LOCUS       NM_026914                608 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus single-pass membrane protein with aspartate rich tail
            1 (Smdt1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026914 XM_193800
VERSION     NM_026914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Chapoy Villanueva,H., Sung,J.H., Stevens,J.A., Zhang,M.J.,
            Nelson,P.M., Denduluri,L.S., Feng,F., O'Connell,T.D., Townsend,D.
            and Liu,J.C.
  TITLE     Distinct effects of cardiac mitochondrial calcium uniporter
            inactivation via EMRE deletion in the short and long term
  JOURNAL   J Mol Cell Cardiol 181, 33-45 (2023)
   PUBMED   37230379
  REMARK    GeneRIF: Distinct effects of cardiac mitochondrial calcium
            uniporter inactivation via EMRE deletion in the short and long
            term.
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Singh,R., Bartok,A., Paillard,M., Tyburski,A., Elliott,M. and
            Hajnoczky,G.
  TITLE     Uncontrolled mitochondrial calcium uptake underlies the
            pathogenesis of neurodegeneration in MICU1-deficient mice and
            patients
  JOURNAL   Sci Adv 8 (11), eabj4716 (2022)
   PUBMED   35302860
REFERENCE   4  (bases 1 to 608)
  AUTHORS   Liu,J.C., Syder,N.C., Ghorashi,N.S., Willingham,T.B., Parks,R.J.,
            Sun,J., Fergusson,M.M., Liu,J., Holmstrom,K.M., Menazza,S.,
            Springer,D.A., Liu,C., Glancy,B., Finkel,T. and Murphy,E.
  TITLE     EMRE is essential for mitochondrial calcium uniporter activity in a
            mouse model
  JOURNAL   JCI Insight 5 (4), 134063 (2020)
   PUBMED   32017711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 608)
  AUTHORS   De La Fuente,S., Fernandez-Sanz,C., Vail,C., Agra,E.J.,
            Holmstrom,K., Sun,J., Mishra,J., Williams,D., Finkel,T., Murphy,E.,
            Joseph,S.K., Sheu,S.S. and Csordas,G.
  TITLE     Strategic Positioning and Biased Activity of the Mitochondrial
            Calcium Uniporter in Cardiac Muscle
  JOURNAL   J Biol Chem 291 (44), 23343-23362 (2016)
   PUBMED   27637331
  REMARK    GeneRIF: MCU and EMRE proteins were mainly targeting to the
            IMM-outer mitochondrial membrane.
REFERENCE   6  (bases 1 to 608)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 608)
  AUTHORS   Liu,J.C., Liu,J., Holmstrom,K.M., Menazza,S., Parks,R.J.,
            Fergusson,M.M., Yu,Z.X., Springer,D.A., Halsey,C., Liu,C.,
            Murphy,E. and Finkel,T.
  TITLE     MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo
            Mitochondrial Calcium Overload
  JOURNAL   Cell Rep 16 (6), 1561-1573 (2016)
   PUBMED   27477272
REFERENCE   8  (bases 1 to 608)
  AUTHORS   Sancak,Y., Markhard,A.L., Kitami,T., Kovacs-Bogdan,E., Kamer,K.J.,
            Udeshi,N.D., Carr,S.A., Chaudhuri,D., Clapham,D.E., Li,A.A.,
            Calvo,S.E., Goldberger,O. and Mootha,V.K.
  TITLE     EMRE is an essential component of the mitochondrial calcium
            uniporter complex
  JOURNAL   Science 342 (6164), 1379-1382 (2013)
   PUBMED   24231807
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC028457.1.
            
            On Jan 24, 2005 this sequence version replaced XM_193800.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028457.1, BF607901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.56 cM"
     gene            1..608
                     /gene="Smdt1"
                     /gene_synonym="1500032L24Rik; Emre"
                     /note="single-pass membrane protein with aspartate rich
                     tail 1"
                     /db_xref="GeneID:69029"
                     /db_xref="MGI:MGI:1916279"
     exon            1..224
                     /gene="Smdt1"
                     /gene_synonym="1500032L24Rik; Emre"
                     /inference="alignment:Splign:2.1.0"
     exon            225..365
                     /gene="Smdt1"
                     /gene_synonym="1500032L24Rik; Emre"
                     /inference="alignment:Splign:2.1.0"
     exon            366..585
                     /gene="Smdt1"
                     /gene_synonym="1500032L24Rik; Emre"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggggtg tggctcccgg cgaggggcgg agctggagat ggcgtccacg gcggctcggc
       61 ggctggcctg ggttgcagtt cgacccgggg ctctctggag cgggccgagg gggaggagag
      121 gtggcgatgt ctacaccgta ccgggcagct caggtctcag ccaggtaccg tcgaggtcag
      181 tcatcgtcac tcgcagcggc gccattttgc ccaagccggt gaaaatgtcc tttggtcttc
      241 tccgagtgtt ctccattgtg atcccctttc tctatgtcgg gacactcatc agcaagaact
      301 tcgctgctct gcttgaggaa catgacattt ttgtcccaga ggatgacgac gacgacgatt
      361 aacagggcac agggagcaca ggagaaagca ctgatgatgt ggtggcatgc tcagctccct
      421 cccgtcggca gaagggtcaa ggaaagccct cagcctcacc tcctcatggt ttgtgacaag
      481 agcccagagt cctgtgcttt gggaggctcc ctcacggctg tccacagagt actggaaata
      541 acaagcaagc aaattaggag tgtataataa atgagtcatg tatgaaaaaa aaaaaaaaaa
      601 aaaaaaaa
//
