LOCUS       NM_001002764            5835 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SMG6 nonsense mediated mRNA decay factor (Smg6), mRNA.
ACCESSION   NM_001002764 NM_146022
VERSION     NM_001002764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5835)
  AUTHORS   Katsioudi,G., Dreos,R., Arpa,E.S., Gaspari,S., Liechti,A., Sato,M.,
            Gabriel,C.H., Kramer,A., Brown,S.A. and Gatfield,D.
  TITLE     A conditional Smg6 mutant mouse model reveals circadian clock
            regulation through the nonsense-mediated mRNA decay pathway
  JOURNAL   Sci Adv 9 (2), eade2828 (2023)
   PUBMED   36638184
REFERENCE   3  (bases 1 to 5835)
  AUTHORS   Li,N., Cai,Y., Zou,M., Zhou,J., Zhang,L., Zhou,L., Xiang,W., Cui,Y.
            and Li,H.
  TITLE     CFIm-mediated alternative polyadenylation safeguards the
            development of mammalian pre-implantation embryos
  JOURNAL   Stem Cell Reports 18 (1), 81-96 (2023)
   PUBMED   36563685
REFERENCE   4  (bases 1 to 5835)
  AUTHORS   Lehtiniemi,T., Bourgery,M., Ma,L., Ahmedani,A., Makela,M.,
            Asteljoki,J., Olotu,O., Laasanen,S., Zhang,F.P., Tan,K.,
            Chousal,J.N., Burow,D., Koskinen,S., Laiho,A., Elo,L.L.,
            Chalmel,F., Wilkinson,M.F. and Kotaja,N.
  TITLE     SMG6 localizes to the chromatoid body and shapes the male germ cell
            transcriptome to drive spermatogenesis
  JOURNAL   Nucleic Acids Res 50 (20), 11470-11491 (2022)
   PUBMED   36259644
  REMARK    GeneRIF: SMG6 localizes to the chromatoid body and shapes the male
            germ cell transcriptome to drive spermatogenesis.
REFERENCE   5  (bases 1 to 5835)
  AUTHORS   Guerra,G.M., May,D., Kroll,T., Koch,P., Groth,M., Wang,Z.Q.,
            Li,T.L. and Grigaravicius,P.
  TITLE     Cell Type-Specific Role of RNA Nuclease SMG6 in Neurogenesis
  JOURNAL   Cells 10 (12), 3365 (2021)
   PUBMED   34943873
  REMARK    GeneRIF: Cell Type-Specific Role of RNA Nuclease SMG6 in
            Neurogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5835)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5835)
  AUTHORS   Li,T., Shi,Y., Wang,P., Guachalla,L.M., Sun,B., Joerss,T.,
            Chen,Y.S., Groth,M., Krueger,A., Platzer,M., Yang,Y.G.,
            Rudolph,K.L. and Wang,Z.Q.
  TITLE     Smg6/Est1 licenses embryonic stem cell differentiation via
            nonsense-mediated mRNA decay
  JOURNAL   EMBO J 34 (12), 1630-1647 (2015)
   PUBMED   25770585
  REMARK    GeneRIF: Smg6/Est1 licenses embryonic stem cell differentiation via
            nonsense-mediated mRNA decay.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY109058.1 and BC066040.1.
            
            On Jul 4, 2018 this sequence version replaced NM_001002764.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066040.1, SRR10223969.10966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY109058.1         4-21
            19-5835             BC066040.1         1-5817
FEATURES             Location/Qualifiers
     source          1..5835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..5835
                     /gene="Smg6"
                     /note="SMG6 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:103677"
                     /db_xref="MGI:MGI:2144117"
     exon            1..150
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..4319
                     /gene="Smg6"
                     /note="telomerase subunit EST1A; EST1-like protein A; ever
                     shorter telomeres 1A; Smg-6 homolog, nonsense mediated
                     mRNA decay factor; nonsense mediated mRNA decay factor
                     SMG6"
                     /codon_start=1
                     /product="telomerase-binding protein EST1A"
                     /protein_id="NP_001002764.1"
                     /db_xref="CCDS:CCDS25039.1"
                     /db_xref="GeneID:103677"
                     /db_xref="MGI:MGI:2144117"
                     /translation="MAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDN
                     RRPDLEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDSSAVGNDTQLIQVCKELDS
                     QQQNGPIDAENSQAQETFPKTVGLEDRSLKIIKRSKKPDLQIYQPGRRLQTITKESAG
                     RADEEEILNQVEQLRIEEDECKGEAIKEEVNNKPDKTEIEKHQSNDRVRTAKGEKGKK
                     IEKGEGSKKVADDSVPGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNG
                     CRRRRQDRAKERPRLKKQVSLSSTDSLDEDRVDEPDVLGSRRSSERKKHLERNWSGCG
                     EGEQKSNGKENRSALRVTFDAETMSKDSPVVRSVKDNVDRMKSDKGPSSGGKGSEKQE
                     LRHPRQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGT
                     TRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASYYKFQNSDNPYY
                     YPRTPGPASQYPYAGYSPLQYPVGPTNGMYPGAYYPGYPAPSGQYVCSPLPASTMSPE
                     EIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYER
                     CILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNSENPEQIRNRLLELLDEGSD
                     FFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQ
                     ANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPI
                     LTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFRHVGDDTTRLEIWI
                     HPSHSRSAQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAV
                     AEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAS
                     LGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSD
                     WMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLL
                     ILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLA
                     FKGGKYVSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIREL
                     RAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLA
                     RLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESR
                     DSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEP
                     IRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG"
     exon            151..1906
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2099
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2210
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2317
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2396
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2507
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2720
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2782
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2928
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3045
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3214
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3416
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3593
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3740
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3894
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4106
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4188
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..5817
                     /gene="Smg6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5792..5797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smg6"
                     /note="hexamer: AATAAA"
     polyA_site      5817
                     /gene="Smg6"
                     /note="major polyA site"
ORIGIN      
        1 gtggtttcct ggctgcgcgc ggcggtggcc gagtcgccgc agctgtagca gccgccgcga
       61 agatggcgga ggggttggag cgtgtgcgga tctccgcatc ggaactgcga gggatcctgg
      121 ccactctggc tccgcaggcc gggagcagag aaaacatgaa ggaactaaag gaacccagac
      181 agcgcaaaga taataggcgt ccagatttgg aaatctataa gcctggactt tctcgactaa
      241 ggaacagacc taaaactaag gaggcttctg ggaatgagga atttaaggat gagatagtaa
      301 atgacagaga ttcttctgct gttgggaatg atacacagct tattcaagtt tgcaaggaat
      361 tggacagcca acagcaaaat ggccctatag atgcagaaaa tagtcaggca caggaaactt
      421 ttccaaagac tgttggacta gaggaccgaa gtctaaagat catcaaaaga agcaagaaac
      481 cagacctgca gatctaccag cctggaaggc ggttgcagac cattaccaaa gagtcagcag
      541 gcagggcaga tgaagaagag atcctcaacc aagtggagca gttgaggata gaggaggatg
      601 agtgtaaggg agaagctata aaagaagaag ttaataacaa accggataaa accgagatag
      661 aaaagcacca aagtaatgac cgtgtaagaa ctgccaaggg agaaaaggga aaaaagattg
      721 aaaaggggga ggggtcaaag aaggtggctg atgactctgt cccaggaaag cctggctctg
      781 taaagagata ctcgagatca gacaagagaa ggaatcgcta ccgcacttgc agtaccagct
      841 cagctggtag caacaacagt gctgagggag ctggcctgac cgataatgga tgtcgccggc
      901 ggcgccagga tcgggccaag gagaggccac gactgaagaa gcaggtatct ttgtcctcaa
      961 ctgattcctt agatgaggac agagttgatg agcctgatgt cctagggtcc aggaggagct
     1021 cagaaaggaa gaagcattta gaaagaaatt ggtctggctg tggtgagggt gaacagaaaa
     1081 gcaatggtaa agaaaaccga agtgcccttc gtgtcacttt tgatgcagaa accatgagta
     1141 aagactcccc tgtggtgagg tcagtcaaag ataatgtgga tagaatgaag tctgacaaag
     1201 gcccaagcag tgggggtaag ggctctgaga agcaggagct cagacacccg agacaagaac
     1261 ttcgagatcg tggtcgtggt atcctgattc tgcctgccca cactgcccta tctgtcagtt
     1321 catcaggttc tccggagtct acacctttgg gacctcgact tttatttgga tctggtagta
     1381 agggatctcg gagttggggc cgtggaggca ctacccgccg actatgggac ccaaacaatc
     1441 ctgaccagaa gcctgcccta aaaagccaga cacctcagct acatttcttg gacactgatg
     1501 atgaaattag ccctacatct tggggtgatt cacgtcaggc ccaagcatct tactataaat
     1561 ttcaaaactc tgataacccc tattattacc ctcggacacc aggccctgcc tctcagtatc
     1621 cctatgcagg ctatagccct ctgcagtacc cagtaggccc tacaaatggt atgtatccag
     1681 gggcttacta cccgggctat cctgccccct caggacaata tgtgtgtagc cctctccctg
     1741 ctagcaccat gagtcctgag gaaatagaac agcacgtgcg gaacatgcag caacaggagc
     1801 tccatcggct tctccgagtg gctgacaacc aggaactgca gctcagcaac ctgctttcca
     1861 gggaccgcat cagcactgag ggcatggaga agatggctca gctcagaact gaactactgc
     1921 agctgtacga gcgctgtatt ctattagata ttgaattctc cgacagtcag aatgtagatc
     1981 agatcctgtg gaagaacgct ttctatcagg tgattgagaa gttcaggcag cttctcaagg
     2041 atccaaacag tgagaaccca gagcagattc ggaacagact cttggagctc ttagatgagg
     2101 gcagtgactt ctttgatagt ttgcttcaga aactacaggt tacttacaag ttcaaactgg
     2161 aggactacat ggatgggctt gccattcgaa gcaagccttt acgaaaaaca gtgaaatatg
     2221 ccttgatcag tgctcaacga agtatgattt gccaaggaga tatctctagg tatcgggagc
     2281 aagccaacga tacagcaaac tatgggaagg ctcgcagttg gtatctgaag gctcagcaca
     2341 ttgctcccaa gaatgggcgc ccctataacc agttggctct actggcagtg tatacgagga
     2401 ggaagcttga tgctgtatat tactatatgc gcagtttagc agccagcaac cctatcctga
     2461 ctgccaagga gagtctcatg agtttatttg aagagactaa acgaaaggct gaacagatgg
     2521 aaaagaagca gcatgaggaa tttgatatga gccctgataa gtggcgaaaa ggaaagaagt
     2581 ctactttccg gcatgttggg gatgacacta ctcgcctgga gatttggatt catccatcac
     2641 attctcggtc tgcccagggc actgagtctg ggaaggattc tgagcaggag aatggtctgg
     2701 gcagcctgag tcccagtgat ctgaacaaaa ggttcatcct cagttttctc catgcccatg
     2761 ggaagctgtt tacccggatt gggatggaga cattccctgc agtggctgag aaggtcctta
     2821 aggagttcca agtattgctg cagcatagcc catctcctat tggaagtacc cgtatgctgc
     2881 agcttatgac catcaacatg tttgccgtgc ataactccca gttgaaagac tgcttctcag
     2941 aggagtgtcg ttctgtgatc caggaacaag ctgcatcctt gggcttggct atgttttctc
     3001 tactggtcca gcgctgcaca tgcctactta aggactctgc taaagctcag ctgtcctctc
     3061 ctgaggacca agaggaccaa gatgacatca aggtatcttc cttcgtcccg gacctgaagg
     3121 agctgctccc cagtgtgaaa gtctggtctg attggatgct tggctaccca gacacctgga
     3181 atcctccacc cacatctttg gatctgccct tgcaggttgc tgtggatgtc tggtcaacac
     3241 tagctgattt ctgtaacata ctgactgcag tcaatcagtc tgaggtgcca ctgtacaagg
     3301 acccagatga tgacctcacc ctgcttatcc tggaagagga tcggcttctc tctggctttg
     3361 tccccttgct ggctgcccct caggacccct gctacgtgga gaaaacctcg gataaggtta
     3421 ttgcagctga ctgcaaaagg gtcacagtgc tgaagtattt tctggaagcc ctttgtggac
     3481 aagaagagcc tctgctggca ttcaagggtg gaaaatatgt gtcagtggca cccgtcccag
     3541 acaccatggg aaaggaaatg ggaagccaag agggaaaaca actggaagat gaggaagaag
     3601 atgtggtgat tgaagacttt gaggaagatt cagaggctga aggcagtggg ggtgaggatg
     3661 acatcaggga acttcgggcc aagaagctgg ctctagcaag gaagatagct gagcagcagc
     3721 gtcgccagga aaagatccag gctgttttgg aagaccagag tcagatgagg cagatggagc
     3781 tggagatcag acccttgttc ctcgtaccag ataccaacgg cttcattgac cacctggcca
     3841 gtctggctcg gctgctggag agcaggaagt acatcctggt ggtgcccctc atcgtgatca
     3901 atgagctgga cggcctcgcc aaagggcagg agacagacca ccgggctggg ggctatgccc
     3961 gtgtggtgca agaaaaggcc cgaaaatcca ttgagttcct cgaacggaga tttgagagtc
     4021 gggactcctg cctgcgggcc ttgaccagcc gtggcaatga acttgaatct atcgccttcc
     4081 gaagtgagga cattactgga cagctgggta acaacgatga cctgatcctc tcttgctgcc
     4141 tgcactactg caaagacaag gctaaggatt acatgcccac cagcaaagag gagccaatcc
     4201 gcctgttacg ggaggtggtg ttgctgaccg atgatcggaa ccttcgtgta aaggcgctga
     4261 caaggaatgt gcctgtgagg gacatcccag ccttccttac gtgggcccag gtgggctgag
     4321 gggaccacac tggggcccac ccccatggag ccattcctga gaggccgcca ggcgcccagt
     4381 gtaacacgga agatgtccac gtgcctgagc taccaatcca cccagacaat aaaccatcct
     4441 cttccaacct cacgccgtgg ccgtgctgtg ggggagccgc tcctcacaga gccctcccaa
     4501 gggtcaggcg gaaactgctg ggaccctcct gggctgccaa gatttagcag ggaggtgact
     4561 ggctacagtg acaacaggtg gacaagccga gtaggccacc aagctcccac cctttttccc
     4621 tctatctggt cccagggctg gagggaggcc tactcacccc gaggacccag ccactctgta
     4681 gtggtaaggg gcagagattc taaagtttcc attagatgca aggaaactga tcaacccctc
     4741 agtctgcaca gtctctgtcc tgaatgtctg agaggcttca gctgtcagga agggtgccca
     4801 ggtgtctcca tctccctgag gcccagatgc cctgtggacc cacgctgact tctgtctgta
     4861 acagcaacag cagccctcgc ccttcaacac acacgcacgc actcacacag cacatgtgca
     4921 catgtttctc ttcctgtcca catcttgcac tttgcccttg ttttcctttt gggcagtcat
     4981 gggcctaagg gaagggccat ctggtcttgg gcccgtgcgt cctgagtggc cctccaccag
     5041 cacatgctcc catccttggc cttcctttca ctgcagtacc ctcttgggga aatttcctca
     5101 gactcttctt tgctgccttc cttttctagt tggccccttt catcacccca aaccccctaa
     5161 acttcctccc ctcagttcct tgtgggactt ctcgttctga atcttacccc taccacctgt
     5221 gacaggaacc aaataaagcc ttcccagctg tccttccttc ccaacccgtc acacctctga
     5281 gaagtctcct agctgggaga gctgaacccc aaggtagagg tgccagggtg ttgagcccgt
     5341 ttctggcttt gtcattgtac ttctttaccc agaagagggg acatggggcc ctttagcctt
     5401 tgagggtttt ggttctttta ggttttttgt ttttgttttt tgctgcctct gtttacaacc
     5461 tcacttggag gctcccgacc aggaatgaat tccttcagtc tagcaaagag gtagaggagg
     5521 attgagaagg ctgtctcagg ctaagcaggg gatcacacaa cccacctcag gaggagcagt
     5581 gcttcaccaa gggtgctctg cccttctcag gcccaggaca gtgcccagga ctcagctcag
     5641 aagctctctt gattgtaagg cgcaggcagg ctacttcctt tgaggtcccc tcctctggct
     5701 gtgagggtca ttggctgggg gttgggggat tgggaatgga agaatacctt tcttctttct
     5761 gtcccacttg gaaccctggt tttgtttcct taataaattt ttagttatga aatataaaaa
     5821 aaaaaaaaaa aaaaa
//
