LOCUS       NM_020561               1791 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus sphingomyelin phosphodiesterase, acid-like 3A
            (Smpdl3a), mRNA.
ACCESSION   NM_020561
VERSION     NM_020561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Hou,Y., Wang,Z., Liu,P., Wei,X., Zhang,Z., Fan,S., Zhang,L.,
            Han,F., Song,Y., Chu,L. and Zhang,C.
  TITLE     SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid
            metabolism to restrict cGAS-STING DNA sensing
  JOURNAL   Immunity 56 (11), 2492-2507 (2023)
   PUBMED   37890481
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Gorelik,A., Illes,K., Superti-Furga,G. and Nagar,B.
  TITLE     Structural Basis for Nucleotide Hydrolysis by the Acid
            Sphingomyelinase-like Phosphodiesterase SMPDL3A
  JOURNAL   J Biol Chem 291 (12), 6376-6385 (2016)
   PUBMED   26792860
  REMARK    GeneRIF: The structural basis for SMPDL3A substrate specificity
            resolve by X-ray crystallography.
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Heinz,L.X., Baumann,C.L., Koberlin,M.S., Snijder,B., Gawish,R.,
            Shui,G., Sharif,O., Aspalter,I.M., Muller,A.C., Kandasamy,R.K.,
            Breitwieser,F.P., Pichlmair,A., Bruckner,M., Rebsamen,M., Bluml,S.,
            Karonitsch,T., Fauster,A., Colinge,J., Bennett,K.L., Knapp,S.,
            Wenk,M.R. and Superti-Furga,G.
  TITLE     The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate
            Immunity
  JOURNAL   Cell Rep 11 (12), 1919-1928 (2015)
   PUBMED   26095358
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Traini,M., Quinn,C.M., Sandoval,C., Johansson,E., Schroder,K.,
            Kockx,M., Meikle,P.J., Jessup,W. and Kritharides,L.
  TITLE     Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel
            nucleotide phosphodiesterase regulated by cholesterol in human
            macrophages
  JOURNAL   J Biol Chem 289 (47), 32895-32913 (2014)
   PUBMED   25288789
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Veenvliet,J.V., Dos Santos,M.T., Kouwenhoven,W.M., von Oerthel,L.,
            Lim,J.L., van der Linden,A.J., Koerkamp,M.J., Holstege,F.C. and
            Smidt,M.P.
  TITLE     Specification of dopaminergic subsets involves interplay of En1 and
            Pitx3
  JOURNAL   Development 140 (16), 3373-3384 (2013)
   PUBMED   23863478
  REMARK    Erratum:[Development. 2013 Oct;140(19):4116]
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Clapp,J., Mitchell,L.M., Bolland,D.J., Fantes,J., Corcoran,A.E.,
            Scotting,P.J., Armour,J.A. and Hewitt,J.E.
  TITLE     Evolutionary conservation of a coding function for D4Z4, the tandem
            DNA repeat mutated in facioscapulohumeral muscular dystrophy
  JOURNAL   Am J Hum Genet 81 (2), 264-279 (2007)
   PUBMED   17668377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168055.3 and AK151683.1.
            
            On Sep 15, 2006 this sequence version replaced NM_020561.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.128735.1, Y08135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC168055.3         179807-179921
            116-1781            AK151683.1         2-1667
            1782-1791           AC168055.3         197084-197093
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.25 cM"
     gene            1..1791
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /note="sphingomyelin phosphodiesterase, acid-like 3A"
                     /db_xref="GeneID:57319"
                     /db_xref="MGI:MGI:1931437"
     exon            1..241
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1476
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /EC_number="3.6.1.15"
                     /note="ASM-like phosphodiesterase 3a; acid
                     sphingomyelinase-like phosphodiesterase 3a; 2',3'-cGAMP
                     phosphodiesterase SMPDL3A; cyclic GMP-AMP
                     phosphodiesterase SMPDL3A"
                     /codon_start=1
                     /product="cyclic GMP-AMP phosphodiesterase SMPDL3A
                     precursor"
                     /protein_id="NP_065586.3"
                     /db_xref="CCDS:CCDS23857.1"
                     /db_xref="GeneID:57319"
                     /db_xref="MGI:MGI:1931437"
                     /translation="MALLGNFLCCLLVAWLCGPGLGVPLAPADRAPAVGQFWHVTDLH
                     LDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFM
                     IWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIV
                     TSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNPGLRIISLNTNLYYGPNIMTL
                     NKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIF
                     RRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRL
                     FQYKPGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQF
                     ATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNLDSMSYDDCLKQHL"
     exon            242..455
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            456..600
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            601..697
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            698..867
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1048
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1173
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1791
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="Smpdl3a"
                     /gene_synonym="0610010C24Rik; ASM3A; ASML3; ASML3A"
                     /note="major polyA site"
ORIGIN      
        1 ggaatctaat attacacgtg atctgcttgc tgggcgtcaa cacaaggaaa ggctctggct
       61 tcctctccac ccctagggcc tgcgggtctc agcggcgccc aagctccagt ctagcgtcct
      121 ggggcagtgg cctccaccat ggcgttgctg ggcaacttcc tttgctgcct actggttgcc
      181 tggctctgcg gcccggggct cggggtgccc ctggcgccgg cggatcgcgc cccagctgtg
      241 gggcagtttt ggcacgtgac tgacttacat ctagacccta cttaccacat tacagatgac
      301 cgtaccaagg tgtgtgcttc atctaaaggc gcaaatgcct ccaaccctgg gcctttcgga
      361 gatgtcctgt gtgactctcc atatcaactt attttgtcag cctttgattt tattaagaat
      421 tcaggacaag aagcatcttt catgatatgg acaggggata gcccacctca tgtgccagta
      481 cctgaactct ccacaggcac cgtgataaag gtgatcacta acatgacaat gactgtccag
      541 aacctgtttc caaacctcca ggttttccct gcactgggca atcatgacta ctggccacag
      601 gaccagctgc caatagtcac cagtaaggtc tacagtgctg tggctgacct ctggaaaccc
      661 tggctgggtg aagaagctat tagcacttta aagaaaggtg gtttttactc acagaaagtt
      721 gcaagtaatc caggcttgag gatcattagc ctaaacacaa acttgtacta tggcccaaac
      781 atcatgaccc tgaacaagac agacccagca aatcagtttg aatggctgga aaatacactc
      841 aacagctctc tatggaataa ggagaaggta tacatcatag cgcatgttcc agtgggctat
      901 ctcccttatg caactgacac cccggcgata aggcagtact ataatgagaa actgcttgat
      961 attttcagaa gatacagctc cgtcattgcg ggacagttct atggccacac ccatagagac
     1021 agccttatgg tcctttcaga taaaaacggg aatccactca attctgtgtt tgtggcacct
     1081 gctgttacac cagtgaaagg agttttacaa aaggagacca acaatcccgg tgtccgccta
     1141 tttcagtaca agcctggtga ttacacattg ctggacatgg tgcagtatta cttgaacttg
     1201 acagaagcca atctaaaagg agaatccaac tggacattgg agtatgtctt gactcaggcc
     1261 tacagtgttg cagatctgca gccaaagagt ttatatgcct tagttcagca atttgccacc
     1321 aaagacagca agcagttcct gaaatactac cattattatt ttgtgagtta tgacagcagt
     1381 gcaacttgtg accagcattg taagacctta caggtctgtg caattatgaa tcttgatagc
     1441 atgtcctatg atgattgcct taaacagcat ttataaagca cagtcactag tattccagtt
     1501 gtgtttgtag aaaaaaaaaa tcacatcatg gtgctcctgc gatcagcttc tgaagtgctg
     1561 ggagcatagg aagattgaca ttctgtgtga cttgtgaggc tcagatgctg ataccagtaa
     1621 cattcaaaat taacttcacg cattgaatac atttaaactg ttcattagcg gagtgatatt
     1681 tggacataaa tatctcgtct tccaatttta tgtaattata cctaacttat acccttgtaa
     1741 aacttgtcat ctatgcaata aagcagttga tttttctgtg gatgccatgg a
//
