkkf
       61 pgpvvnlsei qnvkselkfv pkgeq
//
