LOCUS       NM_008574                938 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus sperm mitochondria-associated cysteine-rich protein
            (Smcp), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_008574
VERSION     NM_008574.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 938)
  AUTHORS   Vourekas,A., Zheng,K., Fu,Q., Maragkakis,M., Alexiou,P., Ma,J.,
            Pillai,R.S., Mourelatos,Z. and Wang,P.J.
  TITLE     The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA
            processing
  JOURNAL   Genes Dev 29 (6), 617-629 (2015)
   PUBMED   25762440
REFERENCE   2  (bases 1 to 938)
  AUTHORS   Cullinane,D.L., Chowdhury,T.A. and Kleene,K.C.
  TITLE     Mechanisms of translational repression of the Smcp mRNA in round
            spermatids
  JOURNAL   Reproduction 149 (1), 43-54 (2015)
   PUBMED   25336347
REFERENCE   3  (bases 1 to 938)
  AUTHORS   Bagarova,J., Chowdhury,T.A., Kimura,M. and Kleene,K.C.
  TITLE     Identification of elements in the Smcp 5' and 3' UTR that repress
            translation and promote the formation of heavy inactive mRNPs in
            spermatids by analysis of mutations in transgenic mice
  JOURNAL   Reproduction 140 (6), 853-864 (2010)
   PUBMED   20876225
  REMARK    GeneRIF: Smcp mRNA translation is regulated by multiple elements in
            the 5' UTR and 3' UTR.
REFERENCE   4  (bases 1 to 938)
  AUTHORS   Turner,L.M., Chuong,E.B. and Hoekstra,H.E.
  TITLE     Comparative analysis of testis protein evolution in rodents
  JOURNAL   Genetics 179 (4), 2075-2089 (2008)
   PUBMED   18689890
REFERENCE   5  (bases 1 to 938)
  AUTHORS   Nam,S.Y., Maeda,S., Ogawa,K., Kurohmaru,M. and Hayashi,Y.
  TITLE     Expression pattern of the mitochondrial capsule selenoprotein mRNA
            in the mouse testis after puberty; in situ hybridization study
  JOURNAL   J Vet Med Sci 59 (11), 983-988 (1997)
   PUBMED   9409512
REFERENCE   6  (bases 1 to 938)
  AUTHORS   Cataldo,L., Baig,K., Oko,R., Mastrangelo,M.A. and Kleene,K.C.
  TITLE     Developmental expression, intracellular localization, and selenium
            content of the cysteine-rich protein associated with the
            mitochondrial capsules of mouse sperm
  JOURNAL   Mol Reprod Dev 45 (3), 320-331 (1996)
   PUBMED   8916043
REFERENCE   7  (bases 1 to 938)
  AUTHORS   Aho,H., Schwemmer,M., Tessman,D., Murphy,D., Mattei,G., Engel,W.
            and Adham,I.M.
  TITLE     Isolation, expression, and chromosomal localization of the human
            mitochondrial capsule selenoprotein gene (MCSP)
  JOURNAL   Genomics 32 (2), 184-190 (1996)
   PUBMED   8833144
REFERENCE   8  (bases 1 to 938)
  AUTHORS   Adham,I.M., Tessmann,D., Soliman,K.A., Murphy,D., Kremling,H.,
            Szpirer,C. and Engel,W.
  TITLE     Cloning, expression, and chromosomal localization of the rat
            mitochondrial capsule selenoprotein gene (MCS): the reading frame
            does not contain potential UGA selenocysteine codons
  JOURNAL   DNA Cell Biol 15 (2), 159-166 (1996)
   PUBMED   8634143
REFERENCE   9  (bases 1 to 938)
  AUTHORS   Karimpour,I., Cutler,M., Shih,D., Smith,J. and Kleene,K.C.
  TITLE     Sequence of the gene encoding the mitochondrial capsule
            selenoprotein of mouse sperm: identification of three in-phase TGA
            selenocysteine codons
  JOURNAL   DNA Cell Biol 11 (9), 693-699 (1992)
   PUBMED   1418626
REFERENCE   10 (bases 1 to 938)
  AUTHORS   Kleene,K.C., Smith,J., Bozorgzadeh,A., Harris,M., Hahn,L.,
            Karimpour,I. and Gerstel,J.
  TITLE     Sequence and developmental expression of the mRNA encoding the
            seleno-protein of the sperm mitochondrial capsule in the mouse
  JOURNAL   Dev Biol 137 (2), 395-402 (1990)
   PUBMED   2303168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY066868.1, BC055104.1 and BY456161.1.
            
            On Aug 3, 2017 this sequence version replaced NM_008574.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055104.1, AK077172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               BY066868.1         2-372
            372-936             BC055104.1         293-857
            937-938             BY456161.1         431-432
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..938
                     /gene="Smcp"
                     /gene_synonym="Mcs; Mcsp"
                     /note="sperm mitochondria-associated cysteine-rich
                     protein"
                     /db_xref="GeneID:17235"
                     /db_xref="MGI:MGI:96945"
     exon            1..245
                     /gene="Smcp"
                     /gene_synonym="Mcs; Mcsp"
                     /inference="alignment:Splign:2.1.0"
     exon            246..938
                     /gene="Smcp"
                     /gene_synonym="Mcs; Mcsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..697
                     /gene="Smcp"
                     /gene_synonym="Mcs; Mcsp"
                     /codon_start=1
                     /product="sperm mitochondrial-associated cysteine-rich
                     protein"
                     /protein_id="NP_032600.3"
                     /db_xref="CCDS:CCDS89661.1"
                     /db_xref="GeneID:17235"
                     /db_xref="MGI:MGI:96945"
                     /translation="MSDPSKTNQCPPPCCPPKPCCPPKPCCPQKPPCCPKSPCCPPKS
                     PCCPPKPCPCPPPCPCPCPATCPCPLKPPCCPQKCSCCPKKCTCCPQPPPCCAQPTCC
                     SSENKTESDSDTSGQTLEKGSQSPQSPPGAQGNWNQKKSNK"
     polyA_site      924
                     /gene="Smcp"
                     /gene_synonym="Mcs; Mcsp"
ORIGIN      
        1 agagaatctt gggggagagt attatgatgt cataaaagag ctgagagttt agaggggagg
       61 gaagcagagc acttgggtca gaagactttg acttctgata gccatggact cactagactg
      121 ctgaggaaga cccagcatct attcaatctg ctgaaacatc caggaaacta cttttaacac
      181 cgagaatcaa gtatggaaat gctgaactaa gaagagccca aggaagaact gtgttgccag
      241 atcaggaact ccaactctaa agaagatgag tgatccatcc aaaaccaacc agtgcccccc
      301 tccatgctgc ccaccaaaac catgttgccc acctaaaccg tgctgtccac agaaaccacc
      361 ttgctgtccc aaatccccat gctgcccacc caagtcccca tgttgccctc caaagccctg
      421 tccctgtcct cccccctgtc cctgtccctg tccagccacc tgtccttgtc cgctgaaacc
      481 accatgctgc ccacagaagt gttcgtgctg ccccaaaaag tgcacctgct gcccacagcc
      541 acctccttgc tgcgctcaac ctacctgctg ctcttcagag aacaagactg agtcagattc
      601 tgatacatct ggccaaactc tggagaaggg ctctcaatca ccacagtccc caccaggtgc
      661 tcaaggcaac tggaaccaga agaagtcaaa caaatagact gtccctgaca ccatgccctt
      721 tttcaaaggg tataggatta ctacaggtca ggctaagact atgttgtaaa gatgctgttt
      781 tcacaataac caacaagtcc actcaaccat aagctaccat ttcgacctaa ctgtaggcta
      841 ctattgcaac tggaaatgga aggtagaaaa ggatagaaac atcttgtcta gtgatcctga
      901 catttagata gcaaagaaat aaaagagcaa ataaaaag
//
