LOCUS       NM_001163721            3454 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus small integral membrane protein 1 (Smim1), transcript
            variant 1, mRNA.
ACCESSION   NM_001163721 XR_035126 XR_035127
VERSION     NM_001163721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004513.1 and BC080682.1.
            
            On or before Jul 31, 2009 this sequence version replaced
            XR_035127.1, XR_035126.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167398.1, AK165247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AK004513.1         108-708
            602-3454            BC080682.1         695-3547
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.79 cM"
     gene            1..3454
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /note="small integral membrane protein 1"
                     /db_xref="GeneID:68859"
                     /db_xref="MGI:MGI:1916109"
     exon            1..136
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            137..254
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            255..458
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..585
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /codon_start=1
                     /product="small integral membrane protein 1"
                     /protein_id="NP_001157193.1"
                     /db_xref="CCDS:CCDS59664.1"
                     /db_xref="GeneID:68859"
                     /db_xref="MGI:MGI:1916109"
                     /translation="MQSQESGVHYSRWDSSSRDEVSMTAMSSSEEASCYRRISQKLCS
                     GKLGIAMKVLGGVALFWIIFILGYITGYYVHKCK"
     exon            459..3442
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      581..586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      602
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /note="major polyA site"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3326
                     /gene="Smim1"
                     /gene_synonym="0610011H04Rik; 1190007F08Rik;
                     2700009I11Rik"
ORIGIN      
        1 gcttcccagg ctggcctctc tcccttggcc ccgcccttca gaccctgccc tctccccggc
       61 ctcggccccg cccccgtcac cccagggggc tggagaagcc tccctggcgt gcgggcggcc
      121 cttgcaagag gcacaggctc gaagcaccaa ccttacctct cagcataatt ggtttgccct
      181 gctggggaaa ggtgggatcc attgaacaga ccctgacagc cttcctgagc accggaggct
      241 tccgacgcgc ctttgcagac cctccccaac cagcagcttc tgtgagtctg gcctgatacc
      301 tgccttatct cctccctgaa tgtggtagct ccaccccagg cctacagcat gcagtcccag
      361 gagagtggtg ttcactacag caggtgggac agcagcagcc gggatgaagt cagcatgacc
      421 gccatgtcca gctcggaaga agcctcatgc tataggagga tctcccagaa gctgtgctct
      481 ggcaagctgg ggatagccat gaaggtgctg ggtggagtgg ccctcttctg gatcatcttc
      541 atcctgggtt acatcactgg ctactacgtg cacaagtgca aataaatgct gccccactcc
      601 cagccctggg gattccctcc catgtacaca ggccatttgt gcagacactc ctccatacag
      661 accccagggc atatgaagat gccagtgtgc actgtcaaca tggctcccca tctccagtac
      721 acagggtaga cccaagactg aaaccccagc ccaggcagcc accagcgaga gtcacacagg
      781 ctggagacta ggctaagctc cagctgagca gcagggaacc acccccaccc cccaccccca
      841 ggttgggctt tgtgccccga ttcctttggc cagtgctcca tcttccccag cctaggcccg
      901 tccctagctg aggttggaat gagtgatggt ctgtgcaggg gggtgcttgg cagccctcag
      961 gggtgagctt ctccctgtgg gcagggctcc tggtcttttg gccttccaga ttcctggttg
     1021 tgcaggatgg gccctgaata acgactgtgg ctcctatttt ttccagggca cacagacagg
     1081 gcctcaaatc tttctgtgca gggcacaggg gcttaccacc tcagggatgg cccggagaga
     1141 agctgtgtgc cctaccggct gcctccccac cagcccccac tccttagaga ctgtagacaa
     1201 atcactgctg aaggaacagt gggtgacaga ctctctccac tagcactgcc cagccaggca
     1261 tgacttgttc caggcctgac cctcctccac agctcctcct gtttggctct gtcttggaat
     1321 gtgcccctcc tgactgggcc ttctcccaag aacacagaga cccaagggtc aggatgtggc
     1381 tggacctgtt ccctccttac tggaccatgt gaggacatga cgctgaacaa gggcactgtg
     1441 actcgatggg gactttggtc ccctctccag tggcccatgt agaacttctc tggaccacac
     1501 cttgttccca gtatgctgtg aattggcgca aggctggcgg gctgtggcta gaaaactgtg
     1561 aggtctgcac actgacctga gagggtggca ggcacagggg ctgctgctat cagtggccaa
     1621 aggaaggagg ccagaagcca acccctgctt ctccctggcc agcgaggctg gtatggctgg
     1681 cctcctcatc ctaagaggct cctggttagg cccgacctaa gcttcagtgg tccttgtgtg
     1741 ggagattgca gtagagctac tccaactgac ctggacctct gtagtacaag tctagacccc
     1801 aagtctaaca gacaactcca cccccacccc tccactcaca ggctccaaat gaggtaagac
     1861 ggtggtgtgt tctccacctc acccgcaccc cccagtcctg agctgccgca aggcgggcat
     1921 cgcaaggcgg gcatcgggag gaagtcccag tgaaggaccc cctaaggcct agtggagctc
     1981 ttgtcaagag gtcatctttg gagcaggtgt gtagcaagac agggcagaca tggctgagcc
     2041 agggacatgg gtgcagtaga gaggtgacag gaaggagtag tatttgatgc aggaggcacc
     2101 atgtggaagg aaaggaacgg gagcactgtc ctcaggcgtc tcctgtagtc ccgggctgac
     2161 agtgaggcgg gcttccagcc acattctgca ctccacactg ggtcaggtgc tcccagccca
     2221 ctcctggcag ctgcccagta atcttgcgga gctgctcagt gagccccatg gtcatggaca
     2281 ccctaccctg gtgggggttc gggctgctct cccatgtatg atgtctgcta cacctgagga
     2341 ctggtgaact gcaacactgt cctgggagac gcatgtgcta aggctgctga tgcagagatg
     2401 tcgttaccaa gggtttttat tagaacaaag aggcgttctg cttgaatctg taaaaacagt
     2461 ttcaaaaatc tcaatgaatc tcacacctgg gctgggctgg gctggaggga acagcaggaa
     2521 ctggggggag acagggtgag cacaggatag ctccacccta aacacttagt aggtgagtac
     2581 ttgccacagc cactcaaagg gacctgtgag cagccgtgtc tcatggagaa cagctaccag
     2641 cgttgtccag ggtctgccac gaggagcctg gagcttcact agttctgaca gctaacggct
     2701 ctcgcacggc cttaggatga aagccgcacg caaccccaaa caggtgttct tttacagaag
     2761 gtagaaatgg tcctttaagg tcagaggtca ccaacgagaa ggtgtcgagg gggaaggctg
     2821 agggtctggt tctcttctca gccagatggc aaggcacggg gccaccaagt cctctgtgca
     2881 gctgctgggt ccttaggacc aggcactgtg gctcgaggga tggcagctgt gtgctggtac
     2941 agatgcgtac acatgcggag atgggatgtg cgcagtcagg atgcacagag atgggacatg
     3001 aatagtggga cacgctgaca tggagcctgc agggccatgt gtgaggcaca gtccacgaag
     3061 catctgtctg actacaaagg actacacgga catagataac ttccttggcc aaggcgcaga
     3121 tgtgccaaca acgaccagca ctacagttcc aagcacagcc gtggaaggca gatgctgccc
     3181 tgggagcatg gcggcagcac ggtgcctgga aacaagctct aagaagatta cactcacaac
     3241 atgatgttct caactgtcta tgcacagctg atttaaaaaa aaattctatt aacatgttgt
     3301 agaaaaataa atactgttca atagaatgcc tgcgttcaac ctgactctcc agcacggcca
     3361 caggccacat gattcagaac atccccagca gttactgagt gatccatgag gacaggagac
     3421 aggagagtca cattggagct ataaaaaaaa aaaa
//
