LOCUS       NM_001195537            1885 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus sphingomyelin phosphodiesterase 5 (Smpd5), mRNA.
ACCESSION   NM_001195537 XM_001475445 XM_001476072
VERSION     NM_001195537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Huttlin,E.L., Jedrychowski,M.P., Elias,J.E., Goswami,T., Rad,R.,
            Beausoleil,S.A., Villen,J., Haas,W., Sowa,M.E. and Gygi,S.P.
  TITLE     A tissue-specific atlas of mouse protein phosphorylation and
            expression
  JOURNAL   Cell 143 (7), 1174-1189 (2010)
   PUBMED   21183079
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Wu,B.X., Rajagopalan,V., Roddy,P.L., Clarke,C.J. and Hannun,Y.A.
  TITLE     Identification and characterization of murine
            mitochondria-associated neutral sphingomyelinase (MA-nSMase), the
            mammalian sphingomyelin phosphodiesterase 5
  JOURNAL   J Biol Chem 285 (23), 17993-18002 (2010)
   PUBMED   20378533
  REMARK    GeneRIF: cloned and characterized a mitochondria-associated nSMase
            (MA-nSMase) that displays significant homology to nSMase2 and
            possesses the same catalytic core residues as members of the
            N-SMase family
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155074.12.
            
            On Jun 25, 2019 this sequence version replaced NM_001195537.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.138186.1,
                                           SRR17253014.1369256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-920               AC155074.12        152927-153846       c
            921-993             AC155074.12        152756-152828       c
            994-1134            AC155074.12        152394-152534       c
            1135-1224           AC155074.12        152234-152323       c
            1225-1288           AC155074.12        152077-152140       c
            1289-1424           AC155074.12        151857-151992       c
            1425-1885           AC155074.12        151322-151782       c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.67 cM"
     gene            1..1885
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /note="sphingomyelin phosphodiesterase 5"
                     /db_xref="GeneID:100503915"
                     /db_xref="MGI:MGI:3709877"
     exon            1..920
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            921..993
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1134
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1224
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1288
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1424
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1885
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /note="hexamer: ATTAAA"
     polyA_site      1885
                     /gene="Smpd5"
                     /gene_synonym="Gm10345; MA-nSMase"
                     /note="major polyA site"
ORIGIN      
        1 attactagcg gcgcgcacag gttgtgccac ctggtcttga cctccgccgc cgctggaaac
       61 caatgagtct ccctgacatt tcgcggcgaa ggagcccagt gccccaagag gactggcccc
      121 tgacacccaa cgccctgagg ccttcacctt tcccgaaccc agtgctgcaa gccctctaca
      181 gtttatcccg cgtgctgctt ttcccgactt actggtccct ggaccagttg ctgggctgct
      241 gggcaccaag cgtccgatcc aaaagcttgg ggtggttcaa agtcctggca ggaagtgggg
      301 tgttgctacc actggtggtg gtcggcctac ccttagcgtt ggtcggcctt gcgctctggc
      361 tgcccctcca ggtctggcgc cgccccttct gctatcagcc ccctccggca tgctgggtgt
      421 ggccacagcc ctggcatccg cctgctgagc gccggcgctg ctttgtcttt ctcactgcta
      481 atctgtgcct attgccccac gggctggctc attttaacaa cctgtcgcac agcctgcagc
      541 gcgccgaggc tgtaggggcc gcactgctag atagccttca atcgtcacag tatagggttt
      601 ccgaatgcag tcagccgccg cctagggtgc ctggtggtga gctgaaggcc acattaccta
      661 tgggcttgga cttcgtgtgt ctgcaggaag tgttcgacct ccgcgcagct cgtcgtcttg
      721 tgcgtgtctt ggtaccaaat ctgggcccgg tgatatatga tgtgggcaca tttggcttaa
      781 tggctgggcc gtacatcaag gtactgggca gtgggcttct actggcctcg cgctacccgt
      841 tgctgcgtgc caccttccgt tgctttccta acgctcgtcg cgaggacgcc atggcctcca
      901 aaggtctact atcagtccag gcgcagctag gcatcgtgga cgggcacccc atcgtgggat
      961 accttcattg tacacatttg catgcacccg ttgaggatgg acatattcgc tgcaaacagc
     1021 taacgctgct gctggaatgg gtggaagagt tcgaggctga gaaccggcag agtgatgagg
     1081 ctgtagcctt cagcgtcctc ctgggagatc taaactttga caactgctcc caagatcatg
     1141 ccaaggagca gggccataaa ctcttcagct gctttcagga cccctgccgg ctaggcgttt
     1201 gccaggaaca gccctgggcc ttagggacaa tcttgaattc ctccatgcta cgccactcca
     1261 ttgcctgctc cccagagatg cttcggaggg ccctgagaca ggaaaagggg cgccgcctgt
     1321 acctgtcagg gccccttcat gggagttacc cagctcagtc ctggaagggc cggcgtctgg
     1381 actacatcac ctaccgcaga gtacccggga gtcgcctgag cccagaggcg gagcaggtga
     1441 cattcagtac tgcctttgct ggactcacgg accacttggc tatgggcctg aagcttcaag
     1501 tggtatgctc ctgacgctgg tgcccagaca aggggatgaa tgtcgagaaa gaccaccatg
     1561 gggggagcgg agcccaataa cccaataacc atgcgactca aaggatcttt attgtggggg
     1621 cactcatact gcttcctggg cgcggcggta ctcatacaca ctgcctcgct ctgggaaggc
     1681 tggatatagc gggggcgagc ctggtggtgg tgctgggtcc tccgggtctc catagccccc
     1741 acccccaggc gtgtggaggc agaacgcgtc ctgagaagaa gagcaagttt taacacaggt
     1801 tgcgtccctg tcccagttaa gacacaatca ctcaaccacc ctatttccgt ttgggagcca
     1861 aattaaattt ttgtatccct attca
//
