LOCUS       NM_024262               3236 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SMG8 nonsense mediated mRNA decay factor (Smg8), mRNA.
ACCESSION   NM_024262 XM_914416
VERSION     NM_024262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3236)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC020005.1.
            
            On Dec 7, 2005 this sequence version replaced XM_914416.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020005.1, AK004714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.89 cM"
     gene            1..3236
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /note="SMG8 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:74133"
                     /db_xref="MGI:MGI:1921383"
     exon            1..1783
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3000
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /note="protein SMG8; protein smg-8 homolog; CG6729 gene
                     product; smg-8 homolog, nonsense mediated mRNA decay
                     factor"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG8"
                     /protein_id="NP_077224.1"
                     /db_xref="CCDS:CCDS25207.1"
                     /db_xref="GeneID:74133"
                     /db_xref="MGI:MGI:1921383"
                     /translation="MAGPVSLRELLMGASAWLGSESPGGPSAEGGGNAAGTPEPPWRE
                     DEICVVGIFGKTALRLNSEKFSLVNTVCDRQVFPLFHHQDPGDPGTGIKTKAVSVGEA
                     GGAGDPGAAAGDSLRGGMATAEGNRAEPGPQDFSLLQAYYNQESKVLYLILTSICDNS
                     QLLRACRALQSGEAGGGLSLPHAETHEFWKHQEKLQCLSLLYLFSVCHILLLVHPTCS
                     FDITYDRVFRALDGLRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALK
                     VEPPRSQDTAHPDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQA
                     FVYIVPGSQEEDPIGMLLDQLRSHCTVKDPESLLVPAPLSGPRRYQAMRQHSRQQLSF
                     HIDSSTSSSSGQLVDFTLREFLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWIS
                     AAAKLYEVAIDGKEEDLGSPTGELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAH
                     SAYQSNLPHNYTMTVHKNQLAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLC
                     EERSLTDQHCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPF
                     DIKAANYDFYQLLEEKCCGKLDHINFPVFEPSTPDPAPAKNEPSPAPPDSDAEKLKEK
                     EPQTQGESTSLSLALSLGQSTDSLGTYPADPQAGGDNPEVHGQGEGKSEKRPNLVDRQ
                     ASTVEYLPGMLHSNCPKGLLPKFSSWSLVKLGPAKSYNFHTGLDQQGFVPGTNYLMPW
                     DIVIRTRAEDEGDLDTNSWPAPNKAIPGKRSAVVMGRGRRRDDIARAFVGFEYEDSRG
                     RRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYILSSSQGRGLKPHYAQLMRLFVVV
                     PDAPLQIILMPQVQPGPPPCPVFYPEKQEITLPPDGLWVLRFPYAYVTERGPCFPPKE
                     NVQLMSYKVLRGVLKAVTQ"
     exon            1784..1929
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2802
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..3221
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3182..3187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3221
                     /gene="Smg8"
                     /gene_synonym="1200011M11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctagaggaa gctctttctc cgccatggcg gggccggtca gcttgcgcga gctgctcatg
       61 ggggcgtcgg cctggctggg ctctgagagt cctggaggcc cctccgctga aggcggggga
      121 aacgcggctg gcacgcccga gcccccgtgg agggaggatg agatctgcgt ggtgggaatc
      181 ttcggcaaga cggctctgcg cctcaactcc gagaagttct ctctggtgaa tactgtgtgc
      241 gatcgacagg ttttcccact ctttcaccat caggatcctg gagatccagg aactggaatc
      301 aagaccaaag ctgtctctgt cggagaggcg ggaggagccg gagaccccgg ggctgcagcc
      361 ggggattcac ttcgcggagg tatggctacg gcggaaggta accgagctga gccaggtccc
      421 caggacttca gtcttttgca ggcctattac aatcaggaaa gcaaagttct gtatcttatt
      481 ctcacttcca tctgtgacaa ctcacagctt ctgcgtgctt gtcgggccct ccagagcggt
      541 gaagccggag ggggcctctc tttacctcat gcagaaacac acgagttctg gaagcatcag
      601 gagaagttac agtgtctcag cctcctttac ctcttctctg tctgtcatat cttgctcctg
      661 gtccatccga cgtgttcctt tgacatcact tatgatcgtg tattcagagc cctggatgga
      721 ctgagacaga aagtactacc cctcctcaaa acagccatta aggattgccc agttggcaaa
      781 gactggaagt taaactgccg accttgccca cctagactcc tcttcctctt tcaactcaat
      841 ggggccctta aggtggaacc gcctcggagc caggatacag ctcatccaga taaacccaag
      901 aagcactctc ccaaaagaag gctgcagcat gccctggagg accagatcta tagaatcttt
      961 cgcaagagtc gagtcttgac taatcagagt atcaactgcc tctttacggt acctgccaac
     1021 caagcttttg tgtacatagt ccccggaagc caggaggagg acccaattgg catgttgctg
     1081 gaccagctta ggagccattg taccgtgaaa gacccagaat cgttgttggt gcccgcaccc
     1141 ctttctggac ctaggcggta ccaagcgatg agacagcaca gccgccaaca gctctccttc
     1201 cacattgata gcagcacctc gagttcttca ggccagctag tggatttcac tcttcgagaa
     1261 ttcctgtggc agcacgtgga gctggtccta agcaaaaaag gttttgatga cagtgtgggc
     1321 aggaacccac agccttccca ttttgaactg cccacttacc agaagtggat ctctgcagca
     1381 gcaaagttgt atgaagtggc tatcgatggg aaggaagagg acttgggctc ccccactggg
     1441 gagctaacat ctaagatttt aagcagtatt aaagtcttag aagggttttt ggatatagac
     1501 acaaaattct cggaaaaccg gtgccaaaaa gctttaccca tggctcatag tgcctaccag
     1561 tcaaacttgc cgcataatta caccatgaca gtccataaga atcagcttgc tcaggctctt
     1621 cgggtataca gtcagcatgc tcgaggtcca gcctttcaca aatatgccat gcaattacac
     1681 gaagactgct acaaattttg gagcaatggc catcagctgt gcgaagagag gagcttgact
     1741 gaccaacact gtgtccacaa atttcattcc ttacctaaat caggagaaaa gccagaggca
     1801 gataggaacc ctcctgtgct ctaccacaat agccgagccc gatccaccgg agcctgcaac
     1861 tgcggaagga agcaggcacc tcgagacgac cccttcgata tcaaggctgc taactatgac
     1921 ttttaccagc ttctggaaga aaaatgttgt gggaaattgg atcatatcaa tttccctgta
     1981 tttgagccaa gtactccaga tcccgctcct gctaaaaatg aaccctctcc tgccccgcca
     2041 gactcggacg ccgagaaact gaaggagaaa gaacctcaaa cccaaggaga gagcacaagc
     2101 ctcagcttag ctttgagctt gggccagtca acagatagcc taggtaccta ccccgctgat
     2161 ccacaggcag gaggagacaa cccagaagtc cacgggcaag gagaaggaaa gtctgagaag
     2221 agaccaaact tggttgaccg tcaggcatcc acagttgaat atctcccagg catgctacat
     2281 tcaaattgcc ccaaaggtct cctacccaaa ttctccagct ggtctttggt taaactaggc
     2341 ccagccaagt cttacaactt tcatacaggt ttggaccaac agggcttcgt tccaggaaca
     2401 aactatctta tgccttggga cattgtcatc aggactagag ctgaagatga aggagactta
     2461 gacacgaact cctggcctgc tccaaataaa gctattcctg ggaagagaag tgcagttgtg
     2521 atgggcagag gaaggcggag ggatgacata gctcgagcct ttgttggctt tgagtatgaa
     2581 gactctcgag gtcggaggtt catgtgctca gggcctgaca aagtaatgaa agtgatggga
     2641 agtggaccca aggagtcggc tttaaaagcc ctcaacagtg acatgcccct gtacatcctg
     2701 tcctcgtcgc agggcagagg gctgaagcca cattatgctc aacttatgag gctttttgtt
     2761 gtggttcctg atgctccttt gcagataata ctgatgcctc aggttcaacc aggcccacca
     2821 ccatgtccag tattttaccc agaaaaacaa gaaatcactc tcccacctga tggcctttgg
     2881 gtcttgagat ttccttatgc ctatgtgact gagagaggac cttgtttccc tcccaaggag
     2941 aatgtgcagc tcatgagcta caaggtgctc cgaggagtcc tcaaagcagt tacacaatga
     3001 gtcttccagc cactctgccg cagactgaag ctgctgtttg tcttgttttt gatgtgtttg
     3061 ggtttttttt taatgtgtat actgtgtctt cccaaaaccc aatgtgtttt ggttacaagt
     3121 attcagtatt tggacaataa ttgttccatt atttcattat attgatattt attgtaaaat
     3181 caataaaagt ttgttctaga aaaaaaagga tacaaaatgt aaaaaaaaaa aaaaaa
//
