LOCUS       NM_001195596             674 bp    mRNA    linear   ROD 20-NOV-2023
DEFINITION  Mus musculus small leucine-rich protein 1 (Smlr1), mRNA.
ACCESSION   NM_001195596 XM_900828 XM_919362
VERSION     NM_001195596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 674)
  AUTHORS   van Zwol W, Rimbert A, Wolters JC, Smit M, Bloks VW, Kloosterhuis
            NJ, Huijkman NCA, Koster MH, Tharehalli U, de Neck SM, Bournez C,
            Fuh MM, Kuipers J, Rajan S, de Bruin A, Ginsberg HN, van Westen
            GJP, Hussain MM, Scheja L, Heeren J, Zimmerman P, van de Sluis B
            and Kuivenhoven JA.
  TITLE     Loss of hepatic SMLR1 causes hepatosteatosis and protects against
            atherosclerosis due to decreased hepatic VLDL secretion
  JOURNAL   Hepatology 78 (5), 1418-1432 (2023)
   PUBMED   36053190
  REMARK    GeneRIF: Loss of hepatic SMLR1 causes hepatosteatosis and protects
            against atherosclerosis due to decreased hepatic VLDL secretion.
REFERENCE   2  (bases 1 to 674)
  AUTHORS   Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen
            A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M,
            Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E,
            Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K,
            Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe
            F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S,
            Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN,
            Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S,
            Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple
            CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P,
            Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez
            S, Baldock RA, Eichele G and Ballabio A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153547.3 and AK008073.1.
            
            On or before Sep 19, 2010 this sequence version replaced
            XM_919362.2, XM_900828.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY034367.1, AK008073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC153547.3         88146-88153
            9-671               AK008073.1         7-669
            672-674             AC153547.3         96473-96475
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     gene            1..674
                     /gene="Smlr1"
                     /gene_synonym="2010003K15Rik"
                     /note="small leucine-rich protein 1"
                     /db_xref="GeneID:100504474"
                     /db_xref="MGI:MGI:1922856"
     exon            1..312
                     /gene="Smlr1"
                     /gene_synonym="2010003K15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..386
                     /gene="Smlr1"
                     /gene_synonym="2010003K15Rik"
                     /codon_start=1
                     /product="small leucine-rich protein 1"
                     /protein_id="NP_001182525.1"
                     /db_xref="CCDS:CCDS56698.1"
                     /db_xref="GeneID:100504474"
                     /db_xref="MGI:MGI:1922856"
                     /translation="MSSVLAIFLQELPGPVLVLGIFLPVTLLLLLLLAYFRIKLMAVE
                     EELAHTSDRQNKFGSSLRKRMR"
     exon            313..674
                     /gene="Smlr1"
                     /gene_synonym="2010003K15Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcttcta caactgtagc tgagttacag agtaacttgc caacagcgct ccagtattca
       61 ctccactaat aagccagagc aaagtccaca acaggtttca tggaaaagca tgagcaaagg
      121 ccagaacttc gggaaaggac aaccacagag cagagccaag tcgcctgtcc cgagcagtgg
      181 ggaccatgag ctccgtgctg gcaatcttct tgcaggaact ccccggccct gtcctggtcc
      241 tggggatctt cctgcctgtg accttgctgc ttctcctcct tcttgcctac ttcaggatca
      301 aactgatggc agttgaagaa gaactggctc acacttctga tcgccagaac aagtttggtt
      361 cttccctgcg caagagaatg aggtgaaggt gggggttggt gtcaccaatg ggcaaagcac
      421 catgaatttc tcaaggtcac ggagcagcag tcaacagggc caccaggaaa cgagaaagaa
      481 cagtgaacac accagttgct ccgggaggac ttcggtggga tccgacgtta atggcagttc
      541 ctccgaaagc accatgaact taaacatttc tttaacgggc gcaatgcacc aggcgtatct
      601 tgagtttctt tgattgttga ctatgcttat ttactttatg gagaatattt ttaaattaaa
      661 acttctagat ctca
//
