LOCUS       NM_009213               1621 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Mus musculus sphingomyelin phosphodiesterase 2, neutral (Smpd2),
            mRNA.
ACCESSION   NM_009213
VERSION     NM_009213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Risner,M.L., Ribeiro,M., McGrady,N.R., Kagitapalli,B.S.,
            Chamling,X., Zack,D.J. and Calkins,D.J.
  TITLE     Neutral sphingomyelinase inhibition promotes local and network
            degeneration in vitro and in vivo
  JOURNAL   Cell Commun Signal 21 (1), 305 (2023)
   PUBMED   37904133
  REMARK    GeneRIF: Neutral sphingomyelinase inhibition promotes local and
            network degeneration in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Zhu,Z., Quadri,Z., Crivelli,S.M., Elsherbini,A., Zhang,L.,
            Tripathi,P., Qin,H., Roush,E., Spassieva,S.D.,
            Nikolova-Karakashian,M., McClintock,T.S. and Bieberich,E.
  TITLE     Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on
            Astrocyte Senescence and Synaptic Plasticity Transcripts
  JOURNAL   Mol Neurobiol 59 (5), 3233-3253 (2022)
   PUBMED   35294731
  REMARK    GeneRIF: Neutral Sphingomyelinase 2 Mediates Oxidative Stress
            Effects on Astrocyte Senescence and Synaptic Plasticity
            Transcripts.
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Zhong,L., Kong,J.N., Dinkins,M.B., Leanhart,S., Zhu,Z.,
            Spassieva,S.D., Qin,H., Lin,H.P., Elsherbini,A., Wang,R., Jiang,X.,
            Nikolova-Karakashian,M., Wang,G. and Bieberich,E.
  TITLE     Increased liver tumor formation in neutral
            sphingomyelinase-2-deficient mice
  JOURNAL   J Lipid Res 59 (5), 795-804 (2018)
   PUBMED   29567647
  REMARK    GeneRIF: results suggest that SMase-2 deficiency plays a role in
            the survival or proliferation of liver cancer stem-like cells,
            leading to spontaneous tumors, which is associated with
            tumor-specific effects on lipid homeostasis
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Nusshold,C., Uellen,A., Bernhart,E., Hammer,A., Damm,S.,
            Wintersperger,A., Reicher,H., Hermetter,A., Malle,E. and Sattler,W.
  TITLE     Endocytosis and intracellular processing of BODIPY-sphingomyelin by
            murine CATH.a neurons
  JOURNAL   Biochim Biophys Acta 1831 (12), 1665-1678 (2013)
   PUBMED   23973266
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Marchesini,N., Luberto,C. and Hannun,Y.A.
  TITLE     Biochemical properties of mammalian neutral sphingomyelinase 2 and
            its role in sphingolipid metabolism
  JOURNAL   J Biol Chem 278 (16), 13775-13783 (2003)
   PUBMED   12566438
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Zumbansen,M. and Stoffel,W.
  TITLE     Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid
            storage disease
  JOURNAL   Mol Cell Biol 22 (11), 3633-3638 (2002)
   PUBMED   11997500
  REMARK    GeneRIF: Neutral sphingomyelinase 1 deficiency in the mouse causes
            no lipid storage disease. (nSMase 1)
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Mizutani,Y., Tamiya-Koizumi,K., Irie,F., Hirabayashi,Y., Miwa,M.
            and Yoshida,S.
  TITLE     Cloning and expression of rat neutral sphingomyelinase:
            enzymological characterization and identification of essential
            histidine residues
  JOURNAL   Biochim Biophys Acta 1485 (2-3), 236-246 (2000)
   PUBMED   10832103
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Levade,T. and Jaffrezou,J.P.
  TITLE     Signalling sphingomyelinases: which, where, how and why?
  JOURNAL   Biochim Biophys Acta 1438 (1), 1-17 (1999)
   PUBMED   10216276
  REMARK    Review article
REFERENCE   9  (bases 1 to 1621)
  AUTHORS   Adam-Klages,S., Schwandner,R., Adam,D., Kreder,D., Bernardo,K. and
            Kronke,M.
  TITLE     Distinct adapter proteins mediate acid versus neutral
            sphingomyelinase activation through the p55 receptor for tumor
            necrosis factor
  JOURNAL   J Leukoc Biol 63 (6), 678-682 (1998)
   PUBMED   9620659
  REMARK    Review article
REFERENCE   10 (bases 1 to 1621)
  AUTHORS   Tomiuk,S., Hofmann,K., Nix,M., Zumbansen,M. and Stoffel,W.
  TITLE     Cloned mammalian neutral sphingomyelinase: functions in
            sphingolipid signaling?
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3638-3643 (1998)
   PUBMED   9520418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010978.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_009213.3.
            
            On Oct 12, 2005 this sequence version replaced NM_009213.1.
            
            Summary: This gene encodes a protein with similarity to the human
            nSMase1 protein. In humans, the nSMase1 protein was initially
            identified as a sphingomyelinase based on sequence similarity
            between bacterial sphingomyelinases and a yeast protein. Subsequent
            studies showed that its biological function is less likely to be as
            a sphingomyelinase and instead as a lysophospholipase. [provided by
            RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010978.1, AJ222800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1621              BC010978.1         11-1631
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.42 cM"
     gene            1..1621
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /note="sphingomyelin phosphodiesterase 2, neutral"
                     /db_xref="GeneID:20598"
                     /db_xref="MGI:MGI:1278330"
     exon            1..358
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1568
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /EC_number="3.1.4.12"
                     /note="neutral sphingomyelinase 1; N-SMase; lyso-PAF-PLC;
                     lyso-platelet-activating factor-phospholipase C"
                     /codon_start=1
                     /product="sphingomyelin phosphodiesterase 2"
                     /protein_id="NP_033239.1"
                     /db_xref="CCDS:CCDS23805.1"
                     /db_xref="GeneID:20598"
                     /db_xref="MGI:MGI:1278330"
                     /translation="MKLNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLENFDL
                     ALLEEVWSEQDFQYLRQRLSLTYPDAHYFRSGMIGSGLCVFSKHPIQEIFQHVYSLNG
                     YPYMFHHGDWFCGKSVGLLVLRLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELA
                     QFIHHTSKNADVVLLCGDLNMHPKDLGCCLLKEWTGLHDAFVETEDFKGSDDGCTMVP
                     KNCYVSQQDLGPFPSGIRIDYVLYKAVSEFHVCCETLKTTTGCDPHSDKPFSDHEALM
                     ATLYVKHSPPQEDPCTACGPLERSDLISVLREARTELGLGIAKARWWAAFSGYVIVWG
                     LSLLVLLCVLAAGEEAREVAIILCIPSVGLVLVAGAVYLFHKQEAKGLCRAQAEMLHV
                     LTRETETQDRGSEPHLAYCLQQEGDRA"
     exon            359..455
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..532
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..626
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..716
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..799
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..932
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1037
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1191
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1602
                     /gene="Smpd2"
                     /gene_synonym="nSMase; nSMase1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggaagcc gagccgggaa caagggagga acctgtaggc cgcggtgcgg agaacccacc
       61 gaaggaccta agaatctgga acagtccacc cgagattcct tccaggactg ccggcggcct
      121 cgcgcagcca gcccgggatt tgcagccgac cttctttccg ggtggaagga cggcctttgt
      181 cccagtaacg caggagtcgc cccccacccc caaccagctc gcgttcctgg gtcggggcag
      241 cgcaggacag ggcaataagc ctgtgcgcgc aatccgcctc gccgcccttg ctccgaagca
      301 ctccagccat gaagctcaac ttttctctac ggctgagagt tttcaatctc aactgctggg
      361 acatccccta cctgagcaaa catagggcgg accgcatgaa gcgcttggga gactttctga
      421 acttggaaaa ctttgatctg gctctcctgg aggaggtgtg gagtgagcag gacttccagt
      481 acctaaggca aaggctatcg ctcacctatc cagatgcaca ctacttcaga agcgggatga
      541 taggcagtgg cctctgtgtg ttctccaaac acccaatcca ggaaatcttc cagcatgtct
      601 acagtctgaa tggttacccc tacatgttcc atcatggaga ctggttctgt gggaagtctg
      661 tggggctgct ggtgctccgt ctaagtggac tggtgctcaa tgcctacgtg actcatctac
      721 atgctgagta cagccgacag aaggacatct actttgcaca ccgtgtggcc caagcttggg
      781 aactggccca gttcatccac cacacatcca agaatgcaga tgtggttcta ttgtgtggag
      841 acctcaatat gcaccccaaa gacctgggct gctgcctgct gaaagagtgg acagggctcc
      901 atgatgcttt cgttgagact gaggacttta agggctctga tgatggctgt accatggtac
      961 ccaagaactg ctacgtcagc cagcaggacc tgggaccgtt tccgtctggt atccggattg
     1021 attacgtgct ttacaaggca gtctctgagt tccacgtctg ctgtgagact ctgaaaacca
     1081 ctacaggctg tgaccctcac agtgacaagc ccttctctga tcacgaggcc ctcatggcta
     1141 ctttgtatgt gaagcacagc ccccctcagg aagacccctg tactgcctgt ggcccactgg
     1201 aaaggtccga tttgatcagc gtgctaaggg aggccaggac agagctgggg ctaggcatag
     1261 ctaaagctcg ctggtgggct gcattctctg gctatgtgat cgtttggggg ctgtcccttc
     1321 tggtgttgct gtgtgtcctg gctgcaggag aagaggccag ggaagtggcc atcatcctct
     1381 gcatacccag tgtgggtctg gtgctggtag caggtgcagt ctacctcttc cacaagcagg
     1441 aggccaaggg cttatgtcgg gcccaggctg agatgctgca cgttctgaca agggaaacgg
     1501 agacccagga ccgaggctca gagcctcacc tagcctactg cttgcagcag gagggggaca
     1561 gagcttaaga gcttaacaat aaaacttgct tgacacactc taaaaaaaaa aaaaaaaaaa
     1621 a
//
