LOCUS       NM_198927               2977 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus submandibular gland protein C (Smgc), mRNA.
ACCESSION   NM_198927 XM_128070
VERSION     NM_198927.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Gao,X., Mukaibo,T., Wei,X., Faustoferri,R.C., Oei,M.S., Hwang,S.K.,
            Yan,A.J., Melvin,J.E. and Ovitt,C.E.
  TITLE     Nkx2.3 transcription factor is a key regulator of mucous cell
            identity in salivary glands
  JOURNAL   Dev Biol 509, 1-10 (2024)
   PUBMED   38311164
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2977)
  AUTHORS   Nakata,H., Terakawa,J., Horike,S.I., Daikoku,T. and Iseki,S.
  TITLE     The lack of terminal tubule cells in the submandibular gland of
            mice deficient in submandibular gland protein C
  JOURNAL   Cell Tissue Res 381 (2), 229-237 (2020)
   PUBMED   32418130
REFERENCE   6  (bases 1 to 2977)
  AUTHORS   Das,B., Cash,M.N., Hand,A.R., Shivazad,A. and Culp,D.J.
  TITLE     Expression of Muc19/Smgc gene products during murine sublingual
            gland development: cytodifferentiation and maturation of salivary
            mucous cells
  JOURNAL   J Histochem Cytochem 57 (4), 383-396 (2009)
   PUBMED   19110483
  REMARK    GeneRIF: Changes in Muc19/Smgc gene expression delineate multiple
            stages of salivary mucous cell cytodifferentiation and subsequent
            maturation during embryonic gland development through the first 4
            weeks of postnatal life.
REFERENCE   7  (bases 1 to 2977)
  AUTHORS   Culp,D.J., Latchney,L.R., Fallon,M.A., Denny,P.A., Denny,P.C.,
            Couwenhoven,R.I. and Chuang,S.
  TITLE     The gene encoding mouse Muc19: cDNA, genomic organization and
            relationship to Smgc
  JOURNAL   Physiol Genomics 19 (3), 303-318 (2004)
   PUBMED   15340121
REFERENCE   8  (bases 1 to 2977)
  AUTHORS   Zinzen,K.M., Hand,A.R., Yankova,M., Ball,W.D. and Mirels,L.
  TITLE     Molecular cloning and characterization of the neonatal rat and
            mouse submandibular gland protein SMGC
  JOURNAL   Gene 334, 23-33 (2004)
   PUBMED   15256252
  REMARK    GeneRIF: SMGC is expressed in the submandibular gland at high
            levels through postnatal day 20, and secreted SMGC visualized by
            SDS-PAGE and silver staining is 105 kDa;localized on chromosome
            15E3
REFERENCE   9  (bases 1 to 2977)
  AUTHORS   Menko,A.S., Kreidberg,J.A., Ryan,T.T., Van Bockstaele,E. and
            Kukuruzinska,M.A.
  TITLE     Loss of alpha3beta1 integrin function results in an altered
            differentiation program in the mouse submandibular gland
  JOURNAL   Dev Dyn 220 (4), 337-349 (2001)
   PUBMED   11307167
REFERENCE   10 (bases 1 to 2977)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FQ976815.4.
            
            On May 2, 2007 this sequence version replaced NM_198927.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY459348.1, BC138091.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                FQ976815.4         74658-74750
            94-225              FQ976815.4         77662-77793
            226-408             FQ976815.4         78229-78411
            409-471             FQ976815.4         78781-78843
            472-642             FQ976815.4         80681-80851
            643-732             FQ976815.4         81776-81865
            733-831             FQ976815.4         83376-83474
            832-1002            FQ976815.4         84245-84415
            1003-1092           FQ976815.4         85359-85448
            1093-1191           FQ976815.4         86890-86988
            1192-1362           FQ976815.4         87759-87929
            1363-1452           FQ976815.4         88873-88962
            1453-1551           FQ976815.4         90882-90980
            1552-1638           FQ976815.4         92882-92968
            1639-1737           FQ976815.4         94949-95047
            1738-1908           FQ976815.4         95964-96134
            1909-2088           FQ976815.4         96595-96774
            2089-2977           FQ976815.4         96872-97760
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 46.14 cM"
     gene            1..2977
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /note="submandibular gland protein C"
                     /db_xref="GeneID:223809"
                     /db_xref="MGI:MGI:1859618"
     exon            1..93
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2243
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /note="neonatal submandibular gland protein C; mucin 19"
                     /codon_start=1
                     /product="submandibular gland protein C precursor"
                     /protein_id="NP_945121.1"
                     /db_xref="CCDS:CCDS27762.1"
                     /db_xref="GeneID:223809"
                     /db_xref="MGI:MGI:1859618"
                     /translation="MKLILLYLAVVLCFVGKARSFRNGAGFYTSLGGQMRVFDFNKKT
                     LDAKSSGGSKDYNLSDGGKSNSRKNLSPATGGSATQQSNLDDSHAPNLGKSETMLSLL
                     GYLGAFRPVLSGLTSLPRVGGGAHGNIGLRAEISRNGVNLSGDSSARGSLNVNPLSGL
                     STKSGNDATVQGQQAAASGGSKHNVENSSLSTGSATSNKGADKPSEHLSNLFLKGLKG
                     IVEPITSAAGGSVSSAVENLKAQIKKFIEPLTEDHGPTSTSASVSGDSSTSSRLDGHS
                     SDGLSKVSGDDPTVQGHDVAASDGSKQNVEDSTLSTGSATSNEGDDKSSDNSSNTFRE
                     DLEKILEQITSAPGGSVSSAVENLKAQIKKFIEPLTEDHGPTSTSASVSGDSSTSSRL
                     DGHSSDGLSKVSGDDPTVQGHDVAASDGSKQNVEDSTLSTGSATSNEGDDKSSDNSSN
                     TFREDLEKILEQITSAPGGSVSTVNNPDEDRLISIIENLAGHIQQSVTEASQSAERPN
                     AQSSNNLSGKLEPKYENPTNGSSSASSADKPYEEGMRKLLKFLEEQYGQTGTDASVSG
                     MSSESSRSNVHLSDGFSMESGDDATVQGQQAAASGGPKQNVESSNSSTGSATSNGGGD
                     SNEVRGPSSSAVDSTDSGDRGNLADKQGPGFNGPEGVGENNGGSFRAGSLDTGSKSDS
                     GSHNLSSGSGSRSNVSTGGEPSDKNEPADPGVSGRVTCPTGKTQSGSPSVA"
     exon            94..225
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            226..408
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            409..471
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            472..642
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            643..732
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            733..831
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1002
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1092
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1191
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1362
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1452
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1551
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1638
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1737
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1908
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2088
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2977
                     /gene="Smgc"
                     /gene_synonym="2310010P21Rik; DXImx49e; Muc19; Muc19/Smgc;
                     Sfc21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcctgaac agtctctaca cttaggtccc agatcgtcac catgaagctg atacttctgt
       61 acctggctgt ggtgctctgc tttgttggca aagctagatc tttcagaaat ggagctggct
      121 tctatacttc cctaggcggt caaatgagag tctttgattt taataaaaag actctggatg
      181 ccaagagttc tggtgggagc aaagattaca atctgtctga tggaggtaaa agtaactcga
      241 gaaagaatct tagtcctgct actggtggct ctgcaacaca acagtctaat ttagatgact
      301 ctcatgcacc caatcttgga aaaagtgaaa ctatgctgag tctgttaggt tacctgggag
      361 cttttcgccc tgtgcttagt ggccttacgt ctctgcccag agtaggaggt ggtgcccatg
      421 gtaatatcgg tttaagagct gaaatcagca gaaatggtgt caacctgtca ggtgactcaa
      481 gtgcaagagg tagtctgaat gtgaatccgt taagtggact ctccaccaag tcaggaaatg
      541 atgccaccgt ccagggtcaa caagcagctg catctggtgg ctctaagcac aatgtagaga
      601 atagcagttt atctacaggc tctgcaacct ccaacaaagg agctgacaaa ccaagtgaac
      661 atctgagtaa ccttttcctt aaaggactga aaggaatagt cgaaccgatc acaagtgctg
      721 ctggtggctc agtttcttcg gctgtcgaga atcttaaagc acaaataaaa aaattcatag
      781 agcccctgac agaggatcat ggaccaacaa gcactagtgc cagtgtctca ggtgactcaa
      841 gtacaagcag taggctggat gggcattcat cagatggact ctccaaggtg tcaggagatg
      901 atcccacagt ccagggtcac gatgtagctg catctgatgg ctctaagcag aatgtagagg
      961 atagcacttt atctacaggc tctgcaacct ccaatgaagg agatgacaaa tctagtgaca
     1021 attcaagtaa cactttcagg gaagatttgg aaaaaatatt agaacagatc acaagtgctc
     1081 ctggtggctc agtttcttcg gctgtcgaga atcttaaagc acaaataaaa aaattcatag
     1141 agcccctgac agaggatcat ggaccaacaa gcactagtgc cagtgtctca ggtgactcaa
     1201 gtacaagcag taggctggat gggcattcat cagatggact ctccaaggtg tcaggagatg
     1261 atcccacagt ccagggtcac gatgtagctg catctgatgg ctctaagcag aatgtagagg
     1321 atagcacttt atctacaggc tctgcaacct ccaatgaagg agatgacaaa tctagtgaca
     1381 attcaagtaa cactttcagg gaagatttgg aaaaaatatt agaacagatc acaagtgctc
     1441 ctggtggctc agtttctaca gttaacaacc ctgatgaaga tagactcata agcatcatag
     1501 agaacttagc tggccacatt caacagtctg tcactgaagc cagtcaatca gctgaaaggc
     1561 ctaatgcaca atcaagcaac aacttgtcag gaaaattgga accaaagtat gagaacccga
     1621 ctaatggcag tagctcagct tcttcagctg acaagcctta tgaagaggga atgagaaaat
     1681 tgttaaagtt cttagaagag caatatggac aaacaggaac tgatgccagt gtctcaggaa
     1741 tgtcaagtga aagtagtagg tcgaatgtgc atctatcaga tggattctcc atggagtcag
     1801 gagatgatgc cacagtccag ggtcaacaag cagctgcatc tggtggccct aagcagaatg
     1861 tagagagcag caattcatct acaggctctg caacctccaa tggaggaggt gactccaatg
     1921 aagtaagagg gccaagctcc tcagcagtag actccacaga ttcaggagac cgtgggaatc
     1981 tggctgataa acaaggacct gggtttaatg gacctgaggg ggttggagag aataatggtg
     2041 gatctttcag ggctggaagc ttggatactg gaagtaagag tgactcagga agccataatt
     2101 tgtcttctgg gtctggaagt agaagtaatg tttccactgg tggtgaacct tctgacaaaa
     2161 acgaacctgc tgaccctggt gttagtggca gagttacctg tcctactggc aagacccaat
     2221 ctggatctcc ttctgtggct tagatattta gagtcatctc tcatttgaaa gtcatgattt
     2281 ttgaaatcta cttttaaagc aacaatgaaa atcatattca taatttgcaa tcaagtcagg
     2341 ttttggggat cataatctac ttagttatta tcagatagaa gccttttatc ttttactggc
     2401 atgtaaggag gcagggctgt tgtctgtttc cttacttgtc ttctttctaa agtgatttgg
     2461 attctgctgc agaagttagt gtcattgtgg atatatttgg cttaatcttt atatcctgga
     2521 tgtggagttg attggctagg tgatttttgc agatacattt tggagatgca tagccatgtt
     2581 gatccatttt tgcaatagca caggaattct acaaagtgtt aagatagtgt ttgtgactgg
     2641 tcatccactt tgatttcttt aactcttagg aattagtaaa aaaatgccct ctcatatcaa
     2701 tgtggccttt agaccttctg aaatgagcat tcaaaaaaaa tattcagtat ttattggaac
     2761 atgatattag gtttaatatc tgtgtagagt gagaaatcta aaaatcaaat gataatgtca
     2821 ttttgtaata atgttgacct tatctcagga ttgactctta atctgctaaa aatggctttg
     2881 tcatacagta ataaaattgt attttagttg gtcttcatct ttgggtataa acattcatag
     2941 ccatcacata ttttaaacta ataaaattga aattatt
//
