LOCUS       NM_027059               1268 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus single-pass membrane protein with coiled-coil domains
            2 (Smco2), mRNA.
ACCESSION   NM_027059 XM_132958 XM_909859 XR_030772
VERSION     NM_027059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1268)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1268)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006257.1 and AC164631.5.
            
            On or before Feb 5, 2009 this sequence version replaced
            XR_030772.1, XM_909859.2, XM_132958.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006257.1, AB046226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK006257.1         8-22
            16-16               AC164631.5         25128-25128         c
            17-1268             AK006257.1         24-1275
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..1268
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /note="single-pass membrane protein with coiled-coil
                     domains 2"
                     /db_xref="GeneID:69371"
                     /db_xref="MGI:MGI:1916621"
     exon            1..122
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            123..260
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1209
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 2"
                     /protein_id="NP_081335.1"
                     /db_xref="CCDS:CCDS51955.1"
                     /db_xref="GeneID:69371"
                     /db_xref="MGI:MGI:1916621"
                     /translation="MMSLQLGTAGKERQLAEKSRDLQNVSMTEGSEEVSEMDHISDRP
                     DEKDKPSENLQTDSLYKMDTEKWDGLEQESEHSQDPPSKPDEQEVTLVCEGPQVSQLS
                     PSTDESTPIPESLTHKLNYWHAKMGLQMKELGADHGDWLERINNIIQNINNTESTVKS
                     LLTEVISLENQSKNLEDSDQEADIEEKITEIRRQLKEVNIKLTQVDACEEARELKEKL
                     VEQIESFHKEMNVLNSKLEMYYTQGSDADSHNSEDVDTEQEEPLVPEASPSLSASPTP
                     PCSAVWKNALKLFVIVYVVTITGLSCYILFVDATFLFERVLPSVLGHRTMWDLREMMA
                     PFLNLEAEDLLPS"
     exon            261..366
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..494
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            495..644
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..720
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            721..777
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            778..834
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1010
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1268
                     /gene="Smco2"
                     /gene_synonym="1700023A16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagagagag caggcccaac tgcaagcttt cctcctcagg tgtggaacaa cttgcaaggc
       61 ctctcgtccc caggagctag gacaggctct gccaccagcc aaaagtccca gggaactctg
      121 agcactgaag tggcagctct cacaccagca gccctcagta aagacatgat gtctctgcag
      181 ttggggacag ctgggaagga acgtcagctg gctgagaaga gccgtgatct ccaaaatgtc
      241 agcatgaccg aaggttcgga ggaagtttcg gaaatggacc acatctcaga cagaccagat
      301 gaaaaagaca aaccttctga aaacctacaa accgattccc tttataagat ggacactgaa
      361 aaatgggatg ggttggagca ggagtccgag cacagccagg acccaccaag caaacccgat
      421 gagcaagaag tgactctagt ttgcgagggc cctcaagtgt ctcagctgtc accgtctacg
      481 gatgagagca ccccgatccc agagagcttg acccacaagc tgaactactg gcatgcaaag
      541 atgggtctcc aaatgaaaga actcggagcc gaccacggtg actggttgga gagaatcaac
      601 aacattatac aaaatataaa taatacagaa agcacggtga agagcttgct aaccgaggtt
      661 atatccctgg aaaaccagtc taaaaatctg gaggactctg atcaggaggc agacattgag
      721 gagaagatca cagaaattag aaggcaatta aaggaagtga acatcaagtt gactcaggtc
      781 gatgcttgcg aagaagcccg tgaattgaag gagaagcttg ttgaacagat agagagcttc
      841 cataaggaaa tgaatgtctt gaacagtaag ctggagatgt actacacgca aggatcggat
      901 gcggactccc ataactctga agacgtggac acggagcaag aagagcccct ggttcccgag
      961 gcttctccga gcctgtcagc atcacccact cccccctgca gtgccgtgtg gaagaacgca
     1021 ctgaagctgt tcgtcatagt ctacgtggtc accatcactg gactgtcgtg ctacatactg
     1081 tttgtggacg ccacgtttct cttcgaaagg gtgctgccca gcgtgctggg gcaccgcacc
     1141 atgtgggatc ttcgggagat gatggcgcct ttcttgaatt tagaagcaga agacttgtta
     1201 ccgtcctaaa gatccaaagt taccgataac tgacactctt cctctccaat aaagcatgtt
     1261 tctaaagc
//
