LOCUS       NM_133888               1925 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sphingomyelin phosphodiesterase, acid-like 3B
            (Smpdl3b), mRNA.
ACCESSION   NM_133888
VERSION     NM_133888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Zhou,Y., Yue,S., Li,L., Zhang,J., Chen,L. and Chen,J.
  TITLE     SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its
            silencing aggravates diabetic retinopathy of db/db mice: Activation
            of NLRP3/NF-kappaB pathway
  JOURNAL   Cell Signal 116, 111064 (2024)
   PUBMED   38266744
  REMARK    GeneRIF: SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its
            silencing aggravates diabetic retinopathy of db/db mice: Activation
            of NLRP3/NF-kappaB pathway.
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Francis,M., Ahmad,A., Bodgi,L., Azzam,P., Youssef,T., Abou
            Daher,A., Eid,A.A., Fornoni,A., Pollack,A., Marples,B. and
            Zeidan,Y.H.
  TITLE     SMPDL3b modulates radiation-induced DNA damage response in renal
            podocytes
  JOURNAL   FASEB J 36 (10), e22545 (2022)
   PUBMED   36094323
  REMARK    GeneRIF: SMPDL3b modulates radiation-induced DNA damage response in
            renal podocytes.
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Mitrofanova,A., Mallela,S.K., Ducasa,G.M., Yoo,T.H.,
            Rosenfeld-Gur,E., Zelnik,I.D., Molina,J., Varona Santos,J., Ge,M.,
            Sloan,A., Kim,J.J., Pedigo,C., Bryn,J., Volosenco,I., Faul,C.,
            Zeidan,Y.H., Garcia Hernandez,C., Mendez,A.J., Leibiger,I.,
            Burke,G.W., Futerman,A.H., Barisoni,L., Ishimoto,Y., Inagi,R.,
            Merscher,S. and Fornoni,A.
  TITLE     SMPDL3b modulates insulin receptor signaling in diabetic kidney
            disease
  JOURNAL   Nat Commun 10 (1), 2692 (2019)
   PUBMED   31217420
  REMARK    GeneRIF: Study reports that Smpdl3b excess, as observed in
            podocytes in diabetic kidney disease, impairs insulin receptor
            isoform B-dependent pro-survival insulin signaling by interfering
            with insulin receptor isoforms binding to caveolin-1 in the plasma
            membrane.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Ahmad,A., Mitrofanova,A., Bielawski,J., Yang,Y., Marples,B.,
            Fornoni,A. and Zeidan,Y.H.
  TITLE     Sphingomyelinase-like phosphodiesterase 3b mediates
            radiation-induced damage of renal podocytes
  JOURNAL   FASEB J 31 (2), 771-780 (2017)
   PUBMED   27836988
  REMARK    GeneRIF: These results demonstrate that radiation injury induces
            early cytoskeletal remodeling, down-regulation of SMPDL3b, and
            elevation of cellular ceramide levels. Overexpression of SMPDL3b
            and pretreatment with rituximab confer a radioprotective effect in
            cultured podocytes.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Gorelik,A., Heinz,L.X., Illes,K., Superti-Furga,G. and Nagar,B.
  TITLE     Crystal Structure of the Acid Sphingomyelinase-like
            Phosphodiesterase SMPDL3B Provides Insights into Determinants of
            Substrate Specificity
  JOURNAL   J Biol Chem 291 (46), 24054-24064 (2016)
   PUBMED   27687724
  REMARK    GeneRIF: Although a potential substrate for SMPDL3B is
            sphingomyelin, we identify other possible substrates such as
            CDP-choline, ATP, and ADP.
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Heinz,L.X., Baumann,C.L., Koberlin,M.S., Snijder,B., Gawish,R.,
            Shui,G., Sharif,O., Aspalter,I.M., Muller,A.C., Kandasamy,R.K.,
            Breitwieser,F.P., Pichlmair,A., Bruckner,M., Rebsamen,M., Bluml,S.,
            Karonitsch,T., Fauster,A., Colinge,J., Bennett,K.L., Knapp,S.,
            Wenk,M.R. and Superti-Furga,G.
  TITLE     The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate
            Immunity
  JOURNAL   Cell Rep 11 (12), 1919-1928 (2015)
   PUBMED   26095358
  REMARK    GeneRIF: our results identify the membrane-modulating enzyme
            SMPDL3B as a negative regulator of TLR signaling that functions at
            the interface of membrane biology and innate immunity.
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Yoo,T.H., Pedigo,C.E., Guzman,J., Correa-Medina,M., Wei,C.,
            Villarreal,R., Mitrofanova,A., Leclercq,F., Faul,C., Li,J.,
            Kretzler,M., Nelson,R.G., Lehto,M., Forsblom,C., Groop,P.H.,
            Reiser,J., Burke,G.W., Fornoni,A. and Merscher,S.
  TITLE     Sphingomyelinase-like phosphodiesterase 3b expression levels
            determine podocyte injury phenotypes in glomerular disease
  JOURNAL   J Am Soc Nephrol 26 (1), 133-147 (2015)
   PUBMED   24925721
  REMARK    GeneRIF: SMPDL3b may be an important modulator of podocyte function
            by shifting suPAR-mediated podocyte injury from a migratory
            phenotype to an apoptotic phenotype and that it represents a novel
            therapeutic glomerular disease target
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL627130.13.
            
            On Nov 17, 2006 this sequence version replaced NM_133888.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009087.1, AK154599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AL627130.13        158093-158279       c
            188-401             AL627130.13        147586-147799       c
            402-499             AL627130.13        146196-146293       c
            500-643             AL627130.13        142496-142639       c
            644-816             AL627130.13        140737-140909       c
            817-997             AL627130.13        139345-139525       c
            998-1131            AL627130.13        139127-139260       c
            1132-1925           AL627130.13        134074-134867       c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.82 cM"
     gene            1..1925
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /note="sphingomyelin phosphodiesterase, acid-like 3B"
                     /db_xref="GeneID:100340"
                     /db_xref="MGI:MGI:1916022"
     exon            1..187
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1497
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /note="acid sphingomyelinase-like phosphodiesterase 3b;
                     ASM-like phosphodiesterase 3b"
                     /codon_start=1
                     /product="acid sphingomyelinase-like phosphodiesterase 3b
                     precursor"
                     /protein_id="NP_598649.1"
                     /db_xref="CCDS:CCDS18733.1"
                     /db_xref="GeneID:100340"
                     /db_xref="MGI:MGI:1916022"
                     /translation="MTLLGWLIFLAPWGVAGAQLGRFWHISDLHLDPNYTVSKDPLQV
                     CPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNES
                     LGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWRP
                     WLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLG
                     DVLSNASRDGEMVYVIGHVPPGFFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFG
                     HHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNL
                     KDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRY
                     YVYNSVSYNHLTCEDSCRIEHVCAIQHVAFNTYATCLHGLGAKLVPGFLLILTLLPSL
                     HVLEVL"
     exon            188..401
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            402..499
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            500..643
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            644..816
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            817..997
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1131
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1925
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="Smpdl3b"
                     /gene_synonym="1110054A24Rik; Asml3b"
                     /note="major polyA site"
ORIGIN      
        1 cttggaacac tggaagcagc caaacgagta gttctgccca gacacgtggc tggccacaag
       61 gtgggaaccc gcggcgcaga cggacttgga ggagcttcgg ccgcccgccg tggggggatc
      121 cagaggatga cgctgctcgg gtggctgata ttcctggccc cctggggagt cgcaggggct
      181 caactaggga ggttctggca catctccgac ctgcatctgg accccaacta caccgtatcc
      241 aaagaccccc tccaggtgtg cccgtcggcc ggctcccagc ctgtgctaaa tgctggcccc
      301 tggggggact acctctgcga ttctccttgg gcccttatca actcgtcctt gtatgccatg
      361 aaggagattg aaccaaagcc tgacttcatt ctctggacag gggacgacac accgcacgtc
      421 cccaatgaga gtctaggaga ggcagctgtg ctggcaattg tggaacgctt gaccaacctc
      481 atcaaggaag tctttccaga cactaaagtc tatgctgctc tgggaaatca tgacttccac
      541 cctaagaacc agttcccagc acagagcaac cgcatctata accaggtggc agagctgtgg
      601 agaccctggc ttagtaacga atcctacgct ctcttcaaaa gaggtgcctt ctattctgag
      661 aagttgccgg gtcccagcag ggcggggcga gttgtggtcc tcaacaccaa tctgtactac
      721 agcaacaacg agcagacagc tggcatggct gaccccggcg agcagttccg gtggctggga
      781 gatgtcctga gcaatgcatc tcgggatggg gagatggtgt atgttattgg ccacgtgccc
      841 ccggggttct ttgagaagac acagaacaag gcctggttcc gagagagctt caatgaggag
      901 tatctgaagg tgatccagaa gcaccatcgg gtcatagcag ggcagttctt tggacaccac
      961 cataccgaca gcttccgaat gttctatgac aacacaggtg cccccataaa cgtcatgttt
     1021 ctcacacccg gggtcacacc gtggaagacc acattacctg gagtggtcga tggggccaac
     1081 aatccaggga tacgcatttt cgagtatgat cgagccacac tcaacttgaa ggacttggtg
     1141 acttacttct tgaacctgag gcaggcgaat gtacaagaga ccccacggtg ggagcaggag
     1201 taccgcctga cggaggccta ccaggtgccg gatgccagcg tcagctccat gcacacggcg
     1261 ctgacccgca ttgccagtga gcctcacatc ctgcaacgtt attacgtcta taactcggtc
     1321 agctacaacc atttgacctg tgaggacagc tgccgcatcg agcacgtttg tgctatacaa
     1381 cacgtggctt tcaacactta tgctacctgc ttgcatggtc ttggtgccaa gctggtgcct
     1441 ggtttcctgc tcatactgac tctgctgcca agcctgcacg tactggaggt gttatgactg
     1501 taggcactgc cagcccaccc actgacttgg ttcatctttc tcctggtaaa attgggcaac
     1561 gttacccaat ggagagagat gaacttttgc catcagtctc cccccgcgga gagtaaagtg
     1621 ggatgggaca cctggattca ccagagaggg cgctaagaag cacaatttct tccaagtttc
     1681 atgttttatc cacaaaactt gtttgcggta catgtcttgg tgcattattc gctttaatac
     1741 aaacatatca aaccaccatg aacttgatca ccacagtgaa gtgagccgac gggaagatgg
     1801 gccttggaga ttctgtgctt tcgatgtagt ccctgctcaa ggtctgaact gggaacgtac
     1861 gtggtgtgca aaacccctta gtacttttaa ataaaagact tttttgattt ggttttgcaa
     1921 cagtg
//
