LOCUS       NM_028047               2174 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus SMG9 nonsense mediated mRNA decay factor (Smg9),
            transcript variant 1, mRNA.
ACCESSION   NM_028047
VERSION     NM_028047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2174)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2174)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2174)
  AUTHORS   Radford,B.N., Zhao,X., Glazer,T., Eaton,M., Blackwell,D.,
            Mohammad,S., Lo Vercio,L.D., Devine,J., Shalom-Barak,T.,
            Hallgrimsson,B., Cross,J.C., Sucov,H.M., Barak,Y., Dean,W. and
            Hemberger,M.
  TITLE     Defects in placental syncytiotrophoblast cells are a common cause
            of developmental heart disease
  JOURNAL   Nat Commun 14 (1), 1174 (2023)
   PUBMED   36859534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2174)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2174)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 2174)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2174)
  AUTHORS   Shaheen,R., Anazi,S., Ben-Omran,T., Seidahmed,M.Z., Caddle,L.B.,
            Palmer,K., Ali,R., Alshidi,T., Hagos,S., Goodwin,L., Hashem,M.,
            Wakil,S.M., Abouelhoda,M., Colak,D., Murray,S.A. and Alkuraya,F.S.
  TITLE     Mutations in SMG9, Encoding an Essential Component of
            Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital
            Anomaly Syndrome in Humans and Mice
  JOURNAL   Am J Hum Genet 98 (4), 643-652 (2016)
   PUBMED   27018474
  REMARK    GeneRIF: Mutations in SMG9 cause a multiple congenital anomaly
            syndrome in humans and mice
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159140.10.
            
            On Mar 24, 2023 this sequence version replaced NM_028047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034211.1, AK005126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC159140.10        40351-40561         c
            212-367             AC159140.10        36695-36850         c
            368-442             AC159140.10        34641-34715         c
            443-707             AC159140.10        34290-34554         c
            708-805             AC159140.10        34110-34207         c
            806-918             AC159140.10        32609-32721         c
            919-1030            AC159140.10        25192-25303         c
            1031-1126           AC159140.10        23648-23743         c
            1127-1212           AC159140.10        23236-23321         c
            1213-1319           AC159140.10        20122-20228         c
            1320-1427           AC159140.10        19559-19666         c
            1428-1556           AC159140.10        19301-19429         c
            1557-1701           AC159140.10        18978-19122         c
            1702-2174           AC159140.10        17470-17942         c
FEATURES             Location/Qualifiers
     source          1..2174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.54 cM"
     gene            1..2174
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /note="SMG9 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:71997"
                     /db_xref="MGI:MGI:1919247"
     exon            1..211
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            212..367
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1780
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SMG9; protein smg-9 homolog; smg-9 homolog,
                     nonsense mediated mRNA decay factor; nonsense-mediated
                     mRNA decay factor SMG9"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG9 isoform
                     1"
                     /protein_id="NP_082323.1"
                     /db_xref="CCDS:CCDS20949.1"
                     /db_xref="GeneID:71997"
                     /db_xref="MGI:MGI:1919247"
                     /translation="MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAP
                     WERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMK
                     PREEGKGPVAGTGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPT
                     AMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKS
                     MVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSP
                     SILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFL
                     QTAEMVKPSTPSPSHESSSSAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMID
                     QLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGS
                     SPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKK
                     SSALAEYSRLLA"
     exon            368..442
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..707
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..805
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            806..918
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1030
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1126
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1212
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1319
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1427
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1556
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1701
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2174
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2174
                     /gene="Smg9"
                     /gene_synonym="1500002O20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcttcc tcctctggga gcttccggga cgccaaggcc tgttccggaa tagccggcac
       61 ccgttttctc ggcctctctc attctctggc ttgtgacctt ccggcaccat ttacacggca
      121 ggtggctgtg gaggaccttc cccgcccacg ctgcactccc gtcactcaga gcgcgcgctg
      181 cgacccagga actaatcagc agctgcccta ggtgaccatg tcggagtctg ggcacagtca
      241 gcctgggctc tacgggatag agcggcggcg gcggtggaag gagccaggct ccagtggccc
      301 ccagaacctt tctggacctg gtggtcggga gagagactac attgccccct gggaaagaga
      361 gagacgggat ggcagcgaag accccagcac taacgtcatg cagaaaaccc ccatcatcct
      421 ctcaaagccc ccagctgagc ggtcaaagca gccgccacct agtacagcgc cagctgcacc
      481 gccagccccg gccccactgg agaaacccat tgtgctcatg aagccacgtg aggaggggaa
      541 ggggcctgtg gctggaacag gggcttccac ccctgaaggt actgcgcccc cgccccccac
      601 ggcccctgca ccacccaagg gagagaagga ggggcagaga cccacacagc ctgtgtacca
      661 gattcaaaac cggggcatgg gcactgctgc cccaactgcc atggaccctg tggtgggcca
      721 ggctaagctc ctgcccccag agcgcatgaa gcacagcatc aagctggtag acgaccagat
      781 gaactggtgt gacagtgcca ttgagtacct gctggatcag acggacgtgt tagtggtcgg
      841 tgtcttaggc ctccagggga caggcaagtc catggtcatg tcactgctgt ctgcaaacac
      901 tccagaggaa gaccagagag cgtatgtctt ccgggctcag agtgcagaga tgaaggaacg
      961 agggggcaac cagaccagtg gcattgactt cttcattacc caagagcgga ttgtcttcct
     1021 agacacacag cccatcctca gcccatccat cttggaccac ctcatcaata acgaccgcaa
     1081 actgcctcca gagtataacc tccctcacac ctatgtggaa atgcagtccc tgcagatagc
     1141 tgccttcctc ttcaccgtgt gccacgtggt gatcgtcgtg caggattggt tcacggacct
     1201 cagtctgtac aggttcctgc agacagcaga gatggtgaag ccatccacac cgtcccccag
     1261 ccacgagtct agcagctctg caggctcaga cgagggtacc gagtactacc cccacctggt
     1321 cttcttgcag aacaaggcac gtagggagga cttctgtccc cggaagctac gtcagatgca
     1381 cctgatgatt gaccagctca tggcacactc ccacctgcgc tacaagggga cgctgtccat
     1441 gctacagtgc aacgtcttcc cagggctgcc gcccgacttc ctggatgctg aggtcaactt
     1501 gttcctggtg cccttcatgg acagtgaagc tgagaacgag aacccacctc gagcaggacc
     1561 tggctccagc cccctctttt ccctcctgcc tgggtaccga ggtcacccca gcttccagtc
     1621 cttggtcagc aagctccgca gccaggtgat gtctatggct cggccacagc tgtcacacac
     1681 gatcctcact gagaagaatt ggttccacta cgctgcccgc atctgggatg gggtgaagaa
     1741 gtcctcagcc ctggcagagt acagccgcct gctggcctga tgccgaggga gcagcagcat
     1801 gcagggaact gccctgtcct gtgggctgtc ctgtggacag tgagggcaca gccaccctcc
     1861 agcaagggag gagagtgaca gaggcctggc agagggatcg tggcttcccg ctgagagacg
     1921 tgaggtgtct gaggccagcc cctccctcaa atggggggct gctcacaggg tgactaagag
     1981 atcccacccc gagcctggta tgagcagcct ttcccaaatc tccatagaga ccagcagcag
     2041 caggaggagg agtcaatgtg ccaggaagcc tgaccccact gagtctgact ccaggccttc
     2101 cgtgggaaac ggggttgggg ctggagagct tttcaagacg agggtctgat ggttcgaata
     2161 aatgtggtca caga
//
