LOCUS       NM_178246               4447 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus SMG5 nonsense mediated mRNA decay factor (Smg5), mRNA.
ACCESSION   NM_178246 XM_130930 XM_909775 XM_987629
VERSION     NM_178246.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4447)
  AUTHORS   Chen,C., Wei,Y., Jiang,X. and Li,T.
  TITLE     RNA Surveillance Factor SMG5 Is Essential for Mouse Embryonic Stem
            Cell Differentiation
  JOURNAL   Biomolecules 14 (8), 1023 (2024)
   PUBMED   39199410
  REMARK    GeneRIF: RNA Surveillance Factor SMG5 Is Essential for Mouse
            Embryonic Stem Cell Differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4447)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4447)
  AUTHORS   Li,T., Shi,Y., Wang,P., Guachalla,L.M., Sun,B., Joerss,T.,
            Chen,Y.S., Groth,M., Krueger,A., Platzer,M., Yang,Y.G.,
            Rudolph,K.L. and Wang,Z.Q.
  TITLE     Smg6/Est1 licenses embryonic stem cell differentiation via
            nonsense-mediated mRNA decay
  JOURNAL   EMBO J 34 (12), 1630-1647 (2015)
   PUBMED   25770585
REFERENCE   4  (bases 1 to 4447)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4447)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 4447)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143911.1, BB869373.1, BC066787.1, AK133688.1 and AV146226.1.
            
            On or before Aug 20, 2006 this sequence version replaced
            XM_130930.8, XM_909775.2, XM_987629.1, NM_178246.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129286.1, SRR7974084.20168.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK143911.1         1-3
            4-107               BB869373.1         3-106
            108-111             AK143911.1         108-111
            112-221             BC066787.1         62-171
            222-820             AK143911.1         223-821
            821-3135            AK143911.1         823-3137
            3136-3413           AK143911.1         3139-3416
            3414-4445           AK133688.1         2238-3269
            4446-4447           AV146226.1         292-293
FEATURES             Location/Qualifiers
     source          1..4447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.8 cM"
     gene            1..4447
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /note="SMG5 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:229512"
                     /db_xref="MGI:MGI:2447364"
     exon            1..238
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3218
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /note="protein SMG5; EST1-like protein B; Smg-5 homolog,
                     nonsense mediated mRNA decay factor; LPTS-interacting
                     protein"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG5"
                     /protein_id="NP_839977.2"
                     /db_xref="CCDS:CCDS38480.1"
                     /db_xref="GeneID:229512"
                     /db_xref="MGI:MGI:2447364"
                     /translation="MSQGPPPGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKAAY
                     QEVFKPENVSLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIH
                     SRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLMGFKKPVSAS
                     GKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQL
                     GTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKSETRKLSP
                     SKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLG
                     LTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFTLALFSHLI
                     NHVNIRLQAELEEGENPVSAFQSDGTDEPESKEALEKEEPEPEPPTVVPQADEGRKSR
                     KHSRLSCLRRRRRHHPPKAGDDSDLSEGFESDSSHDSAQASDGSDSGSDKSLEGRGTA
                     FDAETDSEMNSQESRSDLEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIAS
                     NLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDG
                     SESEGSESSNRSCRNERSLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQS
                     LWNRLSVLLNLLPASAELQDSGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPP
                     LRAAHRRFNFDADRPLLSALEESVVRICCIRSFGHFVARLQGSILQFNPEVGIFVSIA
                     QSEQESLLQQAQAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSP
                     YLIPDTQALCYHLPLIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEF
                     KKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCRQLTLAQGAGEEDPSGMVT
                     IITGLHLDSPSALSGPMQAALQAAAHASVDVKNVLDFYRQWKEIG"
     exon            239..337
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            338..461
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            462..618
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            619..708
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            709..798
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            799..877
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1003
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1072
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1281
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1419
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..2022
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2198
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2274
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2450
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2609
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2669
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2829
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2920
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..2995
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3134
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..4447
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /note="putative"
     polyA_site      4445
                     /gene="Smg5"
                     /gene_synonym="LPTS-RP1; mKIAA1089"
                     /note="putative"
ORIGIN      
        1 gataggtgga ggaggagcca tctcaggcag ccgcctcaca gcgatggcgg ccgagcaggg
       61 ccggcggcag tggcggctgc gggtacagct ggagacggca gtggaggcgc cagtggtggg
      121 tggcgggggc ctgtgaccag gaggtgccct cgggcccagg caccatgagc caaggccctc
      181 ctccagggga gagcagcgaa cccgaggcaa aggtcctcca caccaagcgg ctttaccggg
      241 ctgtggtgga ggctgtgcat cggctagatc tcatcctttg caacaaagct gcttatcagg
      301 aagtgttcaa accagagaac gttagcctga ggaacaagct acgagagctc tgtgtgaagc
      361 ttatgttctt gcatccagta gactatggga ggaaggctga ggaactgctg tggagaaagg
      421 tatactatga agttatccaa cttatcaaga ctaacaaaaa gcacatccac agtcggagca
      481 ccttggaatg tgcctacagg actcatctgg tcgctggcat tggcttctac cagcatctcc
      541 ttctctatat ccagtcccac taccagctgg aactacagtg ctgcatcgac tggactcacg
      601 tcaccgatcc cctcatggga ttcaagaagc cagtatctgc ttcaggaaag gagatggatt
      661 gggcacaaat ggcttgccac cgatgcctgg tgtacctggg ggatctgtca cgctatcaga
      721 atgagttggc tggtgtggac accgagctgc tagctgagag attctactat caagccttgt
      781 cagtggctcc ccagattgga atgcccttca accagctggg tacccttgca ggcagcaagt
      841 attacaacgt ggaagccatg tattgctact tgcgctgcat ccagtcggaa gtgtcctttg
      901 agggagccta tgggaacctc aagagactat atgacaaggc agccaaaatg taccaccagt
      961 tgaagaagtc tgagaccagg aagctctccc ctagcaaaaa gcgatgcaaa gacattaaga
     1021 ggttgttggt gaacttcatg tacctacaaa gcctgttaca gcccaaaagt agctccgtgg
     1081 actcagaact gacctcactc tgccagtcag tcctagagga tttcaacctc tgcctcttct
     1141 acctgccctc ctcacccaac cttggtctaa ccaacgagga tgaggaggag tgtgaaagtg
     1201 gatatgcttt cctccccgac ctgctcatct ttcagatggc catcatctgc ctcatgggtg
     1261 tgcacagttt aaagagagca ggatccaagc attatagtgc agccattgct ttcaccctgg
     1321 ccctcttttc ccaccttatc aatcatgtca acatacggct gcaggcggaa ctggaagagg
     1381 gcgagaaccc tgtctcagct tttcagagtg atggcacaga tgaaccagag tcaaaagaag
     1441 cactagaaaa agaggagcca gagcctgagc ctcccactgt ggtaccccaa gctgatgagg
     1501 gcagaaagag ccgtaagcac tcccgactct cttgtctacg tcgtcgccgc cgccaccatc
     1561 ctcctaaagc tggtgatgac agtgacctga gtgagggttt tgaatctgac tctagccatg
     1621 actctgccca ggccagtgac ggctcagaca gtggctctga taagagcctg gaaggcaggg
     1681 gcactgcttt tgatgcagag acagactcag aaatgaacag ccaggagtcc cggtcagacc
     1741 tggaagatat ggaggatgag gaggggacaa gatctccagc ccaggagccc cctcaggcca
     1801 gatcagaggt tccagattcc ctcaatggcc ccctgggccc cagtgaagca agcattgcca
     1861 gcaatttaca agccatgtcc acccagatgt tccagaccaa gcgctgcttc cgactggctc
     1921 ccactttcag caacctgctc ctgcagccca ccacggaacc taacagtgtg gccagtcaca
     1981 ggccttgtgt caacggggat atggacaagc ctttagaacc agcctctgag gatggctccg
     2041 agtcagaggg gagcgagtcc agcaaccgct cctgtcgcaa cgagcgcagc cttcaggaga
     2101 agctgcaggc cctgatggct gagggcctcc ttcctgctgt gaaggtcttc ctggactggc
     2161 tgcgaaccaa ccctgacctc atcatcgtgt gtgcacagag ctctcaaagt ttgtggaacc
     2221 gcctgtctgt gttgctgaat ctgttgccag catctgctga gctccaggat tctggcctgg
     2281 ctctgtgttc cgaagtccaa ggtctccttg aaggctgcga gctgcctgac ctccctgcca
     2341 gcctgctgct cccagaggac atggcactgc gtaacctacc tcctctgcgg gctgctcata
     2401 gacgctttaa ctttgacgca gatcggcccc tgctcagtgc tttagaggag tcggtggtgc
     2461 gcatctgctg tatccgcagc tttgggcact ttgttgctcg cttacaaggc agcatcctgc
     2521 agttcaatcc agaggtcggc atcttcgtca gcattgctca gtctgagcag gagagcctgc
     2581 tgcagcaggc ccaggcccag tttcgtatgg cagaggagga ggctcggcgg aacaggctca
     2641 tgagagacat ggctcagcta cgattacagc tcgaggtctc ccaactggaa gggagcctac
     2701 agcagcccaa agctcagtca gccatgtctc cctacctcat ccctgacacc caggccctct
     2761 gctaccacct ccctcttatc cgccagcttg ccaccagtgg ccgcttcatc atcatcattc
     2821 caaggacagt gattgatggc ctggatttgc tgaagaaaga acagccaggg gccagggatg
     2881 gcatccggta cctggaggca gagtttaaaa agggaaacag atacattcgc tgccagaagg
     2941 aggtgggaaa gagctttgag cggcataaac tgaagaggca ggatgcagat gcctggactc
     3001 tctataagat cctggacagc tgcagacagc taactctggc ccagggggca ggggaggagg
     3061 acccaagtgg catggtgacc attatcacag gccttcattt ggacagcccc agtgcactct
     3121 ctgggcccat gcaggctgcc ctgcaagctg ctgcccatgc cagtgtggac gtcaagaacg
     3181 ttctagactt ctacaggcag tggaaggaga ttggttgaga ctggtctcca ggccctgccg
     3241 tggggctgac tccagatttc tcctgttctc cctggcgacc aggaccacca cctgtagtca
     3301 ccccaccaca tgcagactca agcaggcaaa caggaaggaa ggccagctgc actgaggctg
     3361 cagggagggc ccaggagcca gcggggagga tgggggcccc tgttgccaag gcgaaatcag
     3421 gaaagtgagg aagtgcttgg cgtaggagtg gccatggacc cccggccagc cttccacctt
     3481 aaacctgcag tccccagggg catgggcagg ggcaggcatg ggggtctgca tttcattgga
     3541 gcagttcctg gacttctgag aggaaaagat gacagaaggg ccctgtcctc acccaagatt
     3601 cagggtgggt ggggctggga gtttggagcc cctagctctt agggaagagt ggggagatac
     3661 tgagtgtctg catggttctc tgcagacccc acccatcctc aaggaccccc tcatcccttg
     3721 tctcccatgg ggaacagggc agctctagag ccagctgtgg gggctcttag ggaagcaggg
     3781 tctgcacact tggaggcccc acttctcctc tgctgctgcc cagcttccag gcccacttag
     3841 ggtgtgggct ggatggctgt acaccagcag tcatcccttc cccaccagca gtcactgtgc
     3901 tttgtgctct tggctgctgt actggataag gggtgccaat gagggagcga aggccaaggc
     3961 cacccctctg accatccagg gagagctgga ggaagggtgg cagaggggca aggtccctgg
     4021 gagctgctta cttagggccc tcctccatcc tagactaccc tccttttgcc cacccccaga
     4081 actagagccc tggtaggctg agcacaggct ggttttggag tgtcaaatga cacaggagca
     4141 gagatcatga atactcaggg gcagagtagc accctgagag cagagctata ggagaggctc
     4201 tggccaggac gaccccagtt ctacccctca ggctggaagc agagcatagc tggggctggg
     4261 ttcttttctg cttccccctc cttgccccaa ctggcctagc tgctttggct gtgcttaaga
     4321 ggagctggct tccagccttc cactaagaaa gaaggtctgg gaaaaccagg gaacagttgg
     4381 ggttaccaca tttccaattc tggcagactt gagactcaag cttaataaag acccccttcc
     4441 caagtgc
//
